KLE Ayur World

BACKGROUND: Herbal formulation standardization by adopting newer technique is need of the hour in the field of Ayurvedic pharmaceutical industry. As very few reports exist. These kind of studies would certainly widen the herbal research area. Chitrakadivati is one such popular herbal formulation used in Ayurveda. Many of its ingredients are known for presence of alkaloids. METHODOLOGY: Presence of alkaloid was tested qualitatively by Dragondroff's method then subjected to quantitative estimation by UV-Spectrophotometer. This method is based on the reaction between alkaloid and bromocresol green (BCG). RESULTS AND CONCLUSION: Study discloses that out of 16 ingredients, 9 contain alkaloid. Chitrakadivati has shown 0.16% of concentration of alkaloid and which is significantly higher than it's individual ingredients.

In Apple CEO Tim Cook's keynote speech at the Chinese government's 2017 World Internet Conference, he extolled the values of “Privacy. Security. Decency” (Apple Newsroom 2017). The last two terms, “security” and “decency,” have long been closely associated with Chinese government efforts to control the Internet. Indeed, in 2017 Apple agreed to turn over user data to Chinese government servers and start a Chinese provincial government-run data storage center. Yet in 2015, Apple refused to turn over the passcode for one user in the United States during the FBI investigation following the San Bernardino terrorist attacks. The company's different policies in the United States and China relate directly back to Apple's concern for market share and access.

Drug safety is a very basic and fundamental concept in medical practice. ADRs play an important role in assessing patient safety in any system of medicine. Pharmacovigilance study is thus significant to understand treatment outcomes. Current raised issue with respect to complementary and alternative system medicine (CAM) like Ayurveda is increased in number of safety reports along with report misinterpretation; this generates the negative impact on system. Although, Ayurveda which is holistic system of medicine from India has elaborated the causes and methods of drug-induced consequences along with preventive measures the available data in classical texts is scattered. The compilation and analysis along with modern concept drug safety is need of the hour. Present literature review was conducted from various compendium of Ayurveda and electronic data base with search terms of 'Vyapad', 'Viruddha', 'Ahita', 'herb-herb interaction', 'idiosyncrasy', 'Prakritiviruddha' etc. The reported information was analysed for the possible correlation on concept of ADR and Pharmacovigilance of current science. Overall review demonstrated that drug interaction, iatrogenic, over dose, administration of unsuitable drugs, reprehensive drug administration with respect to disease, complication from five procedural therapies (Panchakarma) and reprehensible preparation of mineral drug are nearer to the modern causes of ADR. Thus, concept of drug safety and ADR is not new to the Ayurveda. The concept "Drug which is not appropriate to be used as medicine"(Abheshaja) of Ayurveda sounds similar as that of modern pharmacovigilance.

BACKGROUND: Osteoarthritis (OA) is the most common joint disorder. In Ayurveda the disease Sandhigata Vata resembles with OA, which is described under Vatavyadhi. Treatment provides symptomatic relief, but the underlying pathology remains unchecked due to the absence of effective drugs. In the management of Sandhigata Vata, all the Acharyas have described the employment of Bahya Snehan, Swedana, Abhyantara Tikta Snehapana, Basti treatment and Guggulu Prayoga. AIM: To evaluate the effect of Ksheerbala Taila Anuvasana Basti in Sandhigata Vata. MATERIALS AND METHODS: In the present study, 30 patients of Sandhigata Vata were given Anuvasana Basti with Ksheerabala Taila. Subjective assessment of pain by visual analog scale and swelling, tenderness, crepitus and walking velocity were graded according to their severity. RESULTS: Significant results (P < 0.05) were found in all the cardinal symptoms - Pain (Sandhiruja), Swelling (Shotha), tenderness, crepitus and walking velocity. Radiological findings showed no significant changes. CONCLUSION: Anuvasana Basti with Ksheerabala Taila was significant in the subjective symptoms of Sandhigata Vata.

Background: Essential hypertension (EHTN) is emerging as one of the most prevalent disorder with high rate of complications, morbidity and mortality. Brahmi vati, an Ayurvedic medicine is explored for its efficacy in the management of EHTN. Objective: To evaluate the efficacy of Brahmi vati and sarpagandha Ghana vati in the management of EHTN. Methods: Total 68 patients meeting the JNC 7 criteria of EHTN of age group 20 to 60 years of either sex participated in the study. They were randomly divided into two groups, group A received capsule Brahmi vati 500 mg and group B capsule Sarpagandha Ghana vati 500 mg respectively twice a day for 30 days. Assessments were done through various variables like systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), lipid profiles, Hamilton anxiety rating scale, 2 weeks sleep diary, serum creatinine, hemoglobin, total leukocyte count and erythrocyte sedimentation rate. Follow up visit was on every 15th day. Results: Study showed that both Brahmi vati and Sarpagandha Ghana vati produced improvement in most of the variables and were comparable. Improvements were seen in various variables like SBP, DBP, MAP, Hamilton anxiety rating scale, subjective sleep profiles and total cholesterol. However Brahmi vati showed increase in weight and Body Mass Index (BMI). Sarpagandha Ghana vati produced reduction in total cholesterol and LDL. Both groups showed good safety profile evaluated through the assessment of serum creatinine levels. Conclusion: Clinical efficacy of Sarpagandha Ghana vati and Brahmi vati on EHTN showed that both were effective, safe and comparable. Keywords: Essential hypertension, Sleep profiles, Lipid profile, Sarpagandha Ghana vati, Brahmi vati

Rasaka, one among the Maharasas, has been indicated in various diseases like Netrarogas, Prameha, etc. Lately, the use of Rasaka bhasma has been declined as an identification of Rasaka. The present study aims to prepare Rasaka bhasma from two different samples of Rasaka and undertake comparative antimicrobial activity study against Gram-positive and Gram-negative organisms by agar disk diffusion method.

Ayurveda had mentioned various procedures for maintaining oral hygiene. These include procedures like gandusha, kavala, dantadhavana, and jivha lekhana (cleaning tongue). Various plants have been mentioned in Ayurveda for dantakashta. Various Ayurvedic dental formulations are available in market in the form of powders, paste, etc. Present study was conducted for evaluating the effect of one of such Ayurvedic toothpowder named UDM, in controlling plaque and reducing gum inflammation in patients of moderate gingivitis. Scaling, root planning, and polishing were done for all the patients participating in the study. Oral hygiene instructions were given that included brushing twice/day with assigned tooth powder using BASS method for tooth brushing and also massage over gum tissue with finger. All the patients were recalled after 15 days. Scores of plaque index and gingival index was recorded on day 1 and day 15 of treatment. Total of 15 patients were recruited in each group. The mean reduction in gingival index was 1.15 (P<0.05) and 1.26 (P<0.05) in positive control and UDM treatment groups, respectively. However, the mean reduction in plaque indices were found to be 2.03 (P<0.05) and 2.16 (P<0.05) in positive control and UDM groups, respectively. No significant difference was seen in both the parameters between the two groups.

Major Depressive disorder (MDD) is a chronic, episodic disorder which manifests with disturbance in mood, interest, cognition and vegetative symptoms. It has major impact on the quality of life of the patients, by affecting their physical, mental, personal, social, and spiritual wellbeing. Vishada and avasada represents minor depressive episodes and MDD can be equated to Kaphaja Unmada. Current case presented with sadness, worthlessness, helplessness, death wishes, disturbed sleep and was diagnosed as MDD as per DSM V criteria. Ayurveda diagnosis was Kaphaja Unmada involving kapha-dominant vata and tama dosha. Mental examination revealed derangement of mana (mind), buddhi (intellect), smruti (memory), bhakti (desire), sheela (temperament), chesta (psychomotor activity) and achara (conduct) components. Patient was Avara Satwa. Management was planned with integrative treatment comprising of Yukti vypasharaya (pharmacological), Satwawajaya (counselling) and daiwivyapashraya (spiritual-based techniques). Management was with snehapana (internal oleation), virechana (gut cleansing), sarvanga abhyanga (massage of whole body with medicated oil) followed by bashpa sweda (steam therapy to whole body), shirodhara (dripping of medicated oil on fore head), shiropichu (transcranial drug administration by placing cotton pad dipped in medicated oil), katibasti (holding of medicated oil in well-prepared from dough), satwavajaya chikitsa, and daiwi vyapashraya chikitsa. Conventional psychopharmacological interventions taken since last year were tapered and discontinued. Treatment continued for 352 days which included 13 days of hospitalized treatment and follow-ups. Intervention outcome showed reduction in Hamilton depression Rating scores from 31 to 6. Patient's self-assessed worry reduced from 16 h/day to 2 h/day, self-assessed daily relaxed state improved from ½ hour/day to 14 h/day. Patient showed complete remission by 180th day of intervention. Improvements sustained even during the non-interventional observation period. Thus, the Ayurvedic integrative management showed efficacy in management of MDD.

This paper examines the scenario of research orientation in Ayurveda educational institutions of India. We demonstrate through the data obtained by searching the SCOPUS that the actual research output by these institutions is not very significant in terms of number of publications. While a lack of research expertise and infrastructure is one contributing factor to this status, a lack of questioning attitude is more crucial one. Mushrooming of new colleges, laxity in regulations, corruption, lack of atmosphere for ethical and quality research make the problem more complex. We show, with the help of SCOPUS Data, that the recent trend of establishing stand-alone institutions of Ayurveda may not help in invigorating research activities since the research contributions from such institutions have always been very poor. Instead, we suggest that existing stand-alone institutions of Ayurveda be merged with other established Central/State universities or other Medical colleges. The data demonstrates that the research output has been always significant when an institution has many experts working in different streams of science within, than when the institutions have only Ayurveda experts. We also take up the question of designing the clinical trials that are suitable for Ayurveda and propose an algorithm that may be considered for research in educational institutions, at least at doctoral level. We further enlist a set of recommendations that could potentially change the scenario. Evidence-informed policy making, inducting clinicians into the education system, making the curricula more attractive by including recent advances, introducing efficient faculty training programs, and rigorous implementation of the existing regulations - are some of the key recommendations we have made.

Eczema is a form of dermatitis where inflammation of epidermis occurs. The exact cause of eczema is not known. Although it is activated by the immune system and is related to allergic reactions, it is not the same as other allergic reactions. In Ayurveda, the disease is described by the name "Vicharchika." Virechana is the best line of management for skin disorders. Controlling eczema more effectively can make a radical improvement to the patient's quality of life. A case report of 45-year-old male, who presented with complaints of rashes over dorsum of both foot associated with intense itching and burning sensation, oozing wound posterior to lateral malleolus and dorsum of left foot has been presented here.

INTRODUCTION: Though Ayurveda is practiced in the Indian subcontinent since centuries, there is a paucity of systematic documentation related to the occurrence of adverse drug reactions (ADR) and other issues regarding the safety of Ayurveda medicines. AIM: To monitor and analyze the pattern and frequency of ADR to Ayurvedic medicines in an Ayurvedic hospital setup. MATERIALS AND METHODS: In this prospective study, ADR monitoring was done in KLE Ayurveda Secondary Care Hospital, Belgaum, Karnataka, India by spontaneous and intensive monitoring technique for a span of 1-year (June 2010 to May 2011). Data pertaining to patient demography, drug and reaction characteristics, organ system involved and reaction outcomes were collected and evaluated. The reaction severity and predisposing factors were also assessed. RESULTS: In a span of one year, 84 adverse drug events were reported out of which 52 confirmed as ADR. The overall incidence of ADR in the patient population was 1.14%, out of which 23 (44.23%) were related to Panchakarma (detoxification process), 13 (25.00%) related to the herbal formulations and 06 (11.53%) were of Rasa Aushadhi (mineral or herbo-mineral formulations). The commonly affected organ systems were gastrointestinal system 24 (46.15%) and skin 15 (28.84%). The majority of the reactions were moderate 30 (57.69%) to mild 20 (38.46%) in severity. Most patients recovered from the incidence. CONCLUSION: The present work has documented the incidence and characteristic of ADR to Ayurvedic medicine in a typical Ayurveda hospital setup. This will help in developing various strategies for boosting pharmacovigilance in Ayurveda, thereby ensuring safer use of Ayurveda medicines.

Type 2 Diabetes Mellitus (T2DM) is a growing global concern having reached the epidemic proportion in most countries. Achieving glycaemic control decreases the risk of macrovascular and microvascular complications in T2D. To achieve and maintain good glycaemic control, lifestyle changes and pharmacological treatment is necessary. Pharmacological management of T2DM have some limitations as it may lead to vit-B12 deprivation, hypoglycemia, increased cardiovascular risk etc. Treatment algorithm that include integration of Ayurvedic treatment & diet, Panchakarma therapies and Yoga will ensure good glycaemic control and reduce the progression of complications. Diagnosed cases of T2DM without intervention of conventional pharmacological drugs will be safe and beneficial. A female patient aged about 52 years visited to diabetic specialty OPD with the following complaints: increased micturation frequency, vaginal itching, fatigue and increased thirst. Patient reported weight gain in past 1 year, was not on any conventional antidiabetic medication. Her HbA1c status confirmed diagnosis of T2DM. Patient was treated with a course of nityavirechana (medicated purgation) and Sarwanga Udwartana (Dry medicated powder rubbing whole body) for the duration of 7 days along with ayurveda medicines for 1 year. Patient was prescribed Ayurvedic diet and Yoga practices throughout the intervention. This case report reveals the protocol based integrated Ayurveda and Yoga practices for diagnosed case of T2DM without causing any untoward effect along with reversal of the diabetes.

Glycyrrhiza glabra L. (GG), also known as Yashtimadhu, is a traditional plant which is widely used in Ayurveda. It is used to treat a variety of ailments including cough, asthma, bronchitis, diabetes, gastric ulcers, skin problems, inflammation, anaemia, premature greying of hair and others. Clinical and experimental research suggests that it possesses anti-inflammatory, antiviral, immunomodulatory, hepatoprotective, antimicrobial, antioxidant, anticancer, and cardioprotective activities. We gathered material on the phytochemistry, pharmacology, and toxicity of Glycyrrhiza glabra published before March 2022 from PubMed, Springer, SCOPUS, Google Scholar and Science Direct. To compile this study, we conducted a thorough analysis of the classical Ayurvedic treatises in order to obtain a full account of the qualities, actions, and applications stated in Ayurveda about yashtimadhu in order to demonstrate ancient-modern concordance. GG has been studied for a variety of pharmacological properties, including ulcer healing, anti-ulcerogenic, anti-bacterial, antioxidant potential activity, anti-asthmatic activity, hair growth stimulating activity, and memory enhancing action. Licorice in Ayurveda is generally used in Ayurveda as a rejuvenator and aphrodisiac, as well as for boosting memory, complexion, sound quality, dental health, vision, lactation, and healing cancer, ulcers and wounds. Even though GG is a widely used Ayurveda medicine, there is a lack of evidence regarding the true medicinal potential of the drug. There are innumerable actions mentioned in the Ayurveda classical textbooks. Here, an effort is made to find substantiation for the ancient wisdom through a thorough search with the modern available literature.

BACKGROUND: Sports injuries are the second most common type of accident after domestic (3.7%) and occupational accidents (3.1%). There is an average annual estimate of 8.6 million sports and recreational related injury incidents with an age-adjusted rate of 34.1 per 1000 populations. Common sports injuries are musculoskeletal injuries i.e. Sprains, Strains, Joint injuries, soft tissue injury (STI). The sports injury in Ayurveda can be co-related within dissimilar facets of trauma related ailments. OBJECTIVE: To evaluate the efficacy of a protocol-based management of common sports injuries using an integrated approach. MATERIALS AND METHODS: Integration of Ayurveda and Physiotherapy procedures was done and phase wise treatment was framed. Total 30 patients of age between 10 and 60 years ful-filling the inclusion criteria were selected for the present study. The patients were treated with Phase wise protocol consisting of three phase's i.e. Inflammatory (1-5 days), Stabilization and recovery (6-10 days), Muscle strengthening (11-17 days). Assessments were done through various variables like pain, tenderness, swelling, local temperature, manual muscle testing (MMT) and range of motion (ROM) at different time points. STATISTICAL ANALYSIS: Wilcoxon matched pair test was used to assess within group results for subjective parameters and paired t-test (Dependent t-test) was used to assess for objective parameters. RESULT: The study showed that integrated treatment approach has given significant results in the parameters like pain, loss of function, tenderness, local temperature, MMT and ROM. CONCLUSION: Phase wise management through integrated protocol is effective in the management of common sports injuries.

Nutrition is major concern for the mankind. Food determines body condition right from the womb to tomb; it is main source of energy. Abnormal nutrition may cause both over and under nutrition hazards. It causes more than half of the nearly 11 million deaths each year among children under age five. Nutritional deficiency disorders are viewed under Apatarpanajanya vyadhis. Ancient Acharyas explained diseases related to nutritional deficiency such as Phakka, Parigarbhika, Bala shosha etc in different samhitas. This paper highlights Ayurvedic perspective of nutritional deficiency related disorders.

BACKGROUND: Gentamicin (GM) nephrotoxicity accounts for 10-30% of the acute renal failure (ARF) among drug-induced ARF. In Ayurveda such side effects are considered as the poisonous effects of low potent poisons called gara viṣa. Bilvādi agada (BA), a classical formulation is indicated in gara viṣa and most of its ingredients have proven for their nephroprotective activity. AIM: The aim was to evaluate the effect of BA in GM-induced nephrotoxicity in male Wistar rats. MATERIALS AND METHODS: BA, GM, normal saline were procured from standard companies. SETTINGS AND DESIGNS: Eighteen male Wistar rats were randomly divided into three groups, viz. Control group which received normal saline intraperitoneal (i.p.) daily for 8 days; toxic group received GM 80 mg/kg/day i.p. for 8 days, and trial group received both GM 80 mg/kg/day i.p. and BA 216 mg/each rat weighing ~200 g orally 1 h after administration of GM. STATISTICS: All the values were expressed as mean ± standard error and data were analyzed by applying one-way analysis of variance followed by Dunnett's test for multiple comparison. RESULTS: BA treated group showed a significant change (P < 0.05) in levels of serum creatinine, urine creatinine, and urine potassium. There was no significant change (P > 0.05) seen in serum potassium, sodium, chloride, calcium and phosphorus and urine sodium, chloride in all three groups. Glomerular congestion, interstitial edema, tubular necrosis, interstitial hemorrhage was reduced in BA treated group. The results of this study indicate that BA reduces GM-induced nephrotoxicity and it may be due to anti-inflammatory, immunomodulatory, diuretic and anti-oxidant properties of drugs. Further studies are necessary to explore the exact mechanism of BA in nephroprotection.

BACKGROUND: Generalized Anxiety Disorder (GAD) is the most common anxiety disorder. GAD has high comorbidities and it can affect social, professional and personal life. Ayurvedic medicine, Brahmi vati is explored for the possible role in management of GAD and is compared to Manasmitra vataka. AIM: To evaluate the efficacy of B. vati on Generalized Anxiety Disorder. METHODS: A randomized double blind controlled trial, with total 56 patients meeting the DSM V criteria of GAD between 20-60 years of age and either sex participated in the study. Participants were randomly divided into two groups, Brahmi group received capsule B. vati 500 mg and Manasmitra group received capsule M. vataka 500 mg thrice a day with water for 45 days. Assessments were conducted through various clinical parameters such as Hamilton Anxiety Rating Scale (HARS), GAD 7 scale (GAD 7), Beck Depression Inventory scale (BDI), Epworth sleepiness scale (ESS), Pittsburgh Sleep Quality Index (PSQI), WHO Quality of Life- BREF (WHOQOL-BREF), Clinical Global Improvement scale (CGI). Blood variables including Haemoglobin, Erythrocyte Sedimentation Rate (ESR), Liver Function Test (LFT) and serum creatinine were assessed before and after the study. Assessments during intervention were conducted on every 15th day. RESULTS: Study results indicate that both B. vati and M. vataka were comparable and each produced significant improvement (p < 0.001) in HARS, GAD-7, BDI, ESS, PSQI, WHOQOL-BREF and CGI. Brahmi vati also produced significant decrease in systolic (p = 0.002) and diastolic (p < 0.001) blood pressure. Both groups showed good safety profile evaluated through the assessment of serum creatinine levels and LFT. CONCLUSION: B. vati and M. vataka were effective, safe and comparable in the management of GAD. Warrants further studies.

In the crude herbal drug market, the highly medicinal <i>Eclipta alba</i>, popularly known as “Bhringaraja”, is often adulterated with <i>Wedelia calendulacea</i>. To evaluate the ability of simple genetic fingerprinting methods to differentiate between the two species, Inter-Simple Sequence Repeat and Random Amplified Polymorphic DNA assays were performed on 30 individuals of <i>E. alba</i> and 4 individuals of <i>W. calendulacea</i>. Samples of <i>W. calendulacea</i> were found to cluster in clades that distinctly separated from <i>E. alba</i> and at least one band was identified for each of the two species that can serve as a marker for identification. Despite wide variations and a limited number of samples, phylogenetic analysis helped in differentiating the original from the adulterant plant. The study underscores the importance of simple DNA-based fingerprinting as a cost-effective method for the detection of adulteration in plants, particularly with respect to <i>E. alba</i>.

INTRODUCTION: Diabetic Foot ulcer is the commonest burning problem in the society. Many histopathological studies show prolonged inflammatory phase in diabetic wounds. In Sushruta Samhita, Vimlāpanakarma (gentle massage) quoted, as first line of treatment for Vranashotha (inflammation). CASE REPORT: A 70 yrs old male patient, presented with complaints of ulcer associated with severe pain and reddish skin discoloration over ventral aspect of 3(rd) toe of right foot since 2 months. Vimlāpanakarma performed with Jātyādi taila around the wound for about 15-20 minutes daily for 10 days and follow-up done for period of 45 days. DISCUSSION: By Vimlāpanakarma with Jātyādi taila there will be raised local temperature, due to which vasoconstriction is relieved and necessary nutrients, oxygen, insulin etc. are carried to the wound site, thereby improving the anoxic condition of wound. CONCLUSION: Vimlāpanakarma showed significant role in wound healing of Diabetic Foot ulcer, in a short period of time 10 days with no recurrence seen till 45 days follow-up.

BACKGROUND: Rasashastra is a branch which deals with the pharmaceutics of Rasaoushadhis. Bhasmas are one among such Rasaoushadhis which are known for their low doses and fast action. A verse from Rasaratnasamuchchaya says that the bhasma prepared by using Mercury as media is of best quality. MATERIALS AND METHODS: Following this principle, Yashadabhasma (Zinc calx) was prepared by subjecting it to Samanya shodhana (general purification method for all metals), Vishesha shodhana (specific putification method for Zinc), Jarana (roasting) and Marana (incineration) with Parada(Mercury) as a media under Gajaputa (classical heating system with 1000 cowdung cakes). RESULTS AND CONCLUSION: Yellow colored Yashadabhasma which passed all the classical bhasmaparikshas (tests for properly prepared calx) was obtained after two putas. The bhasma did not pass Nishchandratva(free from shining particles) test after 1(st)puta but was passed after giving it 2(nd)puta.