Alzahra University

Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all biologically active compounds are heterocycles or comprise a heterocycle and most frequently, nitrogen heterocycles as a backbone in their complex structures. These facts disclose and emphasize the vital role of heterocycles in modern drug design and drug discovery. In this review, we try to present a comprehensive overview of top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways. It is worth mentioning that the reported examples are actually limited to current top selling drugs, being or containing N-heterocycles and their synthetic information has been extracted from both scientific journals and the wider patent literature.

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTIndoles in Multicomponent Processes (MCPs)Morteza Shiri*View Author Information Department of Chemistry, Faculty of Science, Alzahra University, Vanak, Tehran 1993893973, Iran*Fax: +98 21 88041344. E-mail: [email protected]Cite this: Chem. Rev. 2012, 112, 6, 3508–3549Publication Date (Web):March 5, 2012Publication History Received13 October 2011Published online5 March 2012Published inissue 13 June 2012https://pubs.acs.org/doi/10.1021/cr2003954https://doi.org/10.1021/cr2003954review-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views14040Altmetric-Citations714LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldehydes,Condensation,Cyclization,Indoles,Reaction products Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTBis- and Trisindolylmethanes (BIMs and TIMs)†Morteza Shiri*‡, Mohammad Ali Zolfigol§, Hendrik Gerhardus Kruger⊥, and Zahra Tanbakouchian‡View Author Information Department of Chemistry, College of Science, Alzahra University, Vanak, 1993891176, Tehran, Iran, Faculty of Chemistry, Bu-Ali Sina University, 6517838683, Hamedan, Iran, School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa†This paper is dedicated to Prof. Dr. Junes Ipaktschi on occasion of his 70th birthday.* To whom correspondence should be addressed. Fax: +98 21 88041344. E-mail: [email protected]‡Alzahra University.§Bu-Ali Sina University.⊥University of KwaZulu-Natal.Cite this: Chem. Rev. 2010, 110, 4, 2250–2293Publication Date (Web):December 30, 2009Publication History Received18 May 2009Published online30 December 2009Published inissue 14 April 2010https://pubs.acs.org/doi/10.1021/cr900195ahttps://doi.org/10.1021/cr900195areview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views7054Altmetric-Citations509LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldehydes,Anions,Catalysts,Indoles,Reaction products Get e-Alerts

This is a continuity of a series of taxonomic papers where materials are examined, described and novel combinations are proposed where necessary to improve our traditional species concepts and provide updates on their classification. In addition to extensive morphological descriptions and appropriate asexual and sexual connections, DNA sequence data are also analysed from concatenated datasets (rDNA, TEF-α, RBP2 and β-Tubulin) to infer phylogenetic relationships and substantiate systematic position of taxa within appropriate ranks. Wherever new species or combinations are being proposed, we apply an integrative approach (morphological and molecular data as well as ecological features wherever applicable). Notes on 125 fungal taxa are compiled in this paper, including eight new genera, 101 new species, two new combinations, one neotype, four reference specimens, new host or distribution records for eight species and one alternative morphs. The new genera introduced in this paper are Alloarthopyrenia, Arundellina, Camarosporioides, Neomassaria, Neomassarina, Neotruncatella, Paracapsulospora and Pseudophaeosphaeria. The new species are Alfaria spartii, Alloarthopyrenia italica, Anthostomella ravenna, An. thailandica, Arthrinium paraphaeospermum, Arundellina typhae, Aspergillus koreanus, Asterina cynometrae, Bertiella ellipsoidea, Blastophorum aquaticum, Cainia globosa, Camarosporioides phragmitis, Ceramothyrium menglunense, Chaetosphaeronema achilleae, Chlamydotubeufia helicospora, Ciliochorella phanericola, Clavulinopsis aurantiaca, Colletotrichum insertae, Comoclathris italica, Coronophora myricoides, Cortinarius fulvescentoideus, Co. nymphatus, Co. pseudobulliardioides, Co. tenuifulvescens, Cunninghamella gigacellularis, Cyathus pyristriatus, Cytospora cotini, Dematiopleospora alliariae, De. cirsii, Diaporthe aseana, Di. garethjonesii, Distoseptispora multiseptata, Dis. tectonae, Dis. tectonigena, Dothiora buxi, Emericellopsis persica, Gloniopsis calami, Helicoma guttulatum, Helvella floriforma, H. oblongispora, Hermatomyces subiculosa, Juncaceicola italica, Lactarius dirkii, Lentithecium unicellulare, Le. voraginesporum, Leptosphaeria cirsii, Leptosphaeria irregularis, Leptospora galii, Le. thailandica, Lindgomyces pseudomadisonensis, Lophiotrema bambusae, Lo. fallopiae, Meliola citri-maximae, Minimelanolocus submersus, Montagnula cirsii, Mortierella fluviae, Muriphaeosphaeria ambrosiae, Neodidymelliopsis ranunculi, Neomassaria fabacearum, Neomassarina thailandica, Neomicrosphaeropsis cytisi, Neo. cytisinus, Neo. minima, Neopestalotiopsis cocoës, Neopestalotiopsis musae, Neoroussoella lenispora, Neotorula submersa, Neotruncatella endophytica, Nodulosphaeria italica, Occultibambusa aquatica, Oc. chiangraiensis, Ophiocordyceps hemisphaerica, Op. lacrimoidis, Paracapsulospora metroxyli, Pestalotiopsis sequoiae, Peziza fruticosa, Pleurotrema thailandica, Poaceicola arundinis, Polyporus mangshanensis, Pseudocoleophoma typhicola, Pseudodictyosporium thailandica, Pseudophaeosphaeria rubi, Purpureocillium sodanum, Ramariopsis atlantica, Rhodocybe griseoaurantia, Rh. indica, Rh. luteobrunnea, Russula indoalba, Ru. pseudoamoenicolor, Sporidesmium aquaticivaginatum, Sp. olivaceoconidium, Sp. pyriformatum, Stagonospora forlicesenensis, Stagonosporopsis centaureae, Terriera thailandica, Tremateia arundicola, Tr. guiyangensis, Trichomerium bambusae, Tubeufia hyalospora, Tu. roseohelicospora and Wojnowicia italica. New combinations are given for Hermatomyces mirum and Pallidocercospora thailandica. A neotype is proposed for Cortinarius fulvescens. Reference specimens are given for Aquaphila albicans, Leptospora rubella, Platychora ulmi and Meliola pseudosasae, while new host or distribution records are provided for Diaporthe eres, Di. siamensis, Di. foeniculina, Dothiorella iranica, Do. sarmentorum, Do. vidmadera, Helvella tinta and Vaginatispora fuckelii, with full taxonomic details. An asexual state is also reported for the first time in Neoacanthostigma septoconstrictum. This paper contributes to a more comprehensive update and improved identification of many ascomycetes and basiodiomycetes.

Controlling the morphology and surface passivation in perovskite solar cells is paramount in obtaining optimal optoelectronic properties. This study incorporates N-doped graphene nanosheets in the perovskite layer, which simultaneously induces an improved morphology and surface passivation at the perovskite/spiro interface, resulting in enhancement in all photovoltaic parameters. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Background: Measuring anxiety level in clinical and non-clinical population needs valid and reliable tool. This research examined the validity and reliability of Beck Anxiety Inventory in Iranian normal population as well as clinically anxious patients.Methods: First, a two-session course was run to train research workers. After they were sufficiently prepared, they were dispatched to different regions of the city, Tehran, referring to residential places for men and women volunteer to take part in the research. At the end, 1513 respondents were randomly recruited and tested using Beck Anxiety Inventory (BAI). Of this population, 112 respondents were randomly selected and re-tested in order to measure test-retest reliability with a one-month interval time between first and second tests. Meanwhile, 261 clinically anxious patients (from clinics and mental health centers) were tested. In order to measure validity, 150 patients were interviewed by two parallel clinicians and the anxiety level was rated based on a 10-point scale from 0 (the least) to 10 (the most). The two raters were blind to the BAI scores of the patients.    Results: For data reduction and analysis, the SPSS for Windows-edition 14, was conducted. Findings showed that the Persian version of BAI proved a good reliability (r=0.72, p<0.001), a very good validity (r=0.83, p<0.001), and an excellent internal consistency (Alpha=0.92). Conclusions: The results support the applicability of BAI in Iranian population and suggest the use of this inventory for clinical and research aims. Persian version of BAI not only can help clinicians in assessment and diagnosis, but also assist researchers to evaluate anxiety level when needed.

-Dimethylformamide (DMF) is frequently used as an aprotic solvent in chemical transformations in laboratories of academia as well as in those of chemical industry. In the present review, we will reveal that DMF is actually something much more than a solvent. It is a unique chemical since, as well as being an effective polar aprotic solvent, it can play three other important roles in organic chemistry. It can be used as a reagent, a catalyst, and a stabilizer.

Developed by OpenAI, ChatGPT (Conditional Generative Pre-trained Transformer) is an artificial intelligence technology that is fine-tuned using supervised machine learning and reinforcement learning techniques, allowing a computer to generate natural language conversation fully autonomously. ChatGPT is built on the transformer architecture and trained on millions of conversations from various sources. The system combines the power of pre-trained deep learning models with a programmability layer to provide a strong base for generating natural language conversations. In this study, after reviewing the existing literature, we examine the applications, opportunities, and threats of ChatGPT in 10 main domains, providing detailed examples for the business and industry as well as education. We also conducted an experimental study, checking the effectiveness and comparing the performances of GPT-3.5 and GPT-4, and found that the latter performs significantly better. Despite its exceptional ability to generate natural-sounding responses, the authors believe that ChatGPT does not possess the same level of understanding, empathy, and creativity as a human and cannot fully replace them in most situations.

Inflationary models are usually based on dynamics of one or more scalar fields coupled to gravity. In this work we present a new class of inflationary models, gauge-flation or non-Abelian gauge field inflation, where slow-roll inflation is driven by a non-Abelian gauge field. This class of models is based on a gauge field theory with a generic non-Abelian gauge group minimally coupled to gravity. We then focus on a particular gauge-flation model by specifying the action for the gauge theory. This model has two parameters which can be determined using the current cosmological data and has the prospect of being tested by Planck satellite data. Moreover, the values of these parameters are within the natural range of parameters in generic grand unified theories of particle physics.

The last decade has been transformative for micro(nano)plastic (MnP) research with recent discoveries revealing the extent and magnitude of MnP pollution, even in the world's most remote places. Historically, while researchers recognized that most plastic pollution was derived from land-based sources, it was generally believed that microplastic particles (i.e., plastic fragments <5 mm) was only a marine pollution issue with effects largely impacting marine biota. However, over the last decade MnP research has progressed rapidly with recent discoveries of MnPs in freshwater, snow, ice, soil, terrestrial biota, air and even found in ocean spray. MnPs have now been found in every environmental compartment on earth, within tissues and gastrointestinal tracts of thousands of species, including humans, resulting in harmful effects. The last 10 years has also seen the development of new techniques for MnP analysis, and re-purposing of old technologies allowing us to determine the extent and magnitude of plastic pollution down to the nano size range (<1 µm). This short review summarizes what key milestones and major advances have been made in microplastic and nanoplastic research in the environment, including their sources, fate, and effects over the last decade.

In [A. Maleknejad and M. M. Sheikh-Jabbari, arXiv:1102.1513.] we introduced an inflationary scenario, non-Abelian gauge field inflation or gauge-flation for short, in which slow-roll inflation is driven by non-Abelian gauge field minimally coupled to gravity. We present a more detailed analysis, both numerical and analytical, of the gauge-flation. By studying the phase diagrams of the theory, we show that getting enough number of e-folds during a slow-roll inflation is fairly robust to the choice of initial gauge field values. In addition, we present a detailed analysis of the cosmic perturbation theory in gauge-flation which has many special and interesting features compared the standard scalar-driven inflationary models. The specific gauge-flation model we study in this paper has two parameters, a cutoff scale $\ensuremath{\Lambda}$ and the gauge coupling $g$. Fitting our results with the current cosmological data fixes $\ensuremath{\Lambda}\ensuremath{\sim}10H\ensuremath{\sim}{10}^{15}\text{ }\text{ }\mathrm{GeV}$ ($H$ is the Hubble parameter) and $g\ensuremath{\sim}{10}^{\ensuremath{-}4}$, which are in the natural range of parameters in generic particle physics beyond standard models. Our model also predicts a tensor-to-scalar ratio $r&gt;0.05$, in the range detectable by the Planck satellite.

Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis of natural products. We underscored these achievements in a report published in Tetrahedron up to 2012. Since then, there has been tremendous growth in this field and numerous articles have been published after 2012. In this review, we tried to go insight and highlight the current developments in the applications of SMCR as a key and strategic step (steps) in the total synthesis of biologically active natural products accomplished and reported from 2012 till date.

In the last decades, universities and higher education institutes have widely employed a learning management system (LMS) to monitor and manage electronic learning and teaching. Contrary to the significant role of LMS in educational settings, most research has focused on initial acceptance, and few attempts have been made to investigate factors influencing students’ continuance intention to use LMS. The present study is an effort towards this research direction by proposing an integrated model of expectation-conformation model (ECM), technology acceptance model (TAM), social influence (subjective norm), and perceived enjoyment (hedonic value). The proposed model is tested using statistical data from 153 university students from Mehralborz University (MAU), Tehran, Iran. To verify the proposed theoretical model, we ran partial least squares (PLS)/ structured equation modeling (SEM). The findings of this study reveal that the perceived usefulness is the strongest predictor of students’ continuance intention. Surprisingly, our results also indicate that students’ attitudes toward LMS and their satisfaction level exert no significant influence on continuance intention. The implications of this study and its limitations are also discussed.

Academic stress is the most common emotional or mental state that students experience during their studies. Stress is a result of a wide range of issues, including test and exam burden, a demanding course, a different educational system, and thinking about future plans upon graduation. A sizeable body of literature in stress management research has found that self-regulation and being mindful will help students to cope up with the stress and dodge long-term negative consequences, such as substance abuse. The present study aims to investigate the influence of academic stress, self-regulation, and mindfulness among undergraduate students in Klang Valley, Malaysia, and to identify mindfulness as the mediator between academic stress and self-regulation. For this study, a total of 384 undergraduate students in Klang Valley, Malaysia were recruited. Using Correlational analysis, results revealed that there was a significant relationship between academic stress, self-regulation, and mindfulness. However, using SPSS mediational analysis, mindfulness did not prove the mediator role in the study.

In this review, we update our previous presentation, underscoring the recent applications of isocyanides as privileged synthons in the synthesis of various heterocyclic compounds, especially focused on those synthesized<italic>via</italic>multicomponent reactions.

Nanocarriers as drug/biomolecule delivery systems have been significantly developed during recent decades. Given the stability, reasonable delivery efficiency, and safety of nanocarriers, there are several barriers in the fulfillment of successful clinical application of these delivery systems. These challenges encouraged drug delivery researchers to establish innovative nanocarriers with longer circulation time, high stability, and high compatibility. Exosomes are extracellular nanometer-sized vesicles released through various cells. These vesicles serve as nanocarriers, possessing great potential to overcome some obstacles encountered in gene and drug delivery due to their natural affinity to recipient cells and the inherent capability to shuttle the genes, lipids, proteins, and RNAs between cells. So far, there has been a lot of valuable research on drug delivery by exosomes, but research on RNA delivery, especially mRNA, is very limited. Since mRNA-based vaccines and therapies have recently gained particular prominence in various diseases, it is essential to find a suitable delivery system due to the large size and destructive nature of these nucleic acids. That's why we're going to take a look at the unique features of exosomes and their isolation and loading methods, to embrace this idea that exosome-mediated mRNA-based therapies would be introduced as a very efficient strategy in disease treatment within the near future.

In this review, a number of applications of chiral oxazolidinones in the asymmetric alkylation reaction applied to total synthesis are described.

In this review, various approaches for the construction of benzofurans as an important moiety in different natural products during the total synthesis of the natural of products are underscored.

In this review, we are trying to underscore the application of FIS in one of the crucial step of indole construction in the total synthesis of biologically active natural products.

Among various immobilizing materials, conductive polymer-based nanocomposites have been widely applied to fabricate the biosensors, because of their outstanding properties such as excellent electrocatalytic activity, high conductivity, and strong adsorptive ability compared to conventional conductive polymers. Electrochemical biosensors have played a significant role in delivering the diagnostic information and therapy monitoring in a rapid, simple, and low cost portable device. This paper reviews the recent developments in conductive polymer-based nanocomposites and their applications in electrochemical biosensors. The article starts with a general and concise comparison between the properties of conducting polymers and conducting polymer nanocomposites. Next, the current applications of conductive polymer-based nanocomposites of some important conducting polymers such as PANI, PPy, and PEDOT in enzymatic and nonenzymatic electrochemical biosensors are overviewed. This review article covers an 8-year period beginning in 2010.