Philips (United States)

Semiconducting ${\mathrm{Ni}}_{0.4}$${\mathrm{Zn}}_{0.6}$${\mathrm{Fe}}_{2}$${\mathrm{O}}_{4}$, prepared in different ways, has been investigated. It appeared that the ac resistivity and the apparent dielectric constant of the material show a dispersion which can be explained satisfactorily with the help of a simple model of the solid: there should be well-conducting grains separated by layers of lower conductivity. Dispersion formulas are given. There is good agreement between experiment and theory.

PURPOSE: The development of computer-aided diagnostic (CAD) methods for lung nodule detection, classification, and quantitative assessment can be facilitated through a well-characterized repository of computed tomography (CT) scans. The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI) completed such a database, establishing a publicly available reference for the medical imaging research community. Initiated by the National Cancer Institute (NCI), further advanced by the Foundation for the National Institutes of Health (FNIH), and accompanied by the Food and Drug Administration (FDA) through active participation, this public-private partnership demonstrates the success of a consortium founded on a consensus-based process. METHODS: Seven academic centers and eight medical imaging companies collaborated to identify, address, and resolve challenging organizational, technical, and clinical issues to provide a solid foundation for a robust database. The LIDC/IDRI Database contains 1018 cases, each of which includes images from a clinical thoracic CT scan and an associated XML file that records the results of a two-phase image annotation process performed by four experienced thoracic radiologists. In the initial blinded-read phase, each radiologist independently reviewed each CT scan and marked lesions belonging to one of three categories ("nodule > or =3 mm," "nodule <3 mm," and "non-nodule > or =3 mm"). In the subsequent unblinded-read phase, each radiologist independently reviewed their own marks along with the anonymized marks of the three other radiologists to render a final opinion. The goal of this process was to identify as completely as possible all lung nodules in each CT scan without requiring forced consensus. RESULTS: The Database contains 7371 lesions marked "nodule" by at least one radiologist. 2669 of these lesions were marked "nodule > or =3 mm" by at least one radiologist, of which 928 (34.7%) received such marks from all four radiologists. These 2669 lesions include nodule outlines and subjective nodule characteristic ratings. CONCLUSIONS: The LIDC/IDRI Database is expected to provide an essential medical imaging research resource to spur CAD development, validation, and dissemination in clinical practice.

We report for the first time that doped nanocrystals of semiconductor can yield both high luminescent efficiencies and lifetime shortening at the same time. Nanocrystals of Mn-doped ZnS with sizes varying from 3.5 to 7.5 nm were prepared by a room temperature chemical process. These nanosized particles have an external photoluminescent quantum efficiency as high as 18% at room temperature and a luminescent decay at least 5 orders of magnitude faster than the corresponding ${\mathrm{Mn}}^{2+}$ radiative transition in the bulk crystals. Luminescent measurements show that the efficiency increases with decreasing size of the particles, as expected within the framework of an electron-hole localization theory. These results suggest that doped nanocrystals are indeed a new class of materials heretofore unknown.

Status and future outlook of III-V compound semiconductor visible-spectrum light-emitting diodes (LEDs) are presented. Light extraction techniques are reviewed and extraction efficiencies are quantified in the 60%+ (AlGaInP) and ~80% (InGaN) regimes for state-of-the-art devices. The phosphor-based white LED concept is reviewed and recent performance discussed, showing that high-power white LEDs now approach the 100-lm/W regime. Devices employing multiple phosphors for "warm" white color temperatures (~3000-4000 K) and high color rendering (CRI>80), which provide properties critical for many illumination applications, are discussed. Recent developments in chip design, packaging, and high current performance lead to very high luminance devices (~50 Mcd/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> white at 1 A forward current in 1times1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> chip) that are suitable for application to automotive forward lighting. A prognosis for future LED performance levels is considered given further improvements in internal quantum efficiency, which to date lag achievements in light extraction efficiency for InGaN LEDs

Recognizing the critical need for standardization in strain imaging, in 2010, the European Association of Echocardiography (now the European Association of Cardiovascular Imaging, EACVI) and the American Society of Echocardiography (ASE) invited technical representatives from all interested vendors to participate in a concerted effort to reduce intervendor variability of strain measurement. As an initial product of the work of the EACVI/ASE/Industry initiative to standardize deformation imaging, we prepared this technical document which is intended to provide definitions, names, abbreviations, formulas, and procedures for calculation of physical quantities derived from speckle tracking echocardiography and thus create a common standard.

A general formalism is developed by means of which the radiative heat transfer between macroscopic bodies of arbitrary dispersive and absorptive dielectric properties can be evaluated. The general formalism is applied to the heat transfer across a vacuum gap between two identical semi-infinite bodies at different temperatures. The peculiarities arising when the gap width is of the order of, or smaller than, the dominant thermal radiation wavelengths are studied and quantitatively evaluated for the case of two metal bodies. The predicted strong increase with diminishing gap width is in qualitative agreement with experimental results.

BACKGROUND: As more and more researchers are turning to big data for new opportunities of biomedical discoveries, machine learning models, as the backbone of big data analysis, are mentioned more often in biomedical journals. However, owing to the inherent complexity of machine learning methods, they are prone to misuse. Because of the flexibility in specifying machine learning models, the results are often insufficiently reported in research articles, hindering reliable assessment of model validity and consistent interpretation of model outputs. OBJECTIVE: To attain a set of guidelines on the use of machine learning predictive models within clinical settings to make sure the models are correctly applied and sufficiently reported so that true discoveries can be distinguished from random coincidence. METHODS: A multidisciplinary panel of machine learning experts, clinicians, and traditional statisticians were interviewed, using an iterative process in accordance with the Delphi method. RESULTS: The process produced a set of guidelines that consists of (1) a list of reporting items to be included in a research article and (2) a set of practical sequential steps for developing predictive models. CONCLUSIONS: A set of guidelines was generated to enable correct application of machine learning models and consistent reporting of model specifications and results in biomedical research. We believe that such guidelines will accelerate the adoption of big data analysis, particularly with machine learning methods, in the biomedical research community.

Local binary pattern (LBP) is a nonparametric descriptor, which efficiently summarizes the local structures of images. In recent years, it has aroused increasing interest in many areas of image processing and computer vision and has shown its effectiveness in a number of applications, in particular for facial image analysis, including tasks as diverse as face detection, face recognition, facial expression analysis, and demographic classification. This paper presents a comprehensive survey of LBP methodology, including several more recent variations. As a typical application of the LBP approach, LBP-based facial image analysis is extensively reviewed, while its successful extensions, which deal with various tasks of facial image analysis, are also highlighted.

A simple physical model of 1-3 composite piezoelectrics is advanced for the material properties that are relevant to thickness-mode oscillations. This model is valid when the lateral spatial scale of the composite is sufficiently fine that the composite can be treated as an effective homogeneous medium. Expressions for the composite's material parameters in terms of the volume fraction of piezoelectric ceramic and the properties of the constituent piezoelectric ceramic and passive polymer are derived. A number of examples illustrate the implications of using piezocomposites in medical ultrasonic imaging transducers. While most material properties of the composite roughly interpolate between their values for pure polymer and pure ceramic, the composite's thickness-mode electromechanical coupling can exceed that of the component ceramic. This enhanced electromechanical coupling stems from partially freeing the lateral clamping of the ceramic in the composite structure. Their higher coupling and lower acoustic impedance recommend composites for medical ultrasonic imaging transducers. The model also reveals that the composite's material properties cannot be optimized simultaneously; tradeoffs must be made. Of most significance is the tradeoff between the desired lower acoustic impedance and the undesired smaller electromechanical coupling that occurs as the volume fraction of piezoceramic is reduced.

In November/2004, we witnessed the formation of the first worldwide effort to define a novel wireless air interface standard based on cognitive radios (CRs): the IEEE 802.22 working group (WG). The IEEE 802.22 WG is chartered with the development of a CR-based wireless regional area network (WRAN) physical (PHY) and medium access control (MAC) layers for use by license-exempt devices in the spectrum that is currently allocated to the television (TV) service. Since 802.22 is required to reuse the fallow TV spectrum without causing any harmful interference to incumbents (i.e., the TV receivers), cognitive radio techniques are of primary importance in order to sense and measure the spectrum and detect the presence/absence of incumbent signals. On top of that, other advanced techniques that facilitate coexistence such as dynamic spectrum management and radio environment characterization could be designed. In this paper, we provide a detailed overview of the 802.22 architecture, its requirements, applications, and coexistence considerations that not only form the basis for the definition of this groundbreaking wireless air interface standard, but that will also serve as foundation for future research in the promising area of CRs

The principal reconstructions found on the low-index planes of GaAs and ZnSe can be explained in terms of a simple electron counting model. A surface structure satisfies this model if it is possible to have all the dangling bonds on the electropositive element (Ga or Zn) empty and the dangling bonds on the electronegative element (As or Se) full, given the number of available electrons. This condition will necessarily result in there being no net surface charge. The justification for this model is discussed. The GaAs(001)-(2\ifmmode\times\else\texttimes\fi{}4) reconstruction is known to involve surface dimers. It is shown that a (2\ifmmode\times\else\texttimes\fi{}4) unit cell with three dimers and one dimer vacancy is the smallest unit cell that satisfies the electron counting model for this surface. The electron counting model is used to explain the structure of islands imaged by scanning tunneling microscopy on the GaAs(001)-(2\ifmmode\times\else\texttimes\fi{}4) surface. The model shows that island structures built up from complete (2\ifmmode\times\else\texttimes\fi{}4) unit cells can be stable if they extend in the 2\ifmmode\times\else\texttimes\fi{} direction, but not if they extend in the 4\ifmmode\times\else\texttimes\fi{} direction. These island structures can also provide an explanation for the different step structures seen on GaAs(001) vicinal surfaces. Much less is known experimentally about step and island structures on ZnSe(001). Structures on this surface predicted by the electron counting model differ significantly from those found on GaAs(001).

BACKGROUND AND PURPOSE: Different definitions have been proposed to define the ischemic penumbra from perfusion-CT (PCT) data, based on parameters and thresholds tested only in small pilot studies. The purpose of this study was to perform a systematic evaluation of all PCT parameters (cerebral blood flow, volume [CBV], mean transit time [MTT], time-to-peak) in a large series of acute stroke patients, to determine which (combination of) parameters most accurately predicts infarct and penumbra. METHODS: One hundred and thirty patients with symptoms suggesting hemispheric stroke < or =12 hours from onset were enrolled in a prospective multicenter trial. They all underwent admission PCT and follow-up diffusion-weighted imaging/fluid-attenuated inversion recovery (DWI/FLAIR); 25 patients also underwent admission DWI/FLAIR. PCT maps were assessed for absolute and relative reduced CBV, reduced cerebral blood flow, increased MTT, and increased time-to-peak. Receiver-operating characteristic curve analysis was performed to determine the most accurate PCT parameter, and the optimal threshold for each parameter, using DWI/FLAIR as the gold standard. RESULTS: The PCT parameter that most accurately describes the tissue at risk of infarction in case of persistent arterial occlusion is the relative MTT (area under the curve=0.962), with an optimal threshold of 145%. The PCT parameter that most accurately describes the infarct core on admission is the absolute CBV (area under the curve=0.927), with an optimal threshold at 2.0 ml x 100 g(-1). CONCLUSIONS: In a large series of 130 patients, the optimal approach to define the infarct and the penumbra is a combined approach using 2 PCT parameters: relative MTT and absolute CBV, with dedicated thresholds.

The temperature and pressure dependence of the dielectric constant of a number of cubic halides and oxides with a broad range of dielectric constants have been determined. For low-$\ensuremath{\epsilon}$ compounds the dielectric constant increases with increasing temperature, whereas for high-$\ensuremath{\epsilon}$ compounds the dielectric constant decreases with increasing temperature. Hydrostatic pressure lowers the value of the dielectric constant for all compounds measured. For ferroelectrics and antiferroelectrics a relation has been found between the Curie temperature and the Curie constant. Three effects contribute to the temperature dependence of a dielectric constant: the decrease in the number of polarizable particles per unit volume as the temperature increases, which is a direct result of the volume expansion ($A$), the increase of the macroscopic polarizability due to the volume expansion ($B$), and the temperature dependence of the macroscopic polarizability at constant volume ($C$). The experimental data have been used to calculate these different contributions. It is found that the volume-dependent contribution ($A+B$) is always positive and that the direct temperature contribution ($C$) can be either positive or negative. Where optical data were available in literature they were used to calculate the contributions of the optical and infrared parts of the polarizability to the temperature and volume dependence of the polarizability. The results are discussed with the use of a classical ionic model.

New results on the physics of tunneling in quantum well heterostructures and its device applications are discussed. Following a general review of the field in the Introduction, in the second section resonant tunneling through double barriers is investigated. Recent conflicting interpretations of this effect in terms of a Fabry-Perot mechanism or sequential tunneling are reconciled via an analysis of scattering. It is shown that the ratio of the intrinsic resonance width to the total scattering width (collision broadening) determines which of the two mechanisms controls resonant tunneling. The role of symmetry is quantitatively analyzed and two recently proposed resonant tunneling transistor structures are discussed. The third section deals with perpendicular transport in superlattices. A simple expression for the low field mobility in the miniband conduction regime is derived; localization effects, hopping conduction, and effective mass filtering are discussed. In the following section, experimental results on tunneling superlattice photoconductors based on effective mass filtering are presented. In the fifth section, negative differential resistance resulting from localization in a high electric field is discussed. In the last section, the observation of sequential resonant tunneling in superlattices is reported. We point out a remarkable analogy between this phenomenon and paramagnetic spin resonance. New tunable infrared semiconductor lasers and wavelength selective detectors based on this effect are discussed.

Four-dimensional (4D) methods strive to achieve highly conformal radiotherapy, particularly for lung and breast tumours, in the presence of respiratory-induced motion of tumours and normal tissues. Four-dimensional radiotherapy accounts for respiratory motion during imaging, planning and radiation delivery, and requires a 4D CT image in which the internal anatomy motion as a function of the respiratory cycle can be quantified. The aims of our research were (a) to develop a method to acquire 4D CT images from a spiral CT scan using an external respiratory signal and (b) to examine the potential utility of 4D CT imaging. A commercially available respiratory motion monitoring system provided an 'external' tracking signal of the patient's breathing. Simultaneous recording of a TTL 'X-Ray ON' signal from the CT scanner indicated the start time of CT image acquisition, thus facilitating time stamping of all subsequent images. An over-sampled spiral CT scan was acquired using a pitch of 0.5 and scanner rotation time of 1.5 s. Each image from such a scan was sorted into an image bin that corresponded with the phase of the respiratory cycle in which the image was acquired. The complete set of such image bins accumulated over a respiratory cycle constitutes a 4D CT dataset. Four-dimensional CT datasets of a mechanical oscillator phantom and a patient undergoing lung radiotherapy were acquired. Motion artefacts were significantly reduced in the images in the 4D CT dataset compared to the three-dimensional (3D) images, for which respiratory motion was not accounted. Accounting for respiratory motion using 4D CT imaging is feasible and yields images with less distortion than 3D images. 4D images also contain respiratory motion information not available in a 3D CT image.

In 1995, a consensus statement was published for the purpose of summarizing the salient clinical features of Angelman syndrome (AS) to assist the clinician in making a timely and accurate diagnosis. Considering the scientific advances made in the last 10 years, it is necessary now to review the validity of the original consensus criteria. As in the original consensus project, the methodology used for this review was to convene a group of scientists and clinicians, with experience in AS, to develop a concise consensus statement, supported by scientific publications where appropriate. It is hoped that this revised consensus document will facilitate further clinical study of individuals with proven AS, and assist in the evaluation of those who appear to have clinical features of AS but have normal laboratory diagnostic testing.

Abstract In this paper an attempt is made to establish the nature of free charge carriers and of charge carriers bound to centres in p-type NiO, CoO and MnO and in n-type MnO and α-Fe2O3. For free charge carriers, d.c. conductivity, Seebeck coefficient and Hall effect are considered. Effects arising from inhomogeneous conduction and impurity conduction are discussed. Impurity conduction appears to have a strong influence on transport properties in the case of α-Fe2O3, less so in NiO, whereas no influence of this effect has been found in CoO and MnO. It is shown that NiO and CoO do not exhibit the features characteristic of small-polaron conductors but rather can be consistently conceived of as large-polaron band semiconductors. It is suggested that magnetic resistance due to exchange coupling between charge-carrier spin and cation spins plays an important role. The anomalous behaviour of the Hall effect in NiO and α-Fe2O3 is extensively discussed. In contradistinction to NiO, CoO and n-type MnO, free charge carriers in p-type MnO seem to have small-polaron character. For charge carriers bound to centres, dielectric loss, high-frequency conduction and optical absorption are considered. The dielectric loss data relate to Li or Na centres in NiO, CoO and MnO and to Ti, Zr, Sn, Ta, Nb and presumably oxygen vacancy centres in α-Fe2O3. It is concluded from the dependence of dielectric loss on frequency and temperature that bound charge carriers are small polarons. It is shown for the cases of NiO and α-Fe2O3 that apart from small-polaron effects, disorder due to locally varying electric fields determines the nature of dielectric loss. The small-polaron character of bound charge carriers in NiO is corroborated by the behaviour of high-frequency conduction and optical absorption due to centres and also by the magnitude of impurity conduction.

Advances in wireless technology and supporting infrastructure provide unprecedented opportunity for ubiquitous real-time healthcare and fitness monitoring without constraining the activities of the user. Wirelessly connected miniaturized sensors and actuators placed in, on, and around the body form a body area network for continuous, automated, and unobtrusive monitoring of physiological signs to support medical, lifestyle and entertainment applications. BAN technology is in the early stage of development, and several research challenges have to be overcome for it to be widely accepted. In this article we study the core set of application, functional, and technical requirements of the BAN. We also discuss fundamental research challenges such as scalability (in terms of data rate, power consumption, and duty cycle), antenna design, interference mitigation, coexistence, QoS, reliability, security, privacy, and energy efficiency. Several candidate technologies poised to address the emerging BAN market are evaluated, and their merits and demerits are highlighted. A brief overview of standardization activities relevant to BANs is also presented.

A simple theory of alkali halide gas molecules in the spirit of Born-Mayer lattice theory is presented. The molecule is considered to be constituted of ions, each of which is polarized by the electrostatic field of the other. This deformation polarization has two important consequences: (1) the net dipole moment of the molecule becomes appreciably lower than that given by the product of the electric charge e, and the internuclear separation a; (2) the repulsion constants (determined from empirical data) become different from the corresponding constants for the crystal. The theory yields satisfactory results for the binding energy, vibration frequency, and dipole moment, μ, in all instances where necessary data are available. In cases where the internuclear distances are not known experimentally, they are calculated from the theory using experimental binding energies. It is possible to assign to the ions Goldschmidt-like radii, the sums of which reproduce reasonably well both the calculated and the observed internuclear distances. Finally, item (1) above explains why Pauling's criterion for the fraction of ionic character, f=μ/ea, is not a very good measure of ionicity for these completely ionic substances.

BACKGROUND: Investigation to see if there are key psychological risk indicators for autism in a random population study of children at 18 months of age; and to assess how well these discriminate children who receive a diagnosis of autism from other forms of developmental delay. METHOD: Sixteen thousand children in the southeast of England were screened for autism by their health visitor or GP, during their routine 18-month-old developmental check-up, using the CHAT (Checklist for Autism in Toddlers). From a previous high-risk study we predicted that children at 18 months of age who failed three items ('protodeclarative pointing', 'gaze-monitoring', and 'pretend play') would be at risk for receiving a diagnosis of autism. From other evidence, we further predicted that those 18-month-olds who failed one or two of the key items (either pretend play, or protodeclarative pointing and pretend play) would be at risk for developmental delay without autism. RESULTS: Twelve children out of the total population of 16,000 consistently failed the three key items. Of these, 10 (83.3%) received a diagnosis of autism. Thus, the false positive rate was 16.6% (2 out of 12 cases), and even these 2 cases were not normal. When the 10 children with autism were reassessed at 3.5 years of age, their diagnosis remained the same. Thus the false positive rate among the cases diagnosed with autism was zero. In contrast, of 22 children who consistently failed either protodeclarative pointing and/or pretend play, none received a diagnosis of autism, but 15 (68.2%) received a diagnosis of language delay. CONCLUSIONS: Consistent failure of the three key items from the CHAT at 18 months of age carries an 83.3% risk of autism; and this pattern of risk indicator is specific to autism when compared to other forms of developmental delay.