Maison des Sciences sociales et des Humanités - Lyon St-Étienne

Various estimates of the proportion of all cancers attributable to infections have been proposed but none have been numerically justified. We have reviewed the evidence for "causality" with respect to infectious agents linked with cancer and estimated the fraction of all cancer cases concerned that are attributable to it. The etiological fraction was applied to the estimated annual incidence of cancer at each specific site in 1990, and the number of attributable cases was obtained. We estimate that 15.6% (1,450,000 cases) of the worldwide incidence of cancer in 1990 can be attributed to infection with either the hepatitis B and C viruses, the human papillomaviruses, EBV, human T-cell lymphotrophic virus I, HIV, the bacterium Helicobacter pylori, schistosomes, or liver flukes. There would be 21% fewer cases of cancer in developing countries (1,000,000 fewer cases per year) and 9% fewer cases in developed countries (375,000 fewer cases per year) if these infectious diseases were prevented. The attributable fraction at the specific sites varies from 89% of cervix cancers attributable to the papillomaviruses to 1% of all leukemias attributable to human T-cell lymphotrophic virus I.

ABSTRACT This article analyzes the interaction between a firm's dynamic investment, operating, and financing decisions in a model with operating adjustment and recapitalization costs. Using numerical analysis, we solve the model for cases that highlight interaction effects. We find that higher production flexibility (due to lower costs of shutting down and reopening a production facility) enhances the firm's debt capacity, thereby increasing the net tax shield value of debt financing. While higher financial flexibility (resulting from lower recapitalization costs) has a similar effect, production flexibility and financial flexibility are, to some extent, substitutes. We find that the impact of debt financing on the firm's investment and operating decisions is economically insignificant.

Abstract. On the basis of a multi-proxy approach and a strategy combining lacustrine and marine records along a north–south transect, data collected in the central Mediterranean within the framework of a collaborative project have led to reconstruction of high-resolution and well-dated palaeohydrological records and to assessment of their spatial and temporal coherency. Contrasting patterns of palaeohydrological changes have been evidenced in the central Mediterranean: south (north) of around 40° N of latitude, the middle part of the Holocene was characterised by lake-level maxima (minima), during an interval dated to ca. 10 300–4500 cal BP to the south and 9000–4500 cal BP to the north. Available data suggest that these contrasting palaeohydrological patterns operated throughout the Holocene, both on millennial and centennial scales. Regarding precipitation seasonality, maximum humidity in the central Mediterranean during the middle part of the Holocene was characterised by humid winters and dry summers north of ca. 40° N, and humid winters and summers south of ca. 40° N. This may explain an apparent conflict between palaeoclimatic records depending on the proxies used for reconstruction as well as the synchronous expansion of tree species taxa with contrasting climatic requirements. In addition, south of ca. 40° N, the first millennium of the Holocene was characterised by very dry climatic conditions not only in the eastern, but also in the central- and the western Mediterranean zones as reflected by low lake levels and delayed reforestation. These results suggest that, in addition to the influence of the Nile discharge reinforced by the African monsoon, the deposition of Sapropel 1 has been favoured (1) by an increase in winter precipitation in the northern Mediterranean borderlands, and (2) by an increase in winter and summer precipitation in the southern Mediterranean area. The climate reversal following the Holocene climate optimum appears to have been punctuated by two major climate changes around 7500 and 4500 cal BP. In the central Mediterranean, the Holocene palaeohydrological changes developed in response to a combination of orbital, ice-sheet and solar forcing factors. The maximum humidity interval in the south-central Mediterranean started ca. 10 300 cal BP, in correlation with the decline (1) of the possible blocking effects of the North Atlantic anticyclone linked to maximum insolation, and/or (2) of the influence of the remnant ice sheets and fresh water forcing in the North Atlantic Ocean. In the north-central Mediterranean, the lake-level minimum interval began only around 9000 cal BP when the Fennoscandian ice sheet disappeared and a prevailing positive NAO-(North Atlantic Oscillation) type circulation developed in the North Atlantic area. The major palaeohydrological oscillation around 4500–4000 cal BP may be a non-linear response to the gradual decrease in insolation, with additional key seasonal and interhemispheric changes. On a centennial scale, the successive climatic events which punctuated the entire Holocene in the central Mediterranean coincided with cooling events associated with deglacial outbursts in the North Atlantic area and decreases in solar activity during the interval 11 700–7000 cal BP, and to a possible combination of NAO-type circulation and solar forcing since ca. 7000 cal BP onwards. Thus, regarding the centennial-scale climatic oscillations, the Mediterranean Basin appears to have been strongly linked to the North Atlantic area and affected by solar activity over the entire Holocene. In addition to model experiments, a better understanding of forcing factors and past atmospheric circulation patterns behind the Holocene palaeohydrological changes in the Mediterranean area will require further investigation to establish additional high-resolution and well-dated records in selected locations around the Mediterranean Basin and in adjacent regions. Special attention should be paid to greater precision in the reconstruction, on millennial and centennial timescales, of changes in the latitudinal location of the limit between the northern and southern palaeohydrological Mediterranean sectors, depending on (1) the intensity and/or characteristics of climatic periods/oscillations (e.g. Holocene thermal maximum versus Neoglacial, as well as, for instance, the 8.2 ka event versus the 4 ka event or the Little Ice Age); and (2) on varying geographical conditions from the western to the eastern Mediterranean areas (longitudinal gradients). Finally, on the basis of projects using strategically located study sites, there is a need to explore possible influences of other general atmospheric circulation patterns than NAO, such as the East Atlantic–West Russian or North Sea–Caspian patterns, in explaining the apparent complexity of palaeoclimatic (palaeohydrological) Holocene records from the Mediterranean area.

Abstract Riparian vegetation responds to hydrogeomorphic disturbances and environmental changes and also controls these changes. Here, we propose that the control of sediment erosion and deposition by riparian vegetation is a key geomorphological and ecological (i.e. biogeomorphic) function within fluvial corridors. In a 3 year study, we investigated the correlations between riparian vegetation and hydrogeomorphic dynamics along a transverse gradient from the main channel to the floodplain of the River Tech, France. Sediment erosion and deposition rates varied significantly along the transverse gradient as a function of the vegetation biovolume intercepting water flow. These effects, combined with the extremely strong mechanical resistance of pioneer woody structures and strong resilience of pioneer labile herbaceous communities, Populus nigra and Salix spp., explain the propensity of biogeomorphic succession (i.e. the synergy between vegetation succession and landform construction) to progress between destructive floods. This geomorphological function newly identified as an ‘ecosystem function’ per se encompasses the coupling of habitat and landform creation, maintenance and change with fundamental ecosystem structural changes in space and in time. Three different biogeomorphic functions, all related to the concept of ecosystem engineering, were identified: (i) the function of pioneer herbaceous communities to retain fine sediment and diaspores in the exposed zones of the active tract near the water resource, facilitating recruitment of further herbaceous and Salicacea species; (ii) the function of woody vegetation to drive the construction of forested islands and floodplains; and (iii) the function of stabilised riparian forests to act as ‘diversity reservoirs’ which can support regeneration after destructive floods. Overall, this study based on empirical data points to the fundamental importance of sediment flow control by pioneer riparian vegetation in defining fluvial ecosystem and landform organisation in time and in space. Copyright © 2009 John Wiley & Sons, Ltd.

EuroRotaNet, a laboratory network, was established in order to determine the diversity of co-circulating rotavirus strains in Europe over three or more rotavirus seasons from 2006/2007 and currently includes 16 countries. This report highlights the tremendous diversity of rotavirus strains co-circulating in the European population during three years of surveillance since 2006/2007 and points to the possible origins of these strains including genetic reassortment and interspecies transmission. Furthermore, the ability of the network to identify strains circulating with an incidence of ≥1% allowed the identification of possible emerging strains such as G8 and G12 since the beginning of the study; analysis of recent data indicates their increased incidence. The introduction of universal rotavirus vaccination in at least two of the participating countries, and partial vaccine coverage in some others may provide data on diversity driven by vaccine introduction and possible strain replacement in Europe.

Abstract Antibody–drug conjugates (ADCs) is a fast moving class of targeted biotherapeutics that currently combines the selectivity of monoclonal antibodies with the potency of a payload consisting of cytotoxic agents. For many years microtubule targeting and DNA-intercalating agents were at the forefront of ADC development. The recent approval and clinical success of trastuzumab deruxtecan (Enhertu ® ) and sacituzumab govitecan (Trodelvy ® ), two topoisomerase 1 inhibitor-based ADCs, has shown the potential of conjugating unconventional payloads with differentiated mechanisms of action. Among future developments in the ADC field, payload diversification is expected to play a key role as illustrated by a growing number of preclinical and clinical stage unconventional payload-conjugated ADCs. This review presents a comprehensive overview of validated, forgotten and newly developed payloads with different mechanisms of action.

Au cours des cinq dernières années, la sociologie des sciences a accompli un immense travail. Délaissant pour un temps l’étude des institutions ou celle de l’organisation de la communauté scientifique, elle s’est progressivement intéressée à la science en train de se faire. C’est ainsi que, multipliant les études de cas, les sociologues ont montré que rien n’échappait à la négociation depuis l’interprétation des résultats jusqu’à la reproduction des expériences en passant par l’administration...

Résumé Dans le monde postcolonial, et plus particulièrement depuis le 11 septembre 2001, une norme libérale occidentale renouvelée ajoute aux droits de l’homme la « démocratie sexuelle » (une conception lisse de la féminité à laquelle tend à s’adjoindre une conception lisse de l’homosexualité). Imbriquée à la norme antiraciste, cette « démocratie sexuelle » tend un piège redoutable aux sujets postcoloniaux qui auraient le malheur d’y déroger : accusés de faire le jeu du racisme, ils se trouvent renvoyés à la barbarie et sortis du jeu. Zacarias Moussaoui le sait et il le surjoue ; les jeunes filles françaises issues de l’immigration maghrébine le savent et elles négocient au jour le jour (voile, choix des partenaires sexuels).

By documenting how humans adapted to changes in their environment that are often much greater than those experienced in the instrumental record, archaeology provides our only deep-time laboratory for highlighting the circumstances under which humans managed or failed to find to adaptive solutions to changing climate, not just over a few generations but over the longue durée Patterning between climate-mediated environmental change and change in human societies has, however, been murky because of low spatial and temporal resolution in available datasets, and because of failure to model the effects of climate change on local resources important to human societies. In this paper we review recent advances in computational modeling that, in conjunction with improving data, address these limitations. These advances include network analysis, niche and species distribution modeling, and agent-based modeling. These studies demonstrate the utility of deep-time modeling for calibrating our understanding of how climate is influencing societies today and may in the future.

Abstract The pantropical genus Begonia is the sixth–largest genus of flowering plants, including 1870 species. The sections of Begonia are used frequently as analogues to genera in other families but, despite their taxonomic utility, few of the current sections have been examined in the light of molecular phylogenetic analyses. We present herein the largest, most representative phylogeny of Begonia published to date and a subsequent provisional sectional classification of the genus. We utilised three plastid markers for 574 species and 809 accessions of Begonia and used Hillebrandia as an outgroup to produce a dated phylogeny. The relationships between some species and sections are poorly resolved, but many sections and deeper nodes receive strong support. We recognise 70 sections of Begonia including 5 new sections: Astrothrix, Ephemera, Jackia, Kollmannia, and Stellandrae; 4 sections are reinstated from synonymy: Australes, Exalabegonia, Latistigma and Pereira; and 5 sections are newly synonymised. The new sectional classification is discussed with reference to identifying characters and previous classifications.

This study was undertaken to find a strict, unbiased epidemiological delineation of the VATER non-random association of congenital malformations and, based on registry information, to identify a group of probable VATER association infants suitable for etiological analyses. Information on 5,260 infants with multiple malformations was collected from four large registers of congenital malformations. Data were analyzed using a statistical method in which various putative confounders were controlled for. Our results indicate the existence of a distinct group of malformations corresponding to the VATER association: esophageal atresia, anal atresia, upper preaxial limb reduction defects, and costo-vertebral malformations. A subdivision into an upper and a lower group of VATER association was indicated, with heart malformations associated with the upper group and kidney malformations associated with the lower group. Restricting the inclusion criteria for VATER association to the above mentioned core malformations, few infants seem to belong to the VATER association, thus limiting the possibilities of carrying out etiological analyses. A relatively large number of infants may belong to a family of related conditions among which VATER association is a subgroup. In the search for risk factors, a strict definition of the VATER association is needed in order to not dilute the study material with irrelevant cases. The present study provides such strict inclusion criteria.

L’expression « sociologie de l’acteur réseau » (SAR) combine deux termes habituellement considérés comme opposés : celui d’acteur et celui de réseau. Cette opposition fait écho aux tensions constitutives des sciences sociales, comme celles entre agence et structure ou entre micro et macro-analyse. Cependant, la SAR, connue également comme sociologie de la traduction, n’est pas simplement une tentative supplémentaire pour montrer la nature artificielle ou dialectique de ces oppositions classiq...

ABSTRACT Riverine ecosystems are recurrently rejuvenated during destructive flood events and vegetation succession starts again. Poplars (i.e. species from Populus genera) respond to hydrogeomorphological constraints, but, in turn, also influence these processes. Thus, poplar development on bare mineral substrates is not exclusively a one‐way vegetative process. Reciprocal interactions and adjustments between poplar species and sediment dynamics during their life cycle lead to the emergence of biogeomorphological entities within the fluvial corridor, such as vegetated islands, benches and floodplains. Based on a review of geomorphological, biological and ecological literature, we have identified and described the co‐constructing processes between riparian poplars and their fluvial environment. We have explored the possibility that the modification of the hydrogeomorphological environment exerted, in particular, by the European black poplar ( Populus nigra L.), increases its fitness and thus results in positive niche construction. We focus on the fundamental phases of dispersal, recruitment and establishment until sexual maturity of P . nigra by describing the hierarchy of interactions and the pattern of feedbacks between biotic and abiotic components. We explicitly relate the biological life cycle of P . nigra to the fluvial biogeomorphic succession model by referring to the ‘biogeomorphological life cycle’ of P . nigra . Finally, we propose new research perspectives based on this theoretical framework. Copyright © 2014 John Wiley & Sons, Ltd.

Abstract Little Ice Age lateral moraines represent one of the most important sediment storages and dynamic areas in glacier forelands. Following glacier retreat, simultaneous paraglacial adjustment and vegetation succession affect the moraine slopes. Geomorphic processes (e.g. debris flows, interrill erosion, gullying, solifluction) disturb and limit vegetation development, while increasing vegetation cover decreases geomorphic activity. Thus, feedbacks between geomorphic and vegetation dynamics strongly control moraine slope development. However, the conditions under which these biogeomorphic feedbacks can occur are insufficiently understood and major knowledge gaps remain. This study determines feedback conditions through the analysis of geomorphic and vegetation data from permanent plots in the Turtmann glacier foreland, Switzerland. Results from multivariate statistical analysis (i) confirm that Dryas octopetala L. is an alpine ecosystem engineer species which influences geomorphic processes on lateral moraines and thereby controls ecosystem structure and function, and (ii) demonstrate that biogeomorphic feedbacks can occur once geomorphic activity sufficiently decreases for D. octopetala to establish and cross a cover threshold. In the subsequent ecosystem engineering process, the dominant geomorphic processes change from flow and slide to bound solifluction. Increasing slope stabilization induces a decline in biogeomorphic feedbacks and the suppression of D. octopetala by shrubs. We conceptualize this relationship between process magnitude, frequency and species resilience and resistance to disturbances in a ‘biogeomorphic feedback window’ concept. Our approach enhances the understanding of feedbacks between geomorphic and alpine vegetation dynamics on lateral moraine slopes and highlights the importance of integrating geomorphic and ecological approaches for biogeomorphic research. Copyright © 2015 John Wiley & Sons, Ltd.

In the post-Soviet space, Georgia and Ukraine are broadly perceived as exceptions to the growing authoritarianism in the region owing to the far-reaching political changes triggered by the so-called Colour Revolutions a decade ago. This article examines Russia's reaction to political changes in Georgia and Ukraine in light of the interplay between the democracy-promotion policies implemented by the EU and US and domestic patterns of democratization. We argue that despite the relatively weak impact of EU and US policies vis-à-vis domestic structures, Russia has responded harshly to (what it perceives as) a Western expansionist agenda in pursuit of reasserting its own hegemonic position in the post-Soviet space. However, coercive pressure from Russia has also unintended, counterproductive effects. We argue that the pressure has actually made Georgia and Ukraine more determined to pursue their pro-Western orientation and has spawned democratization, thereby supporting the objectives of the Western democracy promoters.

Résumé Cet article se propose d’interroger les modalités par lesquelles le droit vient encadrer les relations professionnelles et structurer la conflictualité au travail. La juridicisation des relations sociales, désignant un recours accru au droit dans les interactions ordinaires des relations de travail, est en effet trop souvent confondue avec un phénomène de judiciarisation, entendue comme la saisie plus fréquente des tribunaux pour régler des conflits du travail. Ces deux processus sont pourtant à distinguer, tant se dressent entre eux les obstacles liés à l’activité de mobilisation du droit. Fondée sur des sources quantitatives (les enquêtes REPONSE) et qualitatives, l’analyse explore les conditions sociales qui président à ces processus de juridicisation et judiciarisation. Nous cherchons en particulier à montrer l’importance de la structuration des collectifs de travail pour comprendre la place et les usages du droit dans les transformations des formes de conflits du travail contemporains.

International audience

Résumé Cet article envisage, à l’échelle de la France, les interrelations entre l’agriculture, les nouvelles fonctions de l’espace rural et l’organisation territoriale. Face aux profondes mutations des campagnes et alors que les recherches des géographes se sont partiellement détournées de la composante agraire puis agricole, quelle est aujourd’hui la place – économique, mais aussi sociale ou culturelle – de l’agriculture ? L’article décline les trois facettes de la territorialisation, dé-territorialisation et re-territorialisation de l’agriculture ; ce dernier processus profitant de l’engouement pour les produits de qualité liés aux terroirs, des soucis de protection de l’environnement, de la « mise en patrimoine » des campagnes et de leurs paysages, ainsi que des nouvelles « politiques de projet » des territoires institutionnels recomposés. L’étude s’achève par une lecture des grands modèles de développement « agri-ruraux » voire « agri-urbains ».

Abstract Cuwabo (Bantu P34, Mozambique) illustrates a relativization strategy, also attested in some North-Western and Central Bantu languages, whose most salient characteristics are that: (a) the initial agreement slot of the verb form does not express agreement with the subject (as in independent clauses), but agreement with the head noun; (b) the initial agreement slot of the verb form does not express agreement in person and number-gender (or class), but only in number-gender; (c) when a noun phrase other than the subject is relativized, the noun phrase encoded as the subject in the corresponding independent clause occurs in post-verbal position and does not control any agreement mechanism. In this article, we show that, in spite of the similarity between the relative verb forms of Cuwabo and the corresponding independent verb forms, and the impossibility of isolating a morphological element analyzable as a participial formative, the relative verb forms of Cuwabo are participles, with the following two particularities: they exhibit full contextual orientation, and they assign a specific grammatical role to the initial subject, whose encoding in relative clauses coincides neither with that of subjects of independent verb forms, nor with that of adnominal possessors.

This study overlaps with Johnson’s (1987) ideas about the image schemas underlying thought, but rather than grasping them through the deductive analysis of verbal metaphors, they are approached here through the analysis of the symbolic components of gestures which, accompanying speech, refer to abstract entities. The corpus analyzed was compiled from six television interviews with the French Prime Minister, Lionel Jospin. The interviews averaged thirty minutes and took place over a one-year period. Only symbolic variations along the transverse axis, which is both symmetrical and oriented, are studied. The transverse axis appears to encompass several symbolic axes: a value axis, a spatio-temporal axis, and a logico-temporal axis, themselves derived from the axes of physical progression, which are growth, walking, and writing. A fourth, two-directional symbolic axis depicting an evolving process is added to the above. Successive translations of the upward and forward axes on to the rightward axis, achieved for contextual or ergonomic reasons, are mentally possible, since all three are axes of physical progression. This projection on to the side-toside axis accounts for the semiologically motivated complexity of the symbolic system represented on this major axis.