École Nationale Supérieure d'Architecture de Nantes

OBJECTIVE: Glycated hemoglobin (HbA₁(c)), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with increased levels of HbA₁(c). We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA₁(c) levels. RESEARCH DESIGN AND METHODS: We studied associations with HbA₁(c) in up to 46,368 nondiabetic adults of European descent from 23 genome-wide association studies (GWAS) and 8 cohorts with de novo genotyped single nucleotide polymorphisms (SNPs). We combined studies using inverse-variance meta-analysis and tested mediation by glycemia using conditional analyses. We estimated the global effect of HbA₁(c) loci using a multilocus risk score, and used net reclassification to estimate genetic effects on diabetes screening. RESULTS: Ten loci reached genome-wide significant association with HbA(1c), including six new loci near FN3K (lead SNP/P value, rs1046896/P = 1.6 × 10⁻²⁶), HFE (rs1800562/P = 2.6 × 10⁻²⁰), TMPRSS6 (rs855791/P = 2.7 × 10⁻¹⁴), ANK1 (rs4737009/P = 6.1 × 10⁻¹²), SPTA1 (rs2779116/P = 2.8 × 10⁻⁹) and ATP11A/TUBGCP3 (rs7998202/P = 5.2 × 10⁻⁹), and four known HbA₁(c) loci: HK1 (rs16926246/P = 3.1 × 10⁻⁵⁴), MTNR1B (rs1387153/P = 4.0 × 10⁻¹¹), GCK (rs1799884/P = 1.5 × 10⁻²⁰) and G6PC2/ABCB11 (rs552976/P = 8.2 × 10⁻¹⁸). We show that associations with HbA₁(c) are partly a function of hyperglycemia associated with 3 of the 10 loci (GCK, G6PC2 and MTNR1B). The seven nonglycemic loci accounted for a 0.19 (% HbA₁(c)) difference between the extreme 10% tails of the risk score, and would reclassify ∼2% of a general white population screened for diabetes with HbA₁(c). CONCLUSIONS: GWAS identified 10 genetic loci reproducibly associated with HbA₁(c). Six are novel and seven map to loci where rarer variants cause hereditary anemias and iron storage disorders. Common variants at these loci likely influence HbA₁(c) levels via erythrocyte biology, and confer a small but detectable reclassification of diabetes diagnosis by HbA₁(c).

A manual for both designers and users, comprehensively presenting the current state of experts' knowledge on virtual reality (VR) in computer science, mechanics, optics, acoustics, physiology, psychology, ergonomics, ethics, and related area. Designed as a reference book and design guide to help the reader develop a VR project, it presents the read

Abstract In this paper we tackle, for affine non-linear systems, the ‘Morgan Problem’, i.e. the scalar-input-scalar-output decoupling problem for square systems, with dynamic compensation. The result provided here (Theorem 3.1) generalizes that one previously given by Wang (1970) for linear systems.

Simultaneous Localization and Mapping is now widely adopted by many applications, and researchers have produced very dense literature on this topic. With the advent of smart devices, embedding cameras, inertial measurement units, visual SLAM (vSLAM), and visual‐inertial SLAM (viSLAM) are enabling novel general public applications. In this context, this paper conducts a review of popular SLAM approaches with a focus on vSLAM/viSLAM, both at fundamental and experimental levels. It starts with a structured overview of existing vSLAM and viSLAM designs and continues with a new classification of a dozen main state‐of‐the‐art methods. A chronological survey of viSLAM’s development highlights the historical milestones and presents more recent methods into a classification. Finally, the performance of vSLAM is experimentally assessed for the use case of pedestrian pose estimation with a handheld device in urban environments. The performance of five open‐source methods Vins‐Mono, ROVIO, ORB‐SLAM2, DSO, and LSD‐SLAM is compared using the EuRoC MAV dataset and a new visual‐inertial dataset corresponding to urban pedestrian navigation. A detailed analysis of the computation results identifies the strengths and weaknesses for each method. Globally, ORB‐SLAM2 appears to be the most promising algorithm to address the challenges of urban pedestrian navigation, tested with two datasets.

The binding of Norwalk virus (NV) recombinant capsids was tested in a panel of saliva samples collected from 96 donors with different ABO, secretor, and Lewis phenotypes. As previously reported, binding occurred specifically to saliva from secretors, regardless of their Lewis phenotype status. Blood group B saliva was poorly recognized, whereas binding to blood group O saliva was higher and binding to blood group A saliva was highest. Transfection of either blood group A or B enzyme into H epitope-expressing cells showed that masking of H epitopes by the A and B antigens blocked the attachment of NV capsids. The high level of binding to blood group A secretor saliva could be explained by an optimal H type 1 ligand density, which was lower than that in blood group O saliva and much higher than that in blood group B saliva. Indeed, despite a higher ligand density, saliva from homozygotes with 2 functional FUT2 alleles was less strongly recognized than saliva from heterozygotes with 1 functional and 1 inactivated FUT2 allele. Partial fucosidase treatment of duodenal tissue sections and binding to a synthetic probe with varying densities of H type 1 trisaccharide indicated that optimal attachment occurred at medium ligand density.

This paper presents a framework for studying design thinking. Three paradigmatic approaches are described to measure design cognitive processes: design cognition, design physiology and design neurocognition. Specific tools and methods serve each paradigmatic approach. Design cognition is explored through protocol analysis, black-box experiments, surveys and interviews. Design physiology is measured with eye tracking, electrodermal activity, heart rate and emotion tracking. Design neurocognition is measured using electroencephalography, functional near infrared spectroscopy and functional magnetic resonance imaging. Illustrative examples are presented to describe the types of results each method provides about the characteristics of design thinking, such as design patterns, design reasoning, design creativity, design collaboration, the co-evolution of the problem solution space, or design analysis and evaluation. The triangulation of results from the three paradigmatic approaches to studying design thinking provides a synergistic foundation for the understanding of design cognitive processes. Results from such studies generate a source of feedback to designers, design educators and researchers in design science. New models, new tools and new research questions emerge from the integrated approach proposed and lay down future challenges in studying design thinking.

Histiocytic sarcoma (HS) refers to a highly aggressive and frequently disseminated neoplastic disease belonging to the class of canine histiocytic proliferative disorders. Disseminated HS (previously called malignant histiocytosis) is highly breed specific, with Bernese mountain dogs (BMDs), rottweilers, and retrievers having a high prevalence with a frequency of approximately 25% in the BMD breed. We collected DNA samples and clinical information from 800 BMDs, of which 200 are affected by HS. To better characterize the physiopathology and epidemiology, an in-depth analysis of 89 BMD cases has been performed. The mean age of onset was 6.5 years, males and females being equally affected. The clinical features, biochemical parameters, and pathological features have been determined. The life span after diagnosis has been estimated to be 49 days. A large BMD pedigree of 327 dogs, 121 of which are affected, was assembled. Using a subset of 160 BMDs, encompassing 21 complete sibships, we now propose an oligogenic transmission mode of the disease. Whole-genome linkage scans as well as association studies using a case/control analysis, in parallel with expression profiling of neoplastic versus normal histiocytes, are all underway. Altogether, these complementary approaches are expected to localize the genes for HS in the BMD, leading to advances in our knowledge of histiocyte diseases in dogs and humans.

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains a leading cause of death worldwide, despite the development of various therapeutic strategies. Cardiac dysfunction, also referred to as septic cardiomyopathy, is a frequent and well-described complication of sepsis and associated with worse clinical outcomes. Recent research has increased our understanding of the role of mitochondrial dysfunction in the pathophysiology of septic cardiomyopathy. The purpose of this review is to present this evidence as a coherent whole and to highlight future research directions.

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The sense of embodiment refers to the sensations of being inside, having, and controlling a body. In virtual reality, it is possible to substitute a person’s body with a virtual body, referred to as an avatar. Modulations of the sense of embodiment through modifications of this avatar have perceptual and behavioural consequences on users that can influence the way users interact with the virtual environment. Therefore, it is essential to define metrics that enable a reliable assessment of the sense of embodiment in virtual reality to better understand its dimensions, the way they interact, and their influence on the quality of interaction in the virtual environment. In this review, we first introduce the current knowledge on the sense of embodiment, its dimensions (senses of agency, body ownership, and self-location), and how they relate the ones with the others. Then, we dive into the different methods currently used to assess the sense of embodiment, ranging from questionnaires to neurophysiological measures. We provide a critical analysis of the existing metrics, discussing their advantages and drawbacks in the context of virtual reality. Notably, we argue that real-time measures of embodiment, which are also specific and do not require double tasking, are the most relevant in the context of virtual reality. Electroencephalography seems a good candidate for the future if its drawbacks (such as its sensitivity to movement and practicality) are improved. While the perfect metric has yet to be identified if it exists, this work provides clues on which metric to choose depending on the context, which should hopefully contribute to better assessing and understanding the sense of embodiment in virtual reality.

Abstract. The Town Energy Balance (TEB) model has been refined and improved in order to explicitly represent street trees and their impacts on radiative transfer: a new vegetated stratum on the vertical plane, which can shade the road, the walls, and the low vegetation has been added. This modification led to more complex radiative calculations, but has been done with a concern to preserve a certain level of simplicity and to limit the number of new input parameters for TEB to the cover fraction of trees, the mean height of trunks and trees, their specific leaf area index, and albedo. Indeed, the model is designed to be run over whole cities, for which it can simulate the local climatic variability related to urban landscape heterogeneity at the neighborhood scale. This means that computing times must be acceptable, and that input urban data must be available or easy to define. This simplified characterization of high vegetation necessarily induces some uncertainties in terms of the solar radiative exchanges, as quantified by comparison of TEB with a high-spatial-resolution solar enlightenment model (SOLENE). On the basis of an idealized geometry of an urban canyon with various vegetation layouts, TEB is evaluated regarding the total shortwave radiation flux absorbed by the elements that compose the canyon. TEB simulations in summer gathered best scores for all configurations and surfaces considered, which is precisely the most relevant season to assess the cooling effect of deciduous trees under temperate climate. Mean absolute differences and biases of 6.03 and +3.50 W m−2 for road, respectively, and of 3.38 and +2.80 W m−2 for walls have been recorded in vegetationless canyons. In view of the important incident radiation flux, exceeding 1000 W m−2 at solar noon, the mean absolute percentage differences of 3 % for both surfaces remain moderate. Concerning the vegetated canyons, we noted a high variability of statistical scores depending on the vegetation layout. The greater uncertainties are found for the solar radiation fluxes received and absorbed by the high vegetation. The mean absolute differences averaged over the vegetation configurations during summertime are 21.12 ± 13.39 W m−2 or 20.92 ± 10.87 % of mean absolute percentage differences for the total shortwave absorption, but these scores are associated with acceptable biases: −15.96 ± 15.93 W m−2.

The aims of this study are to highlight the microclimatic phenomena to which the energy consumption of a building is the most sensitive and to compare different approaches to coupling microclimate and building energy simulation models. We first present a study in which spatial variations in outdoor air temperature are not taken into account so as to compare the relative effect of convective and radiative heat flux on the outer surface energy balance. Then, several coupling methods are implemented, for which energy consumption in winter and indoor temperature in summer are compared between insulated and non-insulated buildings. Results show that for the urban context, taking into account long-wave radiative heat fluxes is crucial. Moreover, representing local modifications in outdoor air temperature is necessary for non-insulated buildings in summer, but can be neglected in winter. In conclusion, an intermediate coupling method that can be used under certain assumptions is proposed.

This paper reports the first results from a program of work aimed at developing a swimming robot equipped with electric sense. After having presented the principles of a bioinspired electric sensor that is now working, we will build the models for electrolocation of objects that are suited to this kind of sensor. The produced models are in a compact analytical form in order to be tractable on the onboard computers of the future robot. These models are tested by comparing them with numerical simulations based on the boundary elements method. The results demonstrate the feasibility of the approach and its compatibility with online objects electrolocation, i.e., another parallel program of ours.

Résumé L’analyse critique des « bonnes pratiques » dans le champ urbain suppose d’identifier le champ qu’elles recouvrent et l’extension de leurs possibles applications. Nous différencions ainsi des registres (incitatifs, prescriptifs, normatifs), des scènes et des outils qui les font exister et les rendent opérantes. Cette généalogie est doublée, dans un second temps, d’un suivi de configurations locales situées de bonnes pratiques, observées dans le cadre d’un grand projet de ville en action à Nantes. Il ressort de cet examen que les « bonnes pratiques » soit renvoient à des phénomènes de domination, soit se trouvent trop vite constituées dans une exemplarité locale, caricaturant aussi bien le local que les conditions de leurs expériences. Elles sont désormais un opérateur puissant de conformation et de distinction rejoignant aussi bien les doctrines gestionnaires que celles relatives au marketing urbain.

In this paper we present an immersive virtual reality user study aimed at investigating how customers perceive and if they would purchase non-standard (i.e. misshaped) fruits and vegetables (FaVs) in supermarkets and hypermarkets. Indeed, food waste is a major issue for the retail sector and a recent trend is to reduce it by selling non-standard goods. An important question for retailers relates to the FaVs' “level of abnormality” that consumers would agree to buy. However, this question cannot be tackled using “classical” marketing techniques that perform user studies within real shops since fresh produce such as FaVs tend to rot rapidly preventing studies to be repeatable or to be run for a long time. In order to overcome those limitations, we created a virtual grocery store with a fresh FaVs section where 142 participants were immersed using an Oculus Rift DK2 HMD. Participants were presented either “normal”, “slightly misshaped”, “misshaped” or “severely misshaped” FaVs. Results show that participants tend to purchase a similar number of FaVs whatever their deformity. Nevertheless participants' perceptions of the quality of the FaV depend on the level of abnormality.

The concept 'liver disease' includes several pathological conditions affecting liver's functions. It can either consist of a temporary impaired functioning of the liver and/or it can progress to its failure. The purpose of this review is to update the knowledge on hepatobiliary diseases and in particular on equine hyperlipaemia. Hepatobiliary disease's aetiology, clinical signs, diagnosis and nutritional management are thus described in the first part of the review the second part being devoted to hyperlypaemia's lipid metabolism, epidemiology, clinical signs, post-mortem observations and nutritional management. Diagnosis of hepatic disease is usually based on the assessment of the serum activities while hepatic biopsy is considered as the golden standard of diagnosis of hepatic function. Nutritional management is often very useful in management of hepatic diseases: diet should be low in protein (of good biological value) and high in non-structural carbohydrates except for chronic hepatic disease (slightly high protein). Equine hyperlipaemia's mortality is around 70%. It consists of a disorder of lipid metabolism, characterized by increase in plasma triglycerides and deposition of fat on organs. From a nutritional point of view, hyperlipaemia in horses can be approached by maintaining positive energy balance, fighting dehydration and metabolic acidosis, and by the use of lipotropic factors.

Green areas induce smaller increases in the air temperature than built-up areas. They can offer a solution to mitigating the urban heat island impacts during heat waves, since the cool air generated by a park is diffused into its immediate surroundings through forced or natural convection. The purpose of this study is to characterize the effect of several variables (park size, morphology of surrounding urban area, and wind speed) on the spreading of cool air. A parametric study is performed to run computational fluid dynamics simulations. The air temperature entering the computational domain was set at 35 °C, and the 2-m high surface included within the 34 °C isotherm was defined as an indicator of cool air spreading. The effects of park shape and orientation were negligible in comparison with size effects. The number of buildings was better correlated with the cooled surface area than the typical urban parameters identified in the literature (i.e., building density, aspect ratio, or mean building height). Since the number of buildings is obviously related to the number of streets, this result suggests that the greater the number of streets around a park, the wider the area that cool air spreads.

Following development and validation of the SOLENE-microclimat tool, the underlying model was used to compare the impacts of various “greening strategies” on buildings’ summer energy consumption and indoor comfort. This study distinguishes between direct and indirect impacts by successively implementing the test strategies on both the studied building and surrounding ones; it also considers insulated vs. non-insulated buildings. Findings indicate that green walls have a direct effect on indoor comfort throughout the entire building, whereas the effect of green roofs is apparently primarily confined to the upper floor. Moreover, the indirect effect of a green wall is greater, mainly due to the drop in infrared emissions resulting from a lower surface temperature. It has also been proven that the indirect effects of green walls and surrounding lawns can help reduce the loads acting on a non-insulated building.

As stereoscopic devices become widely used (immersion-based working environments, stereoscopically viewed movies, autostereoscopic screens, etc), exposure to stereoscopic images can become lengthy, and some eyestrain can set in. We propose a method for reducing eyestrain induced by stereoscopic vision. After reviewing sources of eyestrain linked to stereoscopic vision, we will focus on one of these sources: images with high-frequency contents associated with large disparities. We will put forward an algorithm for removing irritating high frequencies in high disparity zones (i.e., for virtual objects appearing far from the real screen level). We will elaborate on our testing protocol to establish that our processing reduces eyestrain caused by stereoscopic vision, both objectively and subjectively. We will subsequently quantify the positive effects of our algorithm on the relief of eyestrain. As our processing alters the visual quality of the virtual world, we propose a new adaptation of our method to remove this drawback by coupling an eye tracking to our original processing to keep visual quality on the focus point.

as being significantly tastier and the apple as being significantly healthier. Nevertheless, while we hypothesized that participants embodied in a virtual body with obesity would show differences in their shopping patterns (e.g., more "unhealthy" products bought) there were no significant differences between the groups. Stereotype activation failed for our participants embodied in obese avatars, who did not exhibit a shopping behavior following the (negative) stereotypes related to obese people. conversely, while the opposite hypothesis (participants embodied in obese avatars would buy significantly more healthy products in order to "transform" their virtual bodies) could have been made, it was not the case either. We discuss these results and propose hypotheses as to why the behavior of the manipulated group differed from the one we expected. Indeed, unlike previous research, our participants were embodied in virtual avatars which differed greatly from their real bodies. Obese avatars should not only modify users' visual characteristics such as hair or skin color, etc. We hypothesize that an obese virtual body may require some other non-visual stimulus, e.g., the sensation of the extra weight or the change in body size. This main difference could then explain why we did not notice any important modification on participants' behavior and perceptions of food products. We also hypothesize that the absence of stereotype activation and thus of statistical difference between our N and OB groups might be due to higher-level cognitive processes involved while purchasing food products. Indeed our participants might have rejected their virtual bodies when performing the shopping task, while the embodiment and presence ratings did not show significant differences, and purchased products based on their real (non-obese) bodies. This could mean that stereotype activation is more complex that previously thought.