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Centre d'Énergétique et de Thermique de Lyon

facilityVilleurbanne, Auvergne-Rhône-Alpes, France

Research output, citation impact, and the most-cited recent papers from Centre d'Énergétique et de Thermique de Lyon (France). Aggregated across the NobleBlocks index of 300M+ scholarly works.

Total works
3.1K
Citations
77.6K
h-index
108
i10-index
1.5K
Also known as
Centre d'Énergétique et de Thermique de LyonCentre for Energy and Thermal Sciences of Lyon

Top-cited papers from Centre d'Énergétique et de Thermique de Lyon

The SAFRAN‐ISBA‐MODCOU hydrometeorological model applied over France
Florence Habets, Aaron Boone, Jean-Louis Champeaux, Pierre Etchevers +4 more
2008· Journal of Geophysical Research Atmospheres381doi:10.1029/2007jd008548

The hydrometeorological model SIM consists of a meteorological analysis system (SAFRAN), a land surface model (ISBA), and a hydrogeological model (MODCOU). It generates atmospheric forcing at an hourly time step, and it computes water and surface energy budgets, the river flow at more than 900 river‐gauging stations, and the level of several aquifers. SIM was extended over all of France in order to have a homogeneous nationwide monitoring of the water resources: it can therefore be used to forecast flood risk and to monitor drought risk over the entire nation. The hydrometeorological model was applied over a 10‐year period from 1995 to 2005. In this paper the databases used by the SIM model are presented; then the 10‐year simulation is assessed by using the observations of daily streamflow, piezometric head, and snow depth. This assessment shows that SIM is able to reproduce the spatial and temporal variabilities of the water fluxes. The efficiency is above 0.55 (reasonable results) for 66% of the simulated river gauges, and above 0.65 (rather good results) for 36% of them. However, the SIM system produces worse results during the driest years, which is more likely due to the fact that only few aquifers are simulated explicitly. The annual evolution of the snow depth is well reproduced, with a square correlation coefficient around 0.9 over the large altitude range in the domain. The streamflow observations were used to estimate the overall error of the simulated latent heat flux, which was estimated to be less than 4%.

Scanning thermal microscopy: A review
Séverine Gomès, Ali Assy, Pierre‐Olivier Chapuis
2015· physica status solidi (a)260doi:10.1002/pssa.201400360

Fundamental research and continued miniaturization of materials, components and systems have raised the need for the development of thermal-investigation methods enabling ultra-local measurements of surface temperature and thermo-physical properties in many areas of science and applicative fields. Scanning thermal microscopy (SThM) is a promising technique for nanometer-scale thermal measurements, imaging, and study of thermal transport phenomena. This review focuses on fundamentals and applications of SThM methods. It inventories the main scanning probe microscopy-based techniques developed for thermal imaging with nanoscale spatial resolution. It describes the approaches currently used to calibrate the SThM probes in thermometry and for thermal conductivity measurement. In many cases, the link between the nominal measured signal and the investigated parameter is not straightforward due to the complexity of the micro/nanoscale interaction between the probe and the sample. Special attention is given to this interaction that conditions the tip–sample interface temperature. Examples of applications of SThM are presented, which include the characterization of operating devices, the measurements of the effective thermal conductivity of nanomaterials and local phase transition temperatures. Finally, future challenges and opportunities for SThM are discussed.

Very high spatial resolution imagery for channel bathymetry and topography from an unmanned mapping controlled platform
Jérôme Lejot, Christophe Delacourt, Hervé Piégay, T. Fournier +2 more
2007· Earth Surface Processes and Landforms221doi:10.1002/esp.1595

Abstract The increasing availability of aerial photography and satellite imagery offers new possibilities for characterizing river morphology. The precision of new very high resolution (VHR) images allows smaller scale objects within river corridors to be studied. High survey frequencies provide increased opportunities for the monitoring of river restoration. Following this evolution in platform technology, a small radio‐controlled motorized vehicle flying at low altitude was used to study both channel water depth and gravel bar geometry. The VHR imagery provided by this equipment allowed both channel bathymetry and a high accuracy photogrammetric digital elevation model (DEM) to be realized. Using case studies from the Ain and the Drôme Rivers in France, the accuracy of the results is presented and the various challenges associated with the new platform are discussed. One significant issue is that due to the low elevation of the survey the coverage of a target area is usually based on several photographs, which leads to variations in illumination conditions that stem from atmospheric changes. The images were processed to minimize this source of error but a number of issues have yet to be resolved. Bathymetric models with R 2 values between 0·59 and 0·90 were created in spite of the lack of channel bed homogeneity at the various sites. The gravel bar was also effectively mapped, and the photogrammetrically predicted DEM provided a 5–10 cm pixel resolution with a vertical precision between 2 and 40 cm according to the position within the image. This paper shows that, despite unstable image acquisition, unmanned radio‐controlled platforms provide significant advantages for the study of river processes, offering a flexible very high resolution data source for both channel bathymetry and gravel bar topography. Copyright © 2007 John Wiley & Sons, Ltd.

Thermal Impacts on the Performance of Nanoscale-Gap Thermophotovoltaic Power Generators
Mathieu Francoeur, Rodolphe Vaillon, M. Pınar Mengüç
2011· IEEE Transactions on Energy Conversion201doi:10.1109/tec.2011.2118212

The thermal impacts on the performance of nanoscale-gap thermophotovoltaic (nano-TPV) power generators are investigated using a coupled near-field thermal radiation, charge, and heat transport formulation. A nano-TPV device consisting of a tungsten radiator, maintained at 2000 K, and cells made of indium gallium antimonide (In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.18</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.82</sub> Sb) are considered; the thermal management system is modeled assuming a convective boundary with a fluid temperature fixed at 293 K. Results reveal that nano-TPV performance characteristics are closely related to the temperature of the cell. When the radiator and the junction are separated by a 20 nm vacuum gap, the power output and the conversion efficiency of the system are respectively 5.83 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> Wm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> and 24.8% at 300 K, whereas these values drop to 8.09 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> Wm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> and 3.2% at 500 K. In order to maintain the cell at room temperature, a heat transfer coefficient as high as 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> Wm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> K <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> is required for nanometer-size vacuum gaps. The reason for this is that thermal radiation since thermal radiation enhancement beyond the blackbody from a bulk radiator of tungsten is broadband in nature, while only a certain part of the spectrum is useful for maximizing nano-TPV performance. In future studies, near-field radiation spectral conditions leading to optimal performance characteristics of the device will be investigated.

Spectral tuning of near-field radiative heat flux between two thin silicon carbide films
Mathieu Francoeur, M. Pınar Mengüç, Rodolphe Vaillon
2010· Journal of Physics D Applied Physics180doi:10.1088/0022-3727/43/7/075501

Spectral distributions of radiative heat flux between two thin silicon carbide films separated by sub-wavelength distances in vacuum are analysed. An analytical expression for the near-field flux between two layers of finite thicknesses in terms of film reflection and transmission coefficients is derived for the first time. The resulting equation clearly shows the resonant modes of thermal emission, absorption and the cross-coupling of surface phonon-polaritons (SPhPs) between the layers. When the films are of the same thickness, the resonant frequencies maximizing near-field thermal emission almost match those of absorption. The small discrepancies, due to SPhP coupling between the films, lead to loss of spectral coherence affecting mostly the low frequency mode. The flux profiles also show that splitting of the resonance into two distinct frequencies happens when the ratio thickness of the film over the separation gap is less than unity. When the thickness of one film increases relative to the other, spectral distributions of flux are significantly altered due to an important mismatch between the resonant frequencies of high emission and absorption. This modification of the near-field flux is mostly due to weaker SPhP coupling within the layer of increasing thickness. Based on an asymptotic analysis of the dispersion relation, an approximate approach is proposed to predict the resonant modes maximizing the flux between two films, which can be potentially extended to multiple thin layers. The outcome of this work would allow tailoring near-field radiative heat transfer, and can eventually be used to design customized nanostructures for energy harvesting applications.

Near-field radiative heat transfer enhancement via surface phonon polaritons coupling in thin films
Mathieu Francoeur, M. Pınar Mengüç, Rodolphe Vaillon
2008· Applied Physics Letters179doi:10.1063/1.2963195

We investigate near-field thermal radiation between a nanometric film and a bulk SiC using fluctuational electrodynamics. Results show a narrow spectral band enhancement of the radiative flux for nanometric emitters due to coupling of surface phonon polaritons inside the film. For a 10nm thick SiC emitter, the total radiative flux is 2.2 times larger than for a bulk emitter. The total radiative flux is increased by a factor of 3.3 if a dielectric is coated with a 10nm SiC film due to a splitting of the resonant frequency into two distinct ones, which has practical interests for near-field thermophotovoltaic devices.

Analysis of cavitating flow structure by experimental and numerical investigations
Olivier Coutier-Delgosha, Benoı̂t Stutz, Alexandre Vabre, Samuel Legoupil
2007· Journal of Fluid Mechanics165doi:10.1017/s0022112007004934

The unsteady structure of cavitating flows is investigated by coupled experimental and numerical means. Experiments focus on the structure and dynamics of sheet cavitation on the upper side of a two-dimensional foil section in the ENSTA cavitation tunnel. Various flow conditions are investigated by varying the pressure, the flow velocity, and the incidence of the foil section. High-frequency local measurements of volume fractions of the vapour phase are performed inside the liquid/vapour mixture by a X-ray absorption method. The numerical approach is based on a macroscopic formulation of the balance equations for a two-phase flow. The assumptions required by this formulation are detailed and they are shown to be common to almost all the models used to simulate cavitating flows. In the present case we apply a single-fluid model associated with a barotropic state law that governs the mixture density evolution. Numerical simulations are performed at the experimental conditions and the results are compared to the experimental data. A reliable agreement is obtained for the internal structure of the cavity for incidence varying between 3° and 6°. Special attention is paid to the mechanisms of partial and transitional instabilities, and to the effects of the interaction between the two sides of the foil section.

Blackbody Spectrum Revisited in the Near Field
Arthur Babuty, Karl Joulain, Pierre‐Olivier Chapuis, Jean‐Jacques Greffet +1 more
2013· Physical Review Letters159doi:10.1103/physrevlett.110.146103

We report local spectra of the near-field thermal emission recorded by a Fourier transform infrared spectrometer, using a tungsten tip as a local scatterer coupling the near-field thermal emission to the far field. Spectra recorded on silicon carbide and silicon dioxide exhibit temporal coherence due to thermally excited surface waves. Finally, we evaluate the ability of this spectroscopy to probe the frequency dependence of the electromagnetic local density of states.

Near-Field Thermophotovoltaic Conversion with High Electrical Power Density and Cell Efficiency above 14%
Christophe Lucchesi, Dilek Çakıroğlu, Jean-Philippe Pérez, T. Taliercio +3 more
2021· Nano Letters134doi:10.1021/acs.nanolett.0c04847

A huge amount of thermal energy is available close to material surfaces in radiative and nonradiative states, which can be useful for matter characterization or energy harvesting. Even though a full class of novel nanoengineered devices has been predicted over the last two decades for exploiting near-field thermal photons, efficient near-field thermophotovoltaic conversion could not be achieved experimentally until now. Here, we realize a proof of principle by using a micrometer-sized indium antimonide photovoltaic cell cooled at 77 K and approached at nanometer distances from a hot (∼730 K) graphite microsphere emitter. We demonstrate a near-field power conversion efficiency of the cell above 14% and unprecedented electrical power density outputs (0.75 W cm–2), which are orders of magnitude larger than all previous attempts. These results highlight that near-field thermophotovoltaic converters are now competing with other thermal-to-electrical conversion devices and also pave the way for efficient photoelectric detection of near-field thermal photons.

Skeletal muscle as the major site of nonshivering thermogenesis in cold-acclimated ducklings
Claude Duchamp, Hervé Barré
1993· American Journal of Physiology-Regulatory, Integrative and Comparative Physiology134doi:10.1152/ajpregu.1993.265.5.r1076

Despite their lack of brown adipose tissue, 6-wk-old cold-acclimated muscovy ducklings (4 degrees C; CA) exhibit nonshivering thermogenesis (NST) in the cold. To determine the site of this NST, the regional distribution of blood flow was measured by the microsphere method in the thermoneutral zone (25 degrees C) and during acute exposure to cold (8 degrees C). Ducklings reared at thermal neutrality (TN), which use shivering to produce extra heat in the cold, were compared with CA ducklings, which substitute NST for shivering. Further, the contribution of skeletal muscle thermogenesis to the increased heat production in the cold was estimated by measuring leg muscle blood flow and arteriovenous difference in oxygen content [(a-v)O2] across the leg, enabling an estimation of muscle O2 consumption. During cold exposure, a similar increase in total leg muscle blood flow occurred in TN and CA ducklings (+127 and +130% respectively), while hepatic arterial blood flow increased less (+56 to +37%, respectively). This rise in blood flow was accounted for by an increase in cardiac output, which was smaller in CA than in TN ducklings, and in both groups by a redistribution of blood flow to the most thermogenic organs (skeletal muscles and liver). The (a-v)O2 across the leg was not changed by cold exposure, indicating that the increase in leg muscle O2 consumption resulted mainly from the increase in blood flow.(ABSTRACT TRUNCATED AT 250 WORDS)

Storage of thermal solar energy
Benoı̂t Stutz, Nolwenn Le Pierrès, Frédéric Kuznik, Kévyn Johannes +4 more
2017· Comptes Rendus Physique129doi:10.1016/j.crhy.2017.09.008

Solar thermal energy storage is used in many applications, from building to concentrating solar power plants and industry. The temperature levels encountered range from ambient temperature to more than 1000 °C, and operating times range from a few hours to several months. This paper reviews different types of solar thermal energy storage (sensible heat, latent heat, and thermochemical storage) for low- (40–120 °C) and medium-to-high-temperature (120–1000 °C) applications.

Finite Size Effects in Determination of Thermal Conductivities: Comparing Molecular Dynamics Results With Simple Models
Patrice Chantrenne, Jean‐Louis Barrat
2004· Journal of Heat Transfer122doi:10.1115/1.1777582

Abstract The thermal conductivity of nanometric objects or nanostructured materials can be determined using nonequilibrium molecular dynamics (NEMD) simulations. The technique is simple in its principle, and resembles a numerical guarded hot plate experiment. The “sample” is placed between a hot source and a cold source consisting of thermostatted sets of atoms. The thermal conductivity is obtained from the heat flux crossing the sample and the temperature profile in the system. Simulation results, however, exhibit a strong dependence of the thermal conductivity on the sample size. In this paper, we discuss the physical origin of this size dependence, by comparing MD results with those obtained from simple models of thermal conductivity based on harmonic theory of solids. A model is proposed to explain the variation of the thermal conductivity with system size.

Localization of Propagative Phonons in a Perfectly Crystalline Solid
S. Pailhès, Holger Euchner, Valentina M. Giordano, Régis Debord +4 more
2014· Physical Review Letters120doi:10.1103/physrevlett.113.025506

Perfectly crystalline solids are excellent heat conductors. Prominent counterexamples are intermetallic clathrates, guest-host systems with a high potential for thermoelectric applications due to their ultralow thermal conductivities. Our combined experimental and theoretical investigation of the lattice dynamics of a particularly simple binary representative, Ba(8)Si(46), identifies the mechanism responsible for the reduction of lattice thermal conductivity intrinsic to the perfect crystal structure. Above a critical wave vector, the purely harmonic guest-host interaction leads to a drastic transfer of spectral weight to the guest atoms, corresponding to a localization of the propagative phonons.

Detecting biological responses to flow management: missed opportunities; future directions
Yves Souchon, C. Sabaton, Robert Deibel, Dudley W. Reiser +4 more
2008· River Research and Applications116doi:10.1002/rra.1134

Abstract The conclusions of numerous stream restoration assessments all around the world are extremely clear and convergent: there has been insufficient appropriate monitoring to improve general knowledge and expertise. In the specialized field of instream flow alterations, we consider that there are several opportunities comparable to full‐size experiments. Hundreds of water management decisions related to instream flow releases have been made by government agencies, native peoples, and non‐governmental organizations around the world. These decisions are based on different methods and assumptions and many flow regimes have been adopted by formal or informal rules and regulations. Although, there have been significant advances in analytical capabilities, there has been very little validation monitoring of actual outcomes or research related to the response of aquatic dependent species to new flow regimes. In order to be able to detect these kinds of responses and to better guide decision, a general design template is proposed. The main steps of this template are described and discussed, in terms of objectives, hypotheses, variables, time scale, data management, and information, in the spirit of adaptive management. The adoption of such a framework is not always easy, due to differing interests of actors for the results, regarding the duration of monitoring, nature of funding and differential timetables between facilities managers and technicians. Nevertheless, implementation of such a framework could help researchers and practitioners to coordinate and federate their efforts to improve the general knowledge of the links between the habitat dynamics and biological aquatic responses. Copyright © 2008 John Wiley &amp; Sons, Ltd.

Thermal conductance at the interface between crystals using equilibrium and nonequilibrium molecular dynamics
Samy Mérabia, Konstantinos Termentzidis
2012· Physical Review B114doi:10.1103/physrevb.86.094303

In this article, we compare the results of nonequilibrium (NEMD) and equilibrium (EMD) molecular dynamics methods to compute the thermal conductance at the interface between solids. We propose to probe the thermal conductance using equilibrium simulations measuring the decay of the thermally induced energy fluctuations of each solid. We also show that NEMD and EMD give generally speaking inconsistent results for the thermal conductance: Green-Kubo simulations probe the Landauer conductance between two solids which assumes phonons on both sides of the interface to be at equilibrium. On the other hand, we show that NEMD give access to the out-of-equilibrium interfacial conductance consistent with the interfacial flux describing phonon transport in each solid. The difference may be large and reaches typically a factor 5 for interfaces between usual semiconductors. We analyze finite size effects for the two determinations of the interfacial thermal conductance, and show that the equilibrium simulations suffer from severe size effects as compared to NEMD. We also compare the predictions of the two above-mentioned methods---EMD and NEMD---regarding the interfacial conductance of a series of mass mismatched Lennard-Jones solids. We show that the Kapitza conductance obtained with EMD can be well described using the classical diffuse mismatch model (DMM). On the other hand, NEMD simulation results are consistent with an out-of-equilibrium generalization of the acoustic mismatch model (AMM). These considerations are important in rationalizing previous results obtained using molecular dynamics, and help in pinpointing the physical scattering mechanisms taking place at atomically perfect interfaces between solids, which is a prerequisite to understand interfacial heat transfer across real interfaces.

Hybrid Solar: A Review on Photovoltaic and Thermal Power Integration
Tommy W. S. Chow, G.N. Tiwari, Christophe Ménézo
2012· International Journal of Photoenergy114doi:10.1155/2012/307287

The market of solar thermal and photovoltaic electricity generation is growing rapidly. New ideas on hybrid solar technology evolve for a wide range of applications, such as in buildings, processing plants, and agriculture. In the building sector in particular, the limited building space for the accommodation of solar devices has driven a demand on the use of hybrid solar technology for the multigeneration of active power and/or passive solar devices. The importance is escalating with the worldwide trend on the development of low-carbon/zero-energy buildings. Hybrid photovoltaic/thermal (PVT) collector systems had been studied theoretically, numerically, and experimentally in depth in the past decades. Together with alternative means, a range of innovative products and systems has been put forward. The final success of the integrative technologies relies on the coexistence of robust product design/construction and reliable system operation/maintenance in the long run to satisfy the user needs. This paper gives a broad review on the published academic works, with an emphasis placed on the research and development activities in the last decade.

Diffusion versus Cocrystallization of Very Long Polymer Chains at Interfaces: Experimental Study of Sintering of UHMWPE Nascent Powder
Tiana Deplancke, Olivier Lame, François Rousset, Ilias Aguili +2 more
2013· Macromolecules112doi:10.1021/ma402012f

Ultrahigh-molecular-weight polyethylene (UHMWPE) has been processed by means of sintering of a nascent powder. Particular attention was paid to the precompaction of the powder just below the melting point (Tm) under vacuum. The particle welding was subsequently carried out under pressure at various temperatures above Tm for various durations. Tensile drawing experiments performed on sintered samples either at room temperature or above Tm were specifically aimed at discriminating the role of chain interdiffusion through the particle interfaces from that of cocrystallization in the mechanism of particle welding. It turned out that efficient welding occurred within a very short time. One of the novel results of the work is the much weaker influence of sintering time as compared with temperature, giving evidence that chain interdiffusion is not governed by a reptation process. The entropy-driven melting explosion over distances much larger than the chain length between entanglements is suggested to be the main mechanism of the fast chain re-entanglement and particle welding in the present case of a nascent powder consisting of nonequilibrium chain-disentangled crystals. Another major aspect of this study is the demonstration of the huge cocrystallization efficiency in the interface consolidation in the solid state that significantly hides the kinetics of chain intertwining occurring in the melt.

Influence of soil variables on in situ plasmid transfer from Escherichia coli to Rhizobium fredii
Agnès Richaume, J. S. Angle, Michael J. Sadowsky
1989· Applied and Environmental Microbiology110doi:10.1128/aem.55.7.1730-1734.1989

A model system was established to determine whether intergeneric plasmid transfer occurs in soil and how various soil variables affect the rate of plasmid transfer. The donor bacterium, Escherichia coli HB101 carrying plasmid pBLK1-2 (pRK2073::Tn5), and the recipient bacterium, Rhizobium fredii USDA 201, were inoculated into a sterile Adelphia fine-sandy-loam soil. Transconjugants were enumerated by direct plating on antibiotic-amended HM [N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid; 2-(N-morpholino) ethanesulfonic acid] salts medium. Randomly chosen transconjugants were verified by serological typing and Southern hybridization with a Tn5 gene probe. The maximum transfer frequency was observed after 5 days of incubation (1.8 x 10(-4) per recipient). The influences of clay (0 to 50% addition), organic matter (0 to 15% addition), soil pH (4.3 to 7.25), soil moisture (2 to 40%), and soil incubation temperature (5 to 40 degrees C) on plasmid transfer were examined. Maximum transfer frequencies were noted at a clay addition of 15%, an organic matter addition of 5%, a soil pH of 7.25, a soil moisture content of 8%, and a soil incubation temperature of 28 degrees C. These results indicate that intergeneric plasmid transfer may occur in soil and that soil variables may significantly affect the rate of transfer.

Worsening and newly diagnosed paraneoplastic syndromes following anti-PD-1 or anti-PD-L1 immunotherapies, a descriptive study
Guillaume Manson, Alexandre Maria, F. Poizeau, François‐Xavier Danlos +4 more
2019· Journal for ImmunoTherapy of Cancer105doi:10.1186/s40425-019-0821-8

BACKGROUND: Paraneoplastic syndromes (PNS) are autoimmune disorders specifically associated with cancer. There are few data on anti-PD-1 or anti-PD-L1 immunotherapy in patients with a PNS. Our objective was to describe the outcome for patients with a pre-existing or newly diagnosed PNS following the initiation of anti-PD-1 or anti-PD-L1 immunotherapy. METHODS: We included all adult patients (aged ≥18) treated with anti-PD-1 or anti-PD-L1 immunotherapy for a solid tumor, diagnosed with a PNS, and registered in French pharmacovigilance databases. Patients were allocated to cohorts 1 and 2 if the PNS had been diagnosed before vs. after the initiation of immunotherapy, respectively. FINDINGS: Of the 1304 adult patients screened between June 27th, 2014, and January 2nd, 2019, 32 (2.45%) had a PNS and were allocated to either cohort 1 (n = 16) or cohort 2 (n = 16). The median (range) age was 64 (45-88). The tumor types were non-small-cell lung cancer (n = 15, 47%), melanoma (n = 6, 19%), renal carcinoma (n = 3, 9%), and other malignancies (n = 8, 25%). Eleven (34%) patients presented with a neurologic PNS, nine (28%) had a rheumatologic PNS, eight (25%) had a connective tissue PNS, and four (13%) had other types of PNS. The highest severity grade for the PNS was 1-2 in 10 patients (31%) and ≥ 3 in 22 patients (69%). Four patients (13%) died as a result of the progression of a neurologic PNS (encephalitis in three cases, and Lambert-Eaton syndrome in one case). Following the initiation of immunotherapy, the PNS symptoms worsened in eight (50%) of the 16 patients in cohort 1. INTERPRETATION: Our results show that PNSs tend to be worsened or revealed by anti-PD-1 or anti-PD-L1 immunotherapy. Cases of paraneoplastic encephalitis are of notable concern, in view of their severity. When initiating immunotherapy, physicians should carefully monitor patients with a pre-existing PNS.

Pathways for mitigating thermal losses in solar photovoltaics
Rodolphe Vaillon, Olivier Dupré, Raúl Bayoán Cal, Marc Calaf
2018· Scientific Reports102doi:10.1038/s41598-018-31257-0

To improve the performance of solar photovoltaic devices one should mitigate three types of losses: optical, electrical and thermal. However, further reducing the optical and electrical losses in modern photovoltaic devices is becoming increasingly costly. Therefore, there is a rising interest in minimizing the thermal losses. These correspond to the reduction in electrical power output resultant of working at temperatures above 25 °C and the associated accelerated aging. Here, we quantify the impact of all possible strategies to mitigate thermal losses in the case of the mainstream crystalline silicon technology. Results indicate that ensuring a minimum level of conductive/convective cooling capabilities is essential. We show that sub-bandgap reflection and radiative cooling are strategies worth pursuing and recommend further field testing in real-time operating conditions. The general method we propose is suitable for every photovoltaic technology to guide the research focused on reducing thermal losses.