Mitsubishi Corporation (United States)

This paper presents an application of genetic algorithms (GAs) to nonlinear constrained optimization. GAs are general purpose optimization algorithms which apply the rules of natural genetics to explore a given search space. When GAs are applied to nonlinear constrained problems, constraint handling becomes an important issue. The proposed search algorithm is realized by GAs which utilize a penalty function in the objective function to account for violation. This extension is based on systematic multi-stage assignments of weights in the penalty method as opposed to single-stage assignments in sequential unconstrained minimization. The experimental results are satisfactory and agree well with those of the gradient type methods.

The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) Global Digital Elevation Model (GDEM) was released to the public in My 2009. The GDEM version 2, currently under development, is reproduced using an updated algorithm and contains new ASTER data observed after September 2008. Validation study of the trial and beta version of GDEM version 2 was carried out to investigate its characteristics such as geolocation error, elevation error and horizontal resolution. The results of the study confirmed that elevation offset and horizontal resolution will be greatly improved in version 2 and the enhanced horizontal resolution will serve to reduce the standard deviation of elevation and geolocation error.

RATIONALE: There have been no recent comprehensive studies of the epidemiology of sarcoidosis in the United States. Changes in health care use have made available access to data on large numbers of patients with sarcoidosis. OBJECTIVES: To use a U.S. national health care database to gather data on patients with sarcoidosis identified over a 3-year period who were 18 years of age and older, and to determine health care costs for these patients. METHODS: The Optum health care database was queried for a 3-year period (2010-2013). This database includes approximately 15% of U.S. residents. The incidence rate of sarcoidosis was calculated for new cases identified in each year. Calculation of prevalence was based on any patient with sarcoidosis seen during the year. Incidence and prevalence rates are reported per 100,000 patients. MEASUREMENTS AND MAIN RESULTS: A total of 29,372 adult patients with sarcoidosis were identified. Of these, 14,700 (55%) were over 55 years of age at the time of diagnosis. The incidence and prevalence rates were higher for African Americans (17.8 and 141.4 per 100,000, respectively) than for white individuals (8.1 and 49.8), Hispanics (4.3 and 21.7), or Asians (3.2 and 18.9). Women were two times more likely to have sarcoidosis, with the highest prevalence for sarcoidosis noted in African American women (178.5). Overall, the yearly health care cost reported for patients with sarcoidosis was low, with a median of $18,663 per year. However, the yearly cost for the top 5% was $93,201. CONCLUSIONS: For patients 18 years of age and older enrolled in a U.S. national administrative database, sarcoidosis was more common among African Americans, but it was reported for all four of the major ethnic groups studied. While health care costs were relatively small for most patients, the cost of care for some patients was considerable.

Canonical transient receptor potential (TRPC) channels control influxes of Ca(2+) and other cations that induce diverse cellular processes upon stimulation of plasma membrane receptors coupled to phospholipase C (PLC). Invention of subtype-specific inhibitors for TRPCs is crucial for distinction of respective TRPC channels that play particular physiological roles in native systems. Here, we identify a pyrazole compound (Pyr3), which selectively inhibits TRPC3 channels. Structure-function relationship studies of pyrazole compounds showed that the trichloroacrylic amide group is important for the TRPC3 selectivity of Pyr3. Electrophysiological and photoaffinity labeling experiments reveal a direct action of Pyr3 on the TRPC3 protein. In DT40 B lymphocytes, Pyr3 potently eliminated the Ca(2+) influx-dependent PLC translocation to the plasma membrane and late oscillatory phase of B cell receptor-induced Ca(2+) response. Moreover, Pyr3 attenuated activation of nuclear factor of activated T cells, a Ca(2+)-dependent transcription factor, and hypertrophic growth in rat neonatal cardiomyocytes, and in vivo pressure overload-induced cardiac hypertrophy in mice. These findings on important roles of native TRPC3 channels are strikingly consistent with previous genetic studies. Thus, the TRPC3-selective inhibitor Pyr3 is a powerful tool to study in vivo function of TRPC3, suggesting a pharmaceutical potential of Pyr3 in treatments of TRPC3-related diseases such as cardiac hypertrophy.

We discovered that C-glucosides 4 bearing a heteroaromatic ring formed metabolically more stable inhibitors for sodium-dependent glucose cotransporter 2 (SGLT2) than the O-glucoside, 2 (T-1095). A novel thiophene derivative 4b-3 (canagliflozin) was a highly potent and selective SGLT2 inhibitor and showed pronounced anti-hyperglycemic effects in high-fat diet fed KK (HF-KK) mice.

Distributed generators (DGs) such as fuel cells, solar cells, wind mills and micro gas turbines, etc. are going to be installed on the demand side of power systems. Such distributed generators can reduce distribution loss if they are placed appropriately in the distribution system. In this paper, a tabu search application for finding the optimal allocation of DGs from a viewpoint of loss minimization is illustrated. In other words, the authors discuss about an implementation method of tabu search to find how much distribution loss can be reduced if DGs are optimally allocated at the demand side of a power system. Namely, locations and discrete capacities of DGs to minimize the distribution loss are determined by nested use of the tabu search algorithm. Numerical examples are shown to demonstrate the method.

Although the renin angiotensin system (RAS) is a major regulator of vascular homeostasis, the role of the RAS in tumor angiogenesis is little understood. Here we show that host angiotensin II (ATII) type 1 (AT1) receptor plays an important role in angiogenesis and growth of tumor cells engrafted in mice. Subcutaneous B16-F1 melanoma-induced angiogenesis as assessed by tissue capillary density and microangiography was prominent in WT mice but was reduced in AT1a receptor-deficient (AT1a-/-) mice. Consequently, tumor growth rate was significantly slower, and the mouse survival rate was greater, in AT1a-/- mice than in WT mice. Tumor growth was also reduced in WT mice treated with TCV-116, a selective blocker of AT1 receptor. Because the beta-galactosidase gene was inserted into the AT1a gene locus in AT1a-/- mice, the site of beta-galactosidase expression represents the AT1a receptor expression in these mutant mice. In tumor-implanted AT1a-/- mice, the major site of the beta-galactosidase expression was macrophages in tissues surrounding tumors. Moreover, the number of infiltrated macrophages was significantly lower in AT1a-/- mice than in WT mice, and double-immunofluorescence staining revealed that these macrophages expressed VEGF protein intensively. Therefore, the host ATII-AT1 receptor pathway supports tumor-associated macrophage infiltration, which results in enhanced tissue VEGF protein levels. The host ATII-AT1 receptor pathway thereby plays important roles in tumor-related angiogenesis and growth in vivo.

Alzheimer's disease (AD) brains contain neurofibrillary tangles (NFTs) composed of abnormally hyperphosphorylated tau protein. Regional reductions in cerebral glucose metabolism correlating to NFT densities have been reported in AD brains. Assuming that reduced glucose metabolism might cause abnormal tau hyperphosphorylation, we induced in vivo alterations of glucose metabolism in mice by starvation or intraperitoneal injections of either insulin or deoxyglucose. We found that the treatments led to abnormal tau hyperphosphorylation with patterns resembling those in early AD brains and also resulted in hypothermia. Surprisingly, tau hyperphosphorylation could be traced down to a differential effect of low temperatures on kinase and phosphatase activities. These data indicate that abnormal tau hyperphosphorylation is associated with altered glucose metabolism through hypothermia. Our results imply that serine-threonine protein phosphatase 2A plays a major role in regulating tau phosphorylation in the adult brain and provide in vivo evidence for its crucial role in abnormal tau hyperphosphorylation in AD.

We propose an algorithm utilizing geodesic distances to upsample a low resolution depth image using a registered high resolution color image. Specifically, it computes depth for each pixel in the high resolution image using geodesic paths to the pixels whose depths are known from the low resolution one. Though this is closely related to the all-pair-shortest-path problem which has O(n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> log n) complexity, we develop a novel approximation algorithm whose complexity grows linearly with the image size and achieve realtime performance. We compare our algorithm with the state of the art on the benchmark dataset and show that our approach provides more accurate depth upsampling with fewer artifacts. In addition, we show that the proposed algorithm is well suited for upsampling depth images using binary edge maps, an important sensor fusion application.

Raman spectroscopy was used for analysis of phase transformations and residual stress in machined silicon. Wear debris from dicing of silicon was scanned with a Raman spectrometer. Recorded spectra manifest the presence of amorphous Si, hexagonal phase (Si-IV), bc8 phase (Si-III) and pristine Si-I under residual stress. On surfaces of diced wafers as well as lapped silicon wafers, the r8 phase (Si-XII) was detected in addition to the above phases. The composition of phases in diced cross sections of silicon wafers differs dramatically between high and low speed cuts. The quantification of these phases was attempted by curve fitting each spectrum with corresponding peaks of each phase. Subsequently, relative intensity maps of specific phases were generated. Thus, Raman spectroscopy studies of machined surfaces demonstrated metallization of Si under a variety of machining conditions including lapping, grinding, scratching, dicing and slicing. All metastable phases of silicon disappear after etching and polishing of respective wafers. No evidence of phase transformations was found on a quartz-damaged silicon wafer surface. Residual stress having a characteristic distribution was observed in this case.

&lt;div class="htmlview paragraph"&gt;Investigations of Homogeneous Charge Compression Ignition (HCCI) combustion have been actively conducted as a new combustion technology to substantially and simultaneously reduce NOx and soot to comply with the future stringent exhaust emission regulations. In the past, a method of injecting fuel at the initial stage of the compression stroke has been proposed, but it is known that fuel adheres to the cylinder wall, causing a decline in combustion efficiency and oil dilution. The authors have developed Premixed Compression Ignition (PCI) combustion as a technology of solving the above problem as well as simultaneously reducing NOx and soot. In PCI combustion, fuel is injected into a combustion chamber in the vicinity of the top dead center for preventing fuel from adhering to the wall, and pre-mixture, which is formed shortly before ignition, is burnt. By pre-mixing, this combustion reduces the over-rich region of the mixture to reduce soot emissions, and at the same time lowers the combustion temperature by introducing a large amount of EGR to reduce NOx emissions.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper reports the result of detailed examination of the basic characteristics of PCI combustion using a single-cylinder engine, and that PCI combustion which uses our investigated approaching can achieve substantial and simultaneous reduction of NOx and soot. This paper also studies the possibility of realizing Split-PCI combustion, which uses the two different combustion modes of PCI combustion and diffusion combustion during one cycle, in high-load operation where application of PCI combustion is restricted by diesel knock. As results of this study, this paper reports that it is available to reduce NOx and soot emissions to a large extent by Split-PCI combustion, even in high-load operation.&lt;/div&gt;

We present a simultaneous localization and mapping (SLAM) algorithm for a hand-held 3D sensor that uses both points and planes as primitives. We show that it is possible to register 3D data in two different coordinate systems using any combination of three point/plane primitives (3 planes, 2 planes and 1 point, 1 plane and 2 points, and 3 points). Our algorithm uses the minimal set of primitives in a RANSAC framework to robustly compute correspondences and estimate the sensor pose. As the number of planes is significantly smaller than the number of points in typical 3D data, our RANSAC algorithm prefers primitive combinations involving more planes than points. In contrast to existing approaches that mainly use points for registration, our algorithm has the following advantages: (1) it enables faster correspondence search and registration due to the smaller number of plane primitives; (2) it produces plane-based 3D models that are more compact than point-based ones; and (3) being a global registration algorithm, our approach does not suffer from local minima or any initialization problems. Our experiments demonstrate real-time, interactive 3D reconstruction of indoor spaces using a hand-held Kinect sensor.

In this paper, we will report some recent progress on wireless power transfer (WPT) based on resonant coupling. Two major technologies will be discussed: the use of metamaterials and array of coupled resonators. With a slab of metamaterial, the near-field coupling between two resonant coils can be enhanced; the power transfer efficiency between coils is boosted by the metamaterial. The principle of enhanced coupling with metamaterial will be discussed; the design of metamaterial slabs for near-field wireless power transfer will be shown; recent experimental results on wireless power transfer efficiency improvement with metamaterial will also be presented. By using an array of resonators, the range of efficient power transfer can be greatly extended. More importantly, this new technology can provide wireless power to both static and mobile devices dynamically. The principle of this technology will be explained; analytical and numerical models will be used to evaluate the performance of a WPT system with an array of resonators; recent experimental developments will also be presented.

The decomposition of and the stability of in organic solvents, diethyl carbonate (DEC), dimethyl carbonate (DMC), γ-butyrolactone (GBL), and ethylene carbonate (EC), have been investigated through density functional theory (DFT) calculations, in which solvent was modeled as a dielectric continuum, and also by molecular dynamics (MD) simulations which treated solvents explicitly. Both calculations showed a similar trend in which the decomposition was further promoted in more polar solvents, yet the DFT calculations predicted an endothermic decomposition, while the MD simulations indicated exothermic. This sharp contrast in the results suggests strong solute-solvent interactions, especially for which were not accounted for in the DFT calculations. The specific interaction between and solvent was further investigated by DFT calculations for adduct models and also by the MD simulations for solutions. Both calculations suggest a stable formation of a -solvent adduct in solution and its stability depends on the solvent. It was found that is more stabilized in polar and sterically compact solvents such as EC and GBL than in less polar and bulky, linear carbonates such as DMC and DEC. The reactivity of with organic solvents and the difference in the stability of between organic and aqueous solution are also discussed. © 2003 The Electrochemical Society. All rights reserved.

Using atomic force microscopy with a spherical indenter, we evaluated the surface and bulk elastic modulus of thick and thin polystyrene films. The elastic modulus of the thick films at penetration depths of more than 10nm was equivalent to that of bulk measured by a tensile test. In the thin films, the estimated values were greatly affected by the substrate material at penetration depths of more than 7nm. When the penetration depth was less than 5nm, however, the elastic modulus of both thin and thick films was slightly smaller than that of the bulk values.

This paper describes a divided word-line (DWL) structure which solves inherent problems encountered in VLSI static RAMs. The key feature is to divide the word-line and to select it hierarchically with little area penalty using conventional process technology. In the application of the DWL structure, an 8K /spl times/ 8 full CMOS RAM has been developed with 2-/spl mu/m double polysilicon technology. The RAM has a typical access time of 60 ns. An operating current of 20 mA was obtained with a simple static design. The six-transistor cell configuration achieved a low standby current of less than 10 nA. For further improvement in speed, the second poly-Si layer was replaced with a polycide (poly-Si + MoSi/SUB 2/) layer, thus providing a 50-ns address access time.

RATIONALE: Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because of concerns regarding radiation exposure and cost. OBJECTIVES: To evaluate biomarkers associated with emphysema and COPD-related clinical characteristics, and to assess the relationships of soluble receptor for advanced glycation endproducts (sRAGE), a candidate systemic biomarker identified in this study, with single-nucleotide polymorphisms (SNPs) in the gene coding for RAGE (AGER locus) and with clinical characteristics. METHODS: Circulating levels of 111 biomarkers were analyzed for association with clinical characteristics in 410 patients with COPD enrolled in the TESRA study. sRAGE was also measured in the ECLIPSE cohort in 1,847 patients with COPD, 298 smokers and 204 nonsmokers. The association between 21 SNPs in the AGER locus with sRAGE levels and clinical characteristics was also investigated. MEASUREMENTS AND MAIN RESULTS: sRAGE was identified as a biomarker of diffusing capacity of carbon monoxide and lung density in the TESRA cohort. In the ECLIPSE cohort, lower sRAGE levels were associated with increased emphysema, increased Global Initiative for Chronic Obstructive Lung Disease stage, and COPD disease status. The associations with emphysema in both cohorts remained significant after covariate adjustment (P < 0.0001). One SNP in the AGER locus, rs2070600, was associated with circulating sRAGE levels both in TESRA (P = 0.0014) and ECLIPSE (7.07 × 10(-16)), which exceeded genome-wide significance threshold. Another SNP (rs2071288) was also associated with sRAGE levels (P = 0.01) and diffusing capacity of carbon monoxide (P = 0.01) in the TESRA study. CONCLUSIONS: Lower circulating sRAGE levels are associated with emphysema severity and genetic polymorphisms in the AGER locus are associated with systemic sRAGE levels. Clinical trial registered with www.clinicaltrials.gov (NCT 00413205 and NCT 00292552).

Hypertonic peritoneal dialysis is frequently utilized to remove excess sodium and water from the body. It is shown that the ultrafiltrate is probably of extracellular origin and is invariably hyponatric to serum. Sodium accompanies the bulk flow of water in varying amounts from patient to patient. Factors that influence the transperitoneal transport of sodium, in response to slight diffusion gradients and the solvent drag effect of bulk flow, seem to include peritoneal membrane permeability and the extracellular anionic environment. A method for the proper management of sodium and water removal by hypertonic peritoneal dialysis is described by which hypernatremia, a frequently reported complication, may be prevented. The increase in serum sodium concentration results from the proportionally greater removal of extracellular water than sodium and is not dependent on the development of hyperglycemia or sodium diffusion from dialysate to extracellular fluid, as has been previously reported.

The price of crude oil never exceeded $40 per barrel until mid-2004. By July 2008 it peaked at $145 and by late 2008 it fell to $30 before increasing to $110 in 2011. Are speculators partly to blame for these price changes? Using a simple model of supply and demand in the cash and storage markets, we determine whether speculation is consistent with data on production, inventory changes, and convenience yields. We focus on crude oil, but our approach can be applied to other commodities. We show speculation had little, if any, effect on oil prices. (JEL G13, G18, G23, G31, Q35, Q38)

Degenerative lesions were induced in the knee joint of Wistar rats by intraarticular injection of chondrocyte metabolism inhibitor mono-iodoacetate (MIA) at doses of 0, 0.3 or 3 mg/joint. Histopathological examination and the measurement of hind paw weight ratio as an index of joint pain by incapacitance tester were performed. Histological findings that are similar to those observed in human osteoarthritis (OA), such as disorganization of chondrocytes, erosion and fibrillation of cartilage surface, and subchondral bone exposure etc., were observed in a MIA-dose-dependent manner. Saflanin-O fast green staining revealed that marked diffuse reduction of proteoglycan in cartilage tissue of rats treated with MIA. The clinical scores of the joint pain were closely correlated to the grade of histological findings. We conclude that the present experimental model in combination with a novel dual channel weight averager would be very useful for the study of human OA, and could be applied for estimation of therapeutic effect of new anti-OA drugs.