Gesellschaft für wissenschaftliche Datenverarbeitung mbH Göttingen

The Internet has led to the creation of a digital society, where (almost) everything is connected and is accessible from anywhere. However, despite their widespread adoption, traditional IP networks are complex and very hard to manage. It is both difficult to configure the network according to predefined policies, and to reconfigure it to respond to faults, load, and changes. To make matters even more difficult, current networks are also vertically integrated: the control and data planes are bundled together. Software-defined networking (SDN) is an emerging paradigm that promises to change this state of affairs, by breaking vertical integration, separating the network's control logic from the underlying routers and switches, promoting (logical) centralization of network control, and introducing the ability to program the network. The separation of concerns, introduced between the definition of network policies, their implementation in switching hardware, and the forwarding of traffic, is key to the desired flexibility: by breaking the network control problem into tractable pieces, SDN makes it easier to create and introduce new abstractions in networking, simplifying network management and facilitating network evolution. In this paper, we present a comprehensive survey on SDN. We start by introducing the motivation for SDN, explain its main concepts and how it differs from traditional networking, its roots, and the standardization activities regarding this novel paradigm. Next, we present the key building blocks of an SDN infrastructure using a bottom-up, layered approach. We provide an in-depth analysis of the hardware infrastructure, southbound and northbound application programming interfaces (APIs), network virtualization layers, network operating systems (SDN controllers), network programming languages, and network applications. We also look at cross-layer problems such as debugging and troubleshooting. In an effort to anticipate the future evolution of this new paradigm, we discuss the main ongoing research efforts and challenges of SDN. In particular, we address the design of switches and control platforms - with a focus on aspects such as resiliency, scalability, performance, security, and dependability - as well as new opportunities for carrier transport networks and cloud providers. Last but not least, we analyze the position of SDN as a key enabler of a software-defined environment.

The programs SHELXC, SHELXD and SHELXE are designed to provide simple, robust and efficient experimental phasing of macromolecules by the SAD, MAD, SIR, SIRAS and RIP methods and are particularly suitable for use in automated structure-solution pipelines. This paper gives a general account of experimental phasing using these programs and describes the extension of iterative density modification in SHELXE by the inclusion of automated protein main-chain tracing. This gives a good indication as to whether the structure has been solved and enables interpretable maps to be obtained from poorer starting phases. The autotracing algorithm starts with the location of possible seven-residue alpha-helices and common tripeptides. After extension of these fragments in both directions, various criteria are used to decide whether to accept or reject the resulting poly-Ala traces. Noncrystallographic symmetry (NCS) is applied to the traced fragments, not to the density. Further features are the use of a 'no-go' map to prevent the traces from passing through heavy atoms or symmetry elements and a splicing technique to combine the best parts of traces (including those generated by NCS) that partly overlap.

Diatom Fall 2012 saw the greatest Arctic ice minimum ever recorded. This allowed unprecedented access for research vessels deep into the Arctic Ocean to make high-latitude observations of ice melt and associated phenomena. From the RV Polarstern between 84° to 89° North, Boetius et al. (p. 1430 , published online 14 February; see the cover) observed large-scale algal aggregates of the diatom Melosira arctica hanging beneath multiyear and seasonal ice across a wide range of latitudes. The strands of algae were readily dislodged and formed aggregates on the seabed up to 4400 meters below, where the algae are consumed by large mobile invertebrates, such as sea cucumbers and brittle stars. Although Nansen observed sub-ice algae in the Arctic 100 years ago, the extent of this bloom phenomenon was unknown. The dynamics of such blooms must impinge on global carbon budgets, but how the dynamics will change as ice melt becomes more extensive remains unclear.

Thermoresponsive polymers hold great potential in the biomedical field, since they enable the fabrication of cell sheets, in situ drug delivery and 3D-printing under physiological conditions. In this review we provide an overview of several thermoresponsive polymers and their application, with focus on poly(N-isopropylacrylamide)-surfaces for cell sheet engineering. Basic knowledge of important processes like protein adsorption on surfaces and cell adhesion is provided. For different thermoresponsive polymers, namely PNIPAm, Pluronics, elastin-like polypeptides (ELP) and poly(N-vinylcaprolactam) (PNVCL), synthesis and basic chemical and physical properties have been described and the mechanism of their thermoresponsive behavior highlighted. Fabrication methods of thermoresponsive surfaces have been discussed, focusing on PNIPAm, and describing several methods in detail. The latter part of this review is dedicated to the application of the thermoresponsive polymers and with regard to cell sheet engineering, the process of temperature-dependent cell sheet detachment is explained. We provide insight into several applications of PNIPAm surfaces in cell sheet engineering. For Pluronics, ELP and PNVCL we show their application in the field of drug delivery and tissue engineering. We conclude, that research of thermoresponsive polymers has made big progress in recent years, especially for PNIPAm since the 1990s. However, manifold research possibilities, e.g. in surface fabrication and 3D-printing and further translational applications are conceivable in near future.

. For the first time, a setup is presented for overall high precision and high accuracy relative protein-ligand alchemical free energy calculations based on open-source software.

When users flood in cloud data centers, how to efficiently manage hardware resources and virtual machines (VMs) in a data center to both lower economical cost and ensure a high service quality becomes an inevitable work for cloud providers. VM migration is a cornerstone technology for the majority of cloud management tasks. It frees a VM from the underlying hardware. This feature brings a plenty of benefits to cloud providers and users. Many researchers are focusing on pushing its cutting edge. In this paper, we first give an overview of VM migration and discuss both its benefits and challenges. VM migration schemes are classified from three perspectives: 1) manner; 2) distance; and 3) granularity. The studies on non-live migration are simply reviewed, and then those on live migration are comprehensively surveyed based on the three main challenges it faces: 1) memory data migration; 2) storage data migration; and 3) network connection continuity. The works on quantitative analysis of VM migration performance are also elaborated. With the development and evolution of cloud computing, user mobility becomes an important motivation for live VM migration in some scenarios (e.g., fog computing). Thus, the studies regarding linking VM migration to user mobility are summarized as well. At last, we list the open issues which are waiting for solutions or further optimizations on live VM migration.

To determine the effect of environmental factors on the preservation of DNA, archeological teeth of approximately similar age but greatly differing site milieu were examined for DNA content. The complex relational system of locational milieu of the samples was reduced to its essential and, at the same time, easily measurable factors. These are temperature, humidity, pH value, the geochemical properties of the soil, the amount of postmortal organic substances and the general degree of microbial infestation in the respective soil. The relative DNA content in the samples was established by determining the rate of successful polymerase chain reaction (PCR) amplifications. Differences in quantity and quality of the results are attributed to the respective prevailing environmental factor or to the respective storage conditions. Dryness, low temperature and absence of microorganisms favors the preservation of DNA. The bioapatite of bones and teeth, like the DNA, are preserved under neutral or slightly alkaline conditions. Brief storage at room temperature does not affect the amount of amplifiable DNA but does affect the reproducibility of the results. Long storage outside a lab freezer reduces the amount and the reproducibility of DNA amplifications in ancient specimens.

Rigid fixed-grid wavelength division multiplexing (WDM) optical networks can no longer keep up with the emerging bandwidth-hungry and highly dynamic services in an efficient manner. As the available spectrum in optical fibers becomes occupied and is approaching fundamental limits, the research community has focused on seeking more advanced optical transmission and networking solutions that utilize the available bandwidth more effectively. To this end, the flexible/elastic optical networking paradigm has emerged as a way to offer efficient use of the available optical resources. In this work, we provide a comprehensive view of the different pieces composing the “flexible networking puzzle” with special attention given to capturing the occurring interactions between different research fields. Only when these interrelations are clearly defined, an optimal network-wide solution can be offered. Physical layer technological aspects, network optimization for flexible networks, and control plane aspects are examined. Furthermore, future research directions and open issues are discussed.

Research Article| August 01, 2007 Crystal Zoning as an Archive for Magma Evolution Catherine Ginibre; Catherine Ginibre 1Département de Minéralogie, Université de Genève 13 rue des Maraîchers, 1205 Genève, Switzerland E-mail: catherine.ginibre@terre.unige.ch Search for other works by this author on: GSW Google Scholar Gerhard Wörner; Gerhard Wörner 2Geowissenschaftliches Zentrum Göttinger. Abt. Geochemie Goldschmidtstr. 1, 37077 Göttingen, Germany Search for other works by this author on: GSW Google Scholar Andreas Kronz Andreas Kronz 2Geowissenschaftliches Zentrum Göttinger. Abt. Geochemie Goldschmidtstr. 1, 37077 Göttingen, Germany Search for other works by this author on: GSW Google Scholar Elements (2007) 3 (4): 261–266. https://doi.org/10.2113/gselements.3.4.261 Article history first online: 09 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share MailTo Twitter LinkedIn Tools Icon Tools Get Permissions Search Site Citation Catherine Ginibre, Gerhard Wörner, Andreas Kronz; Crystal Zoning as an Archive for Magma Evolution. Elements 2007;; 3 (4): 261–266. doi: https://doi.org/10.2113/gselements.3.4.261 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyElements Search Advanced Search Abstract Spatial compositional variations in magmatic minerals record chemical and physical changes in the magma from which they grew. Electron-beam techniques allow high-resolution imaging and quantitative analysis of this compositional archive for major, minor and some trace elements. In this way, magmatic processes such as crystallization, recharge in a magma chamber, decompression during ascent, and convection in the magma chamber can be identified and the history of magmatic systems prior to eruption reconstructed. You do not have access to this content, please speak to your institutional administrator if you feel you should have access.

Apomixis in angiosperms is asexual reproduction from seed. Its importance to angiospermous evolution and biodiversity has been difficult to assess mainly because of insufficient taxonomic documentation. Thus, we assembled literature reporting apomixis occurrences among angiosperms and transferred the information to an internet database (http://www.apomixis.uni-goettingen.de). We then searched for correlations between apomixis occurrences and well-established measures of taxonomic diversity and biogeography. Apomixis was found to be taxonomically widespread with no clear tendency to specific groups and to occur with sexuality at all taxonomic levels. Adventitious embryony was the most frequent form (148 genera) followed by apospory (110) and diplospory (68). All three forms are phylogenetically scattered, but this scattering is strongly associated with measures of biodiversity. Across apomictic-containing orders and families, numbers of apomict-containing genera were positively correlated with total numbers of genera. In general, apomict-containing orders, families, and subfamilies of Asteraceae, Poaceae, and Orchidaceae were larger, i.e., they possessed more families or genera, than non-apomict-containing orders, families or subfamilies. Furthermore, many apomict-containing genera were found to be highly cosmopolitan. In this respect, 62% occupy multiple geographic zones. Numbers of genera containing sporophytic or gametophytic apomicts decreased from the tropics to the arctic, a trend that parallels general biodiversity. While angiosperms appear to be predisposed to shift from sex to apomixis, there is also evidence of reversions to sexuality. Such reversions may result from genetic or epigenetic destabilization events accompanying hybridization, polyploidy, or other cytogenetic alterations. Because of increased within-plant genetic and genomic heterogeneity, range expansions and diversifications at the species and genus levels may occur more rapidly upon reversion to sexuality. The significantly-enriched representations of apomicts among highly diverse and geographically-extensive taxa, from genera to orders, support this conclusion.

We present electron microprobe, secondary ion mass spectrometry, and laser ablation inductively coupled mass spectrometry data for common trace elements (Li, Al, Ti, Na, K, Fe) in quartz. Our samples from both magmatic and hydrothermal environments all show heterogeneity at the single grain scale. ConcentrationsofAlandTi determinedbyEPMA,SIMS,andLA-ICP-MSareinroughagreementandconfirmtherobustnessof these analytical methods. The highest precision data were obtained from SIMS, but this is outweighed by the lack of a high quality quartz reference sample for calibrating this technique. Due to its large sampling volume, laser ablation analyses gave only average values for trace elements in zoned quartz. Because of its better spatial resolution in conjunction with the ability to combine spot analyseswithcathodoluminescenceimaging EPMAprovedthemost reliable insitu methodfor obtainingquantitativetraceelement dataofquartzatconcentrationsinexcessof afew10' sofppmandatthe<10µ mscale.However,oursamplecontainedfewelements at such high concentration levels. We found in our samples a positive correlation between CL signature and the observed Ti contents for the samples investigated. In particular, blue luminescing zones were found to have elevated Ti concentrations as compared to other nearby domains. Using a mathematical spectral deconvolution weshow thehighlycomplex natureof CL emission- it appearsthat other trace elementmight play a less pronounced role in this process. Our examples demonstrate the value of CL for documenting multi-phase alteration in quartz. In agreement with previously proposed models, we confirm a significant correlation between mono- and tri-valent cation concentrations in quartz. A very strong correlation in alkali metal contents is particularly obvious. Ti was found to be universally present in magmatic quartz, but at much lower abundance in hydrothermal quartz.

Collaboration et al., (2021). The Pencil Code, a modular MPI code for partial differential equations and particles: multipurpose and multiuser-maintained. Journal of Open Source Software, 6(58), 2807, https://doi.org/10.21105/joss.02807

Network Function Virtualization (NFV) has been emerging as an appealing solution that transforms complex network functions from dedicated hardware implementations to software instances running in a virtualized environment. Due to the numerous advantages such as flexibility, efficiency, scalability, short deployment cycles, and service upgrade, NFV has been widely recognized as the next-generation network service provisioning paradigm. In NFV, the requested service is implemented by a sequence of Virtual Network Functions (VNF) that can run on generic servers by leveraging the virtualization technology. These VNFs are pitched with a predefined order through which data flows traverse, and it is also known as the Service Function Chaining (SFC). In this article, we provide an overview of recent advances of resource allocation in NFV. We generalize and analyze four representative resource allocation problems, namely, (1) the VNF Placement and Traffic Routing problem, (2) VNF Placement problem, (3) Traffic Routing problem in NFV, and (4) the VNF Redeployment and Consolidation problem. After that, we study the delay calculation models and VNF protection (availability) models in NFV resource allocation, which are two important Quality of Service (QoS) parameters. Subsequently, we classify and summarize the representative work for solving the generalized problems by considering various QoS parameters (e.g., cost, delay, reliability, and energy) and different scenarios (e.g., edge cloud, online provisioning, and distributed provisioning). Finally, we conclude our article with a short discussion on the state-of-the-art and emerging topics in the related fields, and highlight areas where we expect high potential for future research.

The plant-specific, B3 domain-containing transcription factor ABSCISIC ACID INSENSITIVE3 (ABI3) is an essential component of the regulatory network controlling the development and maturation of the Arabidopsis thaliana seed. Genome-wide chromatin immunoprecipitation (ChIP-chip), transcriptome analysis, quantitative reverse transcriptase-polymerase chain reaction and a transient promoter activation assay have been combined to identify a set of 98 ABI3 target genes. Most of these presumptive ABI3 targets require the presence of abscisic acid for their activation and are specifically expressed during seed maturation. ABI3 target promoters are enriched for G-box-like and RY-like elements. The general occurrence of these cis motifs in non-ABI3 target promoters suggests the existence of as yet unidentified regulatory signals, some of which may be associated with epigenetic control. Several members of the ABI3 regulon are also regulated by other transcription factors, including the seed-specific, B3 domain-containing FUS3 and LEC2. The data strengthen and extend the notion that ABI3 is essential for the protection of embryonic structures from desiccation and raise pertinent questions regarding the specificity of promoter recognition.

Abstract. The Tommeliten seepage area is part of the Greater Ekofisk area, which is situated above the Tommeliten Delta salt diapir in the central North Sea (56°29.90' N, 2°59.80' E, Norwegian Block 1/9, 75 m water depth). Here, cracks in a buried marl horizon allow methane to migrate into overlying clay-silt and sandy sediments. Hydroacoustic sediment echosounding showed several venting spots coinciding with the apex of marl domes where methane is released into the water column and potentially to the atmosphere. In the vicinity of the gas seeps, sea floor observations showed small mats of giant sulphide-oxidizing bacteria above patches of black sediments as well as carbonate crusts, which are exposed 10 to 50 cm above seafloor forming small reefs. These Methane-Derived Authigenic Carbonates (MDACs) contain 13C-depleted, archaeal lipids indicating previous gas seepage and AOM activity. High amounts of sn2-hydroxyarchaeol relative to archaeol and low abundances of biphytanes in the crusts give evidence that ANaerobic MEthane-oxidising archaea (ANME) of the phylogenetic cluster ANME-2 were the potential mediators of Anaerobic Oxidation of Methane (AOM) at the time of carbonate formation. Small pieces of MDACs were also found subsurface at about 1.7 m sediment depth, associated with the AOM zone. This zone is characterized by elevated AOM and Sulphate Reduction (SR) rates, increased concentrations of 13C-depleted tetraether derived biphytanes, and specific bacterial Fatty Acids (FA). Further biomarker and 16S rDNA based analyses of this horizon give evidence that AOM is mediated by archaea belonging to the ANME-1b group and Sulphate Reducing Bacteria (SRB) most likely belonging to the Seep-SRB1 cluster. The zone of active methane consumption was restricted to a distinct horizon of about 20 cm. Concentrations of 13C-depleted lipid biomarkers (e.g. 500 ng g-dw−1 biphythanes, 140 ng g-dw−1 fatty acid ai-C15:0), cell numbers (1.5×108 cells cm−3), AOM and SR rates (3 nmol cm−3 d−1) in the Tommeliten AOM zone are 2–3 orders of magnitude lower compared to AOM zones of highly active deep water cold seeps such as Hydrate Ridge or the Gulf of Mexico.

Cloud computing materializes the vision of utility computing. Tenants can benefit from on-demand provisioning of compute, storage, and networking resources according to a pay-per-use business model. Tenants have only limited visibility and control over network resources. The owners of cloud computing facilities are also facing challenges in various aspects of providing and efficiently managing IaaS facilities. In this work we present the networking issues in IaaS and federation challenges that are currently addressed with existing technologies. We also present innovative software-defined networking proposals, which are applied to some of the challenges and could be used in future deployments as efficient solutions.

INTRODUCTION: This article is part of the Focus Theme of Methods of Information in Medicine on the German Medical Informatics Initiative. HiGHmed brings together 24 partners from academia and industry, aiming at improvements in care provision, biomedical research and epidemiology. By establishing a shared information governance framework, data integration centers and an open platform architecture in cooperation with independent healthcare providers, the meaningful reuse of data will be facilitated. Complementary, HiGHmed integrates a total of seven Medical Informatics curricula to develop collaborative structures and processes to train medical informatics professionals, physicians and researchers in new forms of data analytics. GOVERNANCE AND POLICIES: We describe governance structures and policies that have proven effective during the conceptual phase. These were further adapted to take into account the specific needs of the development and networking phase, such as roll-out, carerelated aspects and our focus on curricula development in Medical Inform atics. ARCHITECTURAL FRAMEWORK AND METHODOLOGY: To address the challenges of organizational, technical and semantic interoperability, a concept for a scalable platform architecture, the HiGHmed Platform, was developed. We outline the basic principles and design goals of the open platform approach as well as the roles of standards and specifications such as IHE XDS, openEHR, SNOMED CT and HL7 FHIR. A shared governance framework provides the semantic artifacts which are needed to establish semantic interoperability. USE CASES: Three use cases in the fields of oncology, cardiology and infection control will demonstrate the capabilities of the HiGHmed approach. Each of the use cases entails diverse challenges in terms of data protection, privacy and security, including clinical use of genome sequencing data (oncology), continuous longitudinal monitoring of physical activity (cardiology) and cross-site analysis of patient movement data (infection control). DISCUSSION: Besides the need for a shared governance framework and a technical infrastructure, backing from clinical leaders is a crucial factor. Moreover, firm and sustainable commitment by participating organizations to collaborate in further development of their information system architectures is needed. Other challenges including topics such as data quality, privacy regulations, and patient consent will be addressed throughout the project.

Older children with online schooling requirements, unsurprisingly, were reported to have increased screen time during the first COVID-19 lockdown in many countries. Here, we ask whether younger children with no similar online schooling requirements also had increased screen time during lockdown. We examined children's screen time during the first COVID-19 lockdown in a large cohort (n = 2209) of 8-to-36-month-olds sampled from 15 labs across 12 countries. Caregivers reported that toddlers with no online schooling requirements were exposed to more screen time during lockdown than before lockdown. While this was exacerbated for countries with longer lockdowns, there was no evidence that the increase in screen time during lockdown was associated with socio-demographic variables, such as child age and socio-economic status (SES). However, screen time during lockdown was negatively associated with SES and positively associated with child age, caregiver screen time, and attitudes towards children's screen time. The results highlight the impact of the COVID-19 lockdown on young children's screen time.

Benchmark propagation rate coefficient (<italic>k</italic>_p) data for the radical polymerization of methyl acrylate are provided.

The combination of scanning electron microscope–cathodoluminescence (CL), fluid inclusion analysis and high-resolution electron probe microanalysis of Al, Ti, K and Fe in vein quartz has yielded results permitting a greater understanding of the complex mineralisation of the Central Oyu Tolgoi and Zesen Uul porphyry-style deposits, southern Mongolia. These data demonstrate the relationship between quartz precipitation, dissolution and ore deposition as the mineralising fluid chemistry changed through time. Four major quartz generations are identified in the A-type veins from the stockworks of both the Central Oyu Tolgoi (OTi to OTiv) and Zesen Uul deposits (ZUi to ZUiv). Despite differences in the associated alteration and mineralisation style, the observed CL textures and trace element signatures of the quartz generations are comparable between deposits. The OTi and ZUi stage formed both the primary network of A-type veins and pervasive silicification of the host rock. Using the Ti-in-quartz geothermometer, crystallisation temperatures for OTi and ZUi of between 598°C and 880°C are indicated. The main stage of sulphide mineralisation was accompanied by the dissolution of pre-existing quartz (OTi and ZUi) and precipitation of a weakly luminescent generation of quartz (OTii and ZUii) with a low Ti content, reflected in a calculated temperature drop from approximately 700°C to 340°C in Central Oyu Tolgoi and 445°C in Zesen Uul. OTii and ZUii stage quartzes show high and variable Al concentrations. The next stage of quartz in both deposits (OTiii and ZUiii) forms a fine network of veins in cracks formed in pre-existing quartz. OTiii and ZUiii quartz contain measurable fluid inclusions of moderate salinity (3–17.1 wt.% NaCl eq.), entrapped in the temperature range 256°C to 385°C. OTiii and ZUiii are not related to any sulphide mineralisation. The final OTiv and ZUiv stages are characterised by quartz–calcite micro-breccias that penetrate the A-type veins. Based on the calculated entrapment temperatures, the OTiv/ZUiv stage crystallised between 212°C and 335°C, and the quartz is characterised by elevated but variable Al and Fe contents. The CL and trace element signatures of the OTi to OTiii and ZUi to ZUiii stages of the two Mongolian porphyries show similar features to those observed in porphyry-style deposits from other regions. This suggests that a common sequence of quartz crystallisation occurs during the formation of early veins in many porphyry copper systems.