Polydoro Ernani de São Thiago University Hospital

As diferentes formas de revisão da literatura baseiam-se desde a revisão bibliográfica tradicional (revisão narrativa), até o uso de mecanismos e metodologias, utilizados nos campos da saúde e educação por pesquisadores para descrever o estado da arte de um tema, chamado de revisão bibliográfica sistemática. O objetivo deste artigo é discutir o processo de revisão da literatura nos estudos organizacionais, trazendo para esse escopo metodologias de revisão da literatura de outras áreas do saber, como por exemplo, a revisão bibliográfica sistemática. Como metodologia adotada o estudo discute o método da revisão integrativa, pertecente a revisão bibliográfica sistemática. Os resultados da pesquisa mostram que a revisão integrativa, permite ao pesquisador aproximar-se da problemática que deseja apreciar, traçando um panorama sobre a sua produção científica, de forma que o pesquisador possa conhecer a evolução do tema ao longo do tempo e, com isso, visualizar possíveis oportunidades de pesquisa nos estudos organizacionais.

OBJECTIVES: To develop evidence-based recommendations for the use of methotrexate in daily clinical practice in rheumatic disorders. METHODS: 751 rheumatologists from 17 countries participated in the 3E (Evidence, Expertise, Exchange) Initiative of 2007-8 consisting of three separate rounds of discussions and Delphi votes. Ten clinical questions concerning the use of methotrexate in rheumatic disorders were formulated. A systematic literature search in Medline, Embase, Cochrane Library and 2005-7 American College of Rheumatology/European League Against Rheumatism meeting abstracts was conducted. Selected articles were systematically reviewed and the evidence was appraised according to the Oxford levels of evidence. Each country elaborated a set of national recommendations. Finally, multinational recommendations were formulated and agreement among the participants and the potential impact on their clinical practice was assessed. RESULTS: A total of 16 979 references was identified, of which 304 articles were included in the systematic reviews. Ten multinational key recommendations on the use of methotrexate were formulated. Nine recommendations were specific for rheumatoid arthritis (RA), including the work-up before initiating methotrexate, optimal dosage and route, use of folic acid, monitoring, management of hepatotoxicity, long-term safety, mono versus combination therapy and management in the perioperative period and before/during pregnancy. One recommendation concerned methotrexate as a steroid-sparing agent in other rheumatic diseases. CONCLUSIONS: Ten recommendations for the use of methotrexate in daily clinical practice focussed on RA were developed, which are evidence based and supported by a large panel of rheumatologists, enhancing their validity and practical use.

To reduce the spread of COVID-19, the World Health Organization and the majority of governments have recommended that the entire human population should 'stay-at-home'. A significant proportion of the population live alone or are vulnerable to mental health problems yet, in the vast majority of cases, individuals in social isolation have no access to mental healthcare. The only resource is people themselves using self-help, self-medication and self-care. During prolonged COVID-19 isolation, an in-built system of homeostasis can help rebalance activity, thought and feeling. Increased physical activity enables a reset of physical and mental well-being. During periods of lockdown, it is recommended that exercise should be as vigorously promoted as social distancing itself.

Providing security in a distributed system requires more than user authentication with passwords or digital certificates and confidentiality in data transmission. The Grid and Cloud Computing Intrusion Detection System integrates knowledge and behavior analysis to detect intrusions.

People speak different languages, and always have. The Ancient Greeks took no notice of anything unless it was said in Greek; the Romans made everyone speak Latin; and in India, people learned their neighbours' languages - as did many ordinary Europeans in times past. But today, we all use translation to cope with the diversity of languages. Without translation there would be no world news, not much of a reading list in any subject at college, no repair manuals for cars or planes, and we wouldn't even be able to put together flat pack furniture. Is That a Fish in Your Ear? ranges across the whole of human experience, from foreign films to philosophy, to show why translation is at the heart of what we do and who we are. What's the difference between translating unprepared natural speech, and translating Madame Bovary? How do you translate a joke? What's the difference between a native tongue and a learned one? Can you translate between any pair of languages, or only between some? What really goes on when world leaders speak at the UN? Can machines ever replace human translators, and if not, why? And the biggest question is how do we ever really know that we've grasped what anybody else says - in our own language or in another? Surprising, witty and written with great joie de vivre, this book is all about us, and how we understand each other.

An original analytical study is developed concerning the torque undulation due to phase commutation on brushless DC motors. The results indicate that the relative ripple is independent of current, varies with speed, and may reach 50% of the average torque. The amplitude of the torque undulation and the duration of the commutation are analyzed, showing how this affects the torque-speed curve of the drive. Simulation and experimental results are presented that validate the theoretical analysis.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

OBJECTIVE: To evaluate the association between physical activity level and mental health status among elderly people. METHODS: This was a population-based survey with a probabilistic sample of 875 elderly people from a city of Southern Brazil, in 2002. The International Physical Activity Questionnaire and the Brazil Old Age Schedule questionnaire were applied. The mental health problems evaluated were depressions and dementia. Total physical activity (leisure-time, occupation, transportation and housework). After descriptive and bivariate analyses, adjusted analyses were performed by means of logistic regression, with adjustment for the factors of total physical activity, leisure-time activity and depression and dementia scores. RESULTS: There were statistically significant inverse associations between dementia and depression with total physical activity and leisure-time physical activity. The odds ratio for total physical activity adjusted for dementia among sedentary subjects in comparison with active subjects was 2.74 (95% CI: 1.85; 4.08), while the respective value adjusted for depression was 2.38 (95% CI: 1.70; 3.33). CONCLUSIONS: The results reinforce the importance of active lifestyles for preventing mental health problems among elderly people. It is inferred that the physical activity was able to reduce and/or delay the risks of dementia, although it cannot be stated that dementia is avoided through physical activity.

The present study aimed to analyze and compare the effects of four different interval-training protocols on aerobic fitness and muscle strength. Thirty-seven subjects (23.8 ± 4 years; 171.7 ± 9.5 cm; 70 ± 11 kg) were assigned to one of four groups: low-intensity interval training with (BFR, n = 10) or without (LOW, n = 7) blood flow restriction, high-intensity interval training (HIT, n = 10), and combined HIT and BFR (BFR + HIT, n = 10, every session performed 50% as BFR and 50% as HIT). Before and after 4 weeks training (3 days a week), the maximal oxygen uptake (VO2max ), maximal power output (Pmax ), onset blood lactate accumulation (OBLA), and muscle strength were measured for all subjects. All training groups were able to improve OBLA (BFR, 16%; HIT, 25%; HIT + BFR, 22%; LOW, 6%), with no difference between groups. However, VO2max and Pmax improved only for BFR (6%, 12%), HIT (9%, 15%) and HIT + BFR (6%, 11%), with no difference between groups. Muscle strength gains were only observed after BFR training (11%). This study demonstrates the advantage of short-term low-intensity interval BFR training as the single mode of training able to simultaneously improve aerobic fitness and muscular strength.

Resumo A doença causada pelo novo coronavírus (COVID-19) tem sido considerada uma grave crise sob o ponto de vista epidemiológico e, também, psicológico. Além das perdas em massa em curto espaço de tempo, as dificuldades para realização de rituais de despedida entre pessoas na iminência da morte e seus familiares, bem como de rituais funerários, podem dificultar a experiência de luto. O objetivo deste estudo é sistematizar conhecimentos sobre os processos de terminalidade, morte e luto no contexto da pandemia de COVID-19. Por meio de revisão narrativa da literatura, foram sumarizadas experiências relatadas em diferentes países durante a pandemia. Apresentam-se características das demandas psicológicas emergentes e implicações para a prática profissional do psicólogo. Considerando que expressões de afeto, condolências e espiritualidade sofrem alterações nesse cenário, discute-se a importância de potencializar formas alternativas e respeitosas para ritualização dos processos vividos, o que parece essencial para ressignificar perdas e enfrentar desafios durante e após a vigência da pandemia.

Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6±9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8-0.9 per week increase; p<0.001), birthweight (OR: 1.17, 95% CI 1.09-1.12.7 per 100 g decrease; p=0.012) and maternal ventilatory support, including either need for oxygen or CPAP (OR: 4.12, 95% CI 2.3-7.9; p=0.001) were independently associated with composite adverse fetal outcome. Conclusions Early gestational age at infection, maternal ventilatory supports and low birthweight are the main determinants of adverse perinatal outcomes in fetuses with maternal COVID-19 infection. Conversely, the risk of vertical transmission seems negligible.

Ecological theories of facilitation and nucleation are proposed as a basis for environmental restoration in tropical ecosystems. The main goal of this paper is to present restoration techniques based on the concept of nucleation, in which small nuclei of vegetation are established within a degraded land. The nucleation techniques (artificial shelters for animals, planting of herbaceous shrub life forms, soil and seed bank translocation, seed rain translocation, soil and seed rain translocation's seedling set, artificial perches, planting of native trees in groups, and ecological stepping-stones with functional groups) promote the landscape connectivity on two flows: inward: receiver connectivity and outward: donor connectivity. The nuclei development represents an alternative for restoration by prioritizing the natural processes of succession. This methodology appears to take long to generate vegetation corresponding to tropical climates, but is fundamental in the formation of communities capable of acting, in the future, as a new functional nuclei within the current fragmented landscape. This strategy also encourages greater integration between the theories and projects of ecological restoration for the development of human resources and to benefit the restoration practitioner.

Different methods are presented for the calculation of torque as a function of rotation angle in an electrical machine. These methods are integrated in a calculation code by using the finite element method. The movement is taken into account by means of the moving band technique, involving quadrilateral finite elements in the airgap. The torque is calculated during the displacement of the moving part by using the following methods: Maxwell stress tensor, coenergy derivation, Coulomb's virtual work, A. Arkkio's method (1988), and the magnetizing current method. The results obtained by the different methods are compared with experimental data and make it possible to obtain practical information concerning the advantages and limitations of each method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on self-management should be the norm. Mobile Airways Sentinel networK (MASK), the Phase 3 ARIA initiative, is based on the freely available MASK app (the Allergy Diary, Android and iOS platforms). MASK is available in 16 languages and deployed in 23 countries. The present paper provides an overview of the methods used in MASK and the key results obtained to date. These include a novel phenotypic characterization of the patients, confirmation of the impact of allergic rhinitis on work productivity and treatment patterns in real life. Most patients appear to self-medicate, are often non-adherent and do not follow guidelines. Moreover, the Allergy Diary is able to distinguish between AR medications. The potential usefulness of MASK will be further explored by POLLAR (Impact of Air Pollution on Asthma and Rhinitis), a new Horizon 2020 project using the Allergy Diary.

This paper describes a theoretical and experimental study on a control strategy for the parallel operation of single-phase voltage source inverters (VSI), to be applied to uninterruptible power supply. The control system for each inverter consists of two main loops, which both use instantaneous values. The first (parallelism control) employs the feedback of the inductor current from the output filter to modify the input voltage of the same filter and, therefore, to control the power flow of each inverter to the load. Additionally, the second loop (voltage control) is responsible for controlling the output voltage of the LC filter, which coincides with the output voltage of the VSI. Due to the fact that there is no exchange of information among the VSIs regarding their operation points, it is easier to obtain redundant systems. Furthermore, the connection (or disconnection) of inverters in a parallel arrangement is carried out directly, without connection impedance, and can occur at any operation point of the system. The proposed control strategy ensures the proper sharing of the load current and avoids current circulation among the inverters during transient and steady-state operation. Moreover, its design and implementation are very simple. The control technique was verified through experimental results with a maximum load of 10 kVA supplied by three parallel-connected inverters.

In this work chitosan microspheres were prepared by the simple coacervation method and crosslinked using epichlorhydrin or glutaraldehyde for the controlled release of diclofenac sodium. The effects of the crosslinking agents on chitosan microspheres over a 12-hour period were assessed with regard to swelling, hydrolysis, porosity, crosslinking, impregnation of diclofenac sodium (DS), and consequently to the release of DS in buffer solutions, simulating the gastrointestinal tract. The degree of swelling varied with the pH for glutaraldehyde chitosan microspheres (GCM) and epichlorhydrin chitosan microspheres (ECM). Partial acid and basic hydrolysis affected the swelling behavior of the GCM matrix. Release kinetics of diclofenac sodium from these matrices were investigated at pH 1.2, 6.8 and 9.0, simulating the gastrointestinal tract conditions. The results indicated that the release mechanism deviated slightly from Fickian transport.

Estabelece novas diretrizes, novos parâmetros e critérios para o Programa de Fomento às Escolas de Ensino Médio em Tempo Integral - EMTI, em conformidade com a Lei nº 13.415, de 16 de fevereiro de 2017.

RESUMO Objetivo: identificar nas publicações nacionais e internacionais indexadas nas bases de dados os principais métodos adotados pelos pesquisadores para o desenvolvimento de aplicativos móveis em saúde. Método: revisão integrativa da literatura de estudos publicados nas bases de dados MEDLINE/PubMed, Scopus, Web of Science, CINAHL e SciELO, no período de 2012 a 2016. Foram selecionados para análise 21 artigos. Resultados: os principais métodos para desenvolvimento de aplicativos móveis na área da saúde descritos nos artigos foram: design instrucional sistemático, design instrucional contextualizado, design centrado no usuário e ciclo de vida de desenvolvimento de sistemas. Conclusão: independentemente do método de desenvolvimento escolhido, as etapas devem ser bem definidas e estruturadas, a fim de que o aplicativo móvel desenvolvido seja útil ao usuário final.

AIMS: Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases. METHODS: MASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a multi-disciplinary group centred around the patients. STAKEHOLDERS: Include patients, health care professionals (pharmacists and physicians), authorities, patient's associations, private and public sectors. RESULTS: MASK is deployed in 23 countries and 17 languages. 26,000 users have registered. EU GRANTS 2018: MASK is participating in EU projects (POLLAR: impact of air POLLution in Asthma and Rhinitis, EIT Health, DigitalHealthEurope, Euriphi and Vigour). LESSONS LEARNT: (i) Adherence to treatment is the major problem of allergic disease, (ii) Self-management strategies should be considerably expanded (behavioural), (iii) Change management is essential in allergic diseases, (iv) Education strategies should be reconsidered using a patient-centred approach and (v) Lessons learnt for allergic diseases can be expanded to chronic diseases.

BACKGROUND: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. MAIN BODY: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. CONCLUSION: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.

LEARNING OBJECTIVES: After participating in this activity, learners should be better able to:• Determine the prevalence of clinician-diagnosed posttraumatic stress disorder (PTSD) in primary care patients• Identify the prevalence of questionnaire-ascertained PTSD symptoms in primary care patients OBJECTIVE: Determine the prevalence of clinician-diagnosed PTSD and questionnaire-ascertained PTSD symptoms in primary care patients. METHODS: A systematic review of the literature using the PRISMA method, searching MEDLINE, CINAHL, Cochrane Database, PsycINFO, EMBASE, Google Scholar, and relevant book chapter bibliographies. Studies that reported on the prevalence, including point or lifetime prevalence, of PTSD ascertained using diagnostic interviews or self-report questionnaires, or from administrative data, among patients seen in primary care were deemed eligible for inclusion. We abstracted data on the PTSD assessment tool, the mean questionnaire scores/cutoff scores, the time period of PTSD symptoms, and PTSD prevalence reported. RESULTS: Of 10,614 titles screened, 41 studies were eligible for inclusion. The included studies assessed PTSD in a total of 7,256,826 primary care patients. The median point prevalence of PTSD across studies was 12.5%. The median point prevalence in the civilian population was 11.1%; in the special-risk population, 12.5%; and in veterans, 24.5%. The point prevalence of diagnostic interview-ascertained PTSD ranged from 2% to 32.5%, and the point prevalence of questionnaire-based substantial PTSD symptoms ranged from 2.9% to 39.1%. Lifetime prevalence of diagnostic interview-ascertained PTSD ranged from 14.5% to 48.8%. The prevalence of PTSD in administrative data-based studies ranged from 3.5% to 29.2%. CONCLUSIONS: PTSD is common in primary care settings. Additional research on effective and generalizable interventions for PTSD in primary care is needed.