European Council

Heavy ion collision experiments recreating the quark-gluon plasma that filled the microseconds-old universe have established that it is a nearly perfect liquid that flows with such minimal dissipation that it cannot be seen as made of particles. String theory provides a powerful toolbox for studying matter with such properties. This book provides a comprehensive introduction to gauge/string duality and its applications to the study of the thermal and transport properties of quark-gluon plasma, the dynamics of how it forms, the hydrodynamics of how it flows, and its response to probes including jets and quarkonium mesons. Calculations are discussed in the context of data from RHIC and LHC and results from finite temperature lattice QCD. The book is an ideal reference for students and researchers in string theory, quantum field theory, quantum many-body physics, heavy ion physics and lattice QCD.

In the past two decades, a great deal of energy has been dedicated to improving children's education by increasing parents' involvement in school. However, the evidence on the effectiveness of parental involvement is uneven. Whereas policy makers and theorists have assumed that parental involvement has wide-ranging positive consequences, many studies have shown that it is negatively associated with some children's outcomes. This article uses data from the children of the National Longitudinal Survey of Youth 1979 to estimate time-lagged growth models of the effect of several types of parental involvement on scores on elementary school achievement tests and the Behavioral Problems Index. The findings suggest that parental involvement does not independently improve children's learning, but some involvement activities do prevent behavioral problems. Interaction analyses suggest that the involvement of parents with low socioeconomic status may be more effective than that of parents with high socioeconomic status.

BACKGROUND: In this study, the authors analyzed the efficacy and safety of gemtuzumab ozogamicin (GO) (Mylotarg), an antibody-targeted chemotherapy for CD33-positive acute myeloid leukemia (AML). METHODS: Patients with CD33-positive AML in first recurrence were entered in 3 open-label, single-arm, Phase II studies. Patients received monotherapy with GO 9 mg/m(2) as a 2-hour intravenous infusion in 2 doses separated by 2 weeks. Patients were evaluated for remission, survival, and treatment-emergent adverse events. RESULTS: Two hundred seventy-seven patients (median age, 61 yrs) were treated with GO, and 71 patients (26%) achieved remission, which was defined as < or = 5% blasts in the bone marrow without leukemic blasts in the peripheral blood, neutrophil recovery to > or = 1500/microL, hemoglobin > or = 9 g/dL, and independence from red blood cell and platelet transfusions. Complete remission (CR) with platelet recovery (> or = 100,000/microL) or without full platelet recovery (< 100,000/microL) (CRp) was observed in 35 patients (13%) and 36 patients (13%), respectively. The median recurrence-free survival was 6.4 months for patients who achieved CR and 4.5 months for patients who achieved CRp. Although expected incidences of Grade 3 or 4 neutropenia (98%) and thrombocytopenia (99%) were observed, the incidence of Grade 3 or 4 sepsis (17%) and pneumonia (8%) was relatively low. Grade 3 or 4 hyperbilirubinemia and hepatic aspartate aminotransferase and alanine aminotransferase elevations were reported in 29%, 18%, and 9% of patients, respectively; 0.9% of patients who did not undergo prior or subsequent hematopoietic stem cell transplantation developed hepatic venoocclusive disease after GO treatment. CONCLUSIONS: When it was administered to patients with CD33-positive AML in first recurrence, single-agent GO induced a 26% remission rate with a generally acceptable safety profile.

The growth of autistic self-advocacy and the neurodiversity movement has brought about new ethical, theoretical and ideological debates within autism theory, research and practice. These debates have had genuine impact within some areas of autism research but their influence is less evident within early intervention research. In this paper, we argue that all autism intervention stakeholders need to understand and actively engage with the views of autistic people and with neurodiversity as a concept and movement. In so doing, intervention researchers and practitioners are required to move away from a normative agenda and pay diligence to environmental goodness-of-fit, autistic developmental trajectories, internal drivers and experiences, and autistic prioritized intervention targets. Autism intervention researchers must respond to these debates by reframing effectiveness, developing tools to measure autistic prioritized outcomes, and forming partnerships with autistic people. There is a pressing need for increased reflection and articulation around how intervention practices align with a neurodiversity framework and greater emphasis within intervention programmes on natural developmental processes, coping strategies, autonomy, and well-being.

The solution to plastic pollution is not less chemistry but more, greener chemistry in a circular bio-based economy.

Global climate change is a major threat to biodiversity. Large-scale analyses have generally focused on the impacts of climate change on the geographic ranges of species and on phenology, the timing of ecological phenomena. We used long-term monitoring of the abundance of breeding birds across Europe and the United States to produce, for both regions, composite population indices for two groups of species: those for which climate suitability has been either improving or declining since 1980. The ratio of these composite indices, the climate impact indicator (CII), reflects the divergent fates of species favored or disadvantaged by climate change. The trend in CII is positive and similar in the two regions. On both continents, interspecific and spatial variation in population abundance trends are well predicted by climate suitability trends.

Heavy ion collision experiments recreating the quark-gluon plasma that filled the nascent universe have established that it is a nearly perfect liquid that flows with such minimal dissipation that it cannot be seen as made of particles. String theory provides a powerful toolbox for studying matter with such properties. This book provides a comprehensive introduction to gauge/string duality and its applications to the study of the thermal and transport properties of quark-gluon plasma, the dynamics of how it forms, how it flows, and its response to probes including jets and quarkonium mesons. Calculations are discussed in the context of data from RHIC and LHC and results from finite temperature lattice QCD. This is an ideal reference for students and researchers in string theory, quantum field theory, quantum many-body physics, heavy ion physics and lattice QCD. This title from 2014 has been reissued as an Open Access publication on Cambridge Core.

This book explains the underlying physics of synchrotron radiation and derives its main properties. It is divided into four parts. The first covers the general case of the electromagnetic fields created by an accelerated relativistic charge. The second part concentrates on the radiation emitted by a charge moving on a circular trajectory. The third looks at undulator radiation, covering plane weak undulators, strong undulators and other more general undulators. The final part deals with applications and investigates the optics of synchrotron radiation dominated by diffraction due to the small opening angle. It also includes a description of electron storage rings as radiation sources and the effect of the emitted radiation on the electron beam. This book provides a valuable reference for scientists and engineers in the field of accelerators, and all users of synchrotron radiation.

The Energy [R]evolution 2010 scenario is an update of the Energy [R]evolution scenarios published in 2007 and 2008. It takes up recent trends in global energy demand and production and analyses to which extent this affects chances for achieving climate protection targets. The main target is to reduce global CO2 emissions to 3.7 Gt/a in 2050, thus limiting global average temperature increase to below 2°C and preventing dangerous anthropogenic interference with the climate system. A ten-region energy system model is used for simulating global energy supply strategies. A review of sector and region specific energy efficiency measures resulted in the specification of a global energy demand scenario incorporating strong energy efficiency measures. The corresponding supply scenario has been developed in an iterative process in close cooperation with stakeholders and regional counterparts from academia, NGOs and the renewable energy industry. The Energy [R]evolution scenario shows that renewable energy can provide more than 80% of the world’s energy needs by 2050. Developing countries can virtually stabilise their CO2 emissions by 2025 and reduce afterwards, whilst at the same time increasing energy consumption due to economic growth. OECD countries will be able to reduce their emissions by up to 90% by 2050. However, without a comprehensive energy efficiency implementation strategy across all sectors, the renewable energy development alone will not be enough to make these drastic emissions cuts.

The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1) proposing a common framework of care pathways for chronic respiratory diseases, which will facilitate comparability and trans-national initiatives; 2) informing cost-effective policy development, strengthening in particular those on smoking and environmental exposure; 3) aiding risk stratification in chronic disease patients, using a common strategy; 4) having a significant impact on the health of citizens in the short term (reduction of morbidity, improvement of education in children and of work in adults) and in the long-term (healthy ageing); 5) proposing a common simulation tool to assist physicians; and 6) ultimately reducing the healthcare burden (emergency visits, avoidable hospitalisations, disability and costs) while improving quality of life. In the longer term, the incidence of disease may be reduced by innovative prevention strategies. AIRWAYSICPs was initiated by Area 5 of the Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing. All stakeholders are involved (health and social care, patients, and policy makers).

The use of patient reported outcome scales in clinical trials conducted by the pharmaceutical industry has become more widespread in recent years. The use of such outcomes is particularly common for products developed to treat chronic, disabling conditions where the intention is not to cure but to ameliorate symptoms, facilitate functioning or, ultimately, to improve quality of life. In such cases, patient reported evidence is increasingly viewed as an essential complement to traditional clinical evidence for establishing a product's competitive advantage in the marketplace. In a commercial setting, the value of patient reported outcomes is viewed largely in terms of their potential for securing a labelling claim in the USA or inclusion in the summary of product characteristics in Europe. Although, the publication of the recent US Food and Drug Administration guidance makes it difficult for companies to make claims in the USA beyond symptom improvements, the value of these outcomes goes beyond satisfying requirements for a label claim. The European regulatory authorities, payers both in the US and Europe, clinicians and patients all play a part in determining both the availability and the pricing of medicinal products and all have an interest in patient-reported data that go beyond just symptoms. The purpose of the current paper is to highlight the potential added value of patient reported outcome data currently collected and held by the industry for these groups.

Guidelines aim to present all the relevant evidence on a particular issue in order to help physicians to weigh the benefits and risks of a particular diagnostic or therapeutic procedure. They should be helpful in everyday clinical decision-making. A great number of guidelines have been issued in recent years by different organisations--European Society of Cardiology (ESC), American Heart Association (AHA), American College of Cardiology (ACC), and other related societies. By means of links to web sites of National Societies several hundred guidelines are available. This profusion can put at stake the authority and validity of guidelines, which can only be guaranteed if they have been developed by an unquestionable decision-making process. This is one of the reasons why the ESC and others have issued recommendations for formulating and issuing guidelines. In spite of the fact that standards for issuing good quality guidelines are well defined, recent surveys of guidelines published in peer-reviewed journals between 1985 and 1998 have shown that methodological standards were not complied with in the vast majority of cases. It is therefore of great importance that guidelines and recommendations are presented in formats that are easily interpreted. Subsequently, their implementation programmes must also be well conducted. Attempts have been made to determine whether guidelines improve the quality of clinical practice and the utilisation of health resources. In addition, the legal implications of medical guidelines have been discussed and examined, resulting in position documents, which have been published by a specific task force. The ESC Committee for practice guidelines (CPG) supervises and coordinates the preparation of new guidelines and expert consensus documents produced by task forces, expert groups or consensus panels. The Committee is also responsible for the endorsement of these guidelines or statements.

Cancer survivorship has traditionally received little prioritisation and attention. For a long time, the treatment of cancer has been the main focus of healthcare providers' efforts. It is time to increase the amount of attention given to patients' long-term well-being and their ability to return to a productive and good life. This article describes the current state of knowledge and identifies research areas in need of development to enable interventions for improved survivorship for all cancer patients in Europe. The article is summed up with 11 points in need of further focus.

AIMS: Coronary late stent thrombosis, a rare but devastating complication, remains an important concern in particular with the increasing use of drug-eluting stents. Notably, pathological studies have indicated that the proportion of uncovered coronary stent struts represents the best morphometric predictor of late stent thrombosis. Intracoronary optical frequency domain imaging (OFDI), a novel second-generation optical coherence tomography (OCT)-derived imaging method, may allow rapid imaging for the detection of coronary stent strut coverage with a markedly higher precision when compared with intravascular ultrasound, due to a microscopic resolution (axial approximately 10-20 microm), and at a substantially increased speed of image acquisition when compared with first-generation time-domain OCT. However, a histological validation of coronary OFDI for the evaluation of stent strut coverage in vivo is urgently needed. Hence, the present study was designed to evaluate the capacity of coronary OFDI by electron (SEM) and light microscopy (LM) analysis to detect and evaluate stent strut coverage in a porcine model. METHODS AND RESULTS: Twenty stents were implanted into 10 pigs and coronary OFDI was performed after 1, 3, 10, 14, and 28 days. Neointimal thickness as detected by OFDI correlated closely with neointimal thickness as measured by LM (r = 0.90, P < 0.01). The comparison of stent strut coverage as detected by OFDI and SEM analysis revealed an excellent agreement (r = 0.96, P < 0.01). In particular, stents completely covered by OFDI analysis were also completely covered by SEM analysis. All incompletely covered stents by OFDI were also incompletely covered by SEM. Analyses of fibrin-covered stent struts suggested that these may rarely be detected as uncovered stent struts by OFDI. Importantly, optical density measurements revealed a significant difference between fibrin- and neointima-covered coronary stent struts [0.395 (0.35-0.43) vs. 0.53 (0.47-0.57); P < 0.001], suggesting that differences in optical density provide information on the type of stent strut coverage. The sensitivity and specificity for detection of fibrin vs. neointimal coverage was evaluated using receiver-operating characteristic analysis. CONCLUSION: The present study demonstrates that OFDI is a highly promising tool for accurate evaluation of coronary stent strut coverage, as supported by a high agreement between OFDI and light and electron microscopic analysis. Furthermore, our data indicate that optical density measurements can provide additional information with respect to the type of stent strut coverage, i.e. fibrin vs. neointimal coverage. Therefore, coronary OFDI analysis will provide important information on the biocompatibility of coronary stents.

This book is a basic introduction to the principles of circular particle accelerators and storage rings, for scientists, engineers and mathematicians. Particle accelerators used to be the exclusive province of physicists exploring the structure of the most fundamental constituents of matter. Nowadays, particle accelerators have also found uses as tools in many other areas, including materials science, chemistry, and medical science. Many people from these fields of study, as well as from particle physics, have learned about accelerators at various courses organised by CERN, the European Organisation for Nuclear Research which has established a reputation as the world's top accelerator facility. Kjell Johnsen and Phil Bryant, the authors of this book, are distinguished accelerator physicists who have also run the CERN Accelerator School. The text they present here starts with a historical introduction to the field and an outline of the basic concepts of particle acceleration and phase focusing. It goes on to give more details of how the transverse and longitudinal motions of the particle beams can be analysed, including treatments of lattice design, compensation schemes, transition crossing, and other radio frequency effects. The book will be an essential reference to anyone working with particle accelerators as a designer, operator or user, as well as being a good preparation for those intending to go to the frontiers of accelerator physics.

Abstract A growing number of scholars argue that the development of the common security and defence policy (CSDP) should be analysed as the institutionalization of a system of security governance. Although governance approaches carry the promise of a sophisticated, empirically grounded picture of CSDP, they have been criticized for their lack of attention to power. This is because governance approaches focus on institutional rules and ideas rather than the social structure that underpins them. To refine the notion of security governance, this article analyses co‐operation patterns through social network analysis. Confirming the governance image, it maps out a complex constellation of CSDP actors that features cross‐border and cross‐level ties between different national and EU policy actors. It is also found, however, that CSDP is dominated by a handful of traditional state actors – in particular, Brussels‐based national ambassadors – who retain strategic positions vis‐à‐vis weaker supranational and non‐state actors. These actors are not giving up on state power, but reconstituting it at the supranational level.

OBJECTIVE: To study Epstein-Barr virus (EBV) DNA loads in peripheral blood of HIV carriers to determine base-line values and diagnostic relevance of viral load in relation to quantitative serology; to compare EBV presence in parallel plasma and unfractionated whole blood samples; and to correlate EBV DNA load to HIV, CD4 T-cell counts and HAART. DESIGN: One-hundred and nine random patients receiving highly active antiretroviral therapy (HAART) during 1999 and 99 patients on anti-HIV monotherapy during 1993-1996 were included. METHODS: EBV DNA load was determined by quantitative competitive PCR. EBV serology was determined by immunoblot profile and quantitative enzyme-linked immunosorbent assay for responses against VCA-p18 and EBNA-1. RESULTS: Twenty-two out of 109 patients receiving HAART and 28 out of 99 of patients on anti-HIV monotherapy showed elevated EBV DNA loads in whole blood (> 2000 copies/ml), without elevated loads in parallel plasma. EBV DNA load distribution did not differ between the two groups (P = 0.78) and did not correlate with HIV or CD4 T-cell count. In three patients with high EBV DNA loads EBV RNA was virtually absent. Patients with high EBV DNA loads (3610-89 400 copies/ml) had higher anti-VCA-p18 IgG levels than patients with undetectable EBV DNA (P < 0.0001) but lower anti-EBNA-1 IgG levels (P = 0.005). CONCLUSION: Absolute values of EBV DNA load may have poor diagnostic value for defining HIV patients at risk for developing EBV-associated disease. Elevated EBV DNA loads are cell-associated and are not influenced by HAART. Increased anti-p18-VCA and decreased anti-EBNA-1 IgG levels in patients with high EBV loads indicate impaired latency control and increased lytic replication suggesting disturbed overall immunosurveillance against EBV.

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Abstract Aim Climate warming and land use change represent a major challenge for both species and conservation managers. Temporally and spatially explicit projections of the future distribution of species have been extensively developed to support decision‐making in conservation. The aim of this study was to move beyond the simple projections of likely impacts of global change to identify the most vulnerable species. We suggest an original vulnerability index that integrates estimations of projected range change and different proxies of species resilience in a quantitative way. The proposed index is generally applicable, completely quantitative, and it allows ranking species so as to prioritize conservation actions. Location We illustrate the applicability of the vulnerability index using breeding birds in Switzerland as an example of conservation target. Methods The vulnerability index relies on five indicators quantifying different aspects of the projected change in distributional area, the reservoirs available for the species and their recent population trend. Species distribution was modelled using three different techniques (GAM, MARS and BRT) and then projected for 2050 and 2100 according to two different IPCC scenarios of climate change coupled with two regional land use scenarios to represent different magnitudes of the stressors and the range of possible outcomes. Results According to the different contributions of the base indicators, different patterns of vulnerability can be distinguished. In Switzerland, breeding birds inhabiting coniferous woodlands, alpine habitats and wetlands have significantly higher vulnerability to climate and land use change than species in other habitats. Main conclusions The proposed vulnerability index represents an early warning system as it identifies species that are currently not threatened, but are very likely to become so. As such, it complements the assessment of risk of species' extinction based on the Red List and on their international importance.

The Council of the European Academy of Craniomandibular Disorders charged the Educational Committee with the task of establishing Guidelines and Recommendations for the examination, diagnosis, and management of patients with temporomandibular disorders and orofacial pain by the general dental practitioner. It was not their purpose to present a thorough and critical review of the vast amount of literature available but to summarize the at-present generally accepted clinical approach. These recommendations are based as much as possible on scientific evidence and on sound clinical judgment in cases where only partial evidence or contradictory data were found.