Institute of Philosophy

Abstract The representational theory of mind (RTM) has given us the powerful insight that thinking consists of the processing of mental representations. Behaviour is the result of these cognitive processes and makes sense in the light of their contents. There is no widely accepted account of how representations get their content – of the metaphysics of representational content. That question, usually asked about representations at the personal level like beliefs and conscious states, is equally pressing for the subpersonal representations that pervade our best explanatory theories in cognitive science. This book argues that well-understood naturalistic resources can be combined to provide an account of subpersonal representational content. It shows how contents arise in a series of detailed case studies in cognitive science. The account is pluralistic, allowing that content is constituted differently in different cases. Building on insights from previous theories, especially teleosemantics, the accounts combine an appeal to correlational information and structural correspondence with an expanded notion of etiological function, which captures the kinds of stabilizing processes that give rise to content. The accounts support a distinction between descriptive and directive content. They also allow us to see how representational explanation gets its distinctive explanatory purchase.

In cluster randomized trials (CRTs), the units of allocation, intervention, and outcome measurement may differ within a single trial. As a result of the unique design of CRTs, the interpretation of existing research ethics guidelines is complicated.\nThe Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials aims to provide researchers and research ethics committees (RECs) with detailed guidance on the ethical design, conduct, and review of CRTs.\nA five-year mixed methods research project explored the ethical challenges of CRTs. Empirical studies documented the reporting of ethical issues in published CRTs, interviewed experienced trialists, and surveyed trialists and REC chairs. The ethical issues identified were explored in a series of background papers that provided detailed ethical analyses and policy options, and a panel of experts using a systematic process developed a consensus statement.\nThe Ottawa Statement sets out 15 recommendations for the ethical design and conduct of CRTs. The recommendations provide guidance on the justification of a cluster randomized design, the need for REC review, the identification of research participants, obtaining informed consent, the role of gatekeepers in protecting group interests, the assessment of benefits and harms, and the protection of vulnerable participants.

OBJECTIVE: To assess the impact of the 2004 extension of the CONSORT guidelines on the reporting and methodological quality of cluster randomised trials. DESIGN: Methodological review of 300 randomly sampled cluster randomised trials. Two reviewers independently abstracted 14 criteria related to quality of reporting and four methodological criteria specific to cluster randomised trials. We compared manuscripts published before CONSORT (2000-4) with those published after CONSORT (2005-8). We also investigated differences by journal impact factor, type of journal, and trial setting. DATA SOURCES: A validated Medline search strategy. Eligibility criteria for selecting studies Cluster randomised trials published in English language journals, 2000-8. RESULTS: There were significant improvements in five of 14 reporting criteria: identification as cluster randomised; justification for cluster randomisation; reporting whether outcome assessments were blind; reporting the number of clusters randomised; and reporting the number of clusters lost to follow-up. No significant improvements were found in adherence to methodological criteria. Trials conducted in clinical rather than non-clinical settings and studies published in medical journals with higher impact factor or general medical journals were more likely to adhere to recommended reporting and methodological criteria overall, but there was no evidence that improvements after publication of the CONSORT extension for cluster trials were more likely in trials conducted in clinical settings nor in trials published in either general medical journals or in higher impact factor journals. CONCLUSION: The quality of reporting of cluster randomised trials improved in only a few aspects since the publication of the extension of CONSORT for cluster randomised trials, and no improvements at all were observed in essential methodological features. Overall, the adherence to reporting and methodological guidelines for cluster randomised trials remains suboptimal, and further efforts are needed to improve both reporting and methodology.

This review examines recent functional neuroimaging research of resting-state regional connectivity between brain regions in anxiety disorders. Studies compiled in the PubMed- National Center for Biotechnology Information database targeting resting-state functional connectivity in anxiety disorders were reviewed. Diagnoses included posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), panic disorder (PD), and specific phobia (SP). Alterations to network connectivity were demonstrated in PTSD, GAD, SAD, OCD, and PD in several resting-state investigations. Differences from control subjects were primarily observed in the default mode network within PTSD, SAD, and OCD. Alterations within the salience network were observed primarily in PTSD, GAD, and SAD. Alterations in corticostriatal networks were uniquely observed in OCD. Finally, alterations within somatosensory networks were observed in SAD and PD investigations. Resting-state studies involving SPs as a primary diagnosis (with or without comorbidities) were not generated during the literature search. The emerging use of resting-state paradigms may be an effective method for understanding associations between anxiety disorders. Targeted studies of PD and SPs, meta-analyses of the studies conducted to date, and studies of the impact of specific comorbid presentations, are recommended future research directions.

Abstract In § 3. of the first part of my “Contributions to the Physiology of Vision,” published in the Philosophical Transactions for 1838, speaking of the stereoscope, I stated, “The pictures will indeed coincide when the sliding pannels are in a variety of different positions, and consequently when viewed under different inclinations of the optic axes; but there is only one position in which the binocular image will be immediately seen single, of its proper magnitude, and without fatigue to the eyes, because in this position only the ordinary relations between the magnitude of the pictures on the retina, the inclination of the optic axes, and the adaptation of the eye to distinct vision at different distances, are preserved. The alteration in the apparent magnitude of the binocular images, when these usual relations are disturbed, will be discussed in another paper of this series, with a variety of remarkable phenomena depending thereon.” In 1833, five years before the publication of the memoir just mentioned, these yet unpublished investigations were announced in the third edition of Herbert Mayo’s “Outlines of Human Physiology” in the following words:—“ Mr. W heatstone has shown, in a paper he is about to publish, that if by artificial means the usual relations which subsist between the degree of inclination of the optic axes and the visual angle which the object subtends on the retina be disturbed, some extraordinary illusions may be produced. Thus, the magnitude of the image remaining constant on the retina, its apparent size may be made to vary with every alteration of the angular inclination of the optic axes.”

The cluster randomized trial (CRT) is used increasingly in knowledge translation research, quality improvement research, community based intervention studies, public health research, and research in developing countries. However, cluster trials raise difficult ethical issues that challenge researchers, research ethics committees, regulators, and sponsors as they seek to fulfill responsibly their respective roles. Our project will provide a systematic analysis of the ethics of cluster trials. Here we have outlined a series of six areas of inquiry that must be addressed if the cluster trial is to be set on a firm ethical foundation: 1. Who is a research subject? 2. From whom, how, and when must informed consent be obtained? 3. Does clinical equipoise apply to CRTs? 4. How do we determine if the benefits outweigh the risks of CRTs? 5. How ought vulnerable groups be protected in CRTs? 6. Who are gatekeepers and what are their responsibilities? Subsequent papers in this series will address each of these areas, clarifying the ethical issues at stake and, where possible, arguing for a preferred solution. Our hope is that these papers will serve as the basis for the creation of international ethical guidelines for the design and conduct of cluster randomized trials.

LeBlanc, Kimberly; Campbell, Karen E.; Wood, Eleanor; Beeckman, Dimitri Author Information

Robustness is a common platitude: hypotheses are better supported with evidence generated by multiple techniques that rely on different background assumptions. Robustness has been put to numerous epistemic tasks, including the demarcation of artifacts from real entities, countering the “experimenter's regress,” and resolving evidential discordance. Despite the frequency of appeals to robustness, the notion itself has received scant critique. Arguments based on robustness can give incorrect conclusions. More worrying is that although robustness may be valuable in ideal evidential circumstances (i.e., when evidence is concordant), often when a variety of evidence is available from multiple techniques, the evidence is discordant.

ABSTRACT: I contrast an ecological account of natural agency with the traditional Cartesian conception using recent research in bacterial cognition and cellular decision making as a test case. I argue that the Cartesian conception—namely, the view that agency presupposes cognition—generates a dilemma between mechanism, the view that bacteria are mere automata, and intellectualism, the view that they exhibit full-blown cognition. Unicellular organisms, however, occupy a middle ground between these two extremes. On the one hand, their capacities and activities are too adaptive to count as mere machines. On the other hand, they lack the open-ended responsiveness of cognitive agents to rational norms. An ecological conception of agency as the gross behavioral capacity to respond to affordances, I argue, does not presuppose cognition and allows for degrees of agency along a continuum, from the simplest adaptive agents, such as unicellular organisms, to the most sophisticated cognitive agents. Bacteria, I conclude, are adaptive agents , hence not mere automata, but not cognitive agents.

The current interest in laboratory detection of entanglement mediated by gravity was sparked by an information-theoretic argument: entanglement mediated by a local field certifies that the field is not classical. Previous derivations of the effect modeled gravity as instantaneous; here we derive it from linearized quantum general relativity while keeping Lorentz invariance explicit, using the path-integral formalism. In this framework, entanglement is clearly mediated by a quantum feature of the field. We also point out the possibility of observing "retarded" entanglement, which cannot be explained by an instantaneous interaction. This is a difficult experiment for gravity, but is plausible for the analogous electromagnetic case.

We treated 13 patients with progressive MS with mitoxantrone. All patients received a standard IV dose of mitoxantrone (8 mg/m2) every 3 weeks for a total of seven infusions, with dosage adjustments depending on the hematologic profile at the nadir. The treatment was well tolerated, with the most common side effect being mild nausea. Four of seven women developed transient secondary amenorrhea. The postenrollment clinical behavior of these patients was generally more favorable than during the 18 months prior to enrollment (only three of 13 patients developed an increase in the Expanded Disability Status Scale of more than 0.5 points), suggesting a possible treatment effect, but comparison with two historical control groups (both the active and placebo groups from the Canadian Cooperative Trial of Cyclophosphamide and Plasma Exchange) does not suggest that mitoxantrone was efficacious. Eight of 12 patients had evidence of MRI activity on 13 of 29 follow-up visits. This small, open-labeled pilot study did not provide strong support for proceeding with a randomized, controlled trial of this dosage regimen of mitoxantrone in patients with progressive MS.

The diet of red fox Vulpes vulpes was investigated through analysis of 340 scats collected during 1992‐1996 from moorland in south‐west Scotland. Rodents, game‐birds, lagomorphs, carrion and insectivores were the most frequently occurring food types. Fox diet and prey abundance were compared between heather dominant and grass dominant habitat types within the study area. Rodents were the most frequently occurring food type in each habitat and occurred in 63% of seats overall. Rodents occurred more often in scats from grass dominant sites while gamebirds and lagomorphs were more frequent in scats from heather dominant sites. The occurrence of rodents in winter fox scats increased with rodent abundance. In contrast, the occurrence of gamebirds in winter fox scats was unrelated to gamebird abundance but negatively related to rodent abundance. It appeared that foxes switched to gamebirds in years, or habitats, where rodents were uncommon.

In recent works, Časlav Brukner and Jacques Pienaar have raised interesting objections to the relational interpretation of quantum mechanics. We answer these objections in detail and show that, far from questioning the viability of the interpretation, they sharpen and clarify it.

Research Summary: In 1999, Daniel Kessler and Steven Levitt published an article that purported to provide support for the marginal deterrent effects of harsher sanctions on levels of crime. Specifically, they concluded that sentence enhancements that came into effect in California in June 1982 as a result of Proposition 8 were responsible for a subsequent drop in serious crime in this state. Our article examines the analyses and findings of this article and suggests that their conclusion of a deterrent impact fails to withstand scrutiny when more complete and more detailed crime data are used and the comparability of “control” groups is carefully examined. In particular, the addition of annual crime levels for all years (versus only the odd‐numbered years that Kessler and Levitt examine) calls into question the prima facie support for a deterrent effect presented by Kessler and Levitt. Specifically, it demonstrates not only that the crime drop in California began before, rather than after, the passing into law of the sentence enhancements in 1982 but also that the downward slope did not accelerate after the change in law. Furthermore, the comparability of the two “control” groups with the “treatment” group is challenged, rendering suspect any findings based on these comparisons. Policy Implications: Case studies suggesting that crime decreased after the imposition of harsh sentencing policies are often cited as evidence of marginal general deterrence. As has been demonstrated in other contexts, the question that needs to be asked is “Compared with what?” Kessler and Levitt's (1999) article demonstrates that those interested in sentencing policy need to be sensitive not only to the appropriateness of the comparisons that are made, but also to the choice of data that are presented.

Social scientists have a longstanding concern with the relationship between criminal sanctions and offenders’future behavior. This paper uses data from a sample of 528 adult felony offenders to compare the relative probability of rearrest, the severity of rearrest, and the likelihood of probation revocation for offenders with a sentence of incarceration, work release, house arrest, and traditional probation—or a combination of these sentences. Consistent with previous research, prior record, gender, offense type, and education were significantly related to the probability and severity of rearrest. Furthermore, no matter which other sanction it was paired with, house arrest was associated with reduced chances of rearrest and lower rearrest severity. The influence of one of these sanction combinations was gender‐specific: incarceration followed by house arrest was associated with reduced odds of rearrest for women but not for men. However, house arrest was associated with the considerably increased likelihood of probation revocation. In addition, these effects remain after controlling for potential selection bias stemming from the sentencing decision. This paper concludes by discussing the theoretical and correctional implications of these findings and directions for future research.

Selling financial investments with insurance or lottery characteristics should earn positive long-run premiums if investors like positive skewness enough to overpay for these characteristics. The empirical evidence is unambiguous: Selling insurance and selling lottery tickets have delivered positive long-run rewards in a wide range of investment contexts. Conversely, buying financial catastrophe insurance and holding speculative lottery-like investments have delivered poor long-run rewards. Thus, bearing small risks is often well rewarded, bearing large risks not.See comments and response on this article.

ABSTRACT Research on socioeconomic homogamy was developed by stratification researchers who used marriage patterns to describe how open stratification systems are. In cross-national studies primary concern on marriage homogamy lies in examination of commonality and differences in their social structures. Following large-scale international studies we use the European Social Survey data 2004–2005 to examine the association between spouses’ educational levels. Loglinear analysis is applied to assess: (i) degree of association between education of spouses, (ii) patterns of barriers to intermarriage, (iii) variation in homogamy for partners with the same education for primary, uncompleted secondary, secondary, and university levels, and (iv) asymmetry in marriage patterns between women and men. The strongest association between spouses’ education is in Slovakia, followed by Czech Republic, Norway, Germany, Ukraine, Poland, Hungary, Estonia, and Slowenia, whereas the lowest association displays in Luxembourg, France, Sweden, Finland and Belgium. In addition to previous research we found inter-country variation in division into post-communist and Western democracies. In line with all earlier studies we found – upon examination of parameters estimated for educational levels – a uniform tendency according to which the difficulties of intermarriage varies monotonically with differences between educational level of spouses. The tendency toward in-marriage proved to be the strongest in the lowest educational levels – such pattern takes place in the 14 countries. Finally, our analysis substantiated presence of net tendency to ‘marry up’ higher educated husbands by women but we find that it is by no means an universal rule and in seven, out of 22 countries examined, it is men who ‘marry up’ higher educated wives.

OBJECTIVE: This study explores how surgeons define innovation, critically examines and evaluates these views, and uses the findings to develop practical criteria for identifying surgical innovation for ethical and regulatory purposes. BACKGROUND: Surgical innovation is crucial for progress in surgery, but can be harmful to patients and difficult to identify and therefore support appropriately. Current attempts to define surgical innovation lack precision, and do not give enough guidance to identify innovations in practice. This study is the first to give an account of surgeons' own views about defining innovation. METHODS: This qualitative study involved interviews with 18 Australian surgeons. Participants provided examples of innovation and distinguished innovation from variations in practice and from research. Data were collected using audio-recorded semistructured interviews. The data were coded using a template and analyzed to develop a thematic account of innovative surgery in practice. RESULTS: There was no uniform view about innovation, but participants identified 5 features of surgical innovation that distinguish it from variations: newness or novelty; degree of change; level of risk; impact; and requiring formal processes. There was no agreement on the distinction between innovation and research. CONCLUSIONS: Drawing on surgeons' own views is important for the development of a practical definition of surgical innovation. We have used a critical analysis of surgeons' own views as the basis for defining the core features of innovation. A precise definition of innovation will assist surgeons to identify and manage innovation and thereby enhance patient safety.

The city of Warsaw was razed at the end of World War II and rebuilt under a socialist government whose policy was to allocate dwellings, schools, and health facilities without regard to social class. Of the 14,238 children born in 1963 and living in Warsaw, 96 percent were given the Raven's Progressive Matrices Test and an arithmetic and a vocabulary test in March to June of 1974. Information was collected on the families of the children, and on characteristics of schools and city districts. Parental occupation and education were used to form a family factor, and the district data were collapsed into two factors, one relating to social marginality, and the other to distance from city center. Analysis showed that the initial assumption of even distribution of family, school, and district attributes was reasonable. Mental performance was unrelated either to school or district factors; it was related to parental occupation and education in a strong and regular gradient. It is concluded that an egalitarian social policy executed over a generation failed to override the association of social and family factors with cognitive development that is characteristic of more traditional industrial societies.

BACKGROUND: Randomised controlled trials can provide evidence relevant to assessing the equity impact of an intervention, but such information is often poorly reported. We describe a conceptual framework to identify health equity-relevant randomised trials with the aim of improving the design and reporting of such trials. METHODS: An interdisciplinary and international research team engaged in an iterative consensus building process to develop and refine the conceptual framework via face-to-face meetings, teleconferences and email correspondence, including findings from a validation exercise whereby two independent reviewers used the emerging framework to classify a sample of randomised trials. RESULTS: A randomised trial can usefully be classified as 'health equity relevant' if it assesses the effects of an intervention on the health or its determinants of either individuals or a population who experience ill health due to disadvantage defined across one or more social determinants of health. Health equity-relevant randomised trials can either exclusively focus on a single population or collect data potentially useful for assessing differential effects of the intervention across multiple populations experiencing different levels or types of social disadvantage. Trials that are not classified as 'health equity relevant' may nevertheless provide information that is indirectly relevant to assessing equity impact, including information about individual level variation unrelated to social disadvantage and potentially useful in secondary modelling studies. CONCLUSION: The conceptual framework may be used to design and report randomised trials. The framework could also be used for other study designs to contribute to the evidence base for improved health equity.