Duplin General Hospital

BACKGROUND: Pierpont syndrome was first described in 1998 with key characteristics including developmental delay, dysmorphic facial features, fat pads on hands and feet, and feeding difficulties. To date the mechanism of inheritance is unknown. Nine out of ten previously described patients with Pierpont syndrome were boys. This is the first report of a case of a non-white patient with Pierpont syndrome and she is the second female patient to be described as having Pierpont syndrome. CASE PRESENTATION: Our patient is a 16-month-old Hispanic girl with extreme developmental delay, microcephaly, large ears, short and thick upper lip, broad philtrum, widely spaced teeth, constipation, dysphagia, fat pads on feet and hands, autistic behavior and seizure-like episodes. She had a normal karyotype (46,XX), and array testing showed greater than 8 % homozygosity with otherwise normal results. Genes within these areas of homozygosity may provide clues to an etiology and suggest autosomal recessive inheritance. This case report highlights the possibility of ethnic variations in this syndrome's presentation, which may have ramifications in uncovering the pathogenesis as well as expanding the phenotype. CONCLUSION: Pierpont syndrome should be considered in the evaluation of children with the described features, regardless of their gender and ethnicity.

KIAA1199 (also known as CEMIP or HYBID), an archived gene listed in the Human Unidentified Gene-Encoded (HUGE) database, has been implicated in tumor progression and metastasis in a wide range of cancers, including breast, cervical, cholangiocarcinoma, pancreatic, colorectal, gastric, hepatocellular, lung, ovarian, prostate, papillary thyroid, and brain cancers. Overexpression of KIAA1199 is significantly correlated with poor prognosis and metastasis and has been clinically associated with chemoresistance. In addition, KIAA1199 may serve as a novel biomarker for cancer diagnosis and prognosis, particularly due to its role in maintaining cancer stem cell properties. However, the molecular mechanisms by which KIAA1199 regulates chemoresistance, prognosis, and cancer stem cell development remain incompletely understood. Therefore, this review aims to summarize the clinical relevance of KIAA1199 as a novel regulator involved in chemoresistance, cancer prognosis, and cancer stem cell biology.

Background: Type 2 diabetes mellitus (T2DM) is a growing global health concern. Diabetes self-management education and support (DSMES) is associated with reducing blood sugar levels, body mass index (BMI), and cardiovascular risk factors. Online consultations have become essential for monitoring and medical advice. Data about effectiveness of the DSMES program in Vietnam has been very limited. Objectives: To evaluate effectiveness of smartphone application-based lifestyle education program on improving knowledge and behavior about diabetes, improving BMI and waist circumference, lowering blood glucose and lipid profile in Vietnamese patients with T2DM. Materials and methods: This was a non-blinded, randomized controlled trial study on 168 T2DM at Endocrinology clinic of General Hospital, Binh Dinh province between April 2022 to October 2022. Patients would be randomly classified into intervention group or control group. The intervention group received a 10-week intervention with DSMES program via the Dia-B smartphone application, while control group received standard education program. Results: There were 84 patients in the intervention group and 84 patients in the control group. The two groups were similar regarding main baseline characteristics. After the research period, general knowledge about diabetes management of the intervention group improved significantly from 6.3 points to 7.8 points (p<0.001). Body mass index (BMI), waist circumference, fasting blood glucose and HbA1c were statistically significantly lower after every 3 months of intervention. Of notes, after 6 months, while HbA1c in the intervention group decreased by 1.57%, the control group decreased by 0.28% (p<0.001). Conclusions: Smartphone application-based lifestyle education program improves knowledge and behavior about diabetes, decreases BMI, waist circumference, fasting blood glucose and HbA1c.

Summary form only given. Non-equilibrium atmospheric pressure discharges provide an attractive area of industrial interest, largely due to their relative ease of operation and usefulness in fields such as surface treatment of plastics, medical surfaces or even tissue <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> . In recent years there has therefore been a mounting interest in characterising these types of discharges numerically through simulation, as well as through experiment. However due to the computational intensity and complex physics of atmospheric pressure discharges most of the simulation work has been done using the fluid approximation, as opposed to the directly kinetic treatment of the Particle-In-Cell/Monte Carlo collisions approach <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . As a result of these simplifications, the quantitative validity of these simulations has been previously questioned in the literature <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3,4</sup> .

BACKGROUND: Doctoral nursing students often enter programs with limited familiarity and confidence using evidence-based practice (EBP) tools and program expectation uncertainty. This can impede early engagement and scholarly project progress. This quality improvement project, using speed mentoring for guidance on final projects and effective use of EBP tools, aimed to decrease anxiety and increase confidence and understanding among first-year doctoral nursing students. METHOD: A pre-posttest design was used. Two 30-minute virtual speed mentoring sessions were conducted. Five third-year students mentored 25 first-year students. Student mentees completed a survey assessing changes in anxiety, confidence, and topic understanding. RESULTS: Twenty-five students participated in two speed mentoring sessions. Following sessions, mentees reported decreased anxiety, increased confidence, and improved understanding of mentoring topics, improved with plan-do-study-act (PDSA) cycles. CONCLUSION: This speed peer-mentoring approach may support early engagement with academic tools and program expectations, reducing anxiety and improving confidence to succeed in doctoral nursing programs.

Objective To determine and compare dietary and hs‐CRP values of US‐born Afro Caribbean American (USBACA), African American (AA) and Foreign‐born Afro Caribbean (FBAC) adults. Method A cross‐sectional study recruited 62 USBACA (30 males; 32 females), 61 AA (30 males; 31 females) and 66 FBAC (31 males; 35 females) adults (18–40 years) living in the US &lt; 10 years. Socio‐demographic, dietary and hs‐CRP values were determined and analyzed. Findings Compared to the Dietary Guidelines, USBACA and AA adults compared to FBAC adults consumed &lt; 55 % carbohydrates (%) (41.0 &amp; 25.4 vs. 55.4) but, more ≥ 30% energy from fat (%) (65.6 &amp; 72.9 vs. 46.2), &gt; 20g saturated fat (%) (45.9 &amp; 50.8 vs. 35.4), &gt; 300 mg dietary cholesterol (%) (23.0 &amp; 27.1 vs. 16.9) and, &gt; 2400 mg sodium (%) (37.7 &amp; 39.0 vs. 26.2). However, more AA compared to USBACA and FBAC adults (%) (26.7 vs. 8.8 and 10.5) had elevated hs‐CRP (&gt; 3.0 mg/L). Conclusion This study demonstrated that there are significant differences in mean dietary and hs‐CRP values between FBAC and their US‐born counterparts. Understanding the variations in health indicators among different ethnic groups of the same race can provide healthcare professionals and policy planners with the opportunity to develop culturally sensitive programs and strategies for the improvement of health outcomes. Source of funding: Florida International University Foundation

Left ventricular thrombus (LVT) is mostly associated with anterior wall myocardial infarction and reduced ejection fraction. It can also be associated with cardiomyopathy, myocarditis, and hypercoagulable states such as cancer, antiphospholipid syndrome, and protein C or protein S deficiency. Factor V Leiden (FVL) disease is one of the hypercoagulable states where mutant factor V is insensitive to natural anticoagulation factor protein C, and FVL disease increases the risk of peripheral thromboembolism such as pulmonary embolism (PE) and deep vein thrombosis (DVT). We report a 60-year-old female patient with a history of heterozygous factor V Leiden and a remote history of deep vein thrombosis who presented with left-sided weakness and intermittent chest pain. Computed tomography (CT) of the brain ruled out stroke, electrocardiogram (EKG) showed sinus rhythm and some new T-wave inversion, and troponin was mildly elevated. Other laboratory results were unremarkable. A transthoracic echocardiogram showed a left ventricular mass with left ventricular outflow tract (LVOT) obstruction in systole with normal systolic and diastolic function and no wall motion abnormalities. Emergent surgery proved to be a thrombus. The learning objectives of our case are that a normal-sized and functional left ventricle does not preclude left ventricular thrombosis, long-term anticoagulation therapy in patients with factor V Leiden and a first episode of thromboembolism with additional risk factors may prevent further serious thromboembolic event, and timely diagnosis and treatment of cardiac thrombosis may reduce morbidity and mortality.

A Modelagem Matemática nos permite modelar situações decorrentes da necessidade de compreender e resolver problemas do cotidiano, utilizando problemas inteiramente matemáticos. O presente trabalho tem como objetivo utilizar a modelagem matemática para resolver o problema da produção de redes de dormir mescladas, produzidas por uma nova máquina de tear duplo existente na industria têxtil de produção de redes. As redes mescladas são consideradas perdas, pois dificilmente se consegue vendê-las, e assim precisam ser transformadas em tapetes. A questão ao se utilizar este tear é que a única unidade de medida para calcular a quantidade de fio que é colocada em cada carretel, é o número de voltas que o carretel dará enquanto o fio é enrolado. Neste sentido, utilizamos a modelagem matemática para encontrar equações que fornecem o número de voltas necessárias, em cada carretel, para que se produza uma certa quantidade de redes no tear duplo.

An Irish junics Get access W. Adams W. Adams 1Duplin Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s2-VIII, Issue 191, 27 August 1859, Page 166, https://doi.org/10.1093/nq/s2-VIII.191.166a Published: 27 August 1859

\n Neste trabalho promovemos a síntese de sulfóxidos vinílicos ?-substituídos através da reação de acoplamento cruzado de Suzuki-Miyaura. Também foi feita a síntese de sulfóxidos enínicos inéditos, pela adição do nucleófilo no carbono &amp;#946;-sulfóxido. Esses compostos eram passíveis de serem submetidos a reação de rearranjo de Pummerer aditivo e assim gerarem uma pequena biblioteca de compostos &amp;#945;-tioaldeídos. Um desses aldeídos sintetizados foi empregado na reação de formação de uma imina propargílica, com consequente reação de CuAAC formando iminas triazólicas. Outras iminas arílicas foram sintetizadas, passando por uma etapa de redução, com intuito de se obter a amina livre, para que fosse feita a reação de ciclização com auxílio de um agente eletrofílico. Outra classe de composto organoenxofre foi sintetizada, as N-sulfinil imina, que após a reação de acoplamento cruzado de Sonogashira, com consequente remoção de um grupo protetor e a formação do anel heterocíclico, foram obtidos compostos triazólicos N-sulfinil imínicos.\n