MIT Lincoln Laboratory

A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.

Artificial neural net models have been studied for many years in the hope of achieving human-like performance in the fields of speech and image recognition. These models are composed of many nonlinear computational elements operating in parallel and arranged in patterns reminiscent of biological neural nets. Computational elements or nodes are connected via weights that are typically adapted during use to improve performance. There has been a recent resurgence in the field of artificial neural nets caused by new net topologies and algorithms, analog VLSI implementation techniques, and the belief that massive parallelism is essential for high performance speech and image recognition. This paper provides an introduction to the field of artificial neural nets by reviewing six important neural net models that can be used for pattern classification. These nets are highly parallel building blocks that illustrate neural net components and design principles and can be used to construct more complex systems. In addition to describing these nets, a major emphasis is placed on exploring how some existing classification and clustering algorithms can be performed using simple neuron-like components. Single-layer nets can implement algorithms required by Gaussian maximum-likelihood classifiers and optimum minimum-error classifiers for binary patterns corrupted by noise. More generally, the decision regions required by any classification algorithm can be generated in a straightforward manner by three-layer feed-forward nets.

The output of an array of sansors is considered to be a homogeneous random field. In this case there is a spectral representation for this field, similar to that for stationary random processes, which consists of a superposition of traveling waves. The frequency-wavenumber power spectral density provides the mean-square value for the amplitudes of these waves and is of considerable importance in the analysis of propagating waves by means of an array of sensors. The conventional method of frequency-wavenumber power spectral density estimation uses a fixed-wavenumber window and its resolution is determined essentially by the beam pattern of the array of sensors. A high-resolution method of estimation is introduced which employs a wavenumber window whose shape changes and is a function of the wavenumber at which an estimate is obtained. It is shown that the wavenumber resolution of this method is considerably better than that of the conventional method. Application of these results is given to seismic data obtained from the large aperture seismic array located in eastern Montana. In addition, the application of the high-resolution method to other areas, such as radar, sonar, and radio astronomy, is indicated.

The theory of semicovalent exchange is reviewed and applied to the perovskite-type manganites $[\mathrm{La}, M(\mathrm{II})]\mathrm{Mn}{\mathrm{O}}_{3}$. With the hypothesis of covalent and semicovalent bonding between the oxygen and manganese ions plus the mechanism of double exchange, detailed qualitative predictions are made about the magnetic lattice, the crystallographic lattice, the electrical resistivity, and the Curie temperature as functions of the fraction of ${\mathrm{Mn}}^{4+}$ present. These predictions are found to be in accord with recent findings from neutron-diffraction and x-ray data as well as with the earlier experiments on this system by Jonker and van Santen.

Pfinder is a real-time system for tracking people and interpreting their behavior. It runs at 10 Hz on a standard SGI Indy computer, and has performed reliably on thousands of people in many different physical locations. The system uses a multiclass statistical model of color and shape to obtain a 2D representation of head and hands in a wide range of viewing conditions. Pfinder has been successfully used in a wide range of applications including wireless interfaces, video databases, and low-bandwidth coding.

<b><i>Background:</i></b> Clinician rating scales and patient-reported outcomes are the principal means of assessing motor symptoms in Parkinson disease and Huntington disease. However, these assessments are subjective and generally limited to episodic in-person visits. Wearable sensors can objectively and continuously measure motor features and could be valuable in clinical research and care. <b><i>Methods:</i></b> We recruited participants with Parkinson disease, Huntington disease, and prodromal Huntington disease (individuals who carry the genetic marker but do not yet exhibit symptoms of the disease), and controls to wear 5 accelerometer-based sensors on their chest and limbs for standardized in-clinic assessments and for 2 days at home. The study’s aims were to assess the feasibility of use of wearable sensors, to determine the activity (lying, sitting, standing, walking) of participants, and to survey participants on their experience. <b><i>Results:</i></b> Fifty-six individuals (16 with Parkinson disease, 15 with Huntington disease, 5 with prodromal Huntington disease, and 20 controls) were enrolled in the study. Data were successfully obtained from 99.3% (278/280) of sensors dispatched. On average, individuals with Huntington disease spent over 50% of the total time lying down, substantially more than individuals with prodromal Huntington disease (33%, <i>p</i> = 0.003), Parkinson disease (38%, <i>p</i> = 0.01), and controls (34%; <i>p</i> < 0.001). Most (86%) participants were “willing” or “very willing” to wear the sensors again. <b><i>Conclusions:</i></b> Among individuals with movement disorders, the use of wearable sensors in clinic and at home was feasible and well-received. These sensors can identify statistically significant differences in activity profiles between individuals with movement disorders and those without. In addition, continuous, objective monitoring can reveal disease characteristics not observed in clinic.

This paper introduces and motivates the use of Gaussian mixture models (GMM) for robust text-independent speaker identification. The individual Gaussian components of a GMM are shown to represent some general speaker-dependent spectral shapes that are effective for modeling speaker identity. The focus of this work is on applications which require high identification rates using short utterance from unconstrained conversational speech and robustness to degradations produced by transmission over a telephone channel. A complete experimental evaluation of the Gaussian mixture speaker model is conducted on a 49 speaker, conversational telephone speech database. The experiments examine algorithmic issues (initialization, variance limiting, model order selection), spectral variability robustness techniques, large population performance, and comparisons to other speaker modeling techniques (uni-modal Gaussian, VQ codebook, tied Gaussian mixture, and radial basis functions). The Gaussian mixture speaker model attains 96.8% identification accuracy using 5 second clean speech utterances and 80.8% accuracy using 15 second telephone speech utterances with a 49 speaker population and is shown to outperform the other speaker modeling techniques on an identical 16 speaker telephone speech task.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

Data hiding, a form of steganography, embeds data into digital media for the purpose of identification, annotation, and copyright. Several constraints affect this process: the quantity of data to be hidden, the need for invariance of these data under conditions where a "host" signal is subject to distortions, e.g., lossy compression, and the degree to which the data must be immune to interception, modification, or removal by a third party. We explore both traditional and novel techniques for addressing the data-hiding process and evaluate these techniques in light of three applications: copyright protection, tamper-proofing, and augmentation data embedding.

PbSeTe-based quantum dot superlattice structures grown by molecular beam epitaxy have been investigated for applications in thermoelectrics. We demonstrate improved cooling values relative to the conventional bulk (Bi,Sb)2(Se,Te)3 thermoelectric materials using a n-type film in a one-leg thermoelectric device test setup, which cooled the cold junction 43.7 K below the room temperature hot junction temperature of 299.7 K. The typical device consists of a substrate-free, bulk-like (typically 0.1 millimeter in thickness, 10 millimeters in width, and 5 millimeters in length) slab of nanostructured PbSeTe/PbTe as the n-type leg and a metal wire as the p-type leg.

A method is proposed for designing controllers with arbitrarily small tracking error for uncertain, mismatched nonlinear systems in the strict feedback form. This method is another "synthetic input technique," similar to backstepping and multiple surface control methods, but with an important addition, /spl tau/-1 low pass filters are included in the design where /spl tau/ is the relative degree of the output to be controlled. It is shown that these low pass filters allow a design where the model is not differentiated, thus ending the complexity arising due to the "explosion of terms" that has made other methods difficult to implement in practice. The backstepping approach, while suffering from the problem of "explosion of terms" guarantees boundedness of tracking errors globally; however, the proposed approach, while being simpler to implement, can only guarantee boundedness of tracking error semiglobally, when the nonlinearities in the system are non-Lipschitz.

The ability to recognize emotion is one of the hallmarks of emotional intelligence, an aspect of human intelligence that has been argued to be even more important than mathematical and verbal intelligences. This paper proposes that machine intelligence needs to include emotional intelligence and demonstrates results toward this goal: developing a machine's ability to recognize the human affective state given four physiological signals. We describe difficult issues unique to obtaining reliable affective data and collect a large set of data from a subject trying to elicit and experience each of eight emotional states, daily, over multiple weeks. This paper presents and compares multiple algorithms for feature-based recognition of emotional state from this data. We analyze four physiological signals that exhibit problematic day-to-day variations: The features of different emotions on the same day tend to cluster more tightly than do the features of the same emotion on different days. To handle the daily variations, we propose new features and algorithms and compare their performance. We find that the technique of seeding a Fisher Projection with the results of sequential floating forward search improves the performance of the Fisher Projection and provides the highest recognition rates reported to date for classification of affect from physiology: 81 percent recognition accuracy on eight classes of emotion, including neutral.

This paper presents methods for collecting and analyzing physiological data during real-world driving tasks to determine a driver's relative stress level. Electrocardiogram, electromyogram, skin conductance, and respiration were recorded continuously while drivers followed a set route through open roads in the greater Boston area. Data from 24 drives of at least 50-min duration were collected for analysis. The data were analyzed in two ways. Analysis I used features from 5-min intervals of data during the rest, highway, and city driving conditions to distinguish three levels of driver stress with an accuracy of over 97% across multiple drivers and driving days. Analysis II compared continuous features, calculated at 1-s intervals throughout the entire drive, with a metric of observable stressors created by independent coders from videotapes. The results show that for most drivers studied, skin conductivity and heart rate metrics are most closely correlated with driver stress level. These findings indicate that physiological signals can provide a metric of driver stress in future cars capable of physiological monitoring. Such a metric could be used to help manage noncritical in-vehicle information systems and could also provide a continuous measure of how different road and traffic conditions affect drivers.

This paper discusses the problem of the minimization of the distortion of a signal by a quantizer when the number of output levels of the quantizer is fixed. The distortion is defined as the expected value of some function of the error between the input and the output of the quantizer. Equations are derived for the parameters of a quantizer with minimum distortion. The equations are not soluble without recourse to numerical methods, so an algorithm is developed to simplify their numerical solution. The case of an input signal with normally distributed amplitude and an expected squared error distortion measure is explicitly computed and values of the optimum quantizer parameters are tabulated. The optimization of a quantizer subject to the restriction that both input and output levels be equally spaced is also treated, and appropriate parameters are tabulated for the same case as above.

Sixteen English consonants were spoken over voice communication systems with frequency distortion and with random masking noise. The listeners were forced to guess at every sound and a count was made of all the different errors that resulted when one sound was confused with another. With noise or low-pass filtering the confusions fall into consistent patterns, but with high-pass filtering the errors are scattered quite randomly. An articulatory analysis of these 16 consonants provides a system of five articulatory features or “dimensions” that serve to characterize and distinguish the different phonemes: voicing, nasality, affrication, duration, and place of articulation. The data indicate that voicing and nasality are little affected and that place is severely affected by low-pass and noisy systems. The indications are that the perception of any one of these five features is relatively independent of the perception of the others, so that it is as if five separate, simple channels were involved rather than a single complex channel.

The aim of this review is to provide quantum engineers with an introductory guide to the central concepts and challenges in the rapidly accelerating field of superconducting quantum circuits. Over the past twenty years, the field has matured from a predominantly basic research endeavor to a one that increasingly explores the engineering of larger-scale superconducting quantum systems. Here, we review several foundational elements—qubit design, noise properties, qubit control, and readout techniques—developed during this period, bridging fundamental concepts in circuit quantum electrodynamics and contemporary, state-of-the-art applications in gate-model quantum computation.

An adaptive algorithm for radar target detection using an antenna array is proposed. The detector is derived in a manner similar to that of the generalized likelihood-ratio test (GLRT) but contains a simplified test statistic that is a limiting case of the GLRT detector. This simplified detector is analyzed for performance to signals on boresight, as well as when the signal direction is misaligned with the look direction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

A sinusoidal model for the speech waveform is used to develop a new analysis/synthesis technique that is characterized by the amplitudes, frequencies, and phases of the component sine waves. These parameters are estimated from the short-time Fourier transform using a simple peak-picking algorithm. Rapid changes in the highly resolved spectral components are tracked using the concept of "birth" and "death" of the underlying sine waves. For a given frequency track a cubic function is used to unwrap and interpolate the phase such that the phase track is maximally smooth. This phase function is applied to a sine-wave generator, which is amplitude modulated and added to the other sine waves to give the final speech output. The resulting synthetic waveform preserves the general waveform shape and is essentially perceptually indistinguishable from the original speech. Furthermore, in the presence of noise the perceptual characteristics of the speech as well as the noise are maintained. In addition, it was found that the representation was sufficiently general that high-quality reproduction was obtained for a larger class of inputs including: two overlapping, superposed speech waveforms; music waveforms; speech in musical backgrounds; and certain marine biologic sounds. Finally, the analysis/synthesis system forms the basis for new approaches to the problems of speech transformations including time-scale and pitch-scale modification, and midrate speech coding [8], [9].

A general problem of signal detection in a background of unknown Gaussian noise is addressed, using the techniques of statistical hypothesis testing. Signal presence is sought in one data vector, and another independent set of signal-free data vectors is available which share the unknown covariance matrix of the noise in the former vector. A likelihood ratio decision rule is derived and its performance evaluated in both the noise-only and signal-plus-noise cases.

Abstract Ultrawide‐bandgap (UWBG) semiconductors, with bandgaps significantly wider than the 3.4 eV of GaN, represent an exciting and challenging new area of research in semiconductor materials, physics, devices, and applications. Because many figures‐of‐merit for device performance scale nonlinearly with bandgap, these semiconductors have long been known to have compelling potential advantages over their narrower‐bandgap cousins in high‐power and RF electronics, as well as in deep‐UV optoelectronics, quantum information, and extreme‐environment applications. Only recently, however, have the UWBG semiconductor materials, such as high Al‐content AlGaN, diamond and Ga 2 O 3 , advanced in maturity to the point where realizing some of their tantalizing advantages is a relatively near‐term possibility. In this article, the materials, physics, device and application research opportunities and challenges for advancing their state of the art are surveyed.

Spectral unmixing using hyperspectral data represents a significant step in the evolution of remote decompositional analysis that began with multispectral sensing. It is a consequence of collecting data in greater and greater quantities and the desire to extract more detailed information about the material composition of surfaces. Linear mixing is the key assumption that has permitted well-known algorithms to be adapted to the unmixing problem. In fact, the resemblance of the linear mixing model to system models in other areas has permitted a significant legacy of algorithms from a wide range of applications to be adapted to unmixing. However, it is still unclear whether the assumption of linearity is sufficient to model the mixing process in every application of interest. It is clear, however, that the applicability of models and techniques is highly dependent on the variety of circumstances and factors that give rise to mixed pixels. The outputs of spectral unmixing, endmember, and abundance estimates are important for identifying the material composition of mixtures.