Ministry of Government Legislation

Holotype No. 865949, total, length 128mm, standard length 105mm, collected in May 1986 from a subterranean :river at Yiliang county (25°24′N, 103°27′E), Yunnan. Paratypes 7 specimens, total length 83-114mm, standard length 68-93mm; from the same locality as the holotype.D. 4, 7; P. 1, 15-16; V. 1, 8; A. 3, 5. L. I. 52-56. Gill raters on first arch 7-8. Lower pharyngeal teeth in three rows.Depth in standard length 3.8-4.1, head 3.4-3.6, length of caudal peduncle 4.5-5.2, depth of caudal peduncle 9.7-11.0. Wedth of month in head 3.8-4.3, snout of barbele 2.0-2.4, maxillar of barbele 1.9-2.2. Depth of caudal peduncle in its length 1.9-2.3.The new species is similar to Sinocyclocheilus angustiporus Zeng et Xie in having a strong and serrated unbranched dorsal ray and subinferior mouth, but differs from the latter in having more scales (73-76) along the lateral line, as against 52-55 scales in the latter species.All the type specimens are kept in Kunming Institute of Zoology, Academia Sinica.Besides, the present paper deals with the habitat where the new species lives, and the evolution of characters and interspecific relationships.

OBJECTIVE: To fabricate an innovative scaffold for lung cancer cell culture and establish a three-dimensional lung cancer model in vitro, and to reveal the differences in biological functions of lung cancer cells under the two-dimensional and three-dimensional culture conditions. METHODS: We chose agarose and alginate as the scaffold materials, and 3D printing technique was applied to construct cell culture scaffold. 95D cells were co-cultured with this scaffold. The differences of cell morphology, proliferation ability, protein expression, etc. in the cells cultured under 2D and 3D cultural conditions were evaluated by light microscopy using HE staining, MTT assay, scanning electron microscopy, and Western blot analysis. RESULTS: Cells cultured in 2D wells displayed a spindle and polygonal morphology, whereas those grown in the 3D culture aggregated into spheroids, which invaded, migrated and disseminated into the surrounding scaffold. MTT assay showed that the proliferation rates of the 3D-cultured cells for 2-6 days were significantly lower than, but those cultured for 8-9 days were significantly higher than that of the 2D-cultured cells, indicating that proliferative activity of the cells grown in 2D cultures for 8-9 days was inhibited. In contrast, cells grown on 3D scaffolds still maintained a higher proliferation. The Western blot assay showed that the expression of Cdc42, p53, mTOR were significantly down-regulated in 3D scaffold-cultured group (0.529±0.103, 0.820±0.038 vs. 1.967±0.066), compared with that of the 2D-cultured group (3.063±0.139, 1.738±0.122 vs. 2.472±0.151) (P<0.05 for all), while the expression of MMP-2 was up-regulated in the 3D-cultured cells (1.110±0.029), significantly higher than that of the 2D-cultured cells (0.017±0.001) (P<0.05). CONCLUSIONS: The cell morphology, proliferation and associated protein expression of lung cancer cells in 3D-culture systems are distinctively different as compared to those of the 2D-cultural cells. 3D-bioprinted agarose-alginate scaffold can better mimic the growth microenvironment of lung cancer in vivo and may provide a promising model for lung cancer research in vitro.

Threshold technology which is one of the most important and efficiency technology in image segmentation is based on area image segmentation in many arithmetic. Principle and performance of several image segmentation arithmetic in common use has been involved in the thesis. And the improved Otsu arithmetic has been used for detecting abrasion of locomotive pantograph and catenary in warehouse entry system. So their labor intensity has decreased greatly.

Researchers have previously struggled to carry out clinical trials on epidemics and the drugs used to treat them. <b>Ed Yong</b> finds out about the scientists who are changing that by planning ahead…

In order to study the characteristics of energy metabolism in rodents native to high altitudes, the resting metabolic rate (RMR) of the root vole (Microtus oeconomus Pallas) was measured at several ambient temperatures (Ta) between 5℃-35℃ at the Research Station of Alpine Meadow Ecosystem, Menyuan, Qinghai (3200M albove sea level). There were three experiments taken during the green up period (May), the exuberance period (July-Aug. and the withering period (Sep. -Oct.) of the grass growth.The results showed that the RMR decreased while the Ta increased. The critical temperature (Tc) was 30℃ (green up period and the withering period) and 32.5℃ (Exuberance period). The RMR was significantly higher in the exuberance period (5.11 mlO/g.h) and lower in other periods (4.87 mlO/g.h, 4.96 mlO/g.h respectively.The RMR of the root vole was clearly higher than that of the other voles with similar body size. However, the minimum thermal conductance (Cm) of the root vote was nearly the same as that of the other voles. Therefore the root vole ma,y be adapted to cold weather in high altitudes mainly by increasing their metabolic rate.The normal body temperature (Tb) of the root vole was moderately lower (34℃) than that of the other rodents. When the Ta changed between 5℃-35℃, the Tb fluctuates 3℃-4℃.So we found three following characteristics which may be elucidate the root vole's adaptation to environmental temperature in high altitude: the higher level of RMR; the lower level of normal Tb; and the ability of relaxing the precision of homothermy in certian ranges.

This is a report of a screening for scoliosis among 2600 school children, aged 7-16 years of age.The Moire topographic method was employed and showed a 94% conformation with X-ray diagnoses; the forward bending test was also used, a conformation rate of 64% was obtained.These results indicate that the non-invasive Moire topographic examination is not only simple and economical, but also comparatively accurate and can be used for mass surveys.

患者 男，58岁，因右侧丽颊部隐痛伴间歇性鼻出血20年，局部肿痛加重7个月于2010年3月入院。患者20年前无诱因出现右侧面颊部隐痛，伴间歇性鼻出血，近10年来鼻出血症状自行缓解，但仍有局部隐痛，7个月前右侧面颊部被钝物击伤，随即出现朽侧面颊部持续性肿胀疼痛。

OBJECTIVE: To investigate the clinical characteristics, renal pathology, treatment and prognosis of children with atypical hemolytic uremic syndrome associated with H factor antibody. METHOD: Four children less than 18 yr of age admitted from Nov. 2010 to May 2011 in Peking University First Hospital were included. They all met the criteria for atypical hemolytic uremic syndrome and with positive serum anti factor H antibody. They aged from 5 to 11 yr. Data on clinical manifestations, renal pathology, treatment and prognosis were analyzed. RESULT: All of the 4 cases had gastrointestinal symptoms such as vomiting, abdominal pain, or abdominal distension. None of them had diarrhea. Two children had hypertension. One child had episodes of convulsion. One child had history of atypical hemolytic uremic syndrome. All of them had low serum complement C3. Three of them had low serum factor H (38.0, 88.4, 209.4 mg/L). All of them had serum antibody to factor H (1: 7 068, 1: 1 110, 1: 174, and 1: 869). Three of them received renal biopsy, all of them showed thrombotic microangiopathy. All of them were treated with steroid combined with mycophenolate mofetil. Two children received plasma exchange. They were followed up for 8 to 29 months. The renal function became normal and proteinuria relieved in all of them. The serum factor H concentration increased to 405.8, 155.8 and 438.4 mg/L, respectively. The titer of anti factor H antibody decreased to 1: 119, 1: 170, 1: 123, and 1: 674, respectively. CONCLUSION: Gastrointestinal symptom is common in children with atypical hemolytic uremic syndrome associated with H factor antibody. Hypocomplementemia was observed in all of them. Steroid combined with mycophenolate mofetil seemed to be effective for them. The monitoring of serum factor H and antibody to factor H may help diagnosis and treatment.

Frist of all, in expert systems we introduced that, the fuzzy production rule are used for method of knowledge representation. In fuzzy production rule, the rule is executed if the degree of matching is not less than a certain threshold A.Next, the matching function is difined as the degree of similarity between M and D, can be measured. By using the strength of confirmation calculation method, the strength of confirmation that the consequence di, caused by M can be calculated. Finally, an algorithm is proposed to generate the maximum fuzzy cover of M and their application in fuzzy decision-making.

This paper analyed the reason of heterogeneous date produce。compare adapter-based data exchange scheme with Xml-based data exchange scheme and their characteristic.An ontology and push technology-based model is proposed。About how to realize model was introduced briefly。

In this paper, the structure of the finite non-simple groups which possess a simple group as the maximal subgroup is studied and solved.Let G be a finite group, H be a maximal subgroup of G, the main results are:1. If H is of order p (p: prime), G is the group of order p2, or the abelian group of order pq, or the minimal non-nilpotent group of order pqβ (p≠q2 primes, β: the exponent of q (mod p)); and2. If H is non-abelian and simple but G is not simple, G is one of the following groups:(i) H×K; H is a non-abelian simple group, K is of prime order. (ii) H1×H2; H1, H2 are isomorphic non-abelian simple groups. (iii) H≤G; G/H is of prime order, H is the non-abelian simple group which without normal complement in G. And(iv) G=HN; H∩N=1, H is a non-abelian simple group, N is a non-simple characteristic-simple group, and H irreducibly acts on N by conjugation.Further, the relations among the simple maximal subgroups of the finite group have also been discussed in this paper.

The Ancient Chinese Scholar's awakening of the individual values is persistent pursuit of recognition by others and desire for attention,understanding and acceptance by others,thus forming a tradition.The value of life is nothing but recognition for which Scholar would live and die.So the root causes of writing poets is nothing but the inner pain and wounds from the fact not accepted by others.The writing of literary works is in order to relieve the inner pain and to cure the wounds of heart.

Introduction: Systolic blood pressure (SBP) time in target range (TTR) was proven to be a new parameter to predict cardiovascular outcomes. However, the prognostic value for cognitive function is unclear. Hypothesis: Higher TTR was associated with lower incidence of cognitive outcomes. Methods: We performed a post hoc analysis from the Systolic Blood Pressure Intervention Trial (SPRINT), a randomized controlled trial comparing intensive (&lt;120 mm Hg) and standard (&lt;140 mm Hg) SBP interventions in 9361 individuals with hypertension. SBP target range was defined as 110 to 130 mm Hg for the intensive group and 120 to 140 mm Hg for the standard group. Participants who had less than 3 SBP measurements during this period or no cognitive assessment in the follow-up were excluded. TTR was calculated by linear interpolation using SBP from baseline to the first 3 months of follow-up. Cognitive outcomes were probable dementia, mild cognitive impairment (MCI), and a composite of probable dementia or MCI. Cox regression models were used to evaluate the relationship between TTR and cognitive outcomes. Results: A total of 8415 patients were included in this study. In univariate Cox regression analysis, higher time in target range was associated with lower risk of probable dementia. After adjustment for age, sex and race, a 1-SD increase in TTR was independently associated with a 16% lower risk of probable dementia (hazard ratio [HR] =0.84, 95% CI 0.75-0.93, P =0.002) (Figure). When we further added demographics, medical history and mean SBP to the multivariate Cox regression model, TTR remained significantly associated with a decreased risk of probable dementia (HR =0.84, 95% CI 0.74-0.96, P =0.012). No significant relationship was found between TTR and MCI or a composite of probable dementia or MCI. Conclusions: In this post hoc analysis of the SPRINT trial, SBP time in target range was an independent predictor of probable dementia beyond mean SBP levels.

This paper presents the structure and solution for remote monitoring system based on Web mode. A practical application of the remote monitor system in a pumping station has been given. The main programs of WinSock network communication based on TCP/IP protocol are given also in the paper.

The main causes of offences committed by countryside evil forces fall into the followings: weak and poor managemeat of grass-roots organizations in the countryside, increasingly-expanding disparity between the rich and the poor, the masses' fear of evil forces, negative influence from the patriarchal clan, unpowerful cracking down on the evil forces, incorrect behaviour of the governments and corruption in the society.

肿瘤动物模型作为人类肿瘤的复制,是肿瘤研究中不可缺少的手段.肿瘤动物模型阶段的药物实验是药物进入临床各期研究的必要前期阶段[1].食管癌是复杂的疾病,预后差,治疗手段相对较少,因此建立食管癌动物模型可观察肿瘤的发生、发展全过程,并可在人为控制条件下进行各种实验,对食管癌的发生、发展机制及治疗的研究有着重要意义.本文对食管癌动物模型的研究进展进行综述。

With the acceleration of the complete circulation course,the focus problem in capital market is that the restricted shares lift and the major shareholders reduce.This paper,based on the analysis of motivation of the major shareholders’ reduction and the reduction data by July 31,2009,draws the conclusions that the company’s Tobin’s Q value and the ratio of Tobin’s Q value of the company with the industry average Q value have significant positive effect on the major shareholders reduction;the more the ratio of Tobin’s Q value of the company with the A-share average Q value,the more amount of the major shareholders reduction;the amount of restricted shares lifting and the proportion of share of holding of major shareholders have significant positive effect on the major shareholders reduction;the ROE and holding costs have not a significant effect.

This paper presents tail current shaping-filtering technique to design a low phase-noise and low power dissipation differential LC VCO based on the analysis of phase noise of VCO.The circuit was designed in TSMC 0.18um CMOS process, and simulated by the SpectreRF in Cadence under supply voltage of 1.8V. The center frequency of the VCO was 1.8G. The output frequency ranged from 1.430 to 1.820GHz, Phase noise was -121dBc/Hz at an offset of 600kHz. The static current of the circuit was 1.39mA. The static dissipation was 2.5mW.

É com muita satisfação que aceitei o convite para fazer a apresentação do livro do Mestre Manuel Félix, cujo título é Manual prático de Demografia. Quando vi a obra pensei desde logo que ela fosse o resultado de um trabalho de tese, mas depois lhe dar uma pausada vista de olhos, sobretudo na biografia do seu autor, compreendi que estava longe de ser o resultado da tese para um grau académico, não obstante o seu autor, para além de ser engenheiro de minas, ser também gestor. A escrita deste en...

Through statistical analysis of more than1 0 0 times breakdown of cutting tools on the automatic machine tool,the checking and replacing model has been studied for cutting tool to machine only one part continuously.In this paper,by using of the D inspection method for the large- scale sample situation in the probability theory,it has been proved thatthe occurring law of cutting tool′s breakdown accords with the normal distribution.After figuring out the life- span distribution function of the system process,the multi- objective function equation has been obtained in which the unit expected loss of the qualified part is taken as objective and the checking interval as well as the regular replacement interval for cutting tool are variables.By means of enumeration and comparison methods to look for the solution on the microcomputer, the optimum checking interval and the optimum replacing strategy forthe cutting tool have been given which could bring outthe optimal economic profitin the system process.Since the occur- ring law of cutting tool′s breakdown accords the normal distribution,the improved model has been presented by adopting the regular unequal interval checking method and the better results than these of equal interval checking method are obtained. By using the algorithm mentioned above,the function has been solved fairly and the opti- mum solution has been got.In this paper two study cases are described.For case1 ,the inter- vals of replacing and checking are 369and 1 8respectively,the loss of unit qualified part is 4.61 5Yuan and it will be down to4.40 5Yuan if the unequal interval is adopted.For case2 , under complicated conditions,the intervals of replacing and thecking are30 6and2 8respective- ly,the loss of unit qualified part is 9.2 68Yuan and it will change to 9.0 4 7Yuan when using unequal interval.These results provide a more advantage proof for the improved model using the unequal interval checking method