Délégation Paris 11

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The systematic recording of spontaneous electrodermal activity (EDA) on 23 normal subjects during 5 15-min sessions and the self-rating of anxious and/or depressive moods (Q-sort forced choice) shows a positive linear relationship between spontaneous EDA and anxious mood despite a low covariation between those two variables. The same relationship is found with a lower degree of confidence in depression. A greater EDA is observed in the rare pattern of "depression higher than anxiety', than in the opposite case. The discussion of the results deals with the parallelism between a physiological continuum and affective states.

Urban stormwater management is a major challenge for limiting the degradation of surface aquatic environments. Given the limitations of traditional sewer systems, nature-based solutions are now being implemented at various scales to control the pollutants generated by runoff during rain events. Two main families of solutions can be distinguished: 'decentralised' systems, aimed at limiting runoff at source, and 'centralised' systems, aimed at storing or treating volumes associated with catchment areas of several hectares, potentially mixing rainwater and wastewater. While the first type of solution should be more advantageous, the second is no less relevant, particularly in constrained urban contexts where the scope for building new facilities is limited. In this context, the City of Paris set up an experiment involving an innovative centralised system based on the planted filter concept. The main goal of this project is to evaluate the efficiency of this system to reduce the pollutant loadings of stormwater runoff. Mineral and organic micro-pollutants are specially investigated with a focus on the dissolved phase that is not sufficiently taken into account in the classic depollution systems of rainwater. In order to compare the innovative filter to a “classic” planted filter, two filters were built. The two filters have an area of 600m2. The classical one consists of, from the bottom to the top: 30cm of gravel 20/40 within which drains are installed, 20cm of gravel 8/20, 10 cm of gravel 4/8 containing aeration network and the filtration layer composed of 40 cm of sand 0/4. The innovative filter only differs by the 40-cm filtration layer which consists of 10cm of sand 0/4, 20 cm of Rainclean® (Funke Kunststoffe GmbH, Hamm, Germany) and 10cm of sand 0/4. Rainclean® was specially selected during the preliminary design studies to optimise the treatment of dissolved organic and metallic micropollutants. It has never been tested before in planted filters. Filters receive runoff waters coming from 21ha of the ring road of the city of Paris (1.3 million vehicles/day) but also clear water during dry wheather. Since the beginning of the experiment (in May, 2021), each filters received about 56 m and 90 m of water during rain events and dry weather respectively. These large volumes of clear water could affect the pollution reduction efficiency of the filters with faster exhaustement of the filter media. However this impact still has to clarified. More generally, an assessment of the current functioning of the filters is still necessary. To do so, water sampling to estimate the capacity of the filters to reduce pollution is undergoing.

Aural Dissipation is a site-specific sound installation that explores the possibility of perceiving architectural space as an acoustic instrument. The work takes place inside the cooling tower of a decommissioned power plant, where the structure’s volume and reverberant surfaces become sonic material to be investigated through a live performance for harp and electroacoustic processing. The harp, performed directly within the space, activates and modulates the environment: the sound is captured, processed in real time, and diffused through a discrete multichannel spatialization system. The installation is preceded by an acoustic survey phase, including impulse response measurements and reverberation analysis, aimed at understanding the spatial behavior of sound and informing the design of the diffusion setup. The project is part of a broader research framework focused on the role of sound in design processes, and it proposes a critical interplay between musical gesture, architecture, and immersive audio technologies. Expected outcomes include acoustic data, critical reflections, and documentation materials that contribute to formulating new transdisciplinary strategies rooted in sonic design thinking, emphasizing the potential of sound as a tool for interpreting, activating, and reconfiguring space.

Abstract BACKGROUND Isocitrate dehydrogenase-mutant (mIDH) diffuse gliomas, including astrocytomas and oligodendrogliomas, initially grow slowly before transitioning to a malignant phase. Despite advances in surgery, radiotherapy, and chemotherapy, survival remains limited. Assessing tumour size and growth rate is crucial but complicated by measurement variability, impacting treatment decisions and outcome prediction. OBJECTIVES This systematic review examines the correlation between tumour size and growth rate measured after resection with overall survival (OS), progression-free survival (PFS), malignant progression-free survival (M-PFS), and symptom burden (seizures, headaches, neurological deficits) in mIDH gliomas. METHODS A comprehensive literature search was conducted in MEDLINE/PubMed, EMBASE, Cochrane Library, and grey literature sources (scientific congresses and health authority communications) from January 1, 2014, to January 17, 2024. Eligible studies focused on adult patients (≥18 years) with mIDH gliomas and assessed post-resection tumour size (diameter or volume) or tumour growth rate, and clinical outcomes such as OS, PFS, M-PFS, time to treatment (TTT), malignant transformation (MT) and symptoms, including seizures, headaches, and neurological deficits. Two independent reviewers screened articles, extracted data, and assessed study quality. RESULTS A total of 56 studies were selected, of which 28 studies met the inclusion criteria and collectively included 11,510 patients. Of these, 25 assessed tumour volume, 1 measured tumour diameter, and 5 examined tumour growth. Most studies (82.1%, n=23) were retrospective. The selected studies classified tumors according to the 2016 WHO classification, with 46.0% (n=5,295) identified as IDH-mutant, 27.3% (n=3,141) as 1p/19q-codeleted, and 5.2% (n=597) as IDH-WT. Most studies identified a significant correlation between residual tumour size/growth rate and OS (85.7%, n=18/21) or PFS (84.6%, n=11/13). Additionally, of the 14 studies assessing a correlation with other outcomes such as M-PFS, symptom progression, MT and TTT, 92.9% (n=12/13) identified an inverse correlation with tumour size or growth rate. Only 6 studies did not demonstrate a significant association between tumour diameter or volume and OS, PFS or M-PFS. Altogether, these findings suggest that residual tumour size and tumour growth rate may serve as predictors of clinical outcomes, including OS, PFS, M-PFS, MT, TTT, and symptoms such as seizures in mIDH diffuse gliomas. CONCLUSIONS Tumour volume and growth rate are significant predictors of clinical outcomes in mIDH gliomas, especially OS and PFS. Implementing volumetric assessment and tumor growth monitoring into clinical practice may enhance the management and follow-up of patients with mIDH gliomas.

La thèse anthropologique d’un équilibre nécessaire entre don et contre-don s’appliquerait-elle à la relation parents-enfants ? Le déséquilibre pourrait-il entraîner des compensations symboliques et somatiques chez l’enfant ? Pour explorer et approfondir cette hypothèse issue d’observations cliniques, une enquête-pilote a porté sur un échantillon composite de parents et d’enfants suivis ou non par des professionnels de santé pour des troubles liés à l’alimentation. On observe que les parents ont massivement le sentiment de donner plus à leurs enfants qu’ils n’ont reçu eux-mêmes, qu’ils n’attendent pas de retour sinon dans un avenir indéterminé ou sous forme de travail scolaire. Les enfants, de leur côté, n’ont ni l’occasion ni le sentiment de « rendre » quoi que ce soit à leurs parents. Certains se plaignent d’un manque de reconnaissance. L’alimentation constitue un domaine particulier : le sentiment de l’investissement parental y paraît plus problématique, particulièrement chez les mères. Les données recueillies soulèvent des questions nouvelles, en relation avec l’investissement ou le surinvestissement parental et la notion de dette inter- ou transgénérationnelle.

Background: Chronic liver disease is one of the world's leading causes of mortality and morbidity. Thyroid and liver are interdependent in their functioning, Thyroid gland regulates basic metabolic rate in hepatocytes and liver being the site of thyroid hormone metabolism, modulates hormone levels. Assessment of thyroid levels in cirrhosis may prove useful to identify severity of disease and probability of complication rates. In this context we conducted a study to signify the association between thyroid hormones and severity of hepatic disorder in cirrhosis through usage of Child Pugh score. 100 patients a Method: ged 18 years and above, with liver cirrhosis were evaluated in our institute. Thyroid prole and other relevant investigations were carried out to assess severity of liver cirrhosis, correlated with Child Pugh scoring. Results: 74% of the patients in the study were in euthyroid state. Total and free T3, T4 levels were signicantly low and inversely correlated with severity of liver cirrhosis. Most of the patients had normal T4 and TSH levels. Among all, free T3 was found to be the most sensitive marker to assess severity of cirrhosis. Thyroid dysfunction is oft Conclusion: en observed in liver cirrhosis which calls for thyroid prole tests to be conducted with a potential role as prognostic marker.

BACKGROUND: Silencing SOD2 expression upregulates androgen receptor (AR) signaling and expression of SOD2 is downregulated in CRPC, compared with untreated tumors. The decreased SOD2 activity could lead to AR gain-of-function and the development of castration-resistance. METHODS: We genotyped SOD2-rs4880 in a cohort of 753 prostate cancer patients receiving androgen deprivation therapy (ADT) between 1996 and 2010. The rs4880 encodes Ala16Val in SOD2 and the Val variant has been demonstrated to be functionally less efficient than the Ala variant. We assessed the impact of SOD2-rs4880 variants on the time to progression (TTP) and overall survival (OS) on ADT using multivariable Cox regression. RESULTS: Four hundred thirty-two out of 753 (57%) had metastases at the time of ADT initiation. Overall, median TTP on ADT was 18.4 (95%CI: 15.8, 20.9) months and median overall survival (OS) from ADT initiation was 6.3 (95%CI: 5.8, 6.8) years. In unadjusted and adjusted analyses, there was no association between SOD-rs4880 and TTP or OS on ADT (P > 0.05). Results were similarly negative among patients with and without metastatic disease at ADT initiation. CONCLUSIONS: Our result suggests that a functional genetic variant in SOD2 does not determine the efficacy of ADT for prostate cancer. It is possible that the drastic downregulation of SOD2 in advanced prostate cancer cells may have overridden any influence of the genetic variation of SOD2. This study suggests the need for careful consideration about timing if the application of SOD2 mimetics for prostate cancer therapy is considered. Prostate 76:1338-1341, 2016. © 2016 Wiley Periodicals, Inc.