Latin American School of Medicine

In previous papers [3] [4] a ranking method has been described for the rapid approximate determination of the significance of differences between two treatments, when the experimental data consists of unpaired replications, paired replications, or replications occurring in two or more groups. Brief tables were given which furnished the rank totals for the 0.05%o, 0.02% and 0.01% level of significance. These tables were prepared by making use of certain properties of the partitions of numbers, but the method becomes impractical with larger numbers of replicates. A recent paper by Mann and Whitney [1] describes a similar test and gives probability tables covering the range from 3 to 8 replicates per treatment, including the case of unequal numbers of unpaired replicates under the two treatments. These authors tabulated the probabilities against the serial number of possible rank totals, 0-1-2 .... U, instead of the rank total itself. Their tables give probabilities for one tail of the distribution only.

BACKGROUND: We developed an experimental model of ethanol-induced dermatotoxicity and hepatocytoxicity using normal human keratinocytes and normal human hepatocytes that preserve inducible cytochrome p450 activities. The original work was described in several articles. The objective of this study was to determine whether hyaluronic acid attenuates skin necrosis, and to further clarify its uses in wound repair in humans, animal models and in vitro studies. METHODS: We performed a systematic review of the literature using the terms "hyaluronic acid" and "wound healing". PubMed was searched for studies published during the period 2010-2014. RESULTS: Hyaluronic acid is used in tissue regeneration alone or in combination with herbal or Western medicine. Scaffolds made up of hyaluronic acid were used to embed basic fibroblast growth factor. CONCLUSION: Hyaluronic acid extracts are safe and efficacious products to be used in skin repair.

PURPOSE: EGFR is a well-validated target for patients with non-small cell lung cancer (NSCLC). CIMAvax-EGF is a therapeutic cancer vaccine composed of human recombinant EGF conjugated to a carrier protein and Montanide ISA51 as adjuvant. The vaccine is intended to induce antibodies against self EGFs that block EGF-EGFR interaction. EXPERIMENTAL DESIGN: To evaluate overall survival, safety, immunogenicity, and EGF concentration in serum after CIMAvax-EGF, a randomized phase III trial was done in patients with advanced NSCLC. Four to 6 weeks after first-line chemotherapy, 405 patients with stage IIIB/IV NSCLC were randomly assigned to a vaccine group, which received CIMAvax-EGF or a control group, treated with best supportive care. RESULTS: Long-term vaccination was very safe. Most frequent adverse reactions were grade 1 or 2 injection-site pain, fever, vomiting, and headache. Vaccination induced anti-EGF antibodies and decreased serum EGF concentration. In the safety population, median survival time (MST) was 10.83 months in the vaccine arm versus 8.86 months in the control arm. These differences were not significant according the standard log rank (HR, 0.82; P = 0.100), but according a weighted log rank (P = 0.04) that was applied once the nonproportionality of the HR was verified. Survival benefit was significant (HR, 0.77; P = 0.036) in the per-protocol setting (patients receiving at least four vaccine doses): MST was 12.43 months for the vaccine arm versus 9.43 months for the control arm. MST was higher (14.66 months) for vaccinated patients with high EGF concentration at baseline. CONCLUSIONS: Switch maintenance with CIMAvax-EGF was well tolerated and significantly increased MST of patients that completed induction vaccination. Baseline EGF concentration predicted survival benefit. Clin Cancer Res; 22(15); 3782-90. ©2016 AACR.

INTRODUCTION: In El Salvador, end-stage renal disease is the leading cause of hospital deaths in adults, the second cause of death in men and the fifth leading cause of death in adults of both sexes in the general population. OBJECTIVE: Identify risk factors for chronic kidney disease and urinary markers of renal and vascular damage, measure kidney function and characterize prevalence of chronic kidney disease in persons aged ≥18 years in the Bajo Lempa region of El Salvador. METHODS: A cross-sectional analytical epidemiological study was carried out using active screening for chronic kidney disease and associated risk factors in individuals aged ≥18 years in the Bajo Lempa Region, a rural, coastal area in El Salvador. Door-to-door visits and clinical examinations were conducted. Epidemiological and clinical data were collected including: family and personal clinical history of disease; biological, behavioral, social and environmental risk factors; physical measurements; urinalysis for markers of renal and vascular damage; and blood tests (serum creatinine, serum glucose, lipid profile). Glomerular filtration rate was calculated using the Modification of Diet in Renal Disease formula. Chronic kidney disease case confirmation was done three months later. Multiple logistic regression was used for data analysis. RESULTS: A total of 375 families and 775 individuals (343 men, 432 women) were studied-88.3% of the total resident population in the region. Elevated prevalence of risk factors was observed: diabetes mellitus, 10.3%; hypertension,16.9%; family history of chronic kidney disease, 21.6%; dyslipidemias, 63.1%; overweight, 34%; obesity, 22.4%; metabolic syndrome, 28.8%; use of non-steroidal anti-inflammatory drugs, 74.8%; infectious diseases, 86.9%; agricultural occupation, 40.6% (80.6% in men); and contact with agrochemicals, 50.3% (82.5% in men). Prevalence renal damage markers was 15.8% (greater in men): microalbuminuria 6.3%; proteinuria 5.7%; hematuria 3.5%; proteinuria-hematuria 0.3%. Proteinuria of <1 g/L predominated. Prevalence of chronic kidney disease was 17.9% (25.7% in men; 11.8% in women). Distribution by stages: stage 1, 4.6%; stage 2, 3.5%; stage 3, 6.2%; stage 4, 3.0%; stage 5, 0.6%. In patients with chronic kidney disease, most common was non-diabetic chronic kidney disease (86.3%), followed by chronic kidney disease associated with neither diabetes nor hypertension (54.7%). Prevalence of chronic renal failure was 9.8% (17% in men; 4.1% in women). Multiple logistic regression showed significant association with increasing age, male sex, hypertension and family history of chronic kidney disease. CONCLUSIONS: Elevated prevalence of chronic kidney disease, chronic renal failure and risk factors was found, compared to international reports. Most common was chronic kidney disease of unknown cause, associated with neither diabetes nor hypertension. Associations were found with age, male sex, hypertension and family history of chronic kidney disease, with decline in kidney function beginning at early ages. Male farmers have a dual burden of non traditional (occupational, toxic environmental) and traditional (vascular) risk factors that could act in synergy, contributing to kidney damage.

OBJECTIVES/HYPOTHESIS: The aim of this study was to evaluate functional hearing gain, speech understanding, and preoperative bone-conduction thresholds with the bone-conduction implant Bonebridge. STUDY DESIGN: Retrospective study at a tertiary referral center. METHODS: Twenty-four consecutive Bonebridge patients were identified. Nine patients suffered from combined hearing loss (HL), 12 from atresia of the external auditory canal and three from single-sided deafness. One patient was lost to follow-up. Twenty-three patients were therefore analyzed. RESULTS: The overall average functional hearing gain of all patients (n = 23) was 28.8 dB (±16.1 standard deviation [SD]). Monosyllabic word scores at 65 dB sound pressure level in quiet increased statistically significantly from 4.6 (±7.4 SD) percentage points to 53.7 (±23.0 SD) percentage points. Evaluation of preoperative bone-conduction thresholds revealed three patients with thresholds higher than 45 dB HL in the high frequencies starting at 2 kHz. These three patients had a very limited benefit of their bone-conduction implants. CONCLUSIONS: The Bonebridge bone-conduction implant provides satisfactory results concerning functional gain and speech perception if preoperative bone conduction lies within 45 dB HL. LEVEL OF EVIDENCE: 4.

On the basis that ozone (O3) can upregulate cellular antioxidant enzymes, a morphological, biochemical and functional renal study was performed in rats undergoing a prolonged treatment with O3 before renal ischaemia. Rats were divided into four groups: (1) control, a medial abdominal incision was performed to expose the kidneys; (2) ischaemia, in animals undergoing a bilateral renal ischaemia (30 min), with subsequent reperfusion (3 h); (3) O3 + ischaemia, as group 2, but with previous treatment with O3 (0.5 mg/kg per day given in 2.5 ml O2) via rectal administration for 15 treatments; (4) O2 + ischaemia, as group 3, but using oxygen (O2) alone. Biochemical parameters as fructosamine level, phospholipase A, and superoxide dismutases (SOD) activities, as well as renal plasma flow (RPF) and glomerular filtration rate (GFR), were measured by means of plasma clearance of p-amino-hippurate and inulin, respectively. In comparison with groups 1 and 3, the RPF and GFR were significantly decreased in groups 2 and 4. Interestingly, renal homogenates of the latter groups yielded significantly higher values of phospholipase A activity and fructosamine level in comparison with either the control (1) and the O3 (3) treated groups. Moreover renal SOD activity showed a significant increase in group 3 without significant differences among groups 1, 2 and 4. Morphological alterations of the kidney were present in 100%, 88% and 30% of the animals in groups 2, 4 and 3, respectively. It is proposed that the O3 protective effect can be ascribed to the substantial possibility of upregulating the antioxidant defence system capable of counteracting the damaging effect of ischaemia. These findings suggest that, whenever possible, ozone preconditioning may represent a prophylactic approach for minimizing renal damage before transplantation.

Molten salts have been used extensively as solvents for electrochemical processes. The difficulty of removing the last traces of residual moisture from the salts has often necessitated rather arduous drying procedures. If the moisture is not removed, hydrolysis occurs upon fusion. The hydroxide ion thus produced precipitates metal ions, attacks glass, and is reduced more easily than the alkali metals, thus diminishing the usable potential range of the solvent. It was found that if rigorously dried hydrogen chloride is bubbled through the melt for twenty minutes before the argon flush, the hydroxide ion impurity is removed.

Increased blood pressure is a leading risk factor for death worldwide, and improving the control of hypertension is a major health goal to reduce non-communicable disease. Thus, in 2016, as part of a regional effort between the Pan American Health Organization and Cuban Ministry of Public Health to reduce cardiovascular risk and disease, a community demonstration project was implemented to enhance hypertension control. The intervention project was in a population of 25 868 people served by the Carlos Verdugo Martínez Polyclinic in Matanzas, Cuba. The project implemented interventions currently recommended in the World Health Organization HEARTS modules, including a standardized clinical training program with certification for blood pressure measurement, routine screening for hypertension in clinics and in the community, a simple directive pharmacologic treatment algorithm, and a registry with performance reporting and feedback. Qualitative and quantitative program monitoring and evaluation was established. In a 2010 national survey, the prevalence of hypertension and the rate of hypertension control were estimated to be 31% and 36%, respectively. Following less than one year of the full implementation of the program, the prevalence of hypertension, proportion of the hypertensive population registered as having hypertension, proportion of those drug-treated who were controlled, and estimated population rate of control were 30%, 90%, 68%, and 58%, respectively. Based on these positive results, the program has been expanded to include another demonstration program initiated in a second region. In addition, preliminary efforts to disseminate and scale-up aspects of the program to the full Cuban population have started.

BACKGROUND: Some studies showed abnormalities in brain magnetic resonance imaging (MRI) of relapsing neuromyelitis optica (R-NMO) from 12 to 46%. These abnormalities are described as compatible/non-compatible with multiple sclerosis (MS). OBJECTIVE: To describe the abnormal brain MRI lesions in R-NMO with imaging studies conducted with more sensitive white matter change techniques. METHODS: Thirty patients with R-NMO were selected. All MRI brain studies were performed with a 1.5-T Siemens MRI system according to the Standardized MR Imaging Protocol for Multiple Sclerosis from the Consortium of MS Centers Consensus Guidelines. RESULTS: Brain MRI images were evaluated in 29 R-NMO cases because in one case the MRI images were not appropriate for the study. Of these 29 brain MRI studies, 19 cases (65.5%) had at least one or more lesions (1-57) and 10 were negative (34.4%). Brain MRI findings in 19 cases were characterized in T2/fluid-attenuated inversion-recovery (FLAIR) by the presence of subcortical/deep white matter lesions in 16 (84.2%) cases (1-50), most of them <3 mm and without juxtacortical localization. Periventricular lesions were observed in 13 (68.4%) cases, but morphologically they were not oval, ovoid or perpendicularly orientated. Infratentorial lesions, all >3 mm, were observed in 4 (21.05%) cases without cerebellar involvement. T1 studies demonstrated absence of hypointense regions. Optic nerve enhancement was observed in 6/19 patients (31.5%). None of the brain MRI abnormalities observed were compatible with Barkhof et al. criteria of MS. CONCLUSIONS: This study, based on a Cuban patient population, with long duration of disease, good sample size and detailed characterization by MRI, demonstrated the brain MRI pattern of R-NMO patients, which is different from MS.

Ideology, typically defined on a left-right spectrum, should provide a means of communication between elites and masses. After years of leftist party rule, have Brazilian voters internalized ideological divisions? Longitudinal surveys conducted from 2002 to 2006 reveal high nonresponse and instability in ideological self-identification. We find that the capacity to think ideologically is in part a function of political and social context. This capacity has real political consequences. A Heckman selection model reveals that those who refuse to take an ideological position or who exhibit high instability in self-identification tend to be latent rightists and to choose rightist presidential candidates. Moreover, they interpret the ideological spectrum differently from those who are more consistent in ideological self-placement. We thus make two contributions, showing how contextual factors influence ideological thinking and how low levels of ideological thinking affect the measurement of Brazilian public opinion.

A recombinant vaccine that expresses the envelope (E) gene of dengue virus type 4 was tested for immunogenicity and protection in Macaca fascicularis. One hundred micrograms of semipurified recombinant E protein (E4rec) expressed in Pichia pastoris was used to immunize three animals. Neutralizing antibodies to dengue 4 virus with a titer of 1:30 were detected in all immunized monkeys prior to challenge. Animals were challenged with 10(5) plaque-forming units of dengue 4 virus. One vaccine-immunized monkey was protected from viremia, while the other two were partially protected. Monkeys immunized with E4rec elicited the highest neutralizing antibody titers (P < 0.05) ranging from 1:85 to 1:640 at day 30. In both immunized and control animals, the longest duration of viremia correlated with earliest and highest level of IgM antibody to dengue virus. The vaccinated animals showed anamnestic antibody responses upon virus challenge, indicating successful priming by the recombinant vaccine. Our results suggest that E4rec expressed in P. pastoris can provide partial protection against viremia. However, the results were not effective enough to use it as a vaccine candidate. Further work is required to improve the quality of the immunogen.

This research seeks to provide a general overview of educational research in Latin America based on the study of articles published in Latin American impact journals and written by authors of the Region. Specifically, the 1,086 articles on empirical research in education written by Latin American authors and published in journals published in Latin America and indexed in jcr (isi Web of Science), Scopus or scielo, during the years 2014, 2015 and 2016 are reviewed. Four elements are reviewed: the authorship of the articles, the subject of study, the level of education addressed and the research methodology used. The results indicate that three countries (Brazil, Mexico and Chile) concentrate 75% of the papers, 59.1% of the authors are women and 53% of the papers are signed by three or more people. Among the most studied topics include Learning and school performance, Teachers and Teaching strategies, curriculum and teaching practices. Higher Education is clearly the most studied, with 43.1% of the papers. And, finally, there is no priority methodological approach, with practically half of qualitative articles, the other half quantitative. With all this information, it is possible to conclude some elements that translate into the need for greater support for research, a rethinking of topics and levels of study and a boost to collaborative research.

Introducción: Cuba se encuentra entre los países con más alta tasa de incidencia y mortalidad por cáncer de laringe en ambos sexos, ocupa el cuarto lugar en orden de importancia relativa en hombres. Objetivos: Proveer información actualizada y analizar los cambios recientes en la tendencia de la incidencia de cáncer de laringe en Cuba durante el período 1988-2003. Métodos: Utilizando los datos del Registro Nacional de Cáncer y la población estimada, durante el período estudiado, se aborda el estudio de la tendencia temporal de las tasas de incidencia de cáncer de laringe. Se estiman las tasas crudas, específicas y estandarizadas (global y truncada). Se utiliza el método de regresión lineal segmentada (jointpont regression) para estimar el porcentaje de cambio anual e identificar puntos de cambio en la tendencia. Resultados: Los datos mostraron que el cáncer de laringe es más frecuente a partir de la sexta y séptima década de la vida, oscilando alrededor de 5-6 hombres por mujer. Entre 1988 y el 2003, la tasa ajustada total por edades varió entre 8,4/100 000 y 10,4/100 000, en hombres, con un incremento anual promedio estadísticamente significativo (p<0,05) de 1,44 %, mientras que en mujeres el cambio no fue estadísticamente significativo. Después de un incremento estadísticamente significativo hacia 1999, se observó una caída incipiente de las tasas de incidencia en hombres, lo que sugiere que podría guardar relación con la disminución de la prevalencia de tabaquismo y alcoholismo entre 1995 y 2001 informada por la encuesta nacional de factores de riesgo y enfermedades transmisibles (I y II). Conclusiones: Es necesarioseguir insistiendo a todos los niveles, para alcanzar logros importantes en materia de cesación de tabaquismo y alcoholismo y sobretodo de no iniciación por los más jóvenes, principales factores de riesgo putativos de los llamados cánceres de cabeza y cuello.

La presencia del estrés en estudiantes de todos los niveles y edades es una realidad que acontece en las instituciones académicas siendo los perfiles de ciencias médicas los de mayor impacto y niveles de estrés. El objetivo de este trabajo es describir los niveles de estrés autopercibido, sus manifestaciones fisiológicas, psicológicas y posibles causas asociadas a la docencia en una muestra de estudiantes latinoamericanos de primer año de la carrera de medicina. A partir de un diseño no experimental, descriptivo-explicativo, transversal, se realizó un muestreo probabilístico de 205 estudiantes en la Escuela Latinoamericana de Medicina. Se aplicó el cuestionario Inventario de Estrés Autopercibido a la décima semana del primer semestre de la carrera de medicina. Los resultados evidenciaron elevados niveles de estrés autopercibido, con un predominio de manifestaciones cognitivo afectivas, asociados fundamentalmente a los resultados académico, al sexo y a la edad del estudiante. Los principales estresores son eventos asociados al proceso de gestión de la docencia, correspondiendo a la organización y proceso tecnológico como unidades estratégicas.

Abstract Establishing the pattern of crime is fundamental for the successful investigation of international crimes (genocide, war crimes, and crimes against humanity). A pattern of crime is the aggregate of multiple incidents that share common features related to the victims, the perpetrators, and the modus operandi. Pattern evidence and analysis have been used successfully, mainly in the investigation of large-scale killings, destruction, and displacement; the use for sexual violence charges has been remarkably more limited. There is a need to overcome this gap by setting proper methods of data collection and analysis. At the level of evidence collection, under-reporting should be addressed through victimization surveys or secondary analysis of data available from different sources. At the level of analysis, the available evidence needs to be subject to impartial examination beyond the pre-conceptions of the conflict parties and advocacy groups, in compliance with scientific standards for quantitative, qualitative, and GIS (Geographic Information Systems) methods. Reviewing the different investigative experiences and jurisprudence will help to set the right methodology and contribute most efficiently to putting an end to the impunity regarding sexual crimes.

The aim of this study was to assess the physiological profile of America's Cup grinders and mastmen, by measuring energy expenditure during sailing and assessing their aerobic and anaerobic fitness. The study focused on estimating the energy used during grinding activity, by measuring oxygen uptake (VO(2)) during sail setting in real sailing conditions. In the laboratory, using an arm-cranking ergometer, we measured VO(2peak) during an incremental maximal exercise test and total energy expended during the effort and recovery phases of an all-out test that simulated grinding activity, in six grinders and mastmen and ten sailors of the same crew. Total energy used during grinding corresponded to 45% (s = 9) and 51% (s = 5) of that used in the all-out test (234 kJ, s = 21.7) for tacks and gybes, respectively. In both grinding activity and the all-out test, VO(2) increased during and after the effort. The "VO(2) top value" was 53% (s = 8.6), 68% (s = 5.5), and 78% (s = 3.1) of VO(2peak) (4.7 l . min(-1), s = 0.43) in tacks, gybes, and the all-out test, respectively. During fast sequences of grinding activity, the "VO(2) top value" reached 65% (s = 7.1) VO(2peak) in tacks and 91% (s = 3.3) VO(2peak) in gybes. Our results suggest that grinders and mastmen are characterized by a high anaerobic capacity but their performance can be improved by powering aerobic fitness, to increase this energy contribution to all-out efforts and to guarantee fast recovery when grinding activity is repeated with short rest intervals.

UNLABELLED: Ethyl alcohol (ethanol) is commonly applied in cosmetic and pharmaceutical preparations, as well as disinfectant for chronic wounds. OBJECTIVE: The present study aimed to appraise physiological levels of ethanol-induced damage in skin cells in vitro and the possible repair by hyaluronic acid (HA). In addition, we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as tumor necrosis factor-alpha (TNF-B), interferon-alpha (IFN-α), transforming growth factor-beta (TGF-B), interleukins (IL) such as IL1-B and IL-6, as well as matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP). DESIGN AND METHODS: We treated human A431 epidermoid skin cells and mouse fibroblasts with ethanol at a concentration of 100 mM over 24 hours (h). A separate experiment looked at the effects of 2 consecutive treatments with 100 mM ethanol for 24 h each. HA obtained from umbilical cord excision was used at two concentration levels (2% and 4%) to determine its efficacy in the treatment. We measured cytotoxicity and cytokine networks in the media. RESULTS: Treatment of cells with 100 mM ethanol increased cytotoxicity, as well as the release of pro-inflammatory cytokines into the culture medium. CONCLUSIONS: Ethanol may induce cytotoxicity in skin cells by enhancing the effects of pro-inflammatory cytokines. HA reduced the amount of pro-inflammatory cytokines released into the media both in human A431 epidermoid skin cells and in mouse fibroblasts.

Abstract This article analyses the gang policies of the first years of the Funes administration in El Salvador, from June 2009 until July 2012. Using securitisation theory, it explains why the administration returned to an emphasis on extraordinary measures, most of them repressive, to deal with gangs. It argues that these measures were the product of an ongoing and dynamic process in which the government was but one of the players in a complex field constituted by numerous actors. The return to repressive measures as well as the support and facilitation of a ‘gang truce’ were not the result of a rational design or a predetermined agenda, but should be seen as a series of moves in a political conjuncture, in which the Salvadorean government needed to communicate to different audiences messages of being in control.

BACKGROUND: We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the recommended dose. METHODS: Fourteen patients were treated with intralesional injections containing 35 or 70 mg of CIGB-300 in three alternate cycles of three consecutive days each before standard chemoradiotherapy. Tumour uptake was determined using (99)Tc-radiolabelled peptide. In situ B23/nucleophosmin was determined by immunohistochemistry. RESULTS: Maximum tumour uptake for CIGB-300 70-mg dose was significantly higher than the one observed for 35 mg: 16.1 ± 8.9 vs 31.3 ± 12.9 mg (P = 0.01). Both, AUC24h and biological half-life were also significantly higher using 70 mg of CIGB-300 (P < 0.001). Unincorporated CIGB-300 diffused rapidly to blood and was mainly distributed towards kidneys, and marginally in liver, lungs, heart and spleen. There was no DLT and moderate allergic-like reactions were the most common systemic side effect with strong correlation between unincorporated CIGB-300 and histamine levels in blood. CIGB-300, 70 mg, downregulated B23/nucleophosmin (P = 0.03) in tumour specimens. CONCLUSION: Intralesional injections of 70 mg CIGB-300 in two sites (0.5 ml per injection) and this treatment plan are recommended to be evaluated in phase 2 studies.

Introducción La demencia es una enfermedad que afecta tanto al paciente como a la familia y en particular al cuidador, que es la persona que dentro de ella, asume la mayor responsabilidad en el cuidado. Existen diferentes modalidades de intervención que mejoran la calidad del cuidado al paciente y reducen la carga del cuidador. Objetivos Diseñar y evaluar el proceso y la efectividad de un programa de intervención psicoeducativo en un grupo de cuidadores informales de adultos mayores con demencia. Métodos Se realizó un estudio pre-experimental con 16 cuidadores que recibieron atención en el Centro Iberoamericano para la Tercera Edad, de 2004 a 2005. Se diseñó el programa a partir de técnicas participativas de recogida de información con expertos y con cuidadores e información actualizada del tema; se conformó con 10 sesiones y una frecuencia semanal. Se aplicó la Escala Psicosocial del Cuidador para constatar las diferencias entre antes y después de la intervención con respecto a variables socioeconómicas y psicológicas. Los datos se procesaron y analizaron mediante la prueba McNemar para dos variables cualitativas relacionadas, fijándose la significación estadística en a £0,05. Resultados Disminuyeron en general las afectaciones socioeconómicas y psicológicas del cuidador después de la intervención, como son: el poco tiempo libre, las dificultades laborales, los sentimientos de angustia, ira y miedo pero en el caso de las variables socioeconómicas la mejoría no fue significativa. Conclusiones Se demuestra que el programa psicoeducativo "Escuela de Cuidadores"es efectivo para modificar la afectación psicológica de los cuidadores, pero no para mejorar las afectaciones de tipo socioeconómica que produce el cuidado de un anciano con demencia, lo que indica que este tipo de intervención no es suficiente para modificar los aspectos más tangibles de la vida del cuidador debiendo complementarse con otras intervenciones psicosociales.