Malton Community Hospital

Abstract Determining the drivers of non-native plant invasions is critical for managing native ecosystems and limiting the spread of invasive species 1,2 . Tree invasions in particular have been relatively overlooked, even though they have the potential to transform ecosystems and economies 3,4 . Here, leveraging global tree databases 5–7 , we explore how the phylogenetic and functional diversity of native tree communities, human pressure and the environment influence the establishment of non-native tree species and the subsequent invasion severity. We find that anthropogenic factors are key to predicting whether a location is invaded, but that invasion severity is underpinned by native diversity, with higher diversity predicting lower invasion severity. Temperature and precipitation emerge as strong predictors of invasion strategy, with non-native species invading successfully when they are similar to the native community in cold or dry extremes. Yet, despite the influence of these ecological forces in determining invasion strategy, we find evidence that these patterns can be obscured by human activity, with lower ecological signal in areas with higher proximity to shipping ports. Our global perspective of non-native tree invasion highlights that human drivers influence non-native tree presence, and that native phylogenetic and functional diversity have a critical role in the establishment and spread of subsequent invasions.

Abstract This article uses the narrative of one woman, Clara Larson, to explore changes over time in the experiences of illness available to women diagnosed with breast cancer. To claim that different illness experiences become available at different times is simply to acknowledge that experiences of disease are shaped not only by the individual circumstances of disease sufferers and the particular character of their pathologies, but by culturally, spatially and historically specific regimes of practices. This article explores the impact of social movements on the regime of breast cancer and makes four contributions to the scholarship on illness experience. First, it offers the concept disease regime as a way of conceptualising the structural shaping of illness experience. Second, it demonstrates the value of incorporating social movements more thoroughly into the study of illness experience. Third, it proposes that social movements change illness experiences in two ways: (1) by changing the sufferer or her relationship to the regime's practices; and (2) by changing and expanding the regime's actual practices. And fourth, it demonstrates how gender and sexuality are constituted within disease regimes and are challenged by social movements. This article is informed by four years of ethnographic research conducted in the San Francisco Bay Area between 1994 and 1998, supplemented by historical research and more than 40 taped interviews and oral histories with current and former breast cancer patients, activists, educators, scientists, support group leaders and volunteers.

We investigated the half-life of oxytocin in reproductively normal mares and the prostaglandin response after oxytocin administrations. Mares were given oxytocin, 10 or 25 iu, i.v., on the day of, or 2 days after, ovulation, and frequent jugular blood samples were collected for analysis of oxytocin and Prostaglandin F metabolite (PGFM) by RIA. Neither dose of oxytocin nor day of treatment affected the half-life of the exogenous oxytocin, which was determined to be 6.8 min. A significant increase in PGFM was observed within 6 min of oxytocin administration and peak values were observed within 10 min. PGFM response after oxytocin administration on the day of ovulation appeared elevated compared to the response 2 days after ovulation.

A group of 16 psychiatric out-patients in remission, who had been taking lithium carbonate as their sole medication for at least three months, were compared with a control group of 22 healthy volunteers. On a computerised driving simulator which produced measures of reaction time, tracking ability and mistakes made, the patient group had a significantly slower reaction time. Patients should be warned therefore that lithium may affect their ability to drive or operate machinery and that psychomotor impairment and sedation are not synonymous.

BACKGROUND: Equine squamous gastric disease (ESGD) is a highly prevalent disease in horses, particularly in elite athletes. Some horses respond slowly, or fail to respond, to the licensed treatment, oral omeprazole (ORLO). OBJECTIVES: To compare rates of ESGD healing and improvement between ORLO and a long-acting injectable omeprazole preparation (LAIO). STUDY DESIGN: Retrospective clinical study. METHODS: The case records and gastroscopy images of horses presenting to Rainbow Equine Hospital over a 12-month period were reviewed, with images being reviewed blind by one of the authors (David Rendle). Treatment responses were compared between horses that received 2 or 4 injections of 4 mg/kg LAIO at weekly intervals, and horses that received ORLO at 4 mg/kg PO SID for 4 weeks. Data were compared using a Mann-Whitney test with post hoc Dunn's test, chi-squared test or Fisher's exact test. RESULTS: Fifty-six horses met the inclusion criteria: 29 received LAIO and 27 received ORLO. Treatment groups were comparable in terms of signalment and ESGD lesions. There was a difference in rate of healing when LAIO and ORLO treatment groups were compared at 28 days (LAIO-97%; ORLO-67%; p = .005; OR = 14(1.8-158)), but no difference between LAIO at 14 days and ORLO at 28 days (LAIO-86%; ORLO-67%; p = .12; OR = 3.1 (0.9-10)). Five localised and self-limiting injection site reactions were identified in 3 horses out of 98 injections (5.1%). MAIN LIMITATIONS: The study was limited by its retrospective nature, absence of randomisation and limited numbers. CONCLUSIONS: Four weeks of treatment with LAIO resulted in better rates of ESGD healing than 4 weeks of ORLO. Larger more robust studies of LAIO are warranted.

BACKGROUND: Fungating wounds arise from primary, secondary or recurrent malignant disease and are associated with advanced cancer. A small proportion of patients may achieve healing following surgical excision but treatment is usually palliative. Fungating wound management usually aims to slow disease progression and optimise quality of life by alleviating physical symptoms, such as copious exudate, malodour, pain and the risk of haemorrhage, through appropriate dressing and topical agent selection. OBJECTIVES: To conduct a systematic review of the evidence of the effects of dressings and topical agents on quality of life and symptoms that impact on quality of life in people with fungating malignant wounds. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) and the Wounds Group Specialised Register in August 2006. The Cochrane Breast Cancer Group and the Pain and Palliative Care Group were contacted for relevant studies. The Allied and Complementary Medicine (AMED) database was searched in January 2007. There was no restriction on language or date of publication. SELECTION CRITERIA: Randomised controlled trials (RCTs) or, in their absence, controlled clinical trials (CCTs) with a concurrent control group, both published and unpublished, and written in any language, were eligible for inclusion. DATA COLLECTION AND ANALYSIS: Data extraction was undertaken by one author and checked for accuracy by a second author. Two review authors independently assessed trial quality. MAIN RESULTS: Two trials involving 63 people were included. One RCT in women with superficial breast lesions compared 6% miltefosine solution with placebo and found that miltefosine delayed tumour progression. However, this trial had methodological limitations. A second trial compared topical metronidazole with placebo and found that metronidazole reduced malodour. However, this trial also had methodological limitations and was underpowered. AUTHORS' CONCLUSIONS: There is weak evidence from one small trial that 6% miltefosine solution applied topically to people with superficial fungating breast lesions (smaller than 1cm) who have received either previous radiotherapy, surgery, hormonal therapy or chemotherapy for their breast cancer may slow disease progression. There is insufficient evidence in this review to give a clear direction for practice with regard to improving quality of life or managing wound symptoms associated with fungating wounds. More research is needed.

Abstract. The purpose of this paper is to analyse the limits of constitutional reform. Some constitutions, for example, the German (art. 79, sec. 3), the Italian (art. 139), the Portuguese (art. 288), the French (art. 89, sec. 5), and the Brazilian (art. 60, sec. 4), contain an “essential core” of rights, which is usually understood as being immune to change. The initial focus in the paper is on the discussion on whether and to what extent these “essential cores” are indeed immune to change. A second focus is on Ross's paradox. Here I analyse and reject Ross's own solution to the paradox and I show, too, that the paradox admits no solution that does not imply a discontinuity in the legal system.

Abstract The bulk of care in the community is carried out by lay carers. Recent policy initiatives to support them in the United Kingdom are outlined. There remains evidence of significant gaps in support from professional health and social‐care workers including community nurses. This paper reports three studies of lay carers: those caring for older people, carers of technology‐dependent children, and home‐care workers involved in the “direct payments” scheme. Findings are reported in the areas of decisions about appropriate caring roles, the lay–professional boundary, training and respite opportunities and the expertise of lay carers. Recommendations for policy and practices are made.

Abstract Long‐term data are beneficial for monitoring the conservation status of species. Assessments of population change over recent periods of fixed duration will, however, be subject to ‘shifting baselines’, where the accepted norm for the population at the start of the period already represents a reduction from historical levels. International Union for Conservation of Nature Red List criteria for categorizing conservation threat rely on assessing declines against quantitative thresholds, generally measured over 10 years, as indications of the likelihood of extinction in the near future. By contrast, legal frameworks such as the European Habitats Directive require states to achieve and sustain ‘Favourable Conservation Status’ for protected species, while domestic conservation legislation can have more diverse objectives and mechanisms, based on local contexts that extend beyond biological or quantitative criteria. We explore the challenges associated with assessing the risk of extinction and the conservation status that arise from the availability of long‐term monitoring data for hazel dormice Muscardinus avellanarius in the United Kingdom. Numbers of adult dormice counted in the National Dormouse Monitoring Programme are in ongoing decline, amounting to an overall decline of 78% (95% confidence interval = 72%–84%) over 27 years, 1994–2020. If the observed annual rate of decline of 5.7% (95% CI = 4.7%–6.8%) were to continue unabated, dormouse counts would decline by >90% from 1994 to 2034. Despite this, the species would never be categorized as Endangered, under IUCN criteria, which specify a reduction of >50% within 10 years. While such chronic decline may not indicate imminent risk of extinction, justifying a higher Red List category, it is a demonstration of unfavourable conservation status at a national scale. Prioritization based on demonstration of such chronic declines might direct more effective action towards species conservation at a point when their recovery is more attainable, rather than attempting later to reverse a journey to the brink of extinction when the species is finally ‘Endangered’.

On 23 September 1976 a 5-year-old girl was admitted to a hospital in Tokyo suffering from an abdominal contusion. The following day she excreted some fly larvae in her urine. The urine sample was collected in a standard receptacle, using routine precautions to avoid secondary contamination. Within an hour of collection the sample was examined and mature larvae were observed in the urine. Two larvae were recovered for examination. A sketch made from a living larva is given in FIG. 1. The notable features of this larva are the elongation of the tubercles bearing the posterior spiracles and the very conspicuous posterior balloonlike structures, which are presumably anal gills of some sort. These were very evident when the larvae were in urine but were apparently retracted when the larvae were transferred to water. The larvae appeared to be ingesting sediment material when in the urine in the laboratory.

Summary Collections of crabs in the forest zone of West Cameroon produced three species—Potamonautes africanus, P. orthostylis and P. pobeguini. The P. africanus carried populations of immature Simulium ovazzae. Analysis of crabs collected by hand and those collected in traps indicates very little overlap in the sizes of the crabs obtained by the two techniques. This problem is discussed. The infestation rates of S. ovazzae on P. africanus were found to be highest on medium-sized crabs. The attachment sites of the S. ovazzae on the crabs were found to vary with both the size of the crab and the size of the Simulium larva. The size distributions of S. ovazzae larvae on small crabs were found to be different from those on medium and large crabs. The characteristic deficiency of smaller larvae on medium and large crabs reported for other crab-phoretic species was also found with S. ovazzae but the smaller crabs showed a deficiency of larger larvae. A hypothesis is put forward to explain the dearth of larger larvae on the smaller crabs and the higher infestation rate on medium crabs. S. ovazzae are shown to arrive on their hosts as single larvae carried by the current. Six adult S. ovazzae were reared from pupae in the laboratory. Small numbers of presumed S. ovazzae biting man in Cameroon are reported.

BACKGROUND: Horses are reported to return to a variety of disciplines following unilateral enucleation; however, owners of horses with ocular disease are frequently reluctant to consider the procedure. There is little published information investigating owners' attitudes towards, and satisfaction following, enucleation. OBJECTIVES: To investigate the hypotheses: 1) horses return to their previous level of work following unilateral enucleation and 2) their owners are satisfied with the post-operative outcome. STUDY DESIGN: Retrospective case series with cross-sectional survey. METHODS: Clinical records from eight equine referral centres in the United Kingdom were reviewed to identify horses that underwent enucleation between August 2006 and March 2015. Owner questionnaires were completed to corroborate information provided by medical records and obtain information on client perceptions. RESULTS: A total of 170 cases were identified and 119 owner questionnaires completed. The most frequent primary uses of horses in the study were pleasure/leisure riding, showjumping and dressage, with 25.2% (n = 30) of horses used for competition. Following enucleation, 77.3% (n = 92) of horses were performing at an equivalent or higher level than prior to enucleation and 60.0% (n = 18/30) of competition horses were competing at an equivalent or higher level. Complications related to the surgical site (predominantly mild post-operative swelling) were reported in 3.7% of cases and nonocular complications in 3.7% of cases. Of owners who reported being concerned or very concerned about certain factors prior to surgery, ≥86.8% reported that these factors caused little or no issue post-surgery. Most owners, 90.8% (n = 108) were pleased with the outcome following surgery, with 21.3% (n = 23/108) wishing the procedure had been undertaken sooner. MAIN LIMITATIONS: Retrospective data collection from clinical records and the potential for recall bias. CONCLUSIONS: Horses can return successfully to a variety of disciplines following enucleation. Owners are satisfied with the outcome and pleased that enucleation was performed.

Summary Metoclopramide is used for the management of post operative ileus in horses for its gastrointestinal prokinetic effects. Adverse extrapyramidal signs have been reported following its use in horses as well as in man. This report describes the clinical signs exhibited during an adverse reaction suspected to be associated with subcutaneous administration of 0.25 mg/kg bwt metoclopramide at 6 h intervals.

OBJECTIVE: This UK study aimed to identify the factors district nurses use in deciding how frequently to re-apply compression bandaging. METHOD: Qualitative observational data from district nurses' visits to patients and subsequent team meetings were used to structure in-depth interviews with nurses. Data were analysed according to the principles of grounded theory. RESULTS: Ten factors emerged as influences on the frequency of re-application. These included knowledge of leg ulcer care, recognition of the symptoms of wound deterioration, confidence, time management, patient preferences and sources of information. CONCLUSION: The influences reported and observed are likely to be of use in designing future bandaging trials and in the delivery of leg ulcer education. The research identifies links between frequency of bandaging and resource awareness, clinical expertise, patient preference and research evidence. Decision-makers could be taught to organise large numbers of factors into several smaller categories that might result in more accurate decision-making regarding the frequency of re-bandaging.

Journal Article The British Metopina (Diptera: Phoridae) with description of a new species Get access R. H. L. DISNEY R. H. L. DISNEY 1Malham Tarn Field Centre, Settle, North Yorkshire Search for other works by this author on: Oxford Academic Google Scholar Zoological Journal of the Linnean Society, Volume 67, Issue 2, October 1979, Pages 97–113, https://doi.org/10.1111/j.1096-3642.1979.tb01108.x Published: 28 June 2008 Article history Accepted: 01 June 1978 Published: 28 June 2008

Abstract Megaselia sandhui sp. n. is described from specimens of the adult male, female and pupa infesting cultivated mushrooms in India. It is closely related to the other species of Megaselia known to be pests of cultivated mushrooms.

Correction to: Nature Published online 23 August 2023 In the version of the article initially published, Stanislaw Miscicki’s name incorrectly appeared as Miscicki Stanislaw. Additionally, the affiliation for Thomas T. Ibanez has been updated to “AMAP, University of Montpellier, CIRAD, CNRS, INRAE, IRD, Montpellier, France”, and the second affiliation for Sharif A. Mukul has been updated to “Department of Environment and Development Studies, United International University, Dhaka, Bangladesh”. The corrections have been made to the HTML and PDF versions of the article.

Abstract Magaselia corkerae, sp. nov. is described rrom Hong Kong, where it breeds in the pitchers of Nepenthes mirabilis Druce. In discusslop or its affinities it is concluded that the separation of the genus Endonepenthia from Megaselia can no longer be sustained. Endontpenthia is thererore synonymised with Megaselia.

A numerical model of a simple harmonic oscillator is presented and its implementation on a spreadsheet demonstrated. The usefulness of such techniques in modelling at the higher levels of National Curriculum Science Attainment Target 1 and Technology Attainment Target 5 is discussed. An extension of the simple model appropriate for investigation at A-level is given.

Just as there is a spectrum of sciences studying different subject matters and using different methods and concepts, there is a wider spectrum of knowledge which includes the humanities in so far as they employ appropriately rational methods. Theology has a peculiarly intractable subject matter, but it too employs rational methods in bringing together historical understanding and intense personal experience.