Rosemont College

The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13347/full. This compilation of the major pharmacological targets is divided into eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.

In the face of mounting evidence revealing active learning approaches result in improved student learning outcomes compared to traditional passive lecturing, there is a growing need to change the way instructors teach large introductory science courses. However, a large proportion of STEM faculty continues to use traditional instructor-centered lectures in their classrooms. In an effort to create a low barrier approach for the implementation of active learning pedagogies in introductory science courses, flipped classroom modules for large enrollment general chemistry course sequence have been created. Herein is described how student response systems (clickers) and problem-based case studies have been used to increase student engagement, and how flipped classroom modules have integrated these case studies as collaborative group problem solving activities in 250–500 seat lecture halls. Preliminary evaluation efforts found the flipped classroom modules provided convenient access to learning materials that increased the use of active learning in lecture and resulted in a significant improvement in the course grade point average (GPA) compared to a non-flipped class. These results suggest this approach to implementing a flipped classroom can act as a model for integrating active learning into large enrollment introductory chemistry courses that yields successful outcomes.

Competency Model requires knowledge, skills, and abilities needed for fleet and distribution management for ecommerce industry to maintain successful movement of materials between parties within their supply chain to achieve high levels of reliability and cost-efficiency. This research aims to investigate the relationship and impact of information technology competencies and fleet management practices to achieve effective service delivery. A quantitative approach used to examine the model validation. The methodology of this research follow the descriptive correlational design. A real data records used to collect empirical from e-Commerce industry. Results of analysis proved the relationship and impact of information technology competencies and fleet management practices to achieve effective service delivery, as a result of analyzing the data the hypotheses. Some recommendations regarding information technology competencies and its dimensions should be enhanced, also, incorporating the latest innovations to facilitate fleet management.

Relationships among dietary roasted whole soybeans (RSB), milk fatty acid profile, and the development of spontaneous oxidized flavor of milk were investigated by using 20 commercial dairy herds. Diets contained 0 to 15.3% of dry matter as RSB. Concentrations of dietary RSB were correlated positively with concentrations of C18:2 and C18:3 in milk fat. Concentrations of alpha-tocopherol, beta-carotene, and ascorbic acid in milk decreased from 0 to 3 d of storage (4 degrees C), and oxidized flavor in milk increased linearly between 0 and 8 d of storage. Milk fatty acid profile did not change during storage. The development of oxidized flavor at 8 d postsampling was correlated (r) with increased concentrations in milk fat of C18:2 (0.49), C18:3 (0.55), total polyunsaturated milk fatty acids (0.50), and dietary concentrations of RSB (0.38). Multiple regression was used to quantify relationships between variables and oxidized flavor (samples stored 8 d). All significant models included milk concentrations of Cu and dehydroascorbic acid. Concentrations of C18:2, C18:3, or total polyunsaturated fatty acids in milk fat, or dietary RSB concentrations, and interactions of those variables with Cu were included in individual models. Milk with high concentrations of polyunsaturated fatty acids and Cu were most susceptible to oxidation. Feeding RSB increased polyunsaturated fatty acid concentrations in milk fat, which increased the likelihood of oxidized flavor, especially when milk had high concentrations of Cu.

This is the first book to provide objective methods for establishing that a child has been brainwashed by one parent against another. It is based on a ten-year study of 700 cases in the authors' counseling and evaluative work with children of divorced couples.

Handwashing is one of the most important control measures for preventing the spread of bacteria. Although young children are taught the procedure through different types of behavior modification, its effect has not been measured in older children. We have documentation that adults and health care workers have a compliance rate of only 50% with this basic control measure. This article reports on the compliance rate, duration, and handwashing techniques used by middle and high school students after using the bathroom.

BACKGROUND: The aim of the present study was to determine whether the addition of nurse case managers (NCMs) trained in motivational interviewing (MI) to usual care would result in improved outcomes in high-risk type 2 diabetes patients. METHODS: A 2-year randomized controlled pragmatic trial randomized 545 patients to usual care control (n=313) or those who received the intervention (n=232) with additional practice-embedded NCM care, including MI-guided behavior change counseling. The NCMs received intensive MI training with ongoing fidelity assessment. RESULTS: Systolic blood pressure (SBP) was better in the intervention than usual care group (131 ± 15 vs. 135 ± 18 mmHg, respectively; P<0.05). Improvements were seen in both the control and intervention groups in terms of HbA1c (from 9.1% to 8.0% and from 8.8% to 7.8%, respectively), low-density lipoprotein (LDL; from 127 to 100 mg/dL and from 128 to 102 mg/dL, respectively), and diastolic blood pressure (from 78 to 74 mmHg and from 80 to 74 mmHg, respectively). Depression symptom scores were better in the intervention group. The reduction in diabetes-related distress approached statistical significance. CONCLUSIONS: The NCMs and MI improved SBP and complications screening. The large decrease in HbA1C and LDL in the control group may have obscured any further intervention effect. Although nurses prompted providers for medication titration, strategies to reduce provider clinical inertia may also be needed.

Infidelity is one of the most common and the most difficult problems to treat in couples therapy. In this article, the authors present an integrative approach to treating infidelity based on the intersystems approach developed by Weeks. The approach integrates theory and techniques from both individual and systemic psychotherapy and addresses the individual, relational, and intergenerational factors associated with infidelity. The treatment approach reflects the authors' view of infidelity as a systemic, intimacy-based problem. Treatment includes five interrelated phases: (a) crisis management and assessment, (b) systemic considerations, (c) facilitating forgiveness, (d) treating factors that contribute to infidelity, and (e) promoting intimacy through communication. Of particular importance is the development of unifying factors that facilitate healing, unite couples, and reduce their vulnerability to future betrayals.

The part of Arizona south and east of Tucson is underlain by a wide assortment of deformed rocks, as well as by some major mineralized districts. A synthesis of the tectonic evolution of the region is offered in this report, which is based on older studies of mining districts and on more recent field studies by students and by the U.S. Geological Survey, augmented by field review and selective remapping of many key areas. Through this synthesis the rocks of the region are seen to have been deformed in response to diverse stresses, at various times, with an increasing degree of structural anisotropy of the rocks through time. Consequently, reactivated faults are common features, and segments of some of these faults record various kinds of movement, thereby providing unusual interpretive difficulties for many ofthe past local studies.

- spike receptor complexes showed stability throughout the simulation time. The ADME values also supported the drug-like nature of the selected hits. These nine compounds are available in onion, garlic, ginger, peppermint, chili and fenugreek. All the spices are edible and might be used as home remedies against COVID-19 after proper biological evaluation.

We studied effects of breed, dietary fat source, and dietary copper intake as factors known to influence unsaturation of milk fat and its potential for development of spontaneous oxidized flavor in milk. Twelve Holstein and 12 Jersey cows were allotted to three blocks with four cows of each breed. Cows within breed were allotted randomly within blocks and fed control or copper-depleting diets for 2 mo to achieve stable or depleted liver copper stores. Cows then were fed tallow or roasted whole soybeans in a two-period switchback (5 wk per period); during the last week of each period additional vitamin E (2000 IU/d) was added. Copper depletion for 2 mo decreased concentrations of copper in liver. Feed intake and milk yield were influenced only by breed. The proportions of C4:0 to C14:0 and C18:0 in milk fat were higher, whereas C16:1 and cis-C18:1 were lower in Jersey cows. Feeding soybeans increased C4:0 to C14:0, C18:0, C18:2, and C18:3 in milk, and decreased C14:1, C16:0, C16:1, trans-C18:1, and cis-C18:1. Depleted copper status increased conjugated linoleic acid in milk. Several breed x fat source interactions for individual milk fatty acids occurred. Feeding soybeans decreased plasma concentrations of copper and zinc, and increased concentrations of alpha-tocopherol in plasma and milk. The concentration of zinc was higher in milk of Jersey cows. Depleted copper status tended to increase copper concentration in plasma and decreased copper in milk. Fat source did not influence plasma copper concentration when status was adequate, but plasma copper concentration was higher when tallow was fed to cows with depleted copper status. Supplementing vitamin E increased concentration of alpha-tocopherol in plasma and milk and decreased concentration of zinc in milk. Factors influencing the potential for oxidized flavor development in milk can be manipulated by changing the diet of the cow.

We recently encountered an unusual case of composite lymphoma arising in a 73-year-old man with a history of follicular small cleaved cell lymphoma. The neoplasm was composed of follicular small cleaved cell lymphoma and nodular sclerosing Hodgkin disease within a single groin lymph node. In addition to morphologic evidence, the immunologic studies performed in this case demonstrated the simultaneous occurrence of 2 separate lymphocytic proliferations. To the best of our knowledge, only one such histologic type has been reported in the literature.1 Hodgkin lymphoma can develop in patients with non-Hodgkin disease and vice versa, especially after treatment. The simultaneous occurrence of Hodgkin disease and non-Hodgkin lymphoma in a single lymph node is extremely rare. In this article, the relationship between Hodgkin disease and non-Hodgkin lymphoma is explored, possible explanations for the occurrence of composite lymphoma are discussed, and the literature is reviewed.

Summary The case records of 149 dogs examined from 1985 to 1989 with clinical signs of nasal disease were reviewed. Gross rhinoscopy was performed in 119 dogs, and rhinoscopy-assisted pinch biopsy was performed in 109. Rhinoscopy was performed by use of a 2.7-mm rigid fiberoptic endoscope. Mucosal biopsy specimens were obtained with rhinoscopic guidance by use of a 2 × 3-mm biopsy forcep. Gross, cytologic, and histologic findings are summarized. Ninety-four of 119 cases could be evaluated on the basis of diagnostic and follow-up criteria established by the authors. The diagnostic success rate of gross rhinoscopy with rhinoscopy-assisted biopsy was 83% (78 of 94 evaluated cases). Protracted hemorrhage was a complication in 2 of 109 cases in which rhinoscopy-assisted biopsy was performed. It was concluded that rhinoscopy with rhinoscopy-assisted biopsy contributes important diagnostic information in dogs with nasal disease without the relative invasiveness, expense, and risk of surgery.

The paper argues that the point of a business ethics course is to improve behavior in business, and that an essential ingredient in that improved behavior is knowing what's right or wrong. To make that claim, the paper attempts to dispose of three arguments which support the contrary claim, that business ethics courses are useless. First, it is argued that morals can't be taught, since they only result from training. Second, it is argued that such courses are unnecessary because business executives already know right from wrong. Third, it is argued that ethical knowledge is impossible, so there is nothing to teach. The first two arguments are dealt with briefly, and the third is addressed extensively. The paper argues that the scepticism about ethical knowledge is part of a pervasive “relativism” in our society, but shows that such a relativism/scepticism is untenable and indicates how ethical knowledge is possible. If, then, knowledge of right and wrong is an essential ingredient for improving business behavior, and such knowledge can be imparted in an ethics course, there is some point to teaching business ethics.

A significant result of the report “Toward A More Responsible Two-Party System” has been the marked growth of interest in the American party system. It is nevertheless true that our knowledge about the way in which party systems function is far from complete. An area promising fruitful research and presenting many hypotheses susceptible of systematic inquiry is that of the role of party organizations in the legislative process. It is the purpose of this article to examine the legislative role of political parties in the Pennsylvania General Assembly; more precisely, to measure their influence in the formation of the state's public policies in one session of the legislature. The most recent completed session at the time of this study was that of 1951—the longest session in state history. In order to evaluate the impact of party upon legislation, the concept of a “party vote” has been used. This is merely an operating definition by which to measure differences in party attitudes on questions subjected to roll-call votes on the floor. The assumption was made that the interests of the parties can be established best by analyzing the voting behavior of their membership. Questions to which partisan significance is attached will find the parties aligned against each other.

The induction of middle meiotic promoters is a key regulatory event in the life cycle of Saccharomyces cerevisiae that controls exit from prophase, meiosis, and spore formation. The Sum1 repressor and Ndt80 activator proteins control middle promoters by binding to overlapping DNA elements. NDT80 is controlled by a tightly regulated middle meiotic promoter through a positive autoregulatory loop and is repressed in vegetative cells by Sum1. It has previously been shown that the meiosis-specific kinase Ime2 promotes the removal of Sum1 from DNA. Here, we show that Sum1 is also regulated by the cyclin-dependent kinase, Cdk1. While sum1 phosphosite mutants that are insensitive to Cdk1 or Ime2 complete meiosis and form spores, a mutant that is insensitive to both Ime2 and Cdk1 (sum1-ci) blocks meiotic development in prophase with an ndt80Delta-like phenotype. Ectopic expression of NDT80 or mutation of a Sum1-binding element in the NDT80 promoter bypasses the sum1-ci block. Hst1 is a NAD(+)-dependent histone deacetylase that is linked to Sum1 by the Rfm1 tethering factor. Deletion of HST1 or RFM1 also bypasses the sum1-ci block. These results demonstrate that Sum1 functions as a key meiotic brake through the NDT80 promoter and that Cdk1 and Ime2 trigger exit from meiotic prophase by inhibiting the Sum1 transcriptional repression complex.

&lt;div class="htmlview paragraph"&gt;A method for measuring and comparing the flow distribution of a monolithic catalytic converter is developed and the important parameters influencing flow are determined. The pressure losses through a converter are measured and analyzed and a theoretical relationship between flow distribution and converter life is developed.&lt;/div&gt;

The effects of damage to the dorsal and medial cortex of turtles were investigated in two experiments. In the first, damage to the dorsal cortex disrupted acquisition and reversal of a go-no-go discrimination but had no effect on retention of the discrimination if it had been learned preoperatively. Medial cortex damage had no effect. In the second experiment, dorsal cortex damage impaired acquisition, but not extinction or reacquisition, of a discrete-trial keypress. Again, medial cortex damage had no effect. The results suggest that the dorsal cortex is involved in learning in turtles.

This article examines metacognitive-based teaching strategies and provides preliminary evidence about their effectiveness in the political science classroom. In a 2013 Fall semester Introduction to Political Science course, three metacognitive-based teaching strategies were designed and implemented for improving student learning through greater self-regulation and awareness. This article compares the student learning outcomes to a previous version of the course and also assesses student learning over the semester, including a pre- and postassessment of course-based knowledge. By assessing changes in student learning, the article investigates, identifies and isolates specific and transferable classroom interventions for improving student learning and proposes using metacognitive-based teaching strategies in a political science classroom.

Background Parenteral anti-CD3 Mab (OKT3) has been used to treat transplant rejection and parental administration of a humanized anti-CD3 Mab (Teplizumab) showed positive effects in diabetes. Nasal administration of anti-CD3 Mab has not been carried out in humans. Nasal anti-CD3 Mab suppresses autoimmune diseases and central nervous system (CNS) inflammation in animal models. We investigated the safety and immune effects of a fully humanized, previously uncharacterized nasal anti-CD3 Mab (Foralumab) in humans and its in vitro stimulatory properties. Methods In vitro , Foralumab were compared to UCHT1 anti-human CD3 mAb. For human administration, 27 healthy volunteers (9 per group) received nasal Foralumab or placebo at a dose of 10ug, 50ug, or 250ug daily for 5 days. Safety was assessed and immune parameters measured on day 1 (pre-treatment), 7, 14, and 30 by FACS and by scRNAseq. Results In vitro , Foralumab preferentially induced CD8+ T cell stimulation, reduced CD4+ T cell proliferation and lowered expression of IFNg, IL-17 and TNFa. Foralumab induced LAP, TIGIT, and KLRG1 immune checkpoint molecules on CD8+ and CD4+ T cells in a mechanism independent of CD8 T cells. In vivo , nasal Foralumab did not modulate CD3 from the T cell surface at any dose. Immune effects were primarily observed at the 50ug dose and consisted of reduction of CD8+ effector memory cells, an increase in naive CD8+ and CD4+ T cells, and reduced CD8+ T cell granzyme B and perforin expression. Differentially expressed genes observed by scRNAseq in CD8+ and CD4+ populations promoted survival and were anti-inflammatory. In the CD8+ TEMRA population there was induction of TIGIT, TGFB1 and KIR3DL2, indicative of a regulatory phenotype. In the memory CD4+ population, there was induction of CTLA4, KLRG1, and TGFB whereas there was an induction of TGF-B1 in naïve CD4+ T cells. In monocytes, there was induction of genes (HLA-DP, HLA-DQ) that promote a less inflammatory immune response. No side effects were observed, and no subjects developed human anti-mouse antibodies. Conclusion These findings demonstrate that nasal Foralumab is safe and immunologically active in humans and presents a new avenue for the treatment of autoimmune and CNS diseases.