Patrick Air Force Base

We present the impact tests that preceded the most recent operational upgrades to the land surface model used in the National Centers for Environmental Prediction (NCEP) mesoscale Eta model, whose operational domain includes North America. These improvements consist of changes to the “Noah” land surface model (LSM) physics, most notable in the area of cold season processes. Results indicate improved performance in forecasting low‐level temperature and humidity, with improvements to (or without affecting) the overall performance of the Eta model quantitative precipitation scores and upper air verification statistics. Remaining issues that directly affect the Noah LSM performance in the Eta model include physical parameterizations of radiation and clouds, which affect the amount of available energy at the surface, and stable boundary layer and surface layer processes, which affect surface turbulent heat fluxes and ultimately the surface energy budget.

Consumers’ buying behavior is not consistent with their positive attitude toward ethical products. In a survey of 808 Belgian respondents, the actual willingness to pay for fair‐trade coffee was measured. It was found that the average price premium that the consumers were willing to pay for a fair‐trade label was 10%. Ten percent of the sample was prepared to pay the current price premium of 27% in Belgium. Fair‐trade lovers (11%) were more idealistic, aged between 31 and 44 years and less “conventional.” Fair‐trade likers (40%) were more idealistic but sociodemographically not significantly different from the average consumer.

ABSTRACT We use option prices to estimate ex ante higher moments of the underlying individual securities’ risk‐neutral returns distribution. We find that individual securities’ risk‐neutral volatility, skewness, and kurtosis are strongly related to future returns. Specifically, we find a negative (positive) relation between ex ante volatility (kurtosis) and subsequent returns in the cross‐section, and more ex ante negatively (positively) skewed returns yield subsequent higher (lower) returns. We analyze the extent to which these returns relations represent compensation for risk and find evidence that, even after controlling for differences in co‐moments, individual securities’ skewness matters.

cardiac troponin high sensitivity cardiac troponin myocardial injury prior myocardial infarction silent myocardial infarction recurrent myocardial infarction reinfarction cardiac procedural myocardial injury Takotsubo syndrome myocardial infarction with nonobstructive coronary arteries (MINOCA)

BACKGROUND: Photodamaged skin is characterized not only by rhytides, but also by epidermal and dermal atrophy, rough skin texture, irregular pigmentation, telangiectasias, laxity, and enlarged pores. There is growing interest in the development of noninvasive methods to treat photodamaged skin. Skin photorejuvenation is the visible improvement of photodamaged skin using a laser or other light source. A noncoherent, broadband, pulsed light source is effective in the treatment of vascular and pigmented lesions of the skin. This study evaluates the role of intense pulsed light in the rejuvenation of photo aged skin. OBJECTIVE: The purpose of this study was to evaluate and quantify the degree of visible improvement in photodamaged skin following a series of full-face, intense pulsed light treatments. METHODS: Forty-nine subjects with varying degrees of photo-damage were treated with a series of four or more full-face treatments at 3-week intervals using a nonablative, nonlaser intense pulsed visible light source. Fluences varied from 30 to 50 J/cm2. Subject evaluation and skin biopsies were used to assess treatment results. RESULTS: All aspects of photodamage including wrinkling, skin coarseness, irregular pigmentation, pore size, and telangiectasias showed visible improvement in more than 90% of subjects with minimal downtime and no scarring. Eighty-eight percent of subjects were satisfied with the overall results of their treatments. CONCLUSION: Treatment of photodamaged facial skin using a series of full-face treatments with intense pulsed light is a new and effective noninvasive method of skin rejuvenation with minimal risk and no patient downtime.

Satellite‐based precipitation estimates have great potential for a wide range of critical applications, but their error characteristics need to be examined and understood. In this study, six (6) high‐resolution, satellite‐based precipitation data sets are evaluated over the contiguous United States against a gauge‐based product. An error decomposition scheme is devised to separate the errors into three independent components, hit bias, missed precipitation, and false precipitation, to better track the error sources associated with the satellite retrieval processes. Our analysis reveals the following. (1) The three components for each product are all substantial, with large spatial and temporal variations. (2) The amplitude of individual components sometimes is larger than that of the total errors. In such cases, the smaller total errors are resulting from the three components canceling one another. (3) All the products detected strong precipitation (>40 mm/d) well, but with various biases. They tend to overestimate in summer and underestimate in winter, by as much as 50% in either season, and they all miss a significant amount of light precipitation (<10 mm/d), up to 40%. (4) Hit bias and missed precipitation are the two leading error sources. In summer, positive hit bias, up to 50%, dominates the total errors for most products. (5) In winter, missed precipitation over mountainous regions and the northeast, presumably snowfall, poses a common challenge to all the data sets. On the basis of the findings, we recommend that future efforts focus on reducing hit bias, adding snowfall retrievals, and improving methods for combining gauge and satellite data. Strategies for future studies to establish better links between the errors in the end products and the upstream data sources are also proposed.

A Moraxella strain grew on p-nitrophenol with stoichiometric release of nitrite. During induction of the enzymes for growth on p-nitrophenol, traces of hydroquinone accumulated in the medium. In the presence of 2,2'-dipyridyl, p-nitrophenol was converted stoichiometrically to hydroquinone. Particulate enzymes catalyzed the conversion of p-nitrophenol to hydroquinone in the presence of NADPH and oxygen. Soluble enzymes catalyzed the conversion of hydroquinone to gamma-hydroxymuconic semialdehyde, which was identified by high-performance liquid chromatography (HPLC)-mass spectroscopy. Upon addition of catalytic amounts of NAD, gamma-hydroxymuconic semialdehyde was converted to beta-ketoadipic acid. In the presence of pyruvate and lactic dehydrogenase, substrate amounts of NAD were required and gamma-hydroxymuconic semialdehyde was converted to maleylacetic acid, which was identified by HPLC-mass spectroscopy. Similar results were obtained when the reaction was carried out in the presence of potassium ferricyanide. Extracts prepared from p-nitrophenol-growth cells also contained an enzyme that catalyzed the oxidation of 1,2,4-benzenetriol to maleylacetic acid. The enzyme responsible for the oxidation of 1,2,4-benzenetriol was separated from the enzyme responsible for hydroquinone oxidation by DEAE-cellulose chromatography. The results indicate that the pathway for biodegradation of p-nitrophenol involves the initial removal of the nitro group as nitrite and formation of hydroquinone. 1,4-Benzoquinone, a likely intermediate in the initial reaction, was not detected. Hydroquinone is converted to beta-ketoadipic acid via gamma-hydroxymuconic semialdehyde and maleylacetic acid.

A temporally and spatially comprehensive depiction of the tropical tropopause is presented, based on radiosonde data from 83 stations. Climatological statistics for 1961–1990 are computed for three levels: the conventional lapse‐rate tropopause (LRT), the cold‐point tropopause (CPT), and the 100 hPa level. Mean values and seasonal and interannual variations of temperature, pressure, height, potential temperature, and water vapor saturation mixing ratio at these levels are compared. The tropopause is higher, colder, and at lower pressure in the Northern Hemisphere (NH) than in the Southern Hemisphere (SH) in NH winter. This pattern reverses in NH summer, except that the tropopause remains colder in the NH than in the SH. The climatological locations of minimum tropopause temperature differ from those of maximum height and minimum pressure: In NH winter the tropopause is coldest over the western tropical Pacific warm pool region, but it is highest and at lowest pressure over the western Atlantic. Correlations of interannual anomalies in zonal‐mean characteristics reveal that the height of the tropopause reflects the temperature of the underlying troposphere. Tropopause temperature, on the other hand, shows little association with tropospheric characteristics but is significantly correlated with the temperature and pressure of the lower stratosphere. The 100 hPa level is a poor surrogate for the tropical tropopause. Changes in radiosonde instrumentation limit the potential for detecting tropopause trends. However, the following (nonmonotonic) trends in the tropopause in the deep tropics during 1978–1997 seem robust: an increase in height of about 20 m decade −1 , a decrease in pressure of about 0.5 hPa decade −1 , a cooling of about 0.5 K decade −1 , little change in potential temperature, and a decrease in saturation volume mixing ratio of about 0.3 ppmv decade −1 .

Recent metagenomics studies of environmental samples suggested that microbial communities are much more diverse than previously reported, and deep sequencing will significantly increase the estimate of total species diversity. Massively parallel pyrosequencing technology enables ultra-deep sequencing of complex microbial populations rapidly and inexpensively. However, computational methods for analyzing large collections of 16S ribosomal sequences are limited. We proposed a new algorithm, referred to as ESPRIT, which addresses several computational issues with prior methods. We developed two versions of ESPRIT, one for personal computers (PCs) and one for computer clusters (CCs). The PC version is used for small- and medium-scale data sets and can process several tens of thousands of sequences within a few minutes, while the CC version is for large-scale problems and is able to analyze several hundreds of thousands of reads within one day. Large-scale experiments are presented that clearly demonstrate the effectiveness of the newly proposed algorithm. The source code and user guide are freely available at http://www.biotech.ufl.edu/people/sun/esprit.html.

Laparoscopy approach to cholecystectomy has shortened the recovery period, reducing discharge times from 1 to 3 days to same-day discharge. We hypothesize that the use of more than one modality to prevent postoperative pain may be more efficacious than single modality. Patients were randomized to a treatment (n = 24) or control (n = 25) group and studied using a prospective, double-blind design. Preoperatively, at 45 min before induction of anesthesia, the treatment group received an intramuscular (IM) bolus injection of meperidine 0.6 mg/kg and ketorolac 0.5 mg/kg. The control group received two bolus IM injections of placebo (normal saline). Ten minutes before incision, local anesthesia (treatment group) or saline (control group) was infiltrated into the skin of each patient. Anesthetic management, postoperative pain, and nausea treatment were standardized. Pain and nausea assessment were done 1 h preoperatively, 0, 0.5, 1, 2, 3, and 4 h postoperatively, at discharge, and 10, 24, and 48 h postoperatively. Patients were discharged by scoring criteria. Postoperatively, significantly more patients in the treatment group were without pain on arrival in the postanesthesia care unit (PACU), 12/21 (57.1%) vs 1/24 (4.2%) in the control group (P < 0.001). Similarly, the severity of pain was sixfold less in the treatment group than in the control group. The incidence of nausea in the PACU was significantly less in the treatment group; 4.7% vs 29.5% in the control group (P < 0.05). Patients from the treatment group satisfied Postanesthesia Discharge Score significantly earlier than those in the control group (281 +/- 12 min vs 375 +/- 19 min; P < 005). The concomitant use of local anesthetic and nonsteroidal antiinflammatory and opioid drugs proved to be highly effective in our patients, resulting in faster recovery and discharge.

This paper provides an overview of the current body of knowledge surrounding the human response to change and transition. Models of the change process, as perceived by diverse and seemingly unrelated disciplines, are identified, compared, and contrasted by tracing the evolution of these models from seminal works through contemporary research. Surprisingly, a majority of the models studied were found to share two important characteristics: they follow Lewin’s 1952 three‐phase model of change; and they describe a degradation of capabilities in the intermediate stages of the change process. In a practical example, the authors explain their experimental verification of the change models’ applicability to an organizational change involving the introduction of teams. The interrelationship of developmental and change models is discussed. Finally, the importance to leaders and managers of developing an understanding of the current state‐of‐the‐art in human response to change and transition is discussed.

The atmospheric budgets of mass, water vapor, heat, momentum, and mechanical energy have been analyzed for a 5-day undisturbed period (June 22–26, 1969) during the Barbados Oceanographic and Meteorological Experiment (BOMEX). Data were obtained from rawinsondes launched every 1½ hr from the four corner ships of the BOMEX array. Computations were limited to the lowest 500 mb within a 500-km square centered at 15°N, 56°30′W. The mass budget is characterized by mean, low-level divergence and downward motion. Maximum divergence (5 × 10−6 s−1) is found approximately 80 mb above the surface and maximum subsidence near the base of the trade-wind inversion. The computed average evaporation is 6.0 mm/day. The computations show an upward flux of moisture through the trade inversion by subgrid-scale eddies, but the mean downward flux dominates, leading to a net downward transfer of moisture through the trade inversion. A surface stress of 0.065 Newtons (N)·m−2 is computed from the momentum balance with the top of the friction layer approximately 130 mb above the surface. Computed frictional loss of grid-scale kinetic energy within the boundary layer is 0.8 W·m−2. Heat balance computations indicate a Bowen ratio of approximately 0.1. Comparison of profiles of subgrid-scale moisture flux and nonradiative diabatic heating suggests that condensation and evaporation processes associated with the development and dissipation of trade-wind cumulus can make a significant contribution to the heat balance of the cloud and trade inversion layers.

A Pseudomonas pseudoalcaligenes able to use nitrobenzene as the sole source of carbon, nitrogen, and energy was isolated from soil and groundwater contaminated with nitrobenzene. The range of aromatic substrates able to support growth was limited to nitrobenzene, hydroxylaminobenzene, and 2-aminophenol. Washed suspensions of nitrobenzene-grown cells removed nitrobenzene from culture fluids with the concomitant release of ammonia. Nitrobenzene, nitrosobenzene, hydroxylaminobenzene, and 2-aminophenol stimulated oxygen uptake in resting cells and in extracts of nitrobenzene-grown cells. Under aerobic and anaerobic conditions, crude extracts converted nitrobenzene to 2-aminophenol with oxidation of 2 mol of NADPH. Ring cleavage, which required ferrous iron, produced a transient yellow product with a maximum A380. In the presence of NAD, the product disappeared and NADH was produced. In the absence of NAD, the ring fission product was spontaneously converted to picolinic acid, which was not further metabolized. These results indicate that the catabolic pathway involves the reduction of nitrobenzene to nitrosobenzene and then to hydroxylaminobenzene; each of these steps requires 1 mol of NADPH. An enzyme-mediated Bamberger-like rearrangement converts hydroxylaminobenzene to 2-aminophenol, which then undergoes meta ring cleavage to 2-aminomuconic semialdehyde. The mechanism for release of ammonia and subsequent metabolism are under investigation.

The Department of Gynecology, Johns Hopkins Hospital, Baltimore, Maryland * Present Address: Obstetrical and Gynecological Service, 1100th USAF Hospital, Bolling Air Force Base, Washington, 25, D. C.

The degradation of p-nitrophenol (PNP) by Moraxella and Pseudomonas spp. involves an initial monooxygenase-catalyzed removal of the nitro group. The resultant hydroquinone is subject to ring fission catalyzed by a dioxygenase enzyme. We have isolated a strain of an Arthrobacter sp., JS443, capable of degrading PNP with stoichiometric release of nitrite. During induction of the enzymes required for growth on PNP, 1,2,4-benzenetriol was identified as an intermediate by gas chromatography-mass spectroscopy (GC-MS) and radiotracer studies. 1,2,4-Benzenetriol was converted to maleylacetic acid, which was further degraded by the beta-ketoadipate pathway. Conversion of PNP to 1,2,4-benzenetriol is catalyzed by a monooxygenase system in strain JS443 through the formation of 4-nitrocatechol, 4-nitroresorcinol, or both. Our results clearly indicate the existence of an alternative pathway for the biodegradation of PNP.

Exposure to hydrazine and hydrazines' alkylated derivatives is an important occupational health issue, which will increase in significance as space applications increase. Despite their widespread usage as rocket fuels in manned and unmanned space and missile systems, serious exposures to hydrazines are rare. While a significant number of experimental studies were performed in the late 1950s through the mid-1960s, conflicting information exists concerning the most appropriate treatment for these exposures. A cross-sectional study evaluating the most common rocket fuels such as hydrazine; 1,1-dimethylhydrazine (UDMH); mono-methylhydrazine (MMH); and Aerozine-50 against the most commonly suggested therapies, such as pyridoxine, traditional antiseizure therapies, and arginine is needed to clarify the treatment implications for human exposure. Treatments that have been useful for hyperammonemic states, such as those for the six inherited urea cycle defects, have significant potential for the improvement of hydrazine exposure treatment.

Lanza, Frank L MD, FACG the Members of the Ad Hoc Committee on Practice Parameters of the American College of Gastroenterology Author Information

Recent terrorist attacks indicate the improvised explosive device as the choice terror tactic. Over the past decade, the U.S. Department of Defense has encouraged and sponsored research toward developing methods of reinforcing structures to protect building occupants from the effects of external explosion. The focus of wall reinforcement research has recently shifted from applying stiff fiber-reinforced composites to using lower-strength higher-elongation elastomeric polymers that can be easily applied to the wall interior. This paper presents recent efforts that have demonstrated an innovative use of thin-membrane elastomeric polymers to prevent breaching and collapse of unreinforced masonry walls subjected to blast. The complex array of failure mechanisms observed from recent explosive tests is discussed. Effects of structural and nonstructural parameters are described with the aid of finite-element simulations. Finally, the needs and direction of future blast reinforcement developments are outlined.

The operation of a small area p-n junction diode above the breakdown voltage is analyzed. A new formulation in terms of ionization probability is used to derive the rate of turn-on of current in such structures. Two differential equations are given which may be used to compute the probability that a carrier swept into or generated within the space-charge region triggers avalanche breakdown. For a 27-V n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -p diode biased 1 V above breakdown, this probability is close to 0.5 for an electron entering from the p side, or 0.1 for a hole entering from n side. Experimental measurements are in good agreement with the theoretical predictions.

Doppler weather radar imaging enabled the rapid recovery of the Sutter's Mill meteorite after a rare 4-kiloton of TNT-equivalent asteroid impact over the foothills of the Sierra Nevada in northern California. The recovered meteorites survived a record high-speed entry of 28.6 kilometers per second from an orbit close to that of Jupiter-family comets (Tisserand's parameter = 2.8 ± 0.3). Sutter's Mill is a regolith breccia composed of CM (Mighei)-type carbonaceous chondrite and highly reduced xenolithic materials. It exhibits considerable diversity of mineralogy, petrography, and isotope and organic chemistry, resulting from a complex formation history of the parent body surface. That diversity is quickly masked by alteration once in the terrestrial environment but will need to be considered when samples returned by missions to C-class asteroids are interpreted.