Purley War Memorial Hospital

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist.

Delivery of neuropsychological interventions addressing the cognitive, psychological, and behavioural consequences of brain conditions is increasingly recognised as an important, if not essential, skill set for clinical neuropsychologists. It has the potential to add substantial value and impact to our role across clinical settings. However, there are numerous approaches to neuropsychological intervention, requiring different sets of skills, and with varying levels of supporting evidence across different diagnostic groups. This clinical guidance paper provides an overview of considerations and recommendations to help guide selection, delivery, and implementation of neuropsychological interventions for adults and older adults. We aimed to provide a useful source of information and guidance for clinicians, health service managers, policy-makers, educators, and researchers regarding the value and impact of such interventions. Considerations and recommendations were developed by an expert working group of neuropsychologists in Australia, based on relevant evidence and consensus opinion in consultation with members of a national clinical neuropsychology body. While the considerations and recommendations sit within the Australian context, many have international relevance. We include (i) principles important for neuropsychological intervention delivery (e.g. being based on biopsychosocial case formulation and person-centred goals); (ii) a description of clinical competencies important for effective intervention delivery; (iii) a summary of relevant evidence in three key cohorts: acquired brain injury, psychiatric disorders, and older adults, focusing on interventions with sound evidence for improving activity and participation outcomes; (iv) an overview of considerations for sustainable implementation of neuropsychological interventions as 'core business'; and finally, (v) a call to action.

BACKGROUND: Elder abuse often goes unreported and undetected. Older people may be ashamed, fearful, or otherwise reticent to disclose abuse, and many health providers are not confident in asking about it. In the No More Shame study, we will evaluate a co-designed, multi-component intervention that aims to improve health providers' recognition, response, and referral of elder abuse. METHODS: This is a single-blinded, pragmatic, cluster randomised controlled trial. Ten subacute hospital sites (i.e. clusters) across Australia will be allocated 1:1, stratified by state to a multi-component intervention comprising a training programme for health providers, implementation of a screening tool and use of site champions, or no additional training or support. Outcomes will be collected at baseline, 4 and 9 months. Our co-primary outcomes are change in health providers' knowledge of responding to elder abuse and older people's sense of safety and quality of life. We will include all inpatients at participating sites, aged 65 + (or aged 50 + if Aboriginal or Torres Strait Islander), who are able to provide informed consent and all unit staff who provide direct care to older people; a sample size of at least 92 health providers and 612 older people will provide sufficient power for primary analyses. DISCUSSION: This will be one of the first trials in the world to evaluate a multi-component elder abuse intervention. If successful, it will provide the most robust evidence base to date for health providers to draw on to create a safe environment for reporting, response, and referral. TRIAL REGISTRATION: ANZCTR, ACTRN12623000676617p . Registered 22 June 2023.

Alzheimer's dementia (AD) predominantly affects women, and it has no cure when it becomes established. As the current biggest killer of women in the United Kingdom, it became incumbent to explore all preventive strategies. Based on the knowledge that Alzheimer's dementia is homed in the hippocampus and that this area is suffused with estrogen receptors, we explored whether there was a link that might suggest therapeutic or preventive strategies. We found that there was evidence that the hippocampus, the primary area of the brain that we used for declarative memory became deplete with estrogen receptors in the menopause. We also found other pointers which included that hippocampal pathology is central to the development of AD and that the hippocampal shape and volume can predict the onset of AD. There were further of in-vitro and in-vivo support that peri-menopausal estrogens could reduce the incidence of AD in women by up to 35%.

It has come to our attention that the name of one of the authors in our manuscript was incorrectly spelled ‘Jinyoung Byan’; the correct spelling is ‘Jinyoung Byun’ as in the author list above. In addition, the excel files of the supplementary tables were not included during the online publication of our article. These have now been made available online. We apologize for any inconvenience caused.

Background: integrated Rehabilitation and EnAblement Program (iREAP) is an innovative redesign of the traditional day rehabilitation model, providing an anticipatory, early assessment and intervention program that manages care of community-dwelling older people with complex needs. It coordinates access to disciplines across medical, allied health and nursing, with a self-management focus, partnering with primary health in an integrated approach. Objective: This observational study reviews the effectiveness of iREAP on frailty, patient activation, quality of life and physical outcome measures on older people at risk of, or experiencing falls and frailty, or with neurodegenerative conditions, including Parkinson's Disease. Methods: 99 participants completed the eight-week multidisciplinary program. Patient outcome measures included Rockwood Clinical Frailty Scale, quality of life measures, Patient Activation Measure, Timed Up and Go, 6 Minute Walk Test and Berg Balance Scale. Results: On completion of iREAP, participants displayed improvements in their Rockwood Clinical Frailty Scores (mildly frail to vulnerable), 'patient activation' (55.08 to 60.61), quality of life (Parkinson's Disease Questionnaire-39, 49.93 to 47.16; WHO Quality of Life - Bref physical domain, 21 to 22.7) and physical measures including balance (44 to 49/56 Berg Balance scale) and mobility (294 m to 336 m, 6-minute walk test). Falls were not reduced at twelve months post-program (3.40 to 2.01). Conclusion: iREAP is an interdisciplinary, early assessment and intervention program with the potential to reverse frailty and improve quality of life for complex older patients. This paper offers a platform for future research, given the paucity of evidence reviewing the efficacy of integrated anticipatory models of care in older adults with complex needs.

BACKGROUND: We assessed the cost-benefit of person-centered care education for direct care staff of an Australian subacute rehabilitation hospital, with respect to clinical outcomes and service costs of persons with dementia. METHODS: In a nonrandomized pre/post/follow-up design, clinical outcomes and service use were evaluated for matched comparison (n=77) and intervention (n=80) groups for delirium incidence, accidents/injuries, injury treatment, psychotropic medicines, length of stay, hospital readmissions and discharge destination. Group-level outcomes were monetized and included in a cost-benefit analysis (present value of benefits/present value of education and service costs). RESULTS: Relative to the comparison group, there were significant reductions in intervention group delirium (P=0.001), accidents/injuries (P=0.007), treatment for injuries (P=0.007), psychotropic medicines (P=0.030) and hospital readmission within 30 days (P=0.002). After adjusting for the longer length of stay of the intervention subgroup who contracted COVID-19 (n=10), there were no group differences in length of stay (P=0.83). Per participant service costs for comparison and intervention groups were AU$34,870 and AU$33,969, respectively, equating to a per-participant cost saving of AU$914 (P<0.0001). CONCLUSION: Investment in person-centered care education of direct care staff is warranted from both clinical and economic perspectives.

The International Journal of Integrated Care (IJIC) is an online, open-access, peer-reviewed scientific journal that publishes original articles in the field of integrated care on a continuous basis.IJIC has an Impact Factor of 5.120 (2020 JCR, received in June 2021)The IJIC 20th Anniversary Issue was published in 2021.

Cognitive interventions, including cognitive stimulation therapy, cognitive rehabilitation and cognitive training, are increasingly recommended as key components of non-pharmacological post-diagnostic support for people with dementia. Cognitive interventions may help delay cognitive decline, enhance goal-directed functional abilities and improve quality of life. Despite inclusion in clinical guidelines and recommendations, guidance on the delivery of these interventions within Australian community settings remains limited and is underutilised. This article addresses a critical translation gap in cognitive interventions for people with dementia, synthesises the evidence through an Australian practice and policy lens, examines current uptake in community settings and identifies barriers, enablers and delivery models to inform implementation strategies. Community settings are defined as memory clinics, primary care, hospital outpatient services, allied health providers, community aged care and non-government providers. Current evidence indicates cognitive interventions have varying benefits across different outcomes, including cognitive function, social engagement, everyday functioning, quality of life and goal attainment. International practices related to implementation are explored, along with future directions for expanding access through technology, flexible delivery models, group-based approaches and integrating these interventions into existing care structures. Addressing the gap between recommendations and current practices requires building community awareness, improving access to professional education and training, and careful resource allocation. Cognitive interventions should be part of comprehensive rehabilitation and can be personalised to individual needs and goals. Expanding access and improving the availability of a range of cognitive interventions in community settings is crucial to ensure people with dementia receive best practice post-diagnostic support.

INTRODUCTION: To meet older people's physical and mental health needs the built environment is becoming increasingly important for the health and community aged care systems. The usage of an age-friendly outdoor space as an enhancement to standard treatment for rehabilitation in hospital settings holds promise as part of patients' continuum of care. This descriptive case study described the design and development of an age-friendly outdoor rehabilitation space in a hospital setting in Sydney Australia, the OASIS (Outdoor Activity Space for Improving your Strength) program. METHOD: This descriptive case study reports the step-by-step process from initial concept to activation of the space. Drawing on internal planning documents, site plans, meeting records, and project materials, it outlines key phases including stakeholder consultation, site selection, design development, equipment installation, staff training, risk management, and pilot testing of a group-based exercise program. RESULTS: The process took approximately four years which included consultation, examination and selection of suitable feature design and equipment selection. Training and upskilling staff and risk management were undertaken prior to pilot testing an exercise program. Preliminary usage testing of the space demonstrated safe usage by older people in a group setting with successful transition from supervised program into independent usage. CONCLUSION: The OASIS approach offers an innovative adjunctive therapeutic approach to standard treatment for rehabilitation and physical activity participation of older people in out-patient settings. Future work is required to explore its provisional integration as part of the hospital in-patient and out-patient services.