Mississippi University for Women

Worldwide, about 65 million people are estimated to have epilepsy. Epidemiologic studies are necessary to define the full public health burden of epilepsy; to set public health and health care priorities; to provide information needed for prevention, early detection, and treatment; to identify education and service needs; and to promote effective health care and support programs for people with epilepsy. However, different definitions and epidemiologic methods complicate the tasks of these studies and their interpretations and comparisons. The purpose of this document is to promote consistency in definitions and methods in an effort to enhance future population-based epidemiologic studies, facilitate comparison between populations, and encourage the collection of data useful for the promotion of public health. We discuss: (1) conceptual and operational definitions of epilepsy, (2) data resources and recommended data elements, and (3) methods and analyses appropriate for epidemiologic studies or the surveillance of epilepsy. Variations in these are considered, taking into account differing resource availability and needs among countries and differing purposes among studies.

The helix is a common secondary structural motif found in proteins, and the mechanism of helix-coil interconversion is key to understanding the protein-folding problem. We report the observation of the fast kinetics (nanosecond to millisecond) of helix melting in a small 21-residue alanine-based peptide. The unfolding reaction is initiated using a laser-induced temperature jump and probed using time-resolved infrared spectroscopy. The model peptide exhibits fast unfolding kinetics with a time constant of 160 +/- 60 ns at 28 degrees C in response to a laser-induced temperature jump of 18 degrees C which is completed within 20 ns. Using the unfolding time and the measured helix-coil equilibrium constant of the model peptide, a folding rate constant of approximately 6 x 10(7) s-1 (t1/2 = 16 ns) can be inferred for the helix formation reaction at 28 degrees C. These results demonstrate that secondary structure formation is fast enough to be a key event at early times in the protein-folding process and that helices are capable of forming before long range tertiary contacts are made.

Epididymal sperm were added to embryological watch glasses containing 396 F1, hybrid mouse ova in a simple medium under paraffin oil. The dishes were gently agitated for 8 h in an atmosphere of 5% CO2, 5% O2, and 90% N2. The ova were washed and cultured in glass tubes for 96 h during which time 365 ova cleaved and 347 developed to morulae or early blastocysts. Transferred to the uteri of pseudopregnant hosts were 299 of these embryos, and 67 male and 44 female offspring were born. From these findings, it was concluded that normal fertilization in vitro had occurred. Using first cleavage and embryo development in culture as the criterion, we have confirmed these findings and have examined some of the factors that affect fertilization in vitro. Epididymal sperm fertilized 122 of 131 ova whereas 39 of 122 ova were fertilized by uterine sperm. Agitation of sperm and ova during fertilization resulted in fertilization of 139 of 166 ova compared to fertilization of 84 of 168 ova without agitation. The highest fertilization rate (44 of 45) occurred with ova surrounded by cumulus cells and continuous agitation of sperm and ova in 0.5 ml of medium for 8 h at 37°C.

PURPOSE: This study compared the syntax of boys who have fragile X syndrome (FXS) with and without autism spectrum disorder (ASD) with that of (a) boys who have Down syndrome (DS) and (b) typically developing (TD) boys. METHOD: Thirty-five boys with FXS only, 36 boys with FXS with ASD, 31 boys with DS, and 46 TD boys participated. Conversational language samples were evaluated for utterance length and syntactic complexity (i.e., Index of Productive Syntax; H. S. Scarborough, 1990). RESULTS: After controlling for nonverbal mental age and maternal education levels, the 2 FXS groups did not differ in utterance length or syntactic complexity. The FXS groups and the DS group produced shorter, less complex utterances overall and less complex noun phrases, verb phrases, and sentence structures than did the TD boys. The FXS with ASD group and the DS group, but not the FXS-only group, produced less complex questions/negations than did the TD group. Compared with the DS group, both FXS groups produced longer, more complex utterances overall, but on the specific complexity measures, they scored higher only on questions/negations. CONCLUSION: Boys with FXS and DS have distinctive language profiles. Although both groups demonstrated syntactic delays, boys with DS showed greater delays.

BACKGROUND: Empirical evidence suggests that people value emergency medical services (EMS) but that they may not use the service when experiencing chest pain. This study evaluates this phenomenon and the factors associated with the failure to use EMS during a potential cardiac event. METHODS AND RESULTS: Baseline data were gathered from a randomized, controlled community trial (REACT) that was conducted in 20 US communities. A random-digit-dial survey documented bystander intentions to use EMS for cardiac symptoms in each community. An emergency department surveillance system documented the mode of transport among chest pain patients in each community and collected ancillary data, including situational factors surrounding the chest pain event. Logistic regression identified factors associated with failure to use EMS. A total of 962 community members responded to the phone survey, and data were collected on 875 chest pain emergency department arrivals. The mean proportion of community members intending to use EMS during a witnessed cardiac event was 89%; the mean proportion of patients observed using the service was 23%, with significant geographic differences (range, 10% to 48% use). After controlling for covariates, non-EMS users were more likely to try antacids/aspirin and call a doctor and were less likely to subscribe to (or participate in) an EMS prepayment plan. CONCLUSIONS: The results of this study indicate that indecision, self-treatment, physician contact, and financial concerns may undermine a chest pain patient's intention to use EMS.

While the number of elderly men and women continues to grow, an accurate assessment of attitudes toward the elderly remains difficult. Many problems exist that contribute to this difficulty of assessment. The first problem is the age of the Aging Semantic Differential, an instrument often used for the assessment of attitudes toward the elderly. The adjectives employed are not necessarily descriptive of attitudes today. Another problem was the failure to employ women as attitudinal objects as well as men in the original instrument. Therefore, the Aging Semantic Differential is perhaps outdated for such assessments of attitudes toward today's elderly population. The purpose of this study was to refine the Aging Semantic Differential for the purpose of more accurately assessing current attitudes toward older people in general by generating a more up-to-date list of adjectives. Possible differences in attitude toward men and women were assessed in order to establish a refined list of adjectives for use on the generalized elderly population. Three hundred undergraduate students (136 men, 164 women) evaluated men and women 70-85 years of age. The results of the factor analyses revealed strong similarities in item composition on four factors of the factor structures for old men and old women; however, the orders of the loadings were different on each of the four factors. The final list of adjectives has Cronbach alphas of .9737 and .9713, and test-retest reliabilities of .8127 and .7938 for the old men and the old women, respectively. Recommendations are made on the use of the updated list of adjectives, as well as for methodological and conceptual considerations for future research. Also, future research is called for to determine attitudes toward the elderly rather than to debate the number of factors necessary to explain the attitude concept, as has been done in a majority of studies concerning attitudes toward the elderly.

Abstract A large literature has shown that children's beliefs and aspirations about occupations reflect cultural gender stereotypes. One channel that may create or sustain occupational stereotypes is language. Two studies were designed to examine whether children interpret occupational titles as gender specific or gender neutral. In Study 1, children (6- to 11-year-olds, N= 64) were asked directly if various job titles could be used for both men and women doing the job. In Study 2, children (6- to 10-year-olds, N= 51) were shown pictures of men and women engaged in job activities and asked which one(s) showed someone who could be called a(n). Titles were linguistically unmarked for gender (e.g., doctor), strongly marked (e.g., policeman), or weakly marked (e.g., postmaster). Marked titles were given in masculine and feminine forms. Findings reinforced past work showing that marked titles are exclusionary, revealed that some children harbor confusions about even unmarked titles, and demonstrated the mediating role of individual differences in attitudes. Implications for the changing lexicon and for educational programs are discussed.

Abstract Increasing rates of atmospheric deposition of nitrogen (N) present a novel threat to the biodiversity of terrestrial ecosystems. Many forests are particularly susceptible to excess N given their proximity to sources of anthropogenic N emissions. This study summarizes results of a 25‐yr treatment of an entire central Appalachian hardwood forest watershed via aerial applications of N with a focus on effects of added N on the cover, species richness, and composition of the herbaceous layer. Research was carried out on two watersheds of the Fernow Experimental Forest ( FEF ), West Virginia. The long‐term reference watershed at FEF ( WS 4) was used as a reference; WS 3 was experimentally treated, receiving three aerial applications of N per year as ( NH 4 ) 2 SO 4 totaling 35 kg N ha −1 yr −1 , beginning in 1989. Cover of the herbaceous layer (vascular plants ≤1 m in height) was estimated visually in five circular 1‐m 2 subplots within each of seven circular 400‐m 2 sample plots spanning all aspects and elevations of each watershed. Sampling was carried out in early July of each of the following years: 1991, 1992, 1994, 2003, and 2009—2014, yielding 10 yr of data collected over a 23‐yr period. It was anticipated that the N treatment on WS 3 would decrease species richness and alter herb layer composition by enhancing cover of a few nitrophilic species at the expense of numerous N‐efficient species. Following a period of minimal response from 1991 to 1994, cover of the herb layer increased substantially on N‐treated WS 3, and remained high thereafter. There was also a coincidental decrease in herb layer diversity during this period, along with a sharp divergence in community composition between WS 4 and WS 3. Most changes appear to have arisen from unprecedented, N‐mediated increases of Rubus spp., which are normally associated with the high‐light environment of openings, rather than beneath intact forest canopies. These findings support the prediction that N‐mediated changes in the herbaceous layer of impacted forests are driven primarily by increases in nitrophilic species.

Studying the correlation between the molecular structures of SERS-active analytes and their SERS enhancement factors is important to our fundamental understanding of SERS chemical enhancement. Using a common internal reference method, we quantitatively compared the Raman activities, SERS activities, and SERS enhancement factors for a series of organothiols that differ significantly in their structural characteristics and reported chemical enhancements. We find that while the tested molecules vary tremendously in their normal Raman and SERS activities (by more than 4 orders of magnitude), their SERS enhancement factors are very similar (the largest difference is less than 1 order of magnitude). This result strongly suggests that SERS chemical enhancement factors are not as diverse as initially believed. In addition to shedding critical insight on the SERS phenomena, the common internal reference method developed in this work provides a simple and reliable way for systematic investigation of the correlation between molecular structures and their normal Raman and SERS activities.

More than 90% of newborns in the United States are now being screened for hearing loss. A large fraction of cases of unilateral hearing loss and mild bilateral hearing loss are not currently identified through newborn hearing screening. This is of concern because a preponderance of research has demonstrated that unilateral hearing loss and mild bilateral hearing loss can lead to developmental delays and educational problems for some children. To help address this probable underidentification of unilateral hearing loss and mild bilateral hearing loss among infants and children, the Centers for Disease Control and Prevention Early Hearing Detection and Intervention program and the Marion Downs Hearing Center convened a workshop in Breckenridge, Colorado, in July 2005. During this workshop, several issues related to screening and diagnosing unilateral hearing loss and mild bilateral hearing loss were identified, as well as recommendations for future research in this area. Issues identified included the lack of standardized definitions for permanent unilateral hearing loss and mild bilateral hearing loss; the use of screening protocols that are primarily designed to identify bilateral and unilateral hearing losses of a moderate degree or greater (eg, above 40 dB); calibration of screening equipment; availability of facilities that can provide the full range of audiologic, diagnostic, and management services to this pediatric population; and an overall lack of awareness by many professionals and families about the potential effect of unilateral hearing loss and mild bilateral hearing loss. Suggestions for future research, such as identifying ways to improve the identification of cases of unilateral hearing loss and mild bilateral hearing loss, were also discussed.

Personal risk perceptions of acute myocardial infarction (AMI) affect people's preventive health behaviors as well as their beliefs during a heart attack episode. The authors investigated factors that are associated with personal risk perceptions of having an AMI. A random-digit-dial survey was conducted among 1294 respondents, aged 18 years or older, in 20 communities across the nation as part of the Rapid Early Action for Coronary Treatment (REACT) trial. Results of two mixed-model linear regression analyses suggested that worse perceived general health, more risk factors, and greater knowledge were associated with greater perception of AMI risk. The results also showed that women who answered, incorrectly, that heart disease is not the most common cause of death for women in the United States reported significantly lower risk perceptions than women who answered this question correctly. The findings in this study suggest that interventions need to target specific misconceptions regarding AMI risk.

Abstract Students solved mathematics problems from 4 assignment pairs. Each control assignment contained 18 target multiplication problems that were 4 × 1-digit (4 × 1), 4 × 2, 4 × 3, or 4 × 4. Each paired experimental assignment contained 18 similar problems plus 6 interspersed 1 × 1-digit problems. After computing problems from each pair of assignments, the students rated them and chose 1 for homework. Across all assignment pairs, problem completion rates were greater on the experimental assignments, and significantly more students chose a new experimental, rather than control, assignment for homework. Furthermore, as the discrepancy between problem completion rates increased across assignment pairs, the probability of students' choosing the experimental assignment for homework and rating the experimental assignment more favorably with respect to difficulty, effort, and time also increased. The relationship between student choice behaviors and relative problem completion rates has theoretical and applied implications for choice research and the design of activities composed of discrete tasks.

Development in emerging economies leads to a cohabitation of traditional and modern forms of retailing. This diversity allows for centuries' old consumer behavior patterns to continue along with new options. The street markets or Feira Livres 1 of São Paulo, Brazil demonstrate how consumption patterns are culturally determined. Participant observation, both in supermarkets and at feiras , and interviews with consumers and vendors are used to investigate consumer shopping patterns, along with evolving patterns of retail structure. We find that informal markets, such as the feira , are able to coexist with modern, Western‐style retail institutions, partly because of ingrained food preparation habits and deep‐seated consumer impressions about superior qualities offered by feiras ( e.g. , the perceived freshness of the produce). Our findings support the Natural Selection Theory of retail development in that we find evidence of adaptation. Specifically, the supermarkets in Brazil have evolved to include departments that imitate some of the popular characteristics of the feiras .

<h3>ABSTRACT</h3> This research examines the influence of repeated exposure to advertisements on purchase intentions. Contrary to prior findings that wear-out happens after exposure to an advertisement 10 or more times, consumers who saw an advertisement 10 or more times had greater purchase intentions than consumers with less exposure. This research also uncovered different motivations that mediated purchase intentions on the basis of consumers9 stages in the decision-making process. Purchase intentions were driven more by emotional motivations for consumers who had seen an advertisement one to two times, by cognitive factors for consumers who had seen an advertisement three to 10 times, and by emotions for consumers who had seen an advertisement more than 10 times. Implications for advertising development and media-planning strategies are discussed.

In competitive cycling, setting the proper saddle height is important for both performance and injury prevention. This is also true for ergometer use in a laboratory. The cycling literature recommends using a 25 to 35 degrees knee angle to set saddle height for injury prevention and recommends using 109% of inseam length for optimal performance. Prior research has demonstrated that these 2 methods do not produce similar saddle heights. The purpose of this study was to determine if there is a difference in performance between these 2 methods. Trained cyclists (n = 9) and noncyclists (n = 18) participated in this study. Anaerobic power production was compared using a 30s Wingate protocol at a saddle height of 109% of inseam and at 25 and 35 degrees knee angles. Saddle height set using 109% of inseam fell outside the recommended 25 to 35 degrees knee angle 63% of the time. There were no significant differences (p > 0.05) for peak power and mean power in either group between saddle heights. The data when using 109% to set saddle height were then divided into those that fell within the recommended 25 to 35 degrees knee angle and those that fell outside. A 25 degrees knee angle produced a significantly higher mean power compared with 109% in those that fell outside the recommended range. An increase in power, at a 25 degrees angle, can be extrapolated to increased performance. There was no difference in performance detected in those individuals who fell within the recommended range. For this reason it is recommended that saddle height for cycles and ergometers be set using a 25 to 35 degrees knee angle for both trained and untrained cyclists for both injury prevention and increased performance.

Multiple domains of cognition are known to decline in both normal aging and in the trajectory towards Alzheimer's disease (AD). While declines in episodic memory are most well-known in both normal aging and AD, some of these memory differences might stem from early deteriorations in attention that have consequences for later memory. Further complicating the matter is that attention is a multifaceted construct that might be differentially affected in normal aging and AD. According to cognitive neuroscience models of attention, three types of attention networks exist: alerting, orienting, and executive. Efficiency of these three networks can be captured using the Attention Network Test (ANT). We reviewed the literature investigating differences in attention networks using the ANT as a function of normal aging and the AD trajectory, which included people at risk for AD, preclinical stages of AD, mild cognitive impairment, and those diagnosed with AD. We found that normal aging and the AD trajectory evidenced different patterns of attentional declines. Whereas normal aging was most consistently associated with impairments in alerting, early phases of the AD trajectory were most consistently associated with impairments in executive attention, and later phases of the AD trajectory were mixed. The mixed results with AD are largely attributed to small sample sizes and confounding effects of general slowing. These findings highlight key gaps in the literature linking different phases of AD while also highlighting the usefulness of the ANT to distinguish normal aging from the AD trajectory, especially in the earliest phases of the disease process.

The purpose of Science in Action (SIA) was to examine the relationship between implementing quality science, technology, engineering, and math (STEM) service-learning (SL) projects and the effect on students' academic engagement in middle school science, civic responsibility, and resilience to at-risk behaviors. The innovative project funded by the Corporation for National and Community Service (CNCS) included 6,000+ middle school at-risk students (eligible for at least 50% free or reduced-cost lunch), 126 science teachers who integrated STEM problem-based SL pedagogy into science instruction to teach students to solve real problems in schools and communities. The project involved 20 schools and communities with assistance from 120 community partners. Participants completed pre- and post-SL surveys on academic engagement, civic responsibility, and resilience; qualitative data were collected from journals, interviews, focus groups, observations, and field notes. Results highlight exemplary SL projects that demonstrated increased student academic engagement and achievement for students living in high poverty areas with potential at-risk behavior. Implications for future research and educational practices are discussed.

BACKGROUND: Adherence to childhood immunization schedules is a function of various factors. Given the increased use of technology as a strategy to increase immunization coverage, it is important to investigate how parents perceive different forms of communication, including traditional means and text-message reminders. OBJECTIVE: To examine current forms of communication about immunization information, parents' satisfaction levels with these communication modes, perceived barriers and benefits to using text messaging, and the ideal content of text messages for immunization reminders. METHODS: Structured interviews were developed and approved by two Institutional Review Boards. A convenience sample of 50 parents was recruited from two local pediatric clinics. The study included a demographics questionnaire, the shortened form of the Test of Functional Health Literacy for Adults (S-TOFHLA), questions regarding benefits and barriers of text communication from immunization providers, and preferred content for immunization reminders. Content analyses were performed on responses to barriers, benefits, and preferred content (all Cohen's kappas > 0.70). RESULTS: Respondents were mostly female (45/50, 90%), white non-Hispanic (31/50, 62%), between 20-41 years (mean = 29, SD 5), with one or two children (range 1-9). Nearly all (48/50, 96%) had an S-TOFHLA score in the "adequate" range. All parents (50/50, 100%) engaged in face-to-face contact with their child's physician at appointments, 74% (37/50) had contact via telephone, and none of the parents (0/50, 0%) used email or text messages. Most parents were satisfied with the face-to-face (48/50, 96%) and telephone (28/50, 75%) communication. Forty-nine of the 50 participants (98%) were interested in receiving immunization reminders by text message, and all parents (50/50, 100%) were willing to receive general appointment reminders by text message. Parents made 200 comments regarding text-message reminders. Benefits accounted for 63.5% of comments (127/200). The remaining 37.5% (73/200) regarded barriers; however, no barriers could be identified by 26% of participants (13/50). Parents made 172 comments regarding preferred content of text-message immunization reminders. The most frequently discussed topics were date due (50/172, 29%), general reminder (26/172, 26%), and child's name (21/172, 12%). CONCLUSIONS: Most parents were satisfied with traditional communication; however, few had experienced any alternative forms of communication regarding immunizations. Benefits of receiving text messages for immunization reminders far outweighed the barriers identified by parents. Few barriers identified were text specific. Those that were, centered on cost if parents did not have unlimited texting plans.

Rape prevention and education efforts often focus on the need for clear communication regarding sexual intent between women and men. This approach is based on the underlying assumption that acquaintance rape is a relational issue resulting from miscommunication. Findings from two studies challenge that assumption. The first study demonstrates that men who self-report engaging in sexually aggressive behavior are significantly more likely to misperceive women's sexual intent than other men or women. The second study demonstrates that the cognitive, rather than affective, components of rape-supportive attitudes contribute to sexualized interpretations of women's behavior. Thus, it appears that the tendency to rely on miscommunication as a framework for understanding sexual assault may be deflecting attention from sexual overperceptions and the affectively based information processing among men who engage in sexually assaultive behavior.

A combination of crushed garlic (Allium sativum) and black cumin seeds (Nigelia sativum) has been used as a traditional remedy for urinary tract infections. In-vitro antimicrobial testing suggested that the mixture of two spices in the ratio of 1:1 has antimicrobial effects on both Staphylococcus aureus and Escherichia coli species. Analyses of the extract of garlic and black cumin by GC-MS as well as LC–MS & MS2 confirmed that the main components of garlic were allicin, &#947;-glutamyl-S-allylcysteine and allicin transformed products such as diallyldisulfide and vinyldithiins. Components of black cumin were thymoquinone, p-cymene, p-tert-butylcatechol, and pinene. Isolated samples of allicin by preparative HPLC from garlic extract and reference samples of diallyldisulfide and thymoquinone were tested individually and in combination for their antimicrobial activities against S. aureus and E. coli. All of these compounds showed modest antimicrobial effects individually (except diallyldisulfide against E. coli) and in combination. Keywords: garlic, black cumin, diallyldisulfide, thymoquinone, antimicrobial activity African Journal of Traditional, Complementary and Alternative Medicines Vol. 3(2) 2006: 1-7