Intel (Taiwan)

Health Information Exchange (HIE) exhibits remarkable benefits for patient care such as improving healthcare quality and expediting coordinated care. The Office of the National Coordinator (ONC) for Health Information Technology is seeking patient-centric HIE designs that shift data ownership from providers to patients. There are multiple barriers to patient-centric HIE in the current system, such as security and privacy concerns, data inconsistency, timely access to the right records across multiple healthcare facilities. After investigating the current workflow of HIE, this paper provides a feasible solution to these challenges by utilizing the unique features of blockchain, a distributed ledger technology which is considered "unhackable". Utilizing the smart contract feature, which is a programmable self-executing protocol running on a blockchain, we developed a blockchain model to protect data security and patients' privacy, ensure data provenance, and provide patients full control of their health records. By personalizing data segmentation and an "allowed list" for clinicians to access their data, this design achieves patient-centric HIE. We conducted a large-scale simulation of this patient-centric HIE process and quantitatively evaluated the model's feasibility, stability, security, and robustness.

Anomaly detection has been an important research topic in data mining and machine learning. Many real-world applications such as intrusion or credit card fraud detection require an effective and efficient framework to identify deviated data instances. However, most anomaly detection methods are typically implemented in batch mode, and thus cannot be easily extended to large-scale problems without sacrificing computation and memory requirements. In this paper, we propose an online oversampling principal component analysis (osPCA) algorithm to address this problem, and we aim at detecting the presence of outliers from a large amount of data via an online updating technique. Unlike prior principal component analysis (PCA)-based approaches, we do not store the entire data matrix or covariance matrix, and thus our approach is especially of interest in online or large-scale problems. By oversampling the target instance and extracting the principal direction of the data, the proposed osPCA allows us to determine the anomaly of the target instance according to the variation of the resulting dominant eigenvector. Since our osPCA need not perform eigen analysis explicitly, the proposed framework is favored for online applications which have computation or memory limitations. Compared with the well-known power method for PCA and other popular anomaly detection algorithms, our experimental results verify the feasibility of our proposed method in terms of both accuracy and efficiency.

It is believed that vehicle-to-vehicle (V2V) communications and accurate positioning with sub-meter error could bring vehicle safety to a different level. However, to this date it is still unclear whether the envisioned V2V standard, dedicated short-range communications, can become available in commercially available vehicle products, while widely available consumergrade GPS receivers do not provide the required accuracy for many safety applications. In this article, combining visible light communications and visible light positioning, we propose the use of smart automotive lighting in vehicle safety systems. These lights would be able to provide the functions of illumination and signaling, reliable communications, and accurate positioning in a single solution. The proposed solution has low complexity, and is shown to be scalable in high vehicle density and fast topology changing scenarios. In this article, we also present several design guidelines for such a system, based on the results of our analytic and empirical studies. Finally, evaluation of our prototype provides evidence that the system can indeed detect potential risks in advance and provide early warnings to the driver in real-world scenarios, lowering the probability of traffic accidents.

This paper presents a novel solution of a hand-held external controller to a miniaturized capsule endoscope in the gastrointestinal (GI) tract. Traditional capsule endoscopes move passively by peristaltic wave generated in the GI tract and the gravity, which makes it impossible for endoscopists to manipulate the capsule endoscope to the diagnostic disease areas. In this study, the main objective is to present an endoscopic capsule and a magnetic field navigator (MFN) that allows endoscopists to remotely control the locomotion and viewing angle of an endoscopic capsule. The attractive merits of this study are that the maneuvering of the endoscopic capsule can be achieved by the external MFN with effectiveness, low cost, and operation safety, both from a theoretical and an experimental point of view. In order to study the magnetic interactions between the endoscopic capsule and the external MFN, a magnetic-analysis model is established for computer-based finite-element simulations. In addition, experiments are conducted to show the control effectiveness of the MFN to the endoscopic capsule. Finally, several prototype endoscopic capsules and a prototype MFN are fabricated, and their actual capabilities are experimentally assessed via in vitro and ex vivo tests using a stomach model and a resected porcine stomach, respectively. Both in vitro and ex vivo test results demonstrate great potential and practicability of achieving high-precision rotation and controllable movement of the capsule using the developed MFN.

Visible light communication (VLC) has recently emerged to become a promising wireless communication technology. Vehicle lights and traffic lights have started to utilize LEDs and due to their shorter response time, they can be easily modified to become VLC transmitters. In addition, cameras embedded in smartphones can be used as VLC receivers. As a result, Vehicular VLC (V2LC) between vehicle lighting and smartphone cameras has the potential to enable a great number of applications with low cost. In this paper, a prototype V2LC system that utilizes undersampled frequency shift ON-OFF keying (UFSOOK) modulation is proposed. The system utilizes rolling shutter cameras as the receiver and takes advantages of its characteristics to improve the receiving performance. An off- the-shelf vehicle LED taillight is used as the transmitter. Information is transmitted in the continuous state (ON-OFF) changes of LEDs which are invisible to human eyes. The performance evaluation results demonstrate that the communication prototype is robust and can resist common optical interferences and noises within the image.

An approach of robust localization for mobile robot working in indoor is proposed in this paper. A novel method for laser SLAM and visual SLAM fusion is introduced to provide robust localization. This architecture can be applied to a situation where any two kinds of laser-based SLAM and monocular camera-based SLAM can be fused together instead of being limited to single specific SLAM algorithm. While laser-based SLAM and monocular camera-based SLAM have their own strengths and drawbacks, the integration of these two kinds of SLAM algorithm can then promote the algorithmic effectiveness. Instead of using feature matching methods to achieve fusion procedure, trajectories matching is proposed with an attempt to achieve the generalization over all different kinds of SLAM algorithms, since localization is a natural function associated with any SLAM algorithm. It turns out that the hereby proposed approach is very lightweight during the run time, and the calculation can run in real-time without unnecessary computation waste. The experimental results show the localization error in terms of the real distance can be less than 5%. Furthermore, through the experiment the proposed system can be shown able to improve the localization when the sensors are not very powerful.

Battery lifetime is critical for wireless video sensors. To enable battery-powered wireless video sensors, low-power design is required. In this paper, we consider applying multi-view summarization to wireless video sensors to remove redundant contents such that the compression and transmission power can be reduced. A low-complexity online multi-view video summarization scheme is proposed. Experiments show that the proposed summarization method successfully reduces the video content while keeping important events. A power analysis of the system also shows that a significant amount of energy can be saved.

Abstract Background Enhancers are non-coding DNA fragments which are crucial in gene regulation (e.g. transcription and translation). Having high locational variation and free scattering in 98% of non-encoding genomes, enhancer identification is, therefore, more complicated than other genetic factors. To address this biological issue, several in silico studies have been done to identify and classify enhancer sequences among a myriad of DNA sequences using computational advances. Although recent studies have come up with improved performance, shortfalls in these learning models still remain. To overcome limitations of existing learning models, we introduce iEnhancer-ECNN, an efficient prediction framework using one-hot encoding and k -mers for data transformation and ensembles of convolutional neural networks for model construction, to identify enhancers and classify their strength. The benchmark dataset from Liu et al.’s study was used to develop and evaluate the ensemble models. A comparative analysis between iEnhancer-ECNN and existing state-of-the-art methods was done to fairly assess the model performance. Results Our experimental results demonstrates that iEnhancer-ECNN has better performance compared to other state-of-the-art methods using the same dataset. The accuracy of the ensemble model for enhancer identification (layer 1) and enhancer classification (layer 2) are 0.769 and 0.678, respectively. Compared to other related studies, improvements in the Area Under the Receiver Operating Characteristic Curve (AUC), sensitivity, and Matthews’s correlation coefficient (MCC) of our models are remarkable, especially for the model of layer 2 with about 11.0%, 46.5%, and 65.0%, respectively. Conclusions iEnhancer-ECNN outperforms other previously proposed methods with significant improvement in most of the evaluation metrics. Strong growths in the MCC of both layers are highly meaningful in assuring the stability of our models.

Medical volumetric imaging requires high fidelity, high performance rendering algorithms. We motivate and analyze new volumetric rendering algorithms that are suited to modern parallel processing architectures. First, we describe the three major categories of volume rendering algorithms and confirm through an imaging scientist-guided evaluation that ray-casting is the most acceptable. We describe a thread- and data-parallel implementation of ray-casting that makes it amenable to key architectural trends of three modern commodity parallel architectures: multi-core, GPU, and an upcoming many-core Intel architecture code-named Larrabee. We achieve more than an order of magnitude performance improvement on a number of large 3D medical datasets. We further describe a data compression scheme that significantly reduces data-transfer overhead. This allows our approach to scale well to large numbers of Larrabee cores.

"Blockchain" is a distributed ledger technology originally applied in the financial sector. This technology ensures the integrity of transactions without third-party validation. Its functions of decentralized transaction validation, data provenance, data sharing, and data integration are a good fit for the needs of health information exchange and clinical trials. We investigated the current workflow of Health Information Exchange and clinical trials; conducted design thinking processes with clinicians, trial managers, informaticians, and blockchain professionals; and implemented a private blockchain model to tackle known issues. We used coded Smart Contract regulations to simulate several scenarios in healthcare processes. This proof-of-concept work provides a feasible simulation for potential solutions to monitor clinical trials across different census regions persistently. Various levels of data access privileges have been designed to utilize a suite of customized Smart Contract settings. These settings emulate the workflow protocols for the monitoring entities, trial sponsors, clinical sponsors and participating subjects. Keywords: Blockchain, Smart Contract, Health Information Exchange, Clinical Trial, Persistent Monitoring.

This paper focuses on localization that serves as a smart service. Among the primary services provided by Internet of Things (IoT), localization offers automatically discoverable services. Knowledge relating to an object's position, especially when combined with other information collected from sensors and shared with other smart objects, allows us to develop intelligent systems to fast respond to changes in an environment. Today, wireless sensor networks (WSNs) have become a critical technology for various kinds of smart environments through which different kinds of devices can connect with each other coinciding with the principles of IoT. Among various WSN techniques designed for positioning an unknown node, the trilateration approach based on the received signal strength is the most suitable for localization due to its implementation simplicity and low hardware requirement. However, its performance is susceptible to external factors, such as the number of people present in a room, the shape and dimension of an environment, and the positions of objects and devices. To improve the localization accuracy of trilateration, we develop a novel distributed localization algorithm with a dynamic-circle-expanding mechanism capable of more accurately establishing the geometric relationship between an unknown node and reference nodes. The results of real world experiments and computer simulation show that the average error of position estimation is 0.67 and 0.225 m in the best cases, respectively. This suggests that the proposed localization algorithm outperforms other existing methods.

Scientific data repositories have historically made data widely accessible to the scientific community, and have led to better research through comparisons, reproducibility, as well as further discoveries and insights. Despite the growing importance and utilization of data repositories in many scientific disciplines, the design of existing data repositories has not changed for decades. In this paper, we revisit the current design and envision interactive data repositories, which not only make data accessible, but also provide techniques for interactive data exploration, mining, and visualization in an easy, intuitive, and free-flowing manner.

Over the past few years, Light Emitting Diode (LED) has become very common in automotive lighting due to its long service life, high resistance to vibration, and better safety performance due to its short rise time. A number of existing works use LEDs that already exist in vehicles, such as brake lights, turn signals, and headlamps, to carry out vehicle-to-vehicle (V2V) communications with visible light communications (VLC). Nonetheless, very few studies derive analytical models for VLC with empirical data obtained from the real world or with realistic assumptions. In addition, experimental works were often conducted in closed environments with lighting systems that are specifically customized, instead of real-life lighting systems. In this paper, we perform an analytical study that attempts to derive VLC channel models in a realistic V2V setting. The proposed model is evaluated against the real-world data obtained with unmodified off-the-shelf scooter taillights, and the results show that the proposed model is able to accurately estimate the received power of the scooter taillight at distances of up to 10 meters. In addition, this paper also discusses several guidelines for modeling VLC radiation behaviors when different types of LED taillights are used.

Electroencephalography (EEG) signals are often contaminated with artifacts. It is imperative to develop a practical and reliable artifact removal method to prevent the misinterpretation of neural signals and the underperformance of brain-computer interfaces. Based on the U-Net architecture, we developed a new artifact removal model, IC-U-Net, for removing pervasive EEG artifacts and reconstructing brain signals. IC-U-Net was trained using mixtures of brain and non-brain components decomposed by independent component analysis. It uses an ensemble of loss functions to model complex signal fluctuations in EEG recordings. The effectiveness of the proposed method in recovering brain activities and removing various artifacts (e.g., eye blinks/movements, muscle activities, and line/channel noise) was demonstrated in a simulation study and four real-world EEG experiments. IC-U-Net can reconstruct a multi-channel EEG signal and is applicable to most artifact types, offering a promising end-to-end solution for automatically removing artifacts from EEG recordings. It also meets the increasing need to image natural brain dynamics in a mobile setting. The code and pre-trained IC-U-Net model are available at https://github.com/roseDwayane/AIEEG.

Facial micro-expressions indicate brief and subtle facial movements that appear during emotional communication. In comparison to macro-expressions, micro-expressions are more challenging to be analyzed due to the short span of time and the fine-grained changes. In recent years, micro-expression recognition (MER) has drawn much attention because it can benefit a wide range of applications, e.g. police interrogation, clinical diagnosis, depression analysis, and business negotiation. In this survey, we offer a fresh overview to discuss new research directions and challenges these days for MER tasks. For example, we review MER approaches from three novel aspects: macro-to-micro adaptation, recognition based on key apex frames, and recognition based on facial action units. Moreover, to mitigate the problem of limited and biased ME data, synthetic data generation is surveyed for the diversity enrichment of micro-expression data. Since micro-expression spotting can boost micro-expression analysis, the state-of-the-art spotting works are also introduced in this paper. At last, we discuss the challenges in MER research and provide potential solutions as well as possible directions for further investigation.

Although hand tracking algorithm has been widely used in virtual reality and HCI system, it is still a challenging problem in vision-based research area. Due to the robustness and real-time requirements in VR applications, most hand tracking algorithms require special device to achieve satisfactory results. In this paper, we propose an easy-to-use and inexpensive approach to track the hands accurately with a single normal webcam. Outstretched hand is detected by contour & curvature based detection techniques to initialize the tracking region. Robust multi-cue hand tracking is then achieved by velocity-weighted features and color cue. Experiments show that the proposed multi-cue hand tracking approach achieves continuous real-time results even for the situation of cluttered background. The approach fulfills the speed and accuracy requirements of frontal-view vision-based human computer interactions.

According to the theory of clothing design, the genres of clothes can be recognized based on a set of visually differentiable style elements, which exhibit salient features of visual appearance and reflect high-level fashion styles for better describing clothing genres. Instead of using less-discriminative low-level features or ambiguous keywords to identify clothing genres, we proposed a novel approach for automatically classifying clothing genres based on the visually differentiable style elements. A set of style elements, that are crucial for recognizing specific visual styles of clothing genres, were identified based on the clothing design theory. In addition, the corresponding salient visual features of each style element were identified and formulated with variables that can be computationally derived with various computer vision algorithms. To evaluate the performance of our algorithm, a dataset containing 3250 full-body shots crawled from popular online stores was built. Recognition results show that our proposed algorithms achieved promising overall precision, recall, and -score of 88.76%, 88.53%, and 88.64% for recognizing upperwear genres, and 88.21%, 88.17%, and 88.19% for recognizing lowerwear genres, respectively. The effectiveness of each style element and its visual features on recognizing clothing genres was demonstrated through a set of experiments involving different sets of style elements or features. In summary, our experimental results demonstrate the effectiveness of the proposed method in clothing genre recognition.

BACKGROUND: Data coordination across multiple health care facilities has become increasingly important for many emerging health care applications. Distrust has been recognized as a key barrier to the success of such applications. Leveraging blockchain technology could provide potential solutions tobuild trust between data providers and receivers by taking advantage of blockchain properties such as security, immutability, anonymity, decentralization, and smart contracts. Many health technologies have empirically proven that blockchain designs fit well with the needs of health care applications with certain degrees of success. However, there is a lack of robust architecture to provide a practical framework for developers to implement applications and test the performance of stability, efficiency, and scalability using standard blockchain designs. A generalized blockchain model is needed for the health care community to adopt blockchain technology and develop applications in a timely fashion. OBJECTIVE: This study aimed at building a generalized blockchain architecture that provides data coordination functions, including data requests, permission granting, data exchange, and usage tracking, for a wide spectrum of health care application developments. METHODS: An augmented, 3-layered blockchain architecture was built on a private blockchain network. The 3 layers, from bottom to top, are as follows: (1) incorporation of fundamental blockchain settings and smart contract design for data collection; (2) interactions between the blockchain and health care application development environment using Node.js and web3.js; and (3) a flexible development platform that supports web technologies such as HTML, https, and various programing languages. Two example applications, health information exchange (HIE) and clinical trial recruitment, were developed in our design to demonstrate the feasibility of the layered architecture. Case studies were conducted to test the performance in terms of stability, efficiency, and scalability of the blockchain system. RESULTS: A total of 331,142 simulated HIE requests from accounts of 40,000 patients were successfully validated through this layered blockchain architecture with an average exchange time of 11.271 (SD 2.208) seconds. We also simulated a clinical trial recruitment scenario with the same set of patients and various recruitment criteria to match potential subjects using the same architecture. Potential subjects successfully received the clinical trial recruitment information and granted permission to the trial sponsors to access their health records with an average time of 3.07 seconds. CONCLUSIONS: This study proposes a generalized layered blockchain architecture that offers health technology community blockchain features for application development without requiring developers to have extensive experience with blockchain technology. The case studies tested the performance of our design and empirically proved the feasibility of the architecture in 2 relevant health application domains.

O6-Methylguanine-DNA-methyltransferase (MGMT) promoter methylation was shown in many studies to be an important predictive biomarker for temozolomide (TMZ) resistance and poor progression-free survival in glioblastoma multiforme (GBM) patients. However, identifying the MGMT methylation status using molecular techniques remains challenging due to technical limitations, such as the inability to obtain tumor specimens, high prices for detection, and the high complexity of intralesional heterogeneity. To overcome these difficulties, we aimed to test the feasibility of using a novel radiomics-based machine learning (ML) model to preoperatively and noninvasively predict the MGMT methylation status. In this study, radiomics features extracted from multimodal images of GBM patients with annotated MGMT methylation status were downloaded from The Cancer Imaging Archive (TCIA) public database for retrospective analysis. The radiomics features extracted from multimodal images from magnetic resonance imaging (MRI) had undergone a two-stage feature selection method, including an eXtreme Gradient Boosting (XGBoost) feature selection model followed by a genetic algorithm (GA)-based wrapper model for extracting the most meaningful radiomics features for predictive purposes. The cross-validation results suggested that the GA-based wrapper model achieved the high performance with a sensitivity of 0.894, specificity of 0.966, and accuracy of 0.925 for predicting the MGMT methylation status in GBM. Application of the extracted GBM radiomics features on a low-grade glioma (LGG) dataset also achieved a sensitivity 0.780, specificity 0.620, and accuracy 0.750, indicating the potential of the selected radiomics features to be applied more widely on both low- and high-grade gliomas. The performance indicated that our model may potentially confer significant improvements in prognosis and treatment responses in GBM patients.

Background: d-glutamate, which is involved in N-methyl-d-aspartate receptor modulation, may be associated with cognitive ageing. Aims: This study aimed to use peripheral plasma d-glutamate levels to differentiate patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) from healthy individuals and to evaluate its prediction ability using machine learning. Methods: Overall, 31 healthy controls, 21 patients with MCI and 133 patients with AD were recruited. Serum d-glutamate levels were measured using high-performance liquid chromatography (HPLC). Cognitive deficit severity was assessed using the Clinical Dementia Rating scale and the Mini-Mental Status Examination (MMSE). We employed four machine learning algorithms (support vector machine, logistic regression, random forest and naïve Bayes) to build an optimal predictive model to distinguish patients with MCI or AD from healthy controls. Results: The MCI and AD groups had lower plasma d-glutamate levels (1097.79 ± 283.99 and 785.10 ± 720.06 ng/mL, respectively) compared to healthy controls (1620.08 ± 548.80 ng/mL). The naïve Bayes model and random forest model appeared to be the best models for determining MCI and AD susceptibility, respectively (area under the receiver operating characteristic curve: 0.8207 and 0.7900; sensitivity: 0.8438 and 0.6997; and specificity: 0.8158 and 0.9188, respectively). The total MMSE score was positively correlated with d-glutamate levels ( r = 0.368, p < 0.001). Multivariate regression analysis indicated that d-glutamate levels were significantly associated with the total MMSE score ( B = 0.003, 95% confidence interval 0.002–0.005, p < 0.001). Conclusions: Peripheral plasma d-glutamate levels were associated with cognitive impairment and may therefore be a suitable peripheral biomarker for detecting MCI and AD. Rapid and cost-effective HPLC for biomarkers and machine learning algorithms may assist physicians in diagnosing MCI and AD in outpatient clinics.