Carnegie Mellon University Australia

Novel species of fungi described in the present study include the following from Australia: Vermiculariopsiella eucalypti, Mulderomyces natalis (incl. Mulderomyces gen. nov.), Fusicladium paraamoenum, Neotrimmatostroma paraexcentricum, and Pseudophloeospora eucalyptorum on leaves of Eucalyptus spp., Anungitea grevilleae (on leaves of Grevillea sp.), Pyrenochaeta acaciae (on leaves of Acacia sp.), and Brunneocarpos banksiae (incl. Brunneocarpos gen. nov.) on cones of Banksia attenuata. Novel foliicolous taxa from South Africa include Neosulcatispora strelitziae (on Strelitzia nicolai), Colletotrichum ledebouriae (on Ledebouria floridunda), Cylindrosympodioides brabejum (incl. Cylindrosympodioides gen. nov.) on Brabejum stellatifolium, Sclerostagonospora ericae (on Erica sp.), Setophoma cyperi (on Cyperus sphaerocephala), and Phaeosphaeria breonadiae (on Breonadia microcephala). Novelties described from Robben Island (South Africa) include Wojnowiciella cissampeli and Diaporthe cissampeli (both on Cissampelos capensis), Phaeotheca salicorniae (on Salicornia meyeriana), Paracylindrocarpon aloicola (incl. Paracylindrocarpon gen. nov.) on Aloe sp., and Libertasomyces myopori (incl. Libertasomyces gen. nov.) on Myoporum serratum. Several novelties are recorded from La Réunion (France), namely Phaeosphaeriopsis agapanthi (on Agapanthus sp.), Roussoella solani (on Solanum mauritianum), Vermiculariopsiella acaciae (on Acacia heterophylla), Dothiorella acacicola (on Acacia mearnsii), Chalara clidemiae (on Clidemia hirta), Cytospora tibouchinae (on Tibouchina semidecandra), Diaporthe ocoteae (on Ocotea obtusata), Castanediella eucalypticola, Phaeophleospora eucalypticola and Fusicladium eucalypticola (on Eucalyptus robusta), Lareunionomyces syzygii (incl. Lareunionomyces gen. nov.) and Parawiesneriomyces syzygii (incl. Parawiesneriomyces gen. nov.) on leaves of Syzygium jambos. Novel taxa from the USA include Meristemomyces arctostaphylos (on Arctostaphylos patula), Ochroconis dracaenae (on Dracaena reflexa), Rasamsonia columbiensis (air of a hotel conference room), Paecilomyces tabacinus (on Nicotiana tabacum), Toxicocladosporium hominis (from human broncoalveolar lavage fluid), Nothophoma macrospora (from respiratory secretion of a patient with pneumonia), and Penidiellopsis radicularis (incl. Penidiellopsis gen. nov.) from a human nail. Novel taxa described from Malaysia include Prosopidicola albizziae (on Albizzia falcataria), Proxipyricularia asari (on Asarum sp.), Diaporthe passifloricola (on Passiflora foetida), Paramycoleptodiscus albizziae (incl. Paramycoleptodiscus gen. nov.) on Albizzia falcataria, and Malaysiasca phaii (incl. Malaysiasca gen. nov.) on Phaius reflexipetalus. Two species are newly described from human patients in the Czech Republic, namely Microascus longicollis (from toenails of patient with suspected onychomycosis), and Chrysosporium echinulatum (from sole skin of patient). Furthermore, Alternaria quercicola is described on leaves of Quercus brantii (Iran), Stemphylium beticola on leaves of Beta vulgaris (The Netherlands), Scleroderma capeverdeanum on soil (Cape Verde Islands), Scleroderma dunensis on soil, and Blastobotrys meliponae from bee honey (Brazil), Ganoderma mbrekobenum on angiosperms (Ghana), Geoglossum raitviirii and Entoloma kruticianum on soil (Russia), Priceomyces vitoshaensis on Pterostichus melas (Carabidae) (Bulgaria) is the only one for which the family is listed, Ganoderma ecuadoriense on decaying wood (Ecuador), Thyrostroma cornicola on Cornus officinalis (Korea), Cercophora vinosa on decorticated branch of Salix sp. (France), Coprinus pinetorum, Coprinus littoralis and Xerocomellus poederi on soil (Spain). Two new genera from Colombia include Helminthosporiella and Uwemyces on leaves of Elaeis oleifera. Two species are described from India, namely Russula intervenosa (ectomycorrhizal with Shorea robusta), and Crinipellis odorata (on bark of Mytragyna parviflora). Novelties from Thailand include Cyphellophora gamsii (on leaf litter), Pisolithus aureosericeus and Corynascus citrinus (on soil). Two species are newly described from Citrus in Italy, namely Dendryphiella paravinosa on Citrus sinensis, and Ramularia citricola on Citrus floridana. Morphological and culture characteristics along with ITS nrDNA barcodes are provided for all taxa.

A wide range of research has promised new tools for forecasting infectious disease dynamics, but little of that research is currently being applied in practice, because tools do not address key public health needs, do not produce probabilistic forecasts, have not been evaluated on external data, or do not provide sufficient forecast skill to be useful. We developed an open collaborative forecasting challenge to assess probabilistic forecasts for seasonal epidemics of dengue, a major global public health problem. Sixteen teams used a variety of methods and data to generate forecasts for 3 epidemiological targets (peak incidence, the week of the peak, and total incidence) over 8 dengue seasons in Iquitos, Peru and San Juan, Puerto Rico. Forecast skill was highly variable across teams and targets. While numerous forecasts showed high skill for midseason situational awareness, early season skill was low, and skill was generally lowest for high incidence seasons, those for which forecasts would be most valuable. A comparison of modeling approaches revealed that average forecast skill was lower for models including biologically meaningful data and mechanisms and that both multimodel and multiteam ensemble forecasts consistently outperformed individual model forecasts. Leveraging these insights, data, and the forecasting framework will be critical to improve forecast skill and the application of forecasts in real time for epidemic preparedness and response. Moreover, key components of this project-integration with public health needs, a common forecasting framework, shared and standardized data, and open participation-can help advance infectious disease forecasting beyond dengue.

Novel species of fungi described in the present study include the following from Australia: Neoseptorioides eucalypti gen. & sp. nov. from Eucalyptus radiata leaves, Phytophthora gondwanensis from soil, Diaporthe tulliensis from rotted stem ends of Theobroma cacao fruit, Diaporthe vawdreyi from fruit rot of Psidium guajava, Magnaporthiopsis agrostidis from rotted roots of Agrostis stolonifera and Semifissispora natalis from Eucalyptus leaf litter. Furthermore, Neopestalotiopsis egyptiaca is described from Mangifera indica leaves (Egypt), Roussoella mexicana from Coffea arabica leaves (Mexico), Calonectria monticola from soil (Thailand), Hygrocybe jackmanii from littoral sand dunes (Canada), Lindgomyces madisonensis from submerged decorticated wood (USA), Neofabraea brasiliensis from Malus domestica (Brazil), Geastrum diosiae from litter (Argentina), Ganoderma wiiroense on angiosperms (Ghana), Arthrinium gutiae from the gut of a grasshopper (India), Pyrenochaeta telephoni from the screen of a mobile phone (India) and Xenoleptographium phialoconidium gen. & sp. nov. on exposed xylem tissues of Gmelina arborea (Indonesia). Several novelties are introduced from Spain, namely Psathyrella complutensis on loamy soil, Chlorophyllum lusitanicum on nitrified grasslands (incl. Chlorophyllum arizonicum comb. nov.), Aspergillus citocrescens from cave sediment and Lotinia verna gen. & sp. nov. from muddy soil. Novel foliicolous taxa from South Africa include Phyllosticta carissicola from Carissa macrocarpa, Pseudopyricularia hagahagae from Cyperaceae and Zeloasperisporium searsiae from Searsia chirindensis. Furthermore, Neophaeococcomyces is introduced as a novel genus, with two new combinations, N. aloes and N. catenatus. Several foliicolous novelties are recorded from La Réunion, France, namely Ochroconis pandanicola from Pandanus utilis, Neosulcatispora agaves gen. & sp. nov. from Agave vera-cruz, Pilidium eucalyptorum from Eucalyptus robusta, Strelitziana syzygii from Syzygium jambos (incl. Strelitzianaceae fam. nov.) and Pseudobeltrania ocoteae from Ocotea obtusata (Beltraniaceae emend.). Morphological and culture characteristics along with ITS DNA barcodes are provided for all taxa.

Oliver Adams, Adam Makarucha, Graham Neubig, Steven Bird, Trevor Cohn. Proceedings of the 15th Conference of the European Chapter of the Association for Computational Linguistics: Volume 1, Long Papers. 2017.

Array multipliers are well suited for VLSI implementation because of the regularity in their iterative structure. However, most VLSI circuits are difficult to test. This correspondence shows that, with appropriate cell design, array multipliers can be designed to be very easily testable. An array multiplier is called C-testable if all its adder cells can be exhaustively tested while requiring only a constant number of test patterns. The testability of two well-known array multiplier structures is studied in detail. The conventional design of the carry–save array multiplier is modified. The modified design is shown to be C-testable and requires only 16 test patterns. Similar results are obtained for the Baugh–Wooley two's complement array multiplier. A modified design of the Baugh–Wooley array multiplier is shown to be C-testable and requires 55 test patterns. The C-testability of two other array multipliers, namely the carry–propagate and the TRW designs, is also presented.

Direct human control of multi-robot systems is limited by the cognitive ability of humans to coordinate numerous interacting components. In remote environments, such as those encountered during planetary or ocean exploration, a further limit is imposed by communication bandwidth and delay. Market based planning can give humans a higher-level interface to multi-robot systems in these scenarios. Operators provide high level tasks and attach a reward to the achievement of each task. The robots then trade these tasks through a market based mechanism. The challenge for the system designer is to create bidding algorithms for the robots that yield high overall system performance. Opportunity cost provides a nice basis for such bidding algorithms since it encapsulates all the costs and benefits we are interested in. Unfortunately, computing it can be difficult. We propose a method of learning opportunity costs in market based planners. We provide analytic results in simplified scenarios and empirical results on our FIRE simulator, which focuses on exploration of Mars by multiple, heterogeneous rovers.

Elevated pulse pressure can cause blood-brain barrier dysfunction and subsequent adverse neurological changes that may drive or contribute to the development of dementia with age. In short, elevated pulse pressure dysregulates cerebral endothelial cells and increases cellular production of oxidative and inflammatory molecules. The resulting cerebral microvascular damage, along with excessive pulsatile mechanical force, can induce breakdown of the blood-brain barrier, which in turn triggers brain cell impairment and death. We speculate that elevated pulse pressure may also reduce the efficacy of other therapeutic strategies for dementia. For instance, BACE1 inhibitors and anti-amyloid-β biologics reduce amyloid-β deposits in the brain that are thought to be a cause of Alzheimer's disease, the most prevalent form of dementia. However, upregulation of oxidative and inflammatory molecules and increased amyloid-β secretion by cerebral endothelial cells exposed to elevated pulse pressure may hinder cognitive improvements with these drugs. Additionally, stem or progenitor cell therapy has the potential to repair blood-brain barrier damage, but chronic oxidative and inflammatory stress due to elevated pulse pressure can inhibit stem and progenitor cell regeneration. Finally, we discuss current efforts to repurpose blood pressure medications to prevent or treat dementia. We propose that new drugs or devices should be developed to safely reduce elevated pulse pressure specifically to the brain. Such novel technologies may alleviate an entire downstream pathway of cellular dysfunction, oxidation, inflammation, and amyloidogenesis, thereby preventing pulse-pressure-induced cognitive decline. Furthermore, these technologies may also enhance efficacy of other dementia therapeutics when used in combination.

We consider a common indivisible good allocation problem whose popular applications include on‐campus housing, kidney exchange, and school choice. We show that the so‐called New House 4 (NH4) mechanism, which has been in use at MIT since the 1980s, is equivalent to a natural adaptation of the well‐known Gale–Shapley (GS) mechanism. We run two experiments comparing NH4 with the prominently advocated Top Trading Cycles (TTC) mechanism and NH4 with GS. We find that under NH4, the participation rate is significantly higher than under TTC. Based on a new ordinal test of efficiency, NH4 is more likely to Pareto dominate TTC.

A spawning aggregation of the lanternfish Diaphus danae in the Coral Sea, that is fed on by spawning aggregations of yellowfin and bigeye tuna, has been sampled by mid-water trawling for the first time. Males and females in the aggregation occurred at a ratio of 23 to 1 and occupied two non-overlapping size classes (males 71.2–95.1-mm standard length (SL), females 99.0–121.4-mm SL). Hydrated oocytes with single oil droplets, which indicated imminent spawning, were in higher proportion in the first trawl (2134 hours to 2234 hours) than in the final trawl (0324 hours to 0424 hours) through the aggregation. Maximum estimated female D. danae fecundity (25 803) and gonadosomatic index (34.01) were higher than for any other lanternfish species recorded. Bigeye tuna (Thunnus obesus) individuals collected from aggregations were estimated to have 81–319 D. danae specimens in their stomachs. The annual Coral Sea D. danae aggregation is the only confirmed lanternfish spawning aggregation in Australian waters. The D. danae spawning aggregation provides a rich, transient foraging resource for spawning bigeye and yellowfin tuna in the Coral Sea, these being the only known tuna spawning aggregations in the Eastern Tuna and Billfish Fishery.

Enterprise architecture (EA) is useful for effectively structuring digital platforms with digital transformation in information societies. Moreover, digital platforms in the healthcare industry accelerate and increase the efficiency of drug discovery and development processes. However, there is the lack of knowledge concerning relationships between EA and digital platforms, in spite of the needs of it. In this paper, we investigated and analyzed the process of drug design and development within the healthcare industry, together with related work in using an enterprise architecture framework for the digital era named the Adaptive Integrated Digital Architecture Framework (AIDAF), specifically supporting the design of digital platforms there. Based on this analysis, we evaluate a method and propose a new reference architecture for promoting digital platforms in the healthcare industry, with future specific aspects of them making effective use of Artificial Intelligence (AI). The practical and theoretical contributions include: (1) Streamlined processes through digital platforms in organizations. (2) Informal knowledge supply and sharing among organizational members through digital platforms. (3) Efficiency and effectiveness in planning production and business for drug development. The findings indicate that EA with digital platforms using the AIDAF contribute to digital transformation with effectiveness for new drugs in the healthcare industry.

BACKGROUND: It is estimated that approximately 10-15% of pregnant women report antihistamine use during pregnancy. Although antihistamines are generally considered safe during pregnancy, results from published studies are inconsistent. METHODS: Using a case-control study design we analyzed 41,148 pregnancies (30,091 cases and 11,057 controls) from the National Birth Defects Prevention Study (1997-2011). Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals for 64 birth defect groupings in relation to early pregnancy exposure to 14 distinct antihistamines. Models were adjusted for maternal age, race, parity, education level, prenatal care, folic acid use, smoking and alcohol use, and study site. RESULTS: Approximately 13% of cases and controls were exposed to an antihistamine during early pregnancy. Analyses were restricted to those defects where more than five cases were exposed to the antihistamine of interest, generating 340 analyses which yielded 20 (5.9%) significant positive associations (adjusted ORs ranging from 1.21 to 4.34). CONCLUSIONS: Only a few of our findings were consistent with previous studies. There is a lack of strong evidence to conclude that birth defects are associated with exposure to antihistamines during early pregnancy.

Most research comparing different farming systems has been conducted on relatively uniform plots at small scales made necessary by the desire for sufficient replication of the systems and cost limitations. This paper describes an alternative approach to plan the allocation of land to three unreplicated whole-farm management systems such that each farmlet had equivalent starting conditions and yet was at a scale credible to both livestock producers and researchers. The paddocks of each farmlet were distributed across the landscape in a ‘patchwork quilt’ pattern after six iterations of a mapping exercise using a Geographic Information System. Allocation of paddocks took into account those variables of the landscape and natural resource capacity that were not able to be altered. An important benefit of the procedure was that it ensured that the farmlets were co-located with contiguous paddock boundaries so that all farmlets experienced the same climatic as well as biophysical conditions. An electromagnetic survey was conducted of the entire property and used in conjunction with a detailed soils map in order to classify areas into soil conductivity groupings. Equivalent areas of each soil type were allocated across the three farmlets. Similarly, land was distributed according to its topography so that no farmlet would be compromised by being allocated more low lying, flood-prone land than any other farmlet. The third factor used to allocate land to each farmlet was the prior fertiliser history of the original paddocks. This process ensured that each farmlet was objectively allocated equivalent areas of soil type, topography and fertiliser history thus avoiding initial bias among the farmlets. After the plan for all paddocks of each farmlet was finalised, new paddock boundaries were drawn and where necessary, fencing was removed, modified and added, along with re-arranged watering points. The farmlet treatments commenced in July 2000 when the first pasture establishment and differential fertiliser applications were carried out. Evidence from the electromagnetic survey and the Landsat imagery confirmed that the distribution of hydrologic soil conductivity and vegetation greenness were similar between all farmlets just before the commencement of the experiment.

Knowledge Graphs (KGs), as one of the key trends which are driving the next wave of technologies, have now become a new form of knowledge representation, and a cornerstone for several applications from generic to specific industrial use cases. However, in some specific domains such as law enforcement, a real and large domain-oriented KG is often unavailable due to data privacy concerns. In such domains it is necessary to generate a synthetic KG which mimics the properties of a real KG in the domain. Although during the last two decades, a variety of graph data generators has been proposed to achieve the generation of different kinds of networks, the state-of-the-art synthetic graph data generators are not feasible to generate a realistic and synthetic KGs because KGs always contain data characteristics with specified semantics. In this work, we propose a schema-driven synthetic KG generation approach with extended graph differential dependencies (GDD <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sup> ), which is an extension of the recently developed graph entity/differential dependencies that represent formal constraints for graph data to enable the generation of desired graph patterns in synthetic KG. Next, we develop an effective KG generation algorithm that employs the schema and the pre-defined GDD <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sup> s. Finally, we evaluate our synthetic KG generator and compare with several state-of-the-art synthetic graph generators. The results from the experiments show that our KG generation method can generate KGs that exhibit the desired graph patterns, node attributes and degree distributions associated with each entity type in the graph's schema.

Abstract Stearoyl‐coenzyme A desaturase 1 (SCD‐1) in sebaceous glands is a key enzyme in the synthesis of monounsaturated fatty acids essential for acne development. GSK1940029 gel, a novel SCD‐1 inhibitor, is being developed as a potential treatment for acne. To assess the irritation potential, pharmacokinetics (PK), and safety of topical GSK1940029 to the skin of healthy adults, two interdependent studies were conducted in parallel. Study 1 (n = 54) investigated the irritation potential of GSK1940029 (0.3% and 1%, occluded application) to allow for its application to larger surface areas in study 2 (n = 39), which investigated the safety, tolerability, and PK of GSK1940029 after single and repeat doses as occluded and nonoccluded applications. GSK1940029 was not a primary or cumulative irritant after 2 and 21 days of dosing in study 1. In study 2, single and repeat applications of GSK1940029 (0.1% to 1%) doses were well tolerated with little or no influence on AUC and C max under occluded or unoccluded conditions. Systemic exposure increased proportionally with surface area and was higher in occluded conditions. Design of these interdependent studies allowed for the assessment of the irritation potential for topical GSK1940029 in parallel with the investigation of PK and safety profiles.

ABSTRACT An offshore pile load test programme was conducted in calcareous silts and sands off North West Australia. The tests were carried out in 408 feet of water from the semi-submersible exploration drilling vessel the "Ocean Digger". These tests form part of the foundation investigation programme for a proposed gas production platform at the North Rankin "A" location. Both driven and grouted pipe piles were tested, the deepest test being 400 feet below the sea bed. The results disclosed that ultimate skin friction capacity was in excess of 2000 psf for grouted piles, and 300–400 psf for driven piles. Details and results of the testing programme are given, including soil profile data, together with an outline of special equipment combinations and work techniques. The programmes successful conclusion confirmed the feasibility of utilizing a floating vessel and conventional drilling equipment to perform pile load tests to obtain reliable foundation design criteria in deep water. INTRODUCTION The North Rankin "A" Site, (Fig. 1) is located on the North West Shelf of Western Australia, 85 miles offshore from Dampier. It is the location of the recent discovery of a significant gas reservoir. There are no existing offshore production facilities in this isolated area, and there are only very limited local support facilities. Reconnaissance foundation test borings identified the foundation materials to be calcareous silts and sands with varying degrees of cementation. These initial test bores showed the in-situ material to have very high voidratios and high moisture contents, with corresponding low bulk densities. Experience at Bass Strait (Ref. 1) has shown that calcareous sands and silts require special care in evaluating their engineering behaviour, and that it is not possible to apply normal engineering techniques to evaluate pile capacities. The tower type structure proposed for the North Rankin location will require high capacity piles to provide adequate support. Consideration of pile performance in the calcareous soils indicated long grouted piles involving special installation techniques would be required to develop the necessary support capacity. The combination of the location, soil conditions and the type of piles under consideration, dictated the need for a detailed site investigation, together with pile load testing, in order to arrive at reliable design recommendations necessary for planning of the proposed platform. There was no record of a previous significant on-site testing programme carried out from a floating exploration drilling vessel, and this necessitated the development of a new approach to the test programme. The use of a semi-submersible exploration rig, imposed a series of capacity and time restraints which had to be accommodated in defining an acceptable test programme. Taking cognizance of the engineering information required at the site, and the limitations imposed by the use of the floating rig, a programme of investigation and testing was defined to permit evaluation of the soil engineering properties and their extrapolation to the design situation.

Lanternfishes, which are important prey for demersal and diving predators at Macquarie Island in the Southern Ocean, have spatial patterns of distribution over the Macquarie Ridge that suggest biomass is enhanced where the Subantarctic Front (SAF) interacts with a break in the topography of the Ridge (the ‘Ridge Gap’). The summertime lanternfish assemblage, documented here for the first time, comprised 23 taxa, dominated by Krefftichthys anderssoni and Gymnoscopelus braueri. Mean lanternfish biomass was highest (3.13 g 1000 m–3) in the Ridge Gap habitat. Lowest mean biomass (0.71 g 1000 m–3) was recorded up-current of the SAF over the Abyssal Plain and intermediate biomass (1.26 g 1000 m–3) was recorded over the Macquarie Ridge. At Ridge Gap, a high abundance of K. anderssoni was recorded in the shallowest stratum (0–250 m) during the day. We hypothesised that the oceanographic–topographic interaction between the SAF and Ridge Gap creates eddy systems and productivity fronts that passively entrain and/or actively attract lanternfishes to the Ridge Gap area. This oceanographic–topographic interaction depends on the spatial stability of the SAF in relation to the Macquarie Ridge and Ridge Gap and is vulnerable to climate-mediated change that may have flow-on effects to predators with commercial and conservation significance.

Intravenously injected 14C labelled oxalate was rapidly removed from the blood stream via the kidney in 2 sheep, 75% being cleared within 8 h. Mean daily urinary oxalate excretions over 5 days were 21-2 and 27-5 mg and the derived plasma oxalate concentrations were 52-6 and 74-4 mug/100 ml, respectively. Oxalate was both filtered and secreted by the renal tubule with oxalate/inulin ratios varying from 1-11 to 1-57 in 6 normal sheep. A large increase in calcium excretion induced by calcium borogluconate infusion over 5 days was accompanied by a small but consistent increase in urinary oxalate excretion relative to calcium. Oxalate in blood was to be found mainly in the plasma, there being a small (8%) proporation within erythrocytes. This is lower than that reported for man, and yet in its excretion of oxalate via the kidney the sheep appears to closely resemble man and dog.

This article employs the currency invariant index due to Hovanov et al. (2004 Hovanov, N. K., Kolari, J. and Sokolov, M. 2006. Synthetic money. International Review of Economics and Finance, 16: 161–8. [Crossref] , [Google Scholar]) to construct an optimal or stable common G-3 currency basket across different groups of countries in East Asia. Calculated optimal weights show a larger weight for the US dollar but a nonnegligible role for the Japanese yen. The volatility of the optimal common G-3 currency basket is several times smaller than that of a similarly proposed common G-3 currency basket in East Asia.

Reducing the operating energy costs of commercial buildings in the presence of complex tariff structures is an important problem facing several facility managers. In this paper, we explore the use of a data driven pre-cooling methodology for achieving this outcome. Our contributions are twofold. First, we propose a "gray box" approach to model the building thermal dynamics that imposes minimal data requirements from a building management system (BMS). Second, we illustrate how the model can be used to evaluate various "what-if" pre-cooling strategies to reduce peak demand by applying it to data obtained from a large commercial building located in Australia. The proposed approach enables facility managers to take informed decisions for improving the energy and cost footprints of their buildings. This paper sets the ground for a deeper study into using pre-cooling, driven by our gray box model, for energy cost optimization in commercial buildings.

The key objective of this study is to show that two potential shortcomings of the Determinant of Change in Covariance (DCC) matrix procedure of Rigobon (2003 Rigobon, R. 2003. On the measurement of the international propagation of shocks: is the transmission stable?. Journal of International Economics, 61: 261–83. [Crossref], [Web of Science ®] , [Google Scholar]), namely with the arbitrary determination of the windows, i.e. tranquil and crisis periods and the violation of its heteroscedasticity assumption under the null, can be simultaneously addressed via a simple incorporation of a Markov-switching vector autoregressive approach into the overall DCC procedure. To demonstrate this, we revisit the period around the time of the East Asian crises using daily stock exchange of Indonesia, Malaysia, Philippines, Thailand, Singapore, Korea, Hong Kong and Taiwan, and test whether there is a significant break or discontinuity in the stock exchange returns of the eight East Asian markets during crisis periods, especially around the time of the 1997 financial crises. In contrast to that of Rigobon (2003 Rigobon, R. 2003. On the measurement of the international propagation of shocks: is the transmission stable?. Journal of International Economics, 61: 261–83. [Crossref], [Web of Science ®] , [Google Scholar]), our results show that the propagation of shocks shifted significantly starting with the onset of the sharp decline in the Hong Kong stock market.