Ida Darwin hospital

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.

Wild capuchin monkeys inhabiting dry forest were found to customarily use tools as part of their extractive foraging techniques. Tools consisted of twigs and sticks, often modified, which were used to probe for insects and, most frequently, of stones of a variety of sizes and shapes used for cracking and digging. The use of tools for digging has been thought to be restricted to humans. These monkeys, living in a harsh dry habitat, survive food limitation and foraging time constraints through their extensive tool use.

The relative importance of different sources of slaves in the Roman Empire during the Principate cannot be gauged from ancient texts. However, simple demographic models show that, for purely statistical reasons, natural reproduction made a greater contribution to the Roman slave supply than child exposure, warfare, and the slave trade taken together and was in all probability several times as important as any other single source. The most plausible projections also suggest that on average the incidence of manumission was rather low. By implication, overall fertility of ex-slaves in general and of freedwomen in particular would be low as well, which must have reduced their chances of acquiring legal privileges that accrued from sexual reproduction.

The opening pages of the annals of the Roman monarchy tell of long-lived rulers and thriving families. Augustus lived to the ripe age of seventy-six, survived by his wife of fifty-one years, Livia, who died at eighty-six, while her son Tiberius bettered his predecessor's record by two more years. Augustus’ sister Octavia gave birth to five children, all of whom lived long enough to get married; Agrippa left at least half a dozen children, and perhaps more; Germanicus, despite his tender age at death, was survived by no fewer than three sons and three daughters. At the same time, longevity and abundant offspring went hand in hand with early death and misery. More than a few luminaries of Augustus’ court were less fortunate than their elders: Marcellus died at twenty-three, the elder Drusus at twenty-nine, Augustus’ heirs Gaius and Lucius Caesar at twenty-three and eighteen. Drusus had lost a number of children save three that survived; Germanicus buried three of his six sons as infants.

As is widely known, the Bridgewater Treatises on the Power, Wisdom and Goodness of God as Manifested in the Creation (1833–36) were commissioned in accordance with a munificent bequest of the eighth Earl of Bridgewater, the Rev. Francis Henry Egerton (1756–1829), and written by seven leading men of science, together with one prominent theological commentator. Less widely appreciated is the extent to which the Bridgewater Treatises rank among the scientific best-sellers of the early nineteenth century. Their varied blend of natural theology and popular science attracted extraordinary contemporary interest and ‘celebrity’, resulting in unprecedented sales and widespread reviewing. Much read by the landed, mercantile and professional classes, the success of the series ‘encouraged other competitors into the field’, most notably Charles Babbage's unsolicited Ninth Bridgewater Treatise (1837). As late as 1882 the political economist William Stanley Jevons was intending to write an unofficial Bridgewater Treatise , and even an author of the prominence of Lord Brougham could not escape having his Discourse of Natural Theology (1835) described by Edward Lytton Bulwer as ‘the tenth Bridgewater Treatise’.

Abstract The continuous operation of wearable electronics demands reliable sources of energy, currently met through Li‐ion batteries and various energy harvesters. These solutions are being used out of necessity despite potential safety issues and unsustainable environmental impact. Safe and sustainable energy sources can boost the use of wearables systems in diverse applications such as health monitoring, prosthetics, and sports. In this regard, sweat‐ and sweat‐equivalent‐based studies have attracted tremendous attention through the demonstration of energy‐generating biofuel cells, promising power densities as high as 3.5 mW cm −2 , storage using sweat‐electrolyte‐based supercapacitors with energy and power densities of 1.36 Wh kg −1 and 329.70 W kg −1 , respectively, and sweat‐activated batteries with an impressive energy density of 67 Ah kg −1 . A combination of these energy generating, and storage devices can lead to fully energy‐autonomous wearables capable of providing sustainable power in the µW to mW range, which is sufficient to operate both sensing and communication devices. Here, a comprehensive review covering these advances, addressing future challenges and potential solutions related to fully energy‐autonomous wearables is presented, with emphasis on sweat‐based energy storage and energy generation elements along with sweat‐based sensors as applications.

The relative importance of different sources of slaves in the Roman Empire during the Principate cannot be gauged from ancient texts. However, simple demographic models show that, for purely statistical reasons, natural reproduction made a greater contribution to the Roman slave supply than child exposure, warfare, and the slave trade taken together and was in all probability several times as important as any other single source. The most plausible projections also suggest that on average the incidence of manumission was rather low. By implication, overall fertility of ex-slaves in general and of freedwomen in particular would be low as well, which must have reduced their chances of acquiring legal privileges that accrued from sexual reproduction.

There is a growing body of literature on the nature of subjective changes experienced following brain injury. This study employs personal construct and qualitative research methods to address the question of how people make sense of, or construe, themselves after brain injury. Thirty-two individuals who had experienced acquired brain injury engaged in small group exercises based on a personal construct approach. Bipolar constructs were elicited through systematic comparison of pre-injury, current and ideal selves. The constructs elicited in this way were subjected to a thematic analysis. Nine themes were derived and an acceptable level of reliability of the definitions of these themes achieved. The highest proportion of constructs fell into the theme "experience of self in the world", followed by "basic skills" (cognitive, sensory, physical, social) and "experience of self in relation to self". It is concluded that following brain injury, people make sense of themselves in terms of the meanings and felt experiences of social and practical activity. This is consistent with social identity theory and stands in contrast to traditional neuropsychological sense making in terms of impairments and abilities alone, or activity or social participation alone. The implications of these findings for future research and rehabilitation are briefly considered.

A follow-up study to at least the age of 21 years of 135 individuals with an autism spectrum disorder diagnosed in childhood and an IQ of over 30 was conducted. The study is distinctive in its large size, low attrition rate and use of systematic interviews to obtain clinical information. Questionnaires completed by caregivers asked about the development of new psychiatric disorders. For the 39 individuals with a possible new disorder, a detailed psychiatric assessment was undertaken through parental interview. Of all participants, 16 percent developed a definite new psychiatric disorder. A further 6 percent developed a possible new disorder. Five individuals developed an obsessive-compulsive disorder and/or catatonia; eight an affective disorder with marked obsessional features; three complex affective disorders; four more straightforward affective disorders; one a bipolar disorder; and one an acute anxiety state complicated by alcohol excess. There was no case of schizophrenia.

BACKGROUND: Patients with anorexia may have elevated autistic traits. In this study, we tested test whether patients with anorexia nervosa (anorexia) have an elevated score on a dimensional measure of autistic traits, the Autism Spectrum Quotient (AQ), as well as on trait measures relevant to the autism spectrum: the Empathy Quotient (EQ), and the Systemizing Quotient (SQ). METHODS: Two groups were tested: (1) female adolescents with anorexia: n = 66, aged 12 to 18 years; and (2) female adolescents without anorexia: n =1,609, aged 12 to 18 years. Both groups were tested using the AQ, EQ, and SQ, via the parent-report adolescent versions for patients aged 12 to 15 years old, and the self-report adult versions for patients aged over 16 years. RESULTS: As predicted, the patients with anorexia had a higher AQ and SQ. Their EQ score was reduced, but only for the parent-report version in the younger age group. Using EQ-SQ scores to calculate 'cognitive types', patients with anorexia were more likely to show the Type S profile (systemizing (S) better than empathy (E)), compared with typical females. CONCLUSIONS: Females with anorexia have elevated autistic traits. Clinicians should consider if a focus on autistic traits might be helpful in the assessment and treatment of anorexia. Future research needs to establish if these results reflect traits or states associated with anorexia.

This book charts the course of monetary policy in the UK from 1967 to 1982. It shows how events such as the 1967 devaluation, the collapse of Bretton Woods, the stagflation of the 1970s, and the IMF l

In addition to causing distress and disability to the individual, neuropsychiatric disorders are also extremely expensive to society and governments. These disorders are both common and debilitating and impact on cognition, functionality and wellbeing. Cognitive enhancing drugs, such as cholinesterase inhibitors and methylphenidate, are used to treat cognitive dysfunction in Alzheimer's disease and attention deficit hyperactivity disorder, respectively. Other cognitive enhancers include specific computerized cognitive training and devices. An example of a novel form of cognitive enhancement using the technological advancement of a game on an iPad that also acts to increase motivation is presented. Cognitive enhancing drugs, such as methylphenidate and modafinil, which were developed as treatments, are increasingly being used by healthy people. Modafinil not only affects 'cold' cognition, but also improves 'hot' cognition, such as emotion recognition and task-related motivation. The lifestyle use of 'smart drugs' raises both safety concerns as well as ethical issues, including coercion and increasing disparity in society. As a society, we need to consider which forms of cognitive enhancement (e.g. pharmacological, exercise, lifelong learning) are acceptable and for which groups (e.g. military, doctors) under what conditions (e.g. war, shift work) and by what methods we would wish to improve and flourish.

Metagenomic sequencing has allowed for the recovery of previously unexplored microbial genomes. Whereas short-read sequencing platforms often result in highly fragmented metagenomes, nanopore-based sequencers could lead to more contiguous assemblies due to their potential to generate long reads. Nevertheless, there is a lack of updated and systematic studies evaluating the performance of different assembly tools on nanopore data. In this study, we have benchmarked the ability of different assemblers to reconstruct two different commercially-available mock communities that have been sequenced using Oxford Nanopore Technologies platforms. Among the tested tools, only metaFlye, Raven, and Canu performed well in all the datasets. These tools retrieved highly contiguous genomes (or even complete genomes) directly from the metagenomic data. Despite the intrinsic high error of nanopore sequencing, final assemblies reached high accuracy (~ 99.5 to 99.8% of consensus accuracy). Polishing strategies demonstrated to be necessary for reducing the number of indels, and this had an impact on the prediction of biosynthetic gene clusters. Correction with high quality short reads did not always result in higher quality draft assemblies. Overall, nanopore metagenomic sequencing data-adapted to MinION's current output-proved sufficient for assembling and characterizing low-complexity microbial communities.

The concept of empowerment is one which is often invoked in discussions over the nature of nursing practice in a range of health and welfare services. A short excursion through the Cumulative Index to Nursing and Allied Health Literature reveals that over the last 10 years 378 papers are identified which list empowerment as one of the topics discussed. In 1993, the number is 55. These papers cover a diverse range of health related issues: health promotion and HIV; breast feeding; mental health; management and leadership; change, training and education; feminism and women's issues; sexual abuse and violence; advocacy and working with immigrants; professionalism; and nursing theory. However, few of these papers discuss the relationship between empowerment and the notion of power itself. This gives rise to particular problems for nursing practice, for without a clear conceptualization of what is meant by power it is difficult to convincingly argue that one form of practice is more or less empowering than another. Alternatively, this dilemma may be stated in the following question: how do we work to empower others when we have no clear notion of what power is? This paper demonstrates that the concept of power demands a very specific consideration. In order to illustrate this it briefly identifies problems within two models of power which are drawn upon in nursing. It also demonstrates the way in which the work of Michel Foucault can be drawn upon to inform nursing in the analysis of the relationship between power and health.

Abstract Humanoid robots, intelligent machines resembling the human body in shape and functions, cannot only replace humans to complete services and dangerous tasks but also deepen the own understanding of the human body in the mimicking process. Nowadays, attaching a large number of sensors to obtain more sensory information and efficient computation is the development trend for humanoid robots. Nevertheless, due to the constraints of von Neumann‐based structures, humanoid robots are facing multiple challenges, including tremendous energy consumption, latency bottlenecks, and the lack of bionic properties. Memristors, featured with high similarity to the biological elements, play an important role in mimicking the biological nervous system. The memristor‐based nervous system allows humanoid robots to obtain high energy efficiency and bionic sensing properties, which are similar properties to the biological nervous system. Herein, this article first reviews the biological nervous system and memristor‐based nervous system thoroughly, including the structures and also the functions. The applications of memristor‐based nervous systems are introduced, the difficulties that need to be overcome are put forward, and future development prospects are also discussed. This review can hopefully provide an evolutionary perspective on humanoid robots and memristor‐based nervous systems.

Lithium can be found naturally in drinking water. In clinical practice, it is widely used in pharmacological doses for the treatment of bipolar disorder; and may also prevent suicidal behaviour in people with mood disorders. In two studies, lithium levels in tap water have been significantly and negatively correlated with suicide. We measured lithium levels in tap water in the 47 subdivisions of the East of England and correlated these with the respective suicide standardised mortality ratio in each subdivision. We found no association between lithium in drinking water and suicide rates across the East of England from 2006 to 2008.

High-performance power switching devices [insulated-gate bipolar transistors (IGBTs)] realize high-performance power converters. Unfortunately, with a high switching speed of the IGBT-freewheel diode chopper cell, the circuit becomes intrinsic sources of high-level electromagnetic interference (EMI). Therefore, costly EMI filters or shielding is normally demanded on the load and supply sides. An S-shaped voltage transient with a high-order time derivative eliminates the discontinuity in the switching transient and can suppress high-frequency spectrum of EMI emissions. More importantly, it provides an improved tradeoff between EMI generation and switching time, therefore switching losses. This promising tradeoff can be explored further for better high-frequency EMI suppression by using the infinitely differentiable characteristics of Gaussian S-shaped transients. However, current gate drive schemes cannot achieve the S shaping. In this paper, active voltage control is applied and improved successfully to define IGBT switching dynamics with a smoothed Gaussian waveform.

1 Blood samples were obtained from eighty-six chronic schizophrenics receiving a wide range of oral doses of chlorpromazine. Plasma concentrations of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulphoxide were estimated using a sensitive gas-liquid chromatographic method and their relationships to oral dose and to global clinical control were investigated.2 Wide variability was observed in the plasma concentrations of unchanged drug and metabolites between patients receiving similar daily doses.3 In general the plasma concentrations of the 7-hydroxy and sulphoxide metabolites were of similar magnitude to the concentrations of chlorpromazine.4 Global symptom control was unrelated to the plasma concentration of unchanged chlorpromazine. However, patients judged to be under good control had relatively higher concentrations of the biologically active 7-hydroxy metabolite in their plasma than patients who were poorly controlled and in whom the biologically inactive sulphoxide metabolite predominated. When the ratio of 7-hydroxychlorpromazine to chlorpromazine sulphoxide was derived for each patient, a highly significant difference was found to exist between the metabolite ratios of patients grouped according to clinical control.5 It is suggested that a prediction of therapeutic response to chlorpromazine may be provided in the form of the ratio of the plasma concentration of biologically active metabolite to the concentration of either the unchanged drug or its inactive metabolite.

In two randomized double-blind controlled trials on 63 depressed female in-patients subject to recurrent affective disorder (bipolar and unipolar manic-depressive psychosis) lithium was shown to have major acute antidepressant effects. At the end of three weeks lithium produced more uniform improvement than did imipramine; lithium in combination with tryptophan (in the form of Optimax) was superior to tryptophan alone--the latter drug having no discernible antidepressant activity in this group of patients. Lithium did not produce an antidepressant effect until the second and third week of both trials.

The strategic aim of the set of studies I have embarked on in collaboration with the sinologist Nathan Sivin is to examine Greek and Chinese philosophy and science afresh. Limiting our main inquiries to the period down to about A.D. 300, when Christianity came to be a major factor in the Graeco-Roman world and Buddhism began to be an important influence in China, we aim to ask questions concerning the differences in the ways in which philosophy and science were done in ancient Greece and China, why there should have been such differences, and what the philosophy and science done owed to the social, political and institutional background of the circumstances in which they were produced. It is high time that historians of Greek and Chinese science stopped treating their subjects principally as happy hunting grounds for point-scoring, chalking up anticipations of modern science, and especially priority claims as to who did what first. For they could clearly not have been a preoccupation of the ancients themselves.