Indian Institute of Science Bangalore

Clustering is the unsupervised classification of patterns (observations, data items, or feature vectors) into groups (clusters). The clustering problem has been addressed in many contexts and by researchers in many disciplines; this reflects its broad appeal and usefulness as one of the steps in exploratory data analysis. However, clustering is a difficult problem combinatorially, and differences in assumptions and contexts in different communities has made the transfer of useful generic concepts and methodologies slow to occur. This paper presents an overview of pattern clustering methods from a statistical pattern recognition perspective, with a goal of providing useful advice and references to fundamental concepts accessible to the broad community of clustering practitioners. We present a taxonomy of clustering techniques, and identify cross-cutting themes and recent advances. We also describe some important applications of clustering algorithms such as image segmentation, object recognition, and information retrieval.

Multidimensional (MD) separation is a combination of two or more separation techniques that increases peak capacity. There are two requirements or criteria in MD as suggested by Giddings. First is orthogonality, which means that the separation mechanism in each step must be based on different molecular properties such as size, charge, hydrophobicity, or chirality. Second is that the separation obtained in the first dimension must be preserved in the subsequent dimensions. There are two types of MD separation, comprehensive and heart cutting. In the first type, all compounds present in the mixture are separated and detected, while in the second, only selected fractions in the mixture are analyzed. The connection between the dimensions that must be tight and dead-volume free is the most important part of an MD separation system. The most common connection was an interface that joins two or more chromatographic columns and/or electrophoretic capillaries. In the case of capillary electrophoresis (CE), there is an alternative strategy to obtain MD separations without the use of an interface. This is the so-called heart-cutting MD-CE in a single capillary or interface-free MD-CE. In interface-free MD-CE, mobilization of fractions between dimensions is achieved by manipulation of voltage and/or pressure. Although MD-CE has been developed for more than 15 years, applications to real samples were not as prevalent as those reported for MD gas and liquid chromatography. MD-CE research reports were on tighter interfaces development as well as sensitivity and performance enhancements in two-dimension format (2D-CE). This article is devoted to the wide range of interfaces and interface/interface-free methods developed for 2D-CE. CE separation modes used in 2D-CE were also briefly discussed for readers not familiar with CE.

AUTORES: Daniel J Klionsky1745,1749*, Kotb Abdelmohsen840, Akihisa Abe1237, Md Joynal Abedin1762, Hagai Abeliovich425,
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This review summarizes theoretical progress in the field of active matter, placing it in the context of recent experiments. This approach offers a unified framework for the mechanical and statistical properties of living matter: biofilaments and molecular motors in vitro or in vivo, collections of motile microorganisms, animal flocks, and chemical or mechanical imitations. A major goal of this review is to integrate several approaches proposed in the literature, from semimicroscopic to phenomenological. In particular, first considered are ``dry'' systems, defined as those where momentum is not conserved due to friction with a substrate or an embedding porous medium. The differences and similarities between two types of orientationally ordered states, the nematic and the polar, are clarified. Next, the active hydrodynamics of suspensions or ``wet'' systems is discussed and the relation with and difference from the dry case, as well as various large-scale instabilities of these nonequilibrium states of matter, are highlighted. Further highlighted are various large-scale instabilities of these nonequilibrium states of matter. Various semimicroscopic derivations of the continuum theory are discussed and connected, highlighting the unifying and generic nature of the continuum model. Throughout the review, the experimental relevance of these theories for describing bacterial swarms and suspensions, the cytoskeleton of living cells, and vibrated granular material is discussed. Promising extensions toward greater realism in specific contexts from cell biology to animal behavior are suggested, and remarks are given on some exotic active-matter analogs. Last, the outlook for a quantitative understanding of active matter, through the interplay of detailed theory with controlled experiments on simplified systems, with living or artificial constituents, is summarized.

Every few years, a new material with unique properties emerges and fascinates the scientific community, typical recent examples being high-temperature superconductors and carbon nanotubes. Graphene is the latest sensation with unusual properties, such as half-integer quantum Hall effect and ballistic electron transport. This two-dimensional material which is the parent of all graphitic carbon forms is strictly expected to comprise a single layer, but there is considerable interest in investigating two-layer and few-layer graphenes as well. Synthesis and characterization of graphenes pose challenges, but there has been considerable progress in the last year or so. Herein, we present the status of graphene research which includes aspects related to synthesis, characterization, structure, and properties.

We establish the general form of the generator of a completely positive dynamical semigroup of an N-level quantum system, and we apply the result to derive explicit inequalities among the physical parameters characterizing the Markovian evolution of a 2-level system.

Multilevel converters have been under research and development for more than three decades and have found successful industrial application. However, this is still a technology under development, and many new contributions and new commercial topologies have been reported in the last few years. The aim of this paper is to group and review these recent contributions, in order to establish the current state of the art and trends of the technology, to provide readers with a comprehensive and insightful review of where multilevel converter technology stands and is heading. This paper first presents a brief overview of well-established multilevel converters strongly oriented to their current state in industrial applications to then center the discussion on the new converters that have made their way into the industry. In addition, new promising topologies are discussed. Recent advances made in modulation and control of multilevel converters are also addressed. A great part of this paper is devoted to show nontraditional applications powered by multilevel converters and how multilevel converters are becoming an enabling technology in many industrial sectors. Finally, some future trends and challenges in the further development of this technology are discussed to motivate future contributions that address open problems and explore new possibilities.

Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addressing the remaining 8% of the genome, the Telomere-to-Telomere (T2T) Consortium presents a complete 3.055 billion-base pair sequence of a human genome, T2T-CHM13, that includes gapless assemblies for all chromosomes except Y, corrects errors in the prior references, and introduces nearly 200 million base pairs of sequence containing 1956 gene predictions, 99 of which are predicted to be protein coding. The completed regions include all centromeric satellite arrays, recent segmental duplications, and the short arms of all five acrocentric chromosomes, unlocking these complex regions of the genome to variational and functional studies.

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTSupramolecular Coordination: Self-Assembly of Finite Two- and Three-Dimensional EnsemblesRajesh Chakrabarty*†, Partha Sarathi Mukherjee*‡, and Peter J. Stang*†View Author Information† Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States‡ Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, IndiaE-mail: [email protected] (R.C.); [email protected] (P.J.S.); and [email protected] (P.S.M.)Cite this: Chem. Rev. 2011, 111, 11, 6810–6918Publication Date (Web):August 24, 2011Publication History Received12 March 2011Published online24 August 2011Published inissue 9 November 2011https://pubs.acs.org/doi/10.1021/cr200077mhttps://doi.org/10.1021/cr200077mreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views47089Altmetric-Citations2581LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cavities,Ligands,Metals,Self organization,Supramolecular structures and assemblies Get e-Alerts

This planetary boundaries framework update finds that six of the nine boundaries are transgressed, suggesting that Earth is now well outside of the safe operating space for humanity. Ocean acidification is close to being breached, while aerosol loading regionally exceeds the boundary. Stratospheric ozone levels have slightly recovered. The transgression level has increased for all boundaries earlier identified as overstepped. As primary production drives Earth system biosphere functions, human appropriation of net primary production is proposed as a control variable for functional biosphere integrity. This boundary is also transgressed. Earth system modeling of different levels of the transgression of the climate and land system change boundaries illustrates that these anthropogenic impacts on Earth system must be considered in a systemic context.

This fully updated and expanded second edition of Optical Networks: A Practical Perspective succeeds the first as the authoritative source for information on optical networking technologies and techniques. Written by two of the field's most respected individuals, it covers componentry and transmission in detail but also emphasizes the practical networking issues that affect organizations as they evaluate, deploy, or develop optical solutions. This book captures all the hard-to-find information on architecture, control and management, and other communications topics that

autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

In this paper we describe an efficient approach for multimodal function optimization using genetic algorithms (GAs). We recommend the use of adaptive probabilities of crossover and mutation to realize the twin goals of maintaining diversity in the population and sustaining the, convergence capacity of the GA. In the adaptive genetic algorithm (AGA), the probabilities of crossover and mutation, p/sub c/ and p/sub m/, are varied depending on the fitness values of the solutions. High-fitness solutions are 'protected', while solutions with subaverage fitnesses are totally disrupted. By using adaptively varying p/sub c/ and p/sub ,/ we also provide a solution to the problem of deciding the optimal values of p/sub c/ and p/sub m/, i.e., p/sub c/ and p/sub m/ need not be specified at all. The AGA is compared with previous approaches for adapting operator probabilities in genetic algorithms. The Schema theorem is derived for the AGA, and the working of the AGA is analyzed. We compare the performance of the AGA with that of the standard GA (SGA) in optimizing several nontrivial multimodal functions with varying degrees of complexity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

▪ Abstract This review summarizes fundamental results and discoveries concerning vortex-induced vibration (VIV), that have been made over the last two decades, many of which are related to the push to explore very low mass and damping, and to new computational and experimental techniques that were hitherto not available. We bring together new concepts and phenomena generic to VIV systems, and pay special attention to the vortex dynamics and energy transfer that give rise to modes of vibration, the importance of mass and damping, the concept of a critical mass, the relationship between force and vorticity, and the concept of “effective elasticity,” among other points. We present new vortex wake modes, generally in the framework of a map of vortex modes compiled from forced vibration studies, some of which cause free vibration. Some discussion focuses on topics of current debate, such as the decomposition of force, the relevance of the paradigm flow of an elastically mounted cylinder to more complex systems, and the relationship between forced and free vibration.

Cascaded multilevel inverters synthesize a medium-voltage output based on a series connection of power cells which use standard low-voltage component configurations. This characteristic allows one to achieve high-quality output voltages and input currents and also outstanding availability due to their intrinsic component redundancy. Due to these features, the cascaded multilevel inverter has been recognized as an important alternative in the medium-voltage inverter market. This paper presents a survey of different topologies, control strategies and modulation techniques used by these inverters. Regenerative and advanced topologies are also discussed. Applications where the mentioned features play a key role are shown. Finally, future developments are addressed.

Himalayan glaciers are a focus of public and scientific debate. Prevailing uncertainties are of major concern because some projections of their future have serious implications for water resources. Most Himalayan glaciers are losing mass at rates similar to glaciers elsewhere, except for emerging indications of stability or mass gain in the Karakoram. A poor understanding of the processes affecting them, combined with the diversity of climatic conditions and the extremes of topographical relief within the region, makes projections speculative. Nevertheless, it is unlikely that dramatic changes in total runoff will occur soon, although continuing shrinkage outside the Karakoram will increase the seasonality of runoff, affect irrigation and hydropower, and alter hazards.

Genetic algorithms provide an alternative to traditional optimization techniques by using directed random searches to locate optimal solutions in complex landscapes. We introduce the art and science of genetic algorithms and survey current issues in GA theory and practice. We do not present a detailed study, instead, we offer a quick guide into the labyrinth of GA research. First, we draw the analogy between genetic algorithms and the search processes in nature. Then we describe the genetic algorithm that Holland introduced in 1975 and the workings of GAs. After a survey of techniques proposed as improvements to Holland's GA and of some radically different approaches, we survey the advances in GA theory related to modeling, dynamics, and deception.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

Against a backdrop of rising global surface temperature, the stability of the Indian monsoon rainfall over the past century has been a puzzle. By using a daily rainfall data set, we show (i) significant rising trends in the frequency and the magnitude of extreme rain events and (ii) a significant decreasing trend in the frequency of moderate events over central India during the monsoon seasons from 1951 to 2000. The seasonal mean rainfall does not show a significant trend, because the contribution from increasing heavy events is offset by decreasing moderate events. A substantial increase in hazards related to heavy rain is expected over central India in the future.

In recent years there has been immense interest in studying gels derived from low molecular mass gelators (supramolecular, or simply molecular gels). The motivation for this is not only to understand the fundamental aggregate structures in the gels at different length scales, but also to explore their potential for futuristic technological applications. Gels have been made sensitive to external stimuli like light and chemical entities by incorporating a spectroscopically active or a receptor unit as part of the gelator molecule. This makes them suitable for applications such as sensing and actuating. The diversity of gel structural architectures has allowed them to be utilized as templates to prepare novel inorganic superstructures for possible applications in catalysis and separation. Gels derived from liquid crystals (anisotropy gels) that can act as dynamically functional materials have been prepared, for example, for (re-writable) information recording. Supramolecular gels can be important in controlled release applications, in oil recovery, for gelling cryogenic fuels etc. They can also serve as media for a range of applications. This tutorial review highlights some of the instructive work done by various groups to develop smart and functional gels, and covers a wide spectrum of scientific interest ranging from medicine to materials science.

Active particles contain internal degrees of freedom with the ability to take in and dissipate energy and, in the process, execute systematic movement. Examples include all living organisms and their motile constituents such as molecular motors. This article reviews recent progress in applying the principles of nonequilibrium statistical mechanics and hydrodynamics to form a systematic theory of the behavior of collections of active particles–active matter–with only minimal regard to microscopic details. A unified view of the many kinds of active matter is presented, encompassing not only living systems but inanimate analogs. Theory and experiment are discussed side by side.