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Klinik und Poliklinik für Kinder- und Jugendpsychiatrie

Hospital / health systemMainz, Germany

Research output, citation impact, and the most-cited recent papers from Klinik und Poliklinik für Kinder- und Jugendpsychiatrie (Germany). Aggregated across the NobleBlocks index of 300M+ scholarly works.

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Also known as
Klinik und Poliklinik für Kinder- und Jugendpsychiatrie

Top-cited papers from Klinik und Poliklinik für Kinder- und Jugendpsychiatrie

Normierung und Evaluation der deutschen Elternversion des Strengths and Difficulties Questionnaire (SDQ): Ergebnisse einer repräsentativen Felderhebung
Wolfgang Woerner, Andreas Becker, Christine Friedrich, Aribert Rothenberger +2 more
2002· Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie314doi:10.1024//1422-4917.30.2.105

OBJECTIVE: The (SDQ) is a short questionnaire which addresses positive and negative behavioural attributes of children or adolescents. Being rated by parents or teachers, or as an equivalent self-report version, the 25 SDQ items were designed to include both strengths and difficulties. Although several reports have demonstrated the validity of the German SDQ, normative data have not yet been established. METHODS: In a nationwide representative field study, parent ratings were completed for 930 children and adolescents aged between 6 and 16 years. Following verification of the scale structure by factor analysis, the observed distributions of scores were used to define normal, borderline, and abnormal score ranges. Possible effects of gender, age, and social class were also investigated. RESULTS: Factor analysis yielded an exact replication of the original scales. Several associations with gender, age, and social status attained statistical significance, but cut-off scores for the five subscales remained stable in different subgroups. Age- and sex-specific bandings for the total problem score reflected small differences between homogeneous subgroups. CONCLUSIONS: After replication and confirming the original scale factors, the availability of normative data further enhances the diagnostic value of the SDQ and facilitates future validation studies. Present evidence suggests that the SDQ may serve as a useful and economical screening measure, and in many other clinical and research settings.

Association of Trauma and PTSD Symptoms With Openness to Reconciliation and Feelings of Revenge Among Former Ugandan and Congolese Child Soldiers
Christophe Pierre Bayer, Fionna Klasen, Hubertus Adam
2007· JAMA290doi:10.1001/jama.298.5.555

Tens of thousands of the estimated 250,000 child soldiers worldwide are abused or have been abused during the last decade in Africa's Great Lakes Region. In the process of rebuilding the war-torn societies, it is important to understand how psychological trauma may shape the former child soldiers' ability to reconcile.To investigate the association of posttraumatic stress disorder (PTSD) symptoms and openness to reconciliation and feelings of revenge in former Ugandan and Congolese child soldiers.Cross-sectional field study of 169 former child soldiers (aged 11-18 years) in rehabilitation centers in Uganda and the Democratic Republic of the Congo, conducted in 2005.Potentially traumatic war-related experiences assessed via a sample-specific events scale; PTSD symptoms assessed using the Child Posttraumatic Stress Disorder Reaction Index (CPTSD-RI), with a score of 35 or higher indicating clinically important PTSD symptoms; and openness to reconciliation and feelings of revenge assessed via structured questionnaires.Children participating in this study were a mean of 15.3 years old. These former child soldiers reported that they had been (violently) recruited by armed forces at a young age (mean [SD], 12.1 [2] years), had served a mean of 38 months (SD, 24 months), and had been demobilized a mean of 2.3 months before data collection (SD, 2.4 months). The children were exposed to a high level of potentially traumatic events (mean [SD], 11.1 [2.99]). The most commonly reported traumatic experiences were having witnessed shooting (92.9%), having witnessed someone wounded (89.9%), and having been seriously beaten (84%). A total of 54.4% reported having killed someone, and 27.8% reported that they were forced to engage in sexual contact. Of the 169 interviewed, 59 (34.9%; 95% confidence interval, 34.4%-35.4%) had a PTSD symptom score higher than 35. Children who showed more PTSD symptoms had significantly less openness to reconciliation (rho= -0.34, P < .001) and more feelings of revenge (rho= 0.29, P < .001).PTSD symptoms are associated with less openness to reconciliation and more feelings of revenge among former Ugandan and Congolese child soldiers. The effect of psychological trauma should be considered when these children are rehabilitated and reintegrated into civilian society.

Speech Understanding in Quiet and Noise in Bilateral Users of the MED-EL COMBI 40/40+ Cochlear Implant System
J. M??ller, Franz Schön, J. Helms
2002· Ear and Hearing255doi:10.1097/00003446-200206000-00004

OBJECTIVE: The purpose of the study was to investigate speech understanding in quiet and noise in subjects bilaterally implanted with multi-channel cochlear implants. DESIGN: Nine adults bilaterally implanted with MED-EL implants were included in the study. The subjects were tested in three conditions: with both implants, with the right implant only, and with the left implant only. Speech tests included monosyllables in quiet and sentences in noise (10 dB signal to noise ratio). Speech was presented from the front, and noise was presented from either 90 degrees or 270 degrees azimuth. RESULTS: All subjects reported benefit from bilateral stimulation. Speech scores for all subjects were higher with bilateral than with unilateral stimulation. The average score across subjects for sentence understanding was 31.1 percentage points higher with both cochlear implants compared with the cochlear implant ipsilateral to the noise, and 10.7 percentage points higher with both cochlear implants compared with the cochlear implant contralateral to the noise. The average score for recognition of monosyllabic words was 18.7 percentage points higher with both cochlear implants than with one cochlear implant. All of these differences in average scores were significant at the 5% level. CONCLUSIONS: Bilateral cochlear implantation provides a significant benefit in speech understanding in both quiet and noise.

Diffusion-Weighted Echo-Planar MR Imaging of Primary Parotid Gland Tumors: Is a Prediction of Different Histologic Subtypes Possible?
CR Habermann, C Arndt, Joachim Graessner, Leif Diestel +4 more
2009· American Journal of Neuroradiology246doi:10.3174/ajnr.a1412

BACKGROUND AND PURPOSE: Our aim was to determine the value of echo-planar diffusion-weighted MR imaging (epiDWI) in differentiating various types of primary parotid gland tumors. MATERIALS AND METHODS: One hundred forty-nine consecutive patients with suspected tumors of the parotid gland were examined with an epiDWI sequence by using a 1.5T unit. Image analysis was performed by 2 radiologists independently, and the intraclass correlation coefficient was computed. Histologic diagnosis was obtained in every patient. For comparison of apparent diffusion coefficients (ADCs), a paired 2-tailed Student t test with a Bonferroni correction was used. RESULTS: In 136 patients, a primary parotid gland tumor was confirmed by histology. Among the observers, a high correlation was calculated (0.98). ADC values of pleomorphic adenomas were significantly higher than those of all other entities, except for myoepithelial adenomas (P = .054). ADC values of Warthin tumors were different from those of myoepithelial adenomas, lipomas, and salivary duct carcinomas (P < .001, 0.013, and .037, respectively). Mucoepidermoid carcinomas, acinic cell carcinomas, and basal cell adenocarcinomas were not differentiable from Warthin tumors (P = .094, .396, and .604, respectively). CONCLUSION: epiDWI has the potential to differentiate pleomorphic adenoma and myoepithelial adenomas from all other examined entities. Due to an overlap not only within the group of benign and malignant lesions but also between groups, diagnoses should not be addressed on the basis of ADC values solely. Therefore, further studies combining DWI, morphologic criteria, and probably other MR imaging techniques seem warranted.

International Comparisons of Behavioral and Emotional Problems in Preschool Children: Parents' Reports From 24 Societies
Leslie Rescorla, Thomas M. Achenbach, Masha Y. Ivanova, Valerie S. Harder +4 more
2011· Journal of Clinical Child & Adolescent Psychology216doi:10.1080/15374416.2011.563472

International comparisons were conducted of preschool children's behavioral and emotional problems as reported on the Child Behavior Checklist for Ages 1½-5 by parents in 24 societies (N = 19,850). Item ratings were aggregated into scores on syndromes; Diagnostic and Statistical Manual of Mental Disorders-oriented scales; a Stress Problems scale; and Internalizing, Externalizing, and Total Problems scales. Effect sizes for scale score differences among the 24 societies ranged from small to medium (3-12%). Although societies differed greatly in language, culture, and other characteristics, Total Problems scores for 18 of the 24 societies were within 7.1 points of the omnicultural mean of 33.3 (on a scale of 0-198). Gender and age differences, as well as gender and age interactions with society, were all very small (effect sizes < 1%). Across all pairs of societies, correlations between mean item ratings averaged .78, and correlations between internal consistency alphas for the scales averaged .92, indicating that the rank orders of mean item ratings and internal consistencies of scales were very similar across diverse societies.

[German version of the Strength and Difficulties Questionnaire (SDQ-German)--overview and evaluation of initial validation and normative results].
Henrikje Klasen, Wolfgang Woerner, Aribert Rothenberger, Robert Goodman
2003· PubMed161

The Strengths and Difficulties Questionnaire (SDQ) is a short behavioural screening questionnaire which can be completed in about five minutes by parents and teachers of 4- to 16-year-olds or as self-report by 11- to 16-year-olds. The English original has already been fully evaluated and is widely used in research and clinical practice. The instrument was translated into German in 1997, and several evaluative studies have since been completed. The present paper gives an overview of this novel instrument and summarizes the normative and validation studies to date. A normative study on a field sample of 930 children demonstrated that the distributions of raw scores in the German parent SDQ closely resemble those found in the English version, while a factor analysis of the German data yielded a pattern of loadings which convincingly replicated the original scale structure. Initial validation studies showed that the parent-, teacher-, and self-completed SDQ-Deu correlates well with the considerably longer German versions of the Child Behavior Checklist (CBCL) and respective teacher and self-report derivatives (TRF, YSR). Both parent-rated instruments are equally able to distinguish between a community and a clinic sample, and between subgroups with and without specified categories of disorders within a clinic sample. After discussing possible uses of the SDQ-Deu as well as similarities and differences to other scales, we conclude that the German SDQ is just as useful and valid an instrument for many clinical and research purposes as the English original.

Interrater-Reliabilität des Diagnostischen Interviews bei psychischen Störungen im Kindes- und Jugendalter (Kinder-DIPS)
Murielle Neuschwander, Tina In‐Albon, Carmen Adornetto, Binia Roth +1 more
2013· Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie119doi:10.1024/1422-4917//a000247

Fragestellung: Ziel der vorliegenden Studie ist, die Interrater-Reliabilität des Diagnostischen Interviews bei psychischen Störungen im Kindes- und Jugendalter (Kinder-DIPS; Schneider, Unnewehr &amp; Margraf, 2009 ) anhand von Eltern- und Kinderinterviews für verschiedene Störungsklassen zu ermitteln. Zusätzlich wird geprüft, ob sich in Abhängigkeit des Alters oder des Geschlechtes des Kindes, Unterschiede hinsichtlich der Interrater-Reliabilität ergeben. Methodik: 264 Eltern- und 213 Kinderinterviews wurden von 48 geschulten Interviewern in kinder- und jugendpsychiatrischen und schulpsychologischen Einrichtungen sowie im Rahmen eines Forschungsprojektes durchgeführt. Ergebnisse: Die Übereinstimmungsmaße der Eltern- und Kinderinterviews zeigen eine gute bis sehr gute Interrater-Reliabilität der Oberklassen Expansive Störungen, Ticstörungen, Ausscheidungsstörungen, Affektive Störungen, Essstörungen, Schlafstörungen sowie einem Großteil der spezifischen Diagnosen und für den Ausschluss psychischer Störungen. Das Geschlecht und das Alter der interviewten Kinder hatten keinen Einfluss auf die Reliabilitätswerte. Schlussfolgerung: Die Ergebnisse zeigen, dass es sich beim Kinder-DIPS mit trainierten Interviewern für die Oberklassen psychischer Störungen um ein reliables Eltern- und Kinderinterview zur Diagnostik psychischer Störungen handelt.

Creative Thinking in Adolescents with Attention Deficit Hyperactivity Disorder (ADHD)
Anna Abraham, Sabine Windmann, Rainer Georg Siefen, Irene Daum +1 more
2006· Child Neuropsychology114doi:10.1080/09297040500320691

A widened attentional focus, that is typically associated with ADHD, has been postulated to be accompanied by enhanced creative ability. However, creativity has been only limitedly examined in ADHD. Performance across several creativity measures were investigated in three groups: adolescents with ADHD, those with conduct disorder, and a healthy control sample. The ADHD group exhibited selective cognitive advantages and disadvantages by demonstrating an enhanced ability in overcoming the constraining influence of examples, but a reduced capacity to generate a functional invention during an imagery task. These findings are interpreted with reference to inhibitory control mechanisms and the contextual modulation of creative cognition.

The Diagnosis and Treatment of Dyscalculia
Stefan Haberstroh, Gerd Schulte‐Körne
2019· Deutsches Ärzteblatt international109doi:10.3238/arztebl.2019.0107

BACKGROUND: 3-7% of all children, adolescents, and adults suffer from dyscalculia. Severe, persistent difficulty performing arithmetical calculations leads to marked impairment in school, at work, and in everyday life and elevates the risk of comorbid mental disorders. The state of the evidence underlying various methods of diagnosing and treating this condition is unclear. METHODS: Systematic literature searches were carried out from April 2015 to June 2016 in the PsycInfo, PSYNDEX, MEDLINE, ProQuest, ERIC, Cochrane Library, ICTRP, and MathEduc databases. The main search terms on dyscalculia were the German terms "Rechenstörung," "Rechenschwäche," and "Dyskalkulie" and the English terms "dyscalculia," "math disorder, and "math disability." The data from the retrieved studies were evaluated in a meta-analysis, and corresponding recommendations on the diagnosis and treatment of dyscalculia were jointly issued by the 20 societies and associations that participated in the creation of this guideline. RESULTS: The diagnosis of dyscalculia should only be made if the person in question displays below-average mathematical performance when seen in the context of relevant information from the individual history, test findings, clinical examination, and further psychosocial assessment. The treatment should be directed toward the individual mathematical problem areas. The mean effect size found across all intervention trials was 0.52 (95% confidence interval [0.42; 0.62]). Treatment should be initiated early on in the primary-school years and carried out by trained specialists in an individual setting; comorbid symptoms and disorders should also receive attention. Persons with dyscalculia are at elevated risk of having dyslexia as well (odds ratio [OR]: 12.25); the same holds for attention deficit/hyperactivity disorder and for other mental disorders, both internalizing (such as anxiety and depression) and externalizing (e.g., disorders characterized by aggression and rule-breaking). CONCLUSION: Symptom-specific interventions involving the training of specific mathematical content yield the best results. There is still a need for high-quality intervention trials and for suitable tests and learning programs for older adolescents and adults.

The Prevention, Diagnosis, and Treatment of Dyslexia
Gerd Schulte‐Körne
2010· Deutsches Ärzteblatt international109doi:10.3238/arztebl.2010.0718

BACKGROUND: Reading and spelling disorder (dyslexia) is one of the more common specific developmental disorders, with a prevalence of approximately 5%. It is characterized by severe impairment of learning to read and spell. METHODS: We discuss major aspects of the diagnosis, treatment, and prevention of dyslexia on the basis of a selective literature review and the guidelines of the German Society of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy. RESULTS: 40% to 60% of dyslexic children have psychological manifestations, including anxiety, depression, and attention deficit. The diagnostic assessment of dyslexia consists of a battery of standardized reading and spelling tests and an evaluation of the child's psychological state, including additional information obtained from parents and teachers. The treatment of dyslexia is based on two main strategies: specific assistance with the impaired learning areas (reading and spelling) and psychotherapy for any coexisting psychological disturbance that may be present. Evaluated preventive strategies are available for use in kindergarten and at home. CONCLUSION: The diagnosis of dyslexia should be established with the aid of the multiaxial classification system. The benefit of specific treatment strategies for dyslexia has not yet been demonstrated empirically. Nonetheless, evaluated prevention programs are available in kindergarten that have been found to promote children's ability to acquire reading and spelling skills in school.

Was hilft bei der Lese-Rechtschreibstörung?
Elena Ise, Rolf R. Engel, Gerd Schulte‐Körne
2012· Kindheit und Entwicklung105doi:10.1026/0942-5403/a000077

Die Lese-Rechtschreibstörung (LRS) gehört zu den häufigsten Entwicklungsstörungen mit oft chronischem Verlauf. Ziel der vorliegenden Arbeit ist es, den aktuellen Stand der Interventionsforschung zur Wirksamkeit deutschsprachiger LRS-Förderprogramme darzustellen. Anhand einer Metaanalyse wurde zunächst die Effektivität unterschiedlicher LRS-Förderansätze quantifiziert. Anschließend wurde der Frage nachgegangen, welche moderierenden Variablen die Wirksamkeit von LRS-Förderprogrammen beeinflussen. Die Ergebnisse zeigen, dass symptomspezifische Förderprogramme deutlich effektiver sind als Funktions- und Wahrnehmungstrainings. Die Wirksamkeit von LRS-Förderprogrammen wird durch den Interventionsleiter und die Intensität der Förderung beeinflusst, aber nicht durch das Alter oder den Schweregrad der Betroffenheit. Empfehlungen für Praxis und zukünftige Forschung werden aufgezeigt.

The Development of Emotional Concepts in Autism
Christiane Bormann-Kischkel, Markus Vilsmeier, Beate Baude
1995· Journal of Child Psychology and Psychiatry105doi:10.1111/j.1469-7610.1995.tb01368.x

Abstract Forty‐one high‐functioning individuals with autism between the ages of 7 and 36 and an age and intelligence matched comparison group were investigated in their ability to recognise emotions in photographs. A colour identification task served as control condition. The autistic group was significantly impaired on the emotions task only. There was no substantial difference between groups in the structures underlying their emotional concepts (pleasantness and arousal). However, there is a trend for the autistic group to rely on other strategies in the recognition of emotions than the comparison group. These strategies may be insufficient in the appreciation of facial expressions.

Die psychische Gesundheit von Kindern, Jugendlichen und jungen Erwachsenen – Teil 1: Häufigkeit, Störungspersistenz, Belastungsfaktoren, Service-Inanspruchnahme und Behandlungsverzögerung mit Konsequenzen
Martin Lambert, Thomas Böck, Dieter Naber, Bernd Löwe +4 more
2013· Fortschritte der Neurologie · Psychiatrie93doi:10.1055/s-0033-1355843

Numerous birth-control studies, epidemiological studies, and observational studies have investigated mental health and health care in childhood, adolescence and early adulthood, including prevalence, age at onset, adversities, illness persistence, service use, treatment delay and course of illness. Moreover, the impact of the burden of illness, of deficits of present health care systems, and the efficacy and effectiveness of early intervention services on mental health were evaluated. According to these data, most mental disorders start during childhood, adolescence and early adulthood. Many children, adolescents and young adults are exposed to single or multiple adversities, which increase the risk for (early) manifestations of mental diseases as well as for their chronicity. Early-onset mental disorders often persist into adulthood. Service use by children, adolescents and young adults is low, even lower than for adult patients. Moreover, there is often a long delay between onset of illness and first adequate treatment with a variety of linked consequences for a poorer psychosocial prognosis. This leads to a large burden of illness with respect to disability and costs. As a consequence several countries have implemented so-called "early intervention services" at the interface of child and adolescent and adult psychiatry. Emerging studies show that these health-care structures are effective and efficient. Part 1 of the present review summarises the current state of mental health in childhood, adolescence and early adulthood, including prevalence, age at onset, adversities, illness persistence, service use, and treatment delay with consequences.

INCIDENCE OF Pneumocystis carinii PNEUMONIA AFTER RENAL TRANSPLANTATION
Volkmar Lufft, Volker Kliem, Matthias Behrend, R Pichlmayr +2 more
1996· Transplantation90doi:10.1097/00007890-199608150-00022

The incidence and potential risk factors of Pneumocystis carinii pneumonia (PCP) in our population of renal transplant recipients were analyzed retrospectively. Of 1427 patients who received transplants between January 1986 and June 1994, 1192 were evaluated. Four different immunosuppressive regimens were applied: (1) cyclosporine (CsA) + prednisolone (Pred), (2) CsA + azathioprine (Aza, 2 mg/kg/day) + Pred, (3) CsA + Aza + antithymocyte globulin, and (4) (after December 1, 1993, European multicenter trial) FK506 + Aza (1 mg/kg/day) + Pred. No prophylaxis against PCP was performed. Before December 1, 1993, three PCPs in 494 patients on protocol 2 or 3 occurred (0.6%). Afterward, seven PCPs in 77 patients occurred (9%): three in 38 patients on protocol 2 (7.8%) and four in 28 patients on protocol 4 (14.3%). Comparing patients with PCP on CsA and FK506, the mean Aza dose was 2.40 and 1.32 mg/kg/day, five and two patients received additional steroids, antibody treatment was used in three and no patients, and CMV infections occurred in five and two patients, respectively. The incidence of PCP with a moderate CsA-based immunosuppressive regimen is low and seems to occur only in cases of additional immunosuppressive cofactors. Despite a general increase of PCP, its incidence was highest in patients on FK506 with fewer immunosuppressive cofactors. Thus, prophylaxis against PCP after renal transplantation should be performed, if not in every renal transplant recipient, at least in case of treatment with additional steroids, antibodies, or FK506.

Obsessive-Compulsive Disorder in Children and Adolescents
Susanne Walitza, Siebke Melfsen, Thomas Jans, Henrike Zellmann +2 more
2011· Deutsches Ärzteblatt international89doi:10.3238/arztebl.2011.0173

BACKGROUND: Early-onset obsessive-compulsive disorder (OCD) is one of the more common mental illnesses of children and adolescents, with prevalence of 1% to 3%. Its manifestations often lead to severe impairment and to conflict in the family. In this review, we summarize the manifestations, comorbidity, pathophysiology, and course of this disease as well as current modes of diagnosis and treatment. METHODS: We selectively review the relevant literature and the German-language guidelines for the diagnosis and treatment of mental illnesses in children and adolescents. RESULTS: Obsessive-compulsive manifestations are of many types and cause severe impairment. Comorbid mental disturbances are present in as many as 70% of patients. The disease takes a chronic course in more than 40% of patients. Cognitive behavioral therapy is the treatment of first choice, followed by combination pharmacotherapy including selective serotonin reuptake inhibitors (SSRI) and then by SSRI alone. CONCLUSION: OCD often begins in childhood or adolescence. There are empirically based neurobiological and cognitive-behavioral models of its pathophysiology. Multiaxial diagnostic evaluation permits early diagnosis. Behavioral therapy and medications are highly effective treatments, but the disorder nonetheless takes a chronic course in a large percentage of patients.

The economic impact of smoking in Germany
L. Ruff, T Volmer, Dennis Nowak, Andreas Meyer
2000· European Respiratory Journal86doi:10.1034/j.1399-3003.2000.016003385.x

Smoking is a high-risk behaviour affecting health and economic welfare of society. Thus it is important to quantify the economic burden smoking places on social institutions in Germany. Approximately 33.4% of the male and 20.4% of the female population are current smokers. This study investigates the health care costs of smoking based on 1996 figures, focusing on the seven most frequent diseases associated with the inhalation of tobacco smoke: chronic obstructive pulmonary disease (COPD, international classification of diseases (ICD) 490-491); lung cancer (ICD 162); stroke (ICD 434-438); coronary artery disease (ICD 410-414); cancer of the mouth and larynx (ICD 140-149, 161) and artherosclerotic occlusive disease (ICD 440). A data search was carried out on MEDLINE, the German Institute for Medical Documentation and Information, and the Internet as well as in databases of health insurance companies and the German Federal institute of statistics. Direct and indirect costs were calculated separately. The results estimate the total smoking related health care costs (attributable fraction due to smoking) for COPD to be 5.471 billion EURO (73%), for lung cancer 2.593 billion EURO (89%), for cancer of the mouth and larynx 0.996 billion EURO (65%), for stroke 1.774 billion EURO (28%), for coronary artery disease 4.963 billion EURO (35%) and for atherosclerotic occlusive disease 0.761 billion EURO (28%). The economic burden of smoking related health care costs for Germany is 16.6 billion EURO. Smoking is therefore responsible for 47% of the overall costs of these diseases (35.2 billion EURO). In the view of the high costs for smoking, of which almost 50% are due to respiratory disease, pneumologists should enhance their effort in primary, secondary and tertiary prevention.

Rechenstörungen bei Kindern
Michael von Aster, Martin Schweiter, Monika Weinhold Zulauf
2007· Zeitschrift für Entwicklungspsychologie und Pädagogische Psychologie86doi:10.1026/0049-8637.39.2.85

Zusammenfassung. In der vorliegenden Studie wurde die Prävalenz von Rechenstörungen mit einem longitudinalen Design in einer deutsch-schweizer Stichprobe nach zwei Jahren Schulbesuch erhoben. Die Erfassung von numerischem Wissen erfolgte mittels revidierter Versionen der Neuropsychologischen Testbatterie für Zahlenverarbeitung und Rechnen (ZAREKI) für das Kindergarten- (-K) und Schulalter (-R) an einer repräsentativen Stichprobe von N = 337 Kindern aus ländlichen und urbanen Gebieten. Die erste Untersuchung fand im letzen Jahr vor Schuleintritt statt (Durchschnittsalter: 6;5 Jahre), die Nachtestung umfasste zusätzlich die Überprüfung der Schriftsprachkompetenz und erfolgte zwei Jahre später (8;7 Jahre). Die ermittelte Prävalenzrate für Rechenstörungen betrug 6.0% bei Verzicht auf das Intelligenz-Diskrepanz-Kriterium, wobei es sich bei 1.8% um isolierte Rechenstörungen und bei 4.2% um Rechenstörungen mit kombinierter Lese-Rechtschreibstörung handelte. Die Prävalenzrate von isolierten Rechenstörungen fällt damit deutlich niedriger aus als diejenige von isolierten Störungen des Schriftspracherwerbs (5.7%). Bereits im Kindergarten zeigten betroffene Kinder schwächer ausgeprägte numerische Fertigkeiten gegenüber später nicht beeinträchtigten Kindern. Die Testprofile der Gruppe mit kombinierten Rechenstörungen wiesen zu beiden Testzeitpunkten gegenüber der Gruppe mit isolierten Rechenstörungen zusätzliche Schwierigkeiten hauptsächlich bei Aufgaben auf, die hohe Anforderungen an das Arbeitsgedächtnis stellen. Rund eineinhalb Jahre nach Schuleintritt beurteilten die Lehrpersonen die Kinder mit kombinierten Rechenstörungen auch auf der Verhaltensebene als stärker von Aufmerksamkeitsdefiziten und Hyperaktivität betroffen. Die Ergebnisse werden vor dem Hintergrund von Entwicklungsmodellen der Zahlenverarbeitung diskutiert.

The Changing Prevalence of Attention-Deficit/Hyperactivity Disorder and Methylphenidate Prescriptions
Ingrid Schübert, Ingrid Köster, Gerd Lehmkuhl
2010· Deutsches Ärzteblatt international77doi:10.3238/arztebl.2010.0615

BACKGROUND: The goal of this study is to assess changes in the prevalence of attention-deficit/hyperactivity disorder (ADHD) and methylphenidate prescriptions over the period 2000 to 2007 on the basis of data from a German statutory health insurance carrier. METHODS: In a cross-sectional study, we analyzed data from a random sample of insurees of the AOK health insurance company in the German state of Hesse for the years 2000 to 2007. Per calender year, 50,000 to 63,000 children and adolescents were retrospectively observed with respect to the documentation of ADHD diagnosis (ICD-10 diagnosis F90) and the prescribing of methylphenidate (ATC: N06BA04). RESULTS: In 2007, the overall prevalence of ADHD in all age groups (0-18 years) was 2.21% (95% CI: 2.09-2.34). This figure was 45% greater than the corresponding figure for the year 2000. The prevalence increased by a larger amount among girls aged 6 to 18 years than among boys in the same age group (+69% vs. +53%). In 2007, 1.06% (95% CI: 0.98-1.16) of the children/adolescents received at least one prescription for methylphenidate; this was a 96% increase over the prescription rate for 2000. A comparison of the two years 2000 and 2007 reveals a clear prevalence shift towards the older age groups, as well as an 82% increase in the average number of daily doses per recipient. Outpatient departments of child and adolescent psychiatry initiated more treatments in 2007 than in 2000. CONCLUSION: The 1% prevalence of methylphenidate use among children and adolescents that was found in this study is the same as that reported in other European countries, such as Switzerland, the Netherlands, and Norway. A drawback of our study is its limitation to a single insurance carrier in a single region. Nonetheless, data of this type are useful for monitoring. The findings suggest further issues worth studying, e.g., off-label use or the indications for treatment in older age groups.

Assessment of dysplasia in colorectal adenomas: an observer variation and morphometric study.
L J Brown, Nigel Smeeton, Michael F. Dixon
1985· Journal of Clinical Pathology76doi:10.1136/jcp.38.2.174

Observer variation in the grading of dysplasia in 100 colorectal adenomas has been analysed by kappa statistics. Intraobserver agreement was only 70% and 67% for the two principal observers, and, as would be expected, interobserver agreement was even lower at 59% and 66%. Although the kappa values were significantly different from chance at the 0.1% level, there were substantial disagreements. When the study was extended to four observers, agreement between observer pairings was considerably worse (as low as 34%), and in four pairings the kappa values did not differ significantly from those expected by chance alone even at the 5% level. In an endeavour to improve agreement we adopted a percentage estimation grading method; but this failed to achieve any improvement when comparing overall grades. The percentage estimates of the two observers, however, showed a highly significant correlation. To identify the cytological features given most weight by the principal observers in assessing dysplasia we undertook morphometry on 30 adenomas using an image analysis computer. The nuclear to cytoplasmic ratio, variation in nuclear area, and variation in nuclear height above the basement membrane showed significant differences between mild, moderate, and severely dysplastic epithelia. While evaluation of these parameters therefore appears to be most important in the subjective interpretation of dysplasia, this study has shown that such evaluation is poorly standardised between observers and poorly reproduced within observers. Our findings of poor agreement in the grading of dysplasia in colorectal adenomas has serious implications for the assessment of dysplasia in inflammatory bowel disease, where the added problem of reactive cellular atypia brings greater complexity to these subjective judgments.

CHILD DEVELOPMENT AND EARLY TRIADIC RELATIONSHIPS
Kai von Klitzing, Heidi Simoni, Dieter Bürgin
1999· The International Journal of Psychoanalysis64doi:10.1516/0020757991598576

A study of early development beginning in pregnancy and extending to the end of the child's first year of life is presented. The aim is to understand the relational processes of early childhood by using the concepts of triadification and triangulation. A prospective longitudinal study was conducted with forty-one parents and their first-born infants. The parents subjective views about their parenthood and the unborn child were systematically analysed during pregnancy, targeting their representations of their own childhood experiences their partnership, and their relationship with their fantasised child. These dimensions were compared with the quality of dyadic and triadic parent-child interactions observed after the child was born. The pre-natally assessed level of triangulation in the parental fantasies correlated strongly with the quality of triadic interactions with the 4-month-old infant in a play situation and with the quality of dyadic interactions with the one-year-old infant in a stressful situation. The authors conclude that the child's relational development can be understood in triadic terms from the beginning, but that there is a regressive pull towards two-plus-one relationships under conditions of emotional dysregulation. Consequences for a psychoanalytic theory of early development are discussed.