Amir Oncology Hospital

The central nervous system is one of the most common sites of aspergillosis involvement in immunocompromised people, just after sinopulmonary infections. Neuroimaging modalities are crucial for the diagnosis of cerebral aspergillosis (CA). Here, we describe a rare case of concurrent mixed aspergillosis infection with Aspergillus fumigatus and Aspergillus niger in a 2-year-old leukemic boy. The first neuroimaging finding, which was followed by focal seizures, was recognized as extensive cerebral hemorrhage in the absence of thrombocytopenia and coagulopathy. As the patient survived for more than 4 months after diagnosis, we were able to perform a neuroimaging evaluation during long-term observation. In serial neuroimaging studies, a secondary fungal abscess was observed at the site of hemorrhagic infarctions. Finally, the patient died from bacterial sepsis. In this case study, we try to categorize the neuroimaging findings of CA into distinct phases to better understand how CA changes over time.

In present study, silver nanoparticles were produced from interaction the ethanolic extract of Salvadora persica leaf with silver nitrate solution. UV-vis spectroscopy and PSA device confirmed size and formation of silver nanoparticles. The results showed the average size of silver nanoparticles synthesized is 6.2 nm and the minimum size of silver nanoparticles is 4.7 nm. Furthermore, the antifungal activity of silver nanoparticles and ethanolic extract of Salvadora persica leaf against Aspergillus niger and Penicillium digitatum were investigated by using disk diffusion method. The results showed that silver nanoparticles have significant antifungal activities in comparison to other treatmeants. So these silver nanoparticles have unique antifungal activity and can be used of them in pharmaceutical Industries.

We report an 18 year old boy with Aplastic anemia complicated by serious fungal rhinosinusitis. Despite prompt treatment and early repeated surgical debridements, he died after about more than 6 weeks of hard challenges with fungal infections. Current strategies against invasive fungal infections (IFIs) in patients with Aplastic anemia may be inadequate for the management of serious complications. Antifungal prophylaxis is highly recommended in pre-transplant period for severe form of Aplastic anemia.