Kerrville VA Medical Center

Research Article| June 01, 1978 Cenozoic stratigraphy and geologic history of southwestern Arizona L. D. EBERLY; L. D. EBERLY 1Exxon Company, USA, P.O. Box 1600, Midland, Texas 79702 Search for other works by this author on: GSW Google Scholar T. B. STANLEY, JR. T. B. STANLEY, JR. 1Exxon Company, USA, P.O. Box 1600, Midland, Texas 797022Present address: 222 Galbraith Avenue, Kerrville, Texas 78028 Search for other works by this author on: GSW Google Scholar Author and Article Information L. D. EBERLY 1Exxon Company, USA, P.O. Box 1600, Midland, Texas 79702 T. B. STANLEY, JR. 1Exxon Company, USA, P.O. Box 1600, Midland, Texas 797022Present address: 222 Galbraith Avenue, Kerrville, Texas 78028 Publisher: Geological Society of America First Online: 01 Jun 2017 Online ISSN: 1943-2674 Print ISSN: 0016-7606 Geological Society of America GSA Bulletin (1978) 89 (6): 921–940. https://doi.org/10.1130/0016-7606(1978)89<921:CSAGHO>2.0.CO;2 Article history First Online: 01 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Search Site Citation L. D. EBERLY, T. B. STANLEY; Cenozoic stratigraphy and geologic history of southwestern Arizona. GSA Bulletin 1978;; 89 (6): 921–940. doi: https://doi.org/10.1130/0016-7606(1978)89<921:CSAGHO>2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGSA Bulletin Search Advanced Search Abstract Recently obtained seismic data and the results of stratigraphic drilling in southwestern Arizona indicate that several alluvium-covered valleys in this area are underlain by more than 3,000 m of Cenozoic deposits. These deposits, with the exception of the marine late Miocene clastic wedge of the Yuma basin and the Pliocene Bouse Formation of the lower Colorado River valley, are the result of continental sedimentation. For the most part, these continental rocks consist of locally derived clastic sediments and lesser amounts of interbedded volcanic rocks and, in some valleys, thick bodies of evaporites. On the basis of their position in the stratigraphic sequence in relation to regional or semiregional unconformities, the Cenozoic sequence of southwestern Arizona was subdivided into an older Unit I and a younger Unit II. The boundary between these two units is a widespread unconformity surface resulting from an important period of subsidence, block-faulting, and erosion that began in late Miocene time (13 to 12 m.y. ago). The two Cenozoic units have been dated and correlated on the basis of radiometric age determination of the inter-bedded extrusive volcanic rocks, on lithologic character, and with the help of seismic interpretation.Sedimentation during early Cenozoic time (Unit I) took place in broad interior depressions under predominantly continental conditions. The late Miocene block-faulting episode changed the geography of southwestern Arizona and gave the area a typical basin-and-range structure of mountain-forming horsts separated by valleys underlain by grabens or half-grabens. The prevailing structural grain trends in a northwest direction. Unit II sediments were deposited in these troughs or grabens during late Cenozoic time. At least two of the five troughs located in the eastern part of the area studied contain thick sequences of evaporites that indicate interior drainage. These evaporites are assigned a late Miocene age on the basis of K-Ar ages for associated extrusive volcanic rocks and by their position in the stratigraphic sequence in relation to the late Miocene block-faulting episode. Exterior drainage systems were developed beginning sometime between 10.5 and 6 m.y. ago and have evolved progressively to give the area its present-day geomorphology. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.

Genetic alterations in primary prostate cancer (CaP) have been extensively studied, yet little is known about the genetic mechanisms underlying progression of primary CaP to metastatic prostate cancer. As a result, it is not possible to distinguish clinically indolent localized disease from potentially life-threatening tumors with high metastatic potential. To address this question, we collected tissue from 34 autopsy-derived metastases, samples rarely analyzed in previous studies. These were compared to a separate set of 17 prostatectomy specimens containing 22 foci of CaP associated with 49 examples of high-grade prostatic intraepithelial neoplasia (PIN), a histological precursor of CaP. We compared the loss of heterozygosity (LOH) profiles of high-grade PIN, primary CaP and metastases by analyzing 33 microsatellite markers previously found to have high frequencies of LOH in primary CaP. These markers were on chromosomes 5q, 6q, 7q, 8p, 9p, 10q, 11p, 13q, 16q, 17, 18q and 21q. In addition, markers on chromosomes 4p, 11q, 14q and 20q with no reported LOH in primary CaP were analyzed to determine the frequency of background LOH. In PIN lesions, the rate of LOH was significant only at D5S806 (20%) and D16S422 (29%). In addition, different PIN lesions within the same prostate gland were genetically diverse, indicating divergent evolution of synchronous neoplastic precursor lesions. LOH frequency was progressively higher in primary CaP and metastatic lesions. In primary CaP, significant losses occurred at the 8p, 10q, 11p, 16q, 17p, 18q and 21q loci (range 17-43%). Distinct patterns of LOH frequencies were observed in primary CaP compared with metastases. Although some loci (D16S422, D17S960, D21S156) showed similar frequencies of LOH in primary CaP and metastatic CaP, most other loci showed up to 7-fold metastasis-related increases. The metastatic samples revealed previously unrecognized prostate cancer LOH at D5S806, D6S262, D9S157, D13S133 and D13S227. These significant stage-specific differences in LOH frequency specify genetic loci that may play key roles in CaP progression and could represent clinically useful biomarkers for CaP aggressiveness.

Robert Card has written an important and careful paper (2007). It is important because this is clearly a pressing issue with powerful politics attached. One need only do a web search for “pharmacis...

OBJECTIVE: To develop and test a patient questionnaire on treatment satisfaction with diabetes regimens. RESEARCH DESIGN AND METHODS: Survey items were developed from community clinic focus groups, pretested in patients with diabetes, and examined in two samples of treated patients. RESULTS: Sixteen items performed well in assessing treatment experiences: ease and convenience, lifestyle burdens, well-being, and medical control. Construct validity was supported by associations (P < 0.05) with treatment complexity, self-rated glucose control, health worries, and A1C. Internal consistency ranged from 0.89 to 0.95. CONCLUSIONS: The Diabetes Medication Satisfaction Tool offers a comprehensive assessment of patient acceptability, with diabetes therapy useful for individualizing therapeutic decision making.

Groups of Japanese and American scientists, supported by international collaborators, have worked for many years to ensure the accuracy of the radiation dosimetry used in studies of health effects in the Japanese atomic bomb survivors. Reliable dosimetric models and systems are especially critical to epidemiologic studies of this population because of their importance in the development of worldwide radiation protection standards. While dosimetry systems, such as Dosimetry System 1986 (DS86) and Dosimetry System 2002 (DS02), have improved, the research groups that developed them were unable to propose or confirm an additional contribution by residual radiation to the survivor's total body dose. In recognition of the need for an up-to-date review of residual radiation exposures in Hiroshima and Nagasaki, a half-day technical session was held for reports on newer studies at the 59 th Annual HPS Meeting in 2014 in Baltimore, MD. A day-and-a-half workshop was also held to provide time for detailed discussion of the newer studies and to evaluate their potential use in clarifying the residual radiation exposure to atomic bomb survivors at Hiroshima and Nagasaki. The process also involved a re-examination of very early surveys of radioisotope emissions from ground surfaces at Hiroshima and Nagasaki and early reports of health effects. New insights were reported on the potential contribution to residual radiation from neutron-activated radionuclides in the airburst's dust stem and pedestal and in unlofted soil, as well as from fission products and weapon debris from the nuclear cloud. However, disparate views remain concerning the actual residual radiation doses received by the atomic bomb survivors at different distances from the hypocenter. The workshop discussion indicated that measurements made using thermal luminescence and optically stimulated luminescence, like earlier measurements, especially in very thin layers of the samples, could be expanded to detect possible radiation exposures to beta particles and to determine their significance plus the extent of the various residual radiation areas at Hiroshima and Nagasaki. Other suggestions for future residual radiation studies are included in this workshop report.

BACKGROUND: Antagonism of chemoattractant receptor-homologous molecule on T-helper type-2 cells (CRTH2), a G-protein coupled receptor for prostaglandin D2, could be beneficial for treating allergic disorders. We present findings on the efficacy and safety/tolerability of a CRTH2 antagonist (setipiprant) in participants with seasonal allergic rhinitis (AR) in a real-life setting over 2 weeks. METHODS: A Phase 2 trial and a Phase 3 trial were conducted at seven centers in Texas, USA during the Mountain Cedar pollen season. Both were prospective, randomized, double-blind, placebo- and active-referenced (cetirizine) studies. The Phase 2 trial assessed setipiprant 100-1000 mg b.i.d. and 1000 mg o.d. versus placebo in adult and elderly participants. The Phase 3 trial assessed setipiprant 1000 mg b.i.d. in adolescent, adult, and elderly participants. Efficacy was assessed using daytime nasal symptom scores (DNSS), night-time nasal symptom scores (NNSS) and daytime eye symptom scores (DESS). RESULTS: 579 participants were randomized in the Phase 2 trial (mean age 41.6-43.4 years); 630 were randomized in the Phase 3 trial (mean age 37.5-40.7 years). A statistically significant, dose-related improvement in mean change from baseline DNSS was observed over 2 weeks with setipiprant 1000 mg b.i.d. versus placebo in the Phase 2 trial (-0.15 [95% CI -0.29, -0.01]; p = 0.030). Setipiprant 1000 mg b.i.d. had no significant effect on this endpoint in the Phase 3 trial (-0.02 [95% CI -0.12, 0.07]; p = 0.652). Total and individual NNSS and DESS symptom scores were significantly improved with setipiprant 1000 mg b.i.d. versus placebo in the Phase 2 but not the Phase 3 trial. Setipiprant showed a favorable safety/tolerability profile. CONCLUSIONS: NCT01241214 and NCT01484119.

This communication presents our experience with eight patients who were initially evaluated as having normal cerebral computed tomographic (CT) scans. Follow-up scans ranging from 2 to 9 months later showed interval appearance of large contrast enhancing mass producing lesions. All eight of these patients turned out to have glioblastoma multiforme. This phenomenon of "false-negative" CT does not seem to be dependent on the type of equipment used or the age of the patient. Negative CT should not dissuade radiologists and clinicians from believing that a patient with appropriate symptoms and signs does indeed harbor a brain tumor.

Previous research has suggested that differences in subtest scatter may be indicated for diagnostic groups, although no one has applied DSM-III categories or used the WAIS—R for this purpose. This study yielded significant differences between small groups of patients diagnosed with Schizophrenia, Depression, and Personality Disorders on Information, Arithmetic subtests, and over-all Verbal-Performance IQ differences.

Development and validation of the hierarchical single surface Δ0* model for cohesive soils are described in a companion paper, part I. The present paper, part II, first describes the details of the simulation and verification of various stages in the field behavior of piles, e.g. in situ stresses, driving, consolidation, tension tests, and the final cyclic loadings. Undisturbed samples were obtained for testing of cylindrical and cubical specimens, the latter involved design and fabrication of a square, 13×13×13cm(5×5×5in.) sampler. Field measurements were obtained in terms of stresses, strains, and pore‐water pressures for various stages. The constitutive model (part I) is introduced in a general finite‐element (FE) procedure that allows dynamic analysis of porous soil media. The FE procedure is used to back‐predict the field behavior. It is found that the numerical procedure provides very good predictions of the measured responses. It is felt that the proposed unified (parts I and II) procedure can provide an excellent tool for a wide range of dynamic soil‐structure interaction problems.

Context. A growing number of Be and Oe stars, named the γ Cas stars, are known for their unusually hard and intense X-ray emission. This emission could either trace accretion by a compact companion or magnetic interaction between the star and its decretion disk. Aims. To test these scenarios, we carried out a detailed optical monitoring of HD 45314, the hottest member of the class of γ Cas stars, along with dedicated X-ray observations on specific dates. Methods. High-resolution optical spectra were taken to monitor the emission lines formed in the disk, while X-ray spectroscopy was obtained at epochs when the optical spectrum of the Oe star was displaying peculiar properties. Results. Over the last four years, HD 45314 has entered a phase of spectacular variations. The optical emission lines have undergone important morphology and intensity changes including transitions between single- and multiple-peaked emission lines as well as shell events, and phases of (partial) disk dissipation. Photometric variations are found to be anti-correlated with the equivalent width of the H α emission. Whilst the star preserved its hard and bright X-ray emission during the shell phase, the X-ray spectrum during the phase of (partial) disk dissipation was significantly softer and weaker. Conclusions. The observed behaviour of HD 45314 suggests a direct association between the level of X-ray emission and the amount of material simultaneously present in the Oe disk as expected in the magnetic star-disk interaction scenario.

A new nasal aerosol solution formulation of ciclesonide containing a hydrofluoroalkane propellant (CIC-HFA) delivered via a metered-dose inhaler is currently in clinical development as a potential treatment for allergic rhinitis (AR). This study evaluated the efficacy and tolerability of CIC-HFA 74- or 148-microgram doses compared with placebo in patients with perennial AR (PAR). Patients ≥12 years of age with a ≥ 2-year history of PAR were randomized in a placebo-controlled, double-blind, parallel-group, multicenter study to CIC-HFA 74 micrograms, CIC-HFA 148 micrograms, or placebo q.d. in the morning (A.M.) for 26 weeks. Change from baseline in reflective total nasal symptom score (rTNSS), instantaneous total nasal symptom score (iTNSS), and rhinoconjunctivitis quality-of-life questionnaire with standardized activities (RQLQ[S]) in patients with baseline RQLQ of ≥3.00 were evaluated for the first 6 weeks of treatment. Treatment-emergent adverse events (TEAEs) were monitored throughout the study. Eleven hundred eleven patients were randomized. CIC-HFA 74- and 148-microgram doses showed statistically significant improvements in rTNSS (least squares [LS] mean change, 0.70 and 0.54, respectively; p ≤ 0.001 versus placebo for both), iTNSS (LS mean change, 0.58 and 0.42, respectively; p < 0.05 versus placebo for both), and RQLQ[S] (LS mean change, 0.55 and 0.37, respectively; p < 0.01 versus placebo for both) from baseline. The overall incidence of TEAEs was comparable between the CIC-HFA treatment groups and placebo. In this study, once-daily treatment with CIC-HFA 74- or 148-micrograms showed statistically significant improvements in nasal symptoms of PAR. Both doses were well tolerated. Clinical trial registration URL and registration number: www.clinicaltrials.gov/ct2/show/NCT00953147.

Many individuals suffer negative mental health consequences such as anxiety and depression following separation from a romantic partner and/or co-parenting conflict due to divorce. Consequently, treating the psychological aftermath of divorce and partner separation remains a predominant concern for mental health practitioners. According to family systems theory, high interdependence and low differentiation of self are associated with a lessened capacity for managing anxiety or adapting to stressful events since intense emotions may inhibit the ability to cope. To assess the relationship between differentiation of self and psychological adjustment to separation, 84 divorced adults completed an online survey. Multiple regression analysis demonstrated that a model based on fusion with others, I-position, and emotional cutoff was a statistically significant predictor of lonely/negativity. Bivariate correlation analyses confirmed significant linear relationships between fusion with others, lonely/negativity, and co-parenting conflict. No differences between genders were found. There is a continuing need to develop interventions to address the negative consequences of divorce, help reduce emotional suffering, and encourage healthy co-parenting. Individuals struggling with psychological adjustment post-divorce, or those seeking education for managing the psychological effects of divorce and co-parenting, may benefit from counseling strategies that incorporate an assessment of differentiation of self and psychological adjustment to separation.

99mTc-diphosphonate bone scans of 13 patients in acute sickle crisis were analyzed. Twelve of the 13 patients had abnormal scans, with increased activity in joints and skull being a common finding. One patient with splenic calcification and two patients without splenic calcification had splenic uptake of diphosphonate. Most of the abnormal scans showed hot areas, with cold areas seen only in four cases. There was no correlation between the site of pain clinically and the abnormal areas on scanning. The pathophysiology of the abnormal uptake of radioactivity and the role of bone scanning on sickle cell disease are discussed.

BACKGROUND: A new, hydrofluoroalkane nasal aerosol solution formulation of ciclesonide (CIC-HFA) delivered via a metered dose inhaler is currently in clinical development for treatment of allergic rhinitis. OBJECTIVE: To study tolerability and quality of life following administration of CIC-HFA 74- or 148-μg doses once-daily compared with placebo in patients with perennial allergic rhinitis (PAR) over 26 weeks. METHODS: Patients ≥12 years of age with a ≥2 year history of PAR were randomized in a placebo-controlled, double-blind, parallel group, multicenter study to CIC-HFA 74 μg, 148 μg, or placebo QD AM for 26 weeks. Safety was assessed by monitoring treatment-emergent adverse events (TEAEs). Quality of life was assessed by using a rhinoconjunctivitis quality of life questionnaire with standardized activities (RQLQ[S]) in patients with baseline RQLQ ≥3.00. Reflective total nasal symptom scores (rTNSS) and instantaneous total nasal symptom scores (iTNSS) over 26 weeks were also evaluated. RESULTS: In this study, 1111 patients were randomized. The overall incidence of TEAEs was comparable between the treatment groups. Treatment with CIC-HFA 74- or 148-μg doses showed improvements in RQLQ[S] [least squares (LS) mean change 0.40 and 0.37, respectively from baseline, p < 0.01 versus placebo for both], rTNSS (LS mean change 0.65 and 0.52, respectively from baseline; p ≤ 0.01 versus placebo for both), and iTNSS (LS mean change 0.51 and 0.42, respectively from baseline; p < 0.05 versus placebo for both) from baseline. CONCLUSION: In this study, once-daily treatment with CIC-HFA 74- or 148-μg doses over 26 weeks was well tolerated with comparable incidence of TEAEs between the treatment groups.

No abstract available for this article.

OBJECTIVE: Firefighting-related environmental and physiological factors associated with cardiovascular strain may promote arrhythmias and myocardial ischemia, which induce sudden cardiac events (SCE) in susceptible individuals. The present study evaluated electrocardiographic (ECG) changes that may reflect increased SCE risk following simulated live-firefighting. METHODS: Using a repeated measures design, ECG tracings from 32 firefighters were recorded 12-hours post-firefighting in a residential structure and compared with a 12-hour control period. RESULTS: Ventricular arrhythmias were present in 20%, and ST segment changes indicative of myocardial ischemia in 16%, of firefighters 12-hours post-firefighting that were not detected in the control period. CONCLUSION: Live-firefighting induces significant ECG changes that include ventricular arrhythmias and ST segment changes, which may reflect myocardial ischemia. The implications of such ECG changes explaining increased cardiovascular risk in firefighters warrants further research.

Attempts to induce a demonstrable cattle Babesia infection by feeding known infected ticks on two white-tailed (Odocoileus virginianus) deer were unsuccessful. The injection of known Babesia carrier blood into an intact and a splenectomized deer failed to result in evidence of infection. All deer were checked for possible sub-patent infections by inoculating their blood into splenectomized calves at weekly intervals for 5 weeks following exposure, but no infections were produced in the calves. Babsia infected ticks having undergone one generation on deer were unable to transmit infection to splenectomized calves on the succeeding generation.

INH is stable for several weeks in aqueous and buffered solution at pH values below 8 and at low temperature. It is unstable in human and rabbit plasma whether added to pure plasma or present after oral or parenteral administration. Instability is enhanced by increased temperature, but is quite marked at refrigerator temperature. The presence of a factor in blood causes changes in chemical state of INH so that it no longer reacts with reagent used in the assay method.

Turkey IgA was isolated from bile by three methods: ammonium sulfate precipitation, polyethylene glycol (PEG) extraction, and lambda-carrageenan extraction. The isolated immunoglobulin fractions were compared using double diffusion, immunoelectrophoresis (IE), and enzyme-linked immunosorbent assay (ELISA). Results indicated that all three methods of isolation are sufficient for the initial isolation step for purification of the immunoglobulin fraction in turkey bile. Because of contaminating IgG, IgM, and other high-molecular-weight proteins, further purification by column chromatography is needed to isolate pure IgA. The lambda-carrageenan extraction method appears to be the method of choice for precipitating the immunoglobulin fraction in bile, because of the high antibody activity after extraction. Like ammonium sulfate precipitation, lambda-carrageenan and PEG extraction are not sufficient as single-step purification methods and should be used as the initial step in the purification of IgA.

Genome size estimates and chromosome number information can be useful for studying the evolution or taxonomy of a group and also can be useful for plant breeders in predicting cross-compatibility. Callicarpa L. is a group of ≈140 species with nearly worldwide distribution. There are no estimates of genome size in the literature and the information on chromosome numbers is limited. Genome size estimates based on flow cytometry are reported here for 16 accessions of Callicarpa comprising 14 species in addition to chromosome counts on six species. Chromosome counts were conducted by staining meristematic cells of roots tips using modified carbol fuchsin. Holoploid genome size estimates ranged from 1.34 pg to 3.48 pg with a mean of 1.74 pg. Two tetraploids (2 n = 4 x = 68; C. salicifolia P'ei &amp; W. Z. Fang and C. macrophylla Vahl GEN09-0081) were identified based on holoploid genome size and confirmed by chromosome counts. There was little variation among species for monoploid genome size. 1Cx-values ranged from 0.67 pg to 0.88 pg with a mean of 0.77 pg. Chromosome counts for six species revealed a base chromosome number of x = 17. Callicarpa chejuensis Y. H. Chung &amp; H. Kim, C. japonica Thunb. ‘Leucocarpa’, C. longissima Merr., and C. rubella Lindl. were confirmed as diploids (2 n = 2 x = 34). Cytology supported flow cytometry data that C. salicifolia and C. macrophylla GEN09-0081 were tetraploids. The two accessions of C. macrophylla included in the study were found to be of different ploidy levels. The presence of two ploidy levels among and within species indicates that polyploidization events have occurred in the genus.