Sanford Broadway Medical Center

People learning new concepts can often generalize successfully from just a single example, yet machine learning algorithms typically require tens or hundreds of examples to perform with similar accuracy. People can also use learned concepts in richer ways than conventional algorithms-for action, imagination, and explanation. We present a computational model that captures these human learning abilities for a large class of simple visual concepts: handwritten characters from the world's alphabets. The model represents concepts as simple programs that best explain observed examples under a Bayesian criterion. On a challenging one-shot classification task, the model achieves human-level performance while outperforming recent deep learning approaches. We also present several "visual Turing tests" probing the model's creative generalization abilities, which in many cases are indistinguishable from human behavior.

Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding angiogenic growth factors, which are secreted by hypoxic cells and stimulate endothelial cells, leading to angiogenesis. To determine whether HIF-1 also mediates cell-autonomous responses to hypoxia, we have compared gene expression profiles in arterial endothelial cells cultured under nonhypoxic versus hypoxic conditions and in nonhypoxic cells infected with adenovirus encoding beta-galactosidase versus a constitutively active form of HIF-1alpha (AdCA5). There were 245 gene probes that showed at least 1.5-fold increase in expression in response to hypoxia and in response to AdCA5; 325 gene probes showed at least 1.5-fold decrease in expression in response to hypoxia and in response to AdCA5. The largest category of genes down-regulated by both hypoxia and AdCA5 encoded proteins involved in cell growth/proliferation. Many genes up-regulated by both hypoxia and AdCA5 encoded cytokines/growth factors, receptors, and other signaling proteins. Transcription factors accounted for the largest group of HIF-1-regulated genes, indicating that HIF-1 controls a network of transcriptional responses to hypoxia in endothelial cells. Infection of endothelial cells with AdCA5 under nonhypoxic conditions was sufficient to induce increased basement membrane invasion and tube formation similar to the responses induced by hypoxia, indicating that HIF-1 mediates cell-autonomous activation of endothelial cells.

Abstract The mirroring hypothesis predicts that organizational ties within a project, firm, or group of firms (e.g., communication, collocation, employment) will correspond to the technical dependencies in the work being performed. This article presents a unified picture of mirroring in terms of theory, evidence, and exceptions. First, we formally define mirroring and argue that it is an approach to technical problem-solving that conserves scarce cognitive resources. We then review 142 empirical studies, divided by organizational form into (i) industry studies, (ii) firm studies, and (iii) studies of open collaborative projects. The industry and firm studies indicate that mirroring is a prevalent pattern but not universal. However, in technologically dynamic industries, partial mirroring, where knowledge boundaries are drawn more broadly than operational boundaries, is likely to be a superior strategy. Firms can also strategically ‘break the mirror’ by implementing modular partitions within their boundaries, or by building relational contracts across their boundaries. Finally, studies of open collaborative projects, most of which focused on software, were not supportive of the hypothesis. We argue that digital technologies make possible new modes of coordination that enable groups to deviate from classical mirroring as seen in firms.

We introduce a conditional generative model for learning to disentangle the hidden factors of variation within a set of labeled observations, and separate them into complementary codes. One code summarizes the specified factors of variation associated with the labels. The other summarizes the remaining unspecified variability. During training, the only available source of supervision comes from our ability to distinguish among different observations belonging to the same class. Examples of such observations include images of a set of labeled objects captured at different viewpoints, or recordings of set of speakers dictating multiple phrases. In both instances, the intra-class diversity is the source of the unspecified factors of variation: each object is observed at multiple viewpoints, and each speaker dictates multiple phrases. Learning to disentangle the specified factors from the unspecified ones becomes easier when strong supervision is possible. Suppose that during training, we have access to pairs of images, where each pair shows two different objects captured from the same viewpoint. This source of alignment allows us to solve our task using existing methods. However, labels for the unspecified factors are usually unavailable in realistic scenarios where data acquisition is not strictly controlled. We address the problem of disentanglement in this more general setting by combining deep convolutional autoencoders with a form of adversarial training. Both factors of variation are implicitly captured in the organization of the learned embedding space, and can be used for solving single-image analogies. Experimental results on synthetic and real datasets show that the proposed method is capable of generalizing to unseen classes and intra-class variabilities.

We are trying to extend the boundary of Information Extraction (IE) systems. Existing IE systems require a lot of time and human effort to tune for a new scenario. Preemptive Information Extraction is an attempt to automatically create all feasible IE systems in advance without human intervention. We propose a technique called Unrestricted Relation Discovery that discovers all possible relations from texts and presents them as tables. We present a preliminary system that obtains reasonably good results.

Six types of macroturbulence phenomena in natural streams are discussed: Velocity and stage surges which are rhythmic or cyclic; eddying which is continuous; upward and downward vortex actions which are intermittent; transverse oscillations of water surface and helicoidal effects, which are continuous. These are all caused by channel roughness but do not appear to be related to microturbulence. However, the eddy and vortex types, which are flow separations, dissipate through disintegration at their peripheries into macroturbulence. A new term, “kolk,” is introduced to supplement a deficiency for designating upward vortex action, considered one of the most prolific as well as important forms of stream dynamics. The need for additional research is emphasized.

Metal biochemistry drives a diverse range of cellular processes associated with development, health and disease. Determining metal distribution, concentration and flux defines our understanding of these fundamental processes. A comprehensive analysis of biological systems requires a balance of analytical techniques that inform on metal quantity (sensitivity), chemical state (selectivity) and location (spatial resolution) with a high degree of certainty. A number of approaches are available for imaging metals from whole tissues down to subcellular organelles, as well as mapping metal turnover, protein association and redox state within these structures. Technological advances in micro- and nano-scale imaging are striving to achieve multi-dimensional and in vivo measures of metals while maintaining the native biochemical environment and physiological state. This Tutorial Review discusses state-of-the-art imaging technology as a guide to obtaining novel insight into the biology of metals, with sensitivity, selectivity and spatial resolution in focus.

Improved street lighting serves many functions and is used in both public and private settings. The prevention of personal and property crime is one of its objectives in public space, which is the main focus of this systematic review. There are two main theories of why improved street lighting may cause a reduction in crime. The first suggests that improved lighting leads to increased surveillance of potential offenders (both by improving visibility and by increasing the number of people on the street) and hence to increased deterrence of potential offenders. The second suggests that improved lighting signals community investment in the area and that the area is improving, leading to increased community pride, community cohesiveness, and informal social control. The first theory predicts decreases in crime especially during the hours of darkness, while the second theory predicts decreases in crime during both daytime and nighttime. Results of this review indicate that improved street lighting significantly reduces crime. This lends support for the continued use of improved street lighting to prevent crime in public space. The review also found that nighttime crimes did not decrease more than daytime crimes. This suggests that a theory of street lighting focusing on its role in increasing community pride and informal social control may be more plausible than a theory focusing on increased surveillance and increased deterrence. Future research should be designed to test the main theories of the effects of improved street lighting more explicitly, and future lighting schemes should employ high quality evaluation designs with long‐term followups. Abstract Background Improved street lighting is intended to serve many purposes, one of them being the prevention of crime. While street lighting improvements may not often be implemented with the expressed aim of preventing crime – pedestrian safety and traffic safety may be viewed as more important aims – and the notion of lighting streets to deter lurking criminals may be too simplistic, its relevance to the prevention of crime has been suggested in urban centers, residential areas, and other places frequented by criminals and potential victims. Objectives The main objective of this review is to assess the available research evidence on the effects of improved street lighting on crime in public space. In addition to assessing the overall impact of improved street lighting on crime, this review will also investigate in which settings, against which crimes, and under what conditions it is most effective. Search strategy Four search strategies were employed to identify studies meeting the criteria for inclusion in this review: (1) searches of electronic bibliographic databases; (2) searches of literature reviews on the effectiveness of improved street lighting in preventing crime; (3) searches of bibliographies of street lighting studies; and (4) contacts with leading researchers. Both published and unpublished reports were considered in the searches. Searches were international in scope and were not limited to the English language. Selection criteria Studies that investigated the effects of improved street lighting on crime were included. For studies involving one or more other interventions, only those studies in which improved street lighting was the main intervention were included. Studies were included if they had, at a minimum, an evaluation design that involved before‐and‐after measures of crime in experimental and control areas. There needed to be at least one experimental area and one reasonably comparable control area. Data collection & analysis Narrative findings are reported for the 13 studies included in this review. A meta‐analysis of all 13 of these studies was carried out. The “relative effect size” or RES (which can be interpreted as an incident rate ration) was used to measure effect size. Results are reported for total crime and, where possible, property and violent crime categories using (mostly) official data. In the case of studies that measure the impact of improved street lighting programs on crime at multiple points in time, similar time periods before and after are compared (as far as possible). The review also addresses displacement of crime and diffusion of crime prevention benefits. Main results The studies included in this systematic review indicate that improved street lighting significantly reduces crime, is more effective in reducing crime in the United Kingdom than in the United States, and that nighttime crimes do not decrease more than daytime crimes. Reviewers’ conclusions We conclude that improved street lighting should continue to be used to prevent crime in public areas. It has few negative effects and clear benefits for law‐abiding citizens.

For physicians to admit that a group of patients remains for whom no cure is available in modern medicine is intellectually unsatisfying. Pulmonary arterial hypertension is a rare condition. Because the symptoms are nonspecific and the physical finding can be subtle, the disease is often diagnosed in its later stages. The natural history of pulmonary arterial hypertension is usually progressive and fatal. At the 1998 Primary Pulmonary Hypertension World Symposium, clinical scientists from around the world gathered to review and discuss the future of pulmonary arterial hypertension. Bringing together experts from a variety of disciplines provided the opportunity for a better understanding of the pathology, pathobiology, risk factors, genetics, diagnosis and treatment for pulmonary arterial hypertension. Remarkable progress has been made in the field of pulmonary arterial hypertension over the past several decades. The pathology is now better defined and significant advances have occurred in understanding the pathobiological mechanisms. Risk factors have been identified and the genetics have been characterised. Advances in technology allow earlier diagnosis as well as better assessment of disease severity. Therapeutic modalities such as new drugs, e.g. epoprostenol, treprostinil and bosentan, and surgical interventions, e.g. transplantation and blade septostomy, which were unavailable several decades ago, have had a significant impact on prognosis and outcome. Thus, despite the inability to really cure pulmonary arterial hypertension, therapeutic advances over the past two decades have resulted in significant improvements in the outcome for children with various forms of pulmonary arterial hypertension. This review of pulmonary arterial hypertension will highlight the key features of pulmonary hypertension in infants and children and the current understanding of pulmonary arterial hypertension with specific recommendations for current practice and future directions.

Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei. The compound and its two principal metabolites, sulfoxide and sulfone, have been assessed for their ability to kill a range of T. brucei parasite strains in vitro and to cure both acute and chronic HAT disease models in the mouse. The parent molecule and both metabolites have shown trypanocidal activity in vitro in the 0.7-to-3.3 μM (0.2-to-0.9 μg/ml) range against all parasite strains tested. In vivo, fexinidazole is orally effective in curing both acute and chronic diseases in the mouse at doses of 100 mg/kg of body weight/day for 4 days and 200 mg/kg/day for 5 days, respectively. Pharmacokinetic data indicate that it is likely that the sulfoxide and sulfone metabolites provide most, if not all, of the in vivo killing activity. Fexinidazole and its metabolites require up to 48 h exposure in order to induce maximal trypanocidal efficacy in vitro. The parent drug and its metabolites show no in vitro cross-reactivity in terms of trypanocidal activity with either themselves or other known trypanocidal drugs in use in humans. The in vitro and in vivo antitrypanosomal activities of fexinidazole and its two principal metabolites provide evidence that the compound has the potential to be an effective oral treatment for both the T. b. gambiense and T. b. rhodesiense forms of human sleeping sickness and both stages of the disease.

A novel solar water-energy nexus technology is presented that combines the solar desalination of saline water and desalination-driven wastewater remediation coupled with the production of H₂.

BACKGROUND: Urine tests for Chlamydia trachomatis permit expansion of screening beyond traditional clinic environments. Prevention of infection in teenagers is a high priority. OBJECTIVE: To define the prevalence of C. trachomatis among teenagers by using the ligase chain reaction assay on urine specimens and to evaluate leukocyte esterase testing of urine specimens as an indicator of infection. DESIGN: Cross-sectional study. SETTING: An adolescent clinic, a juvenile detention facility, seven school-based clinics, and three community-based youth organizations in Seattle, Washington. PARTICIPANTS: 10,118 sexually active teenagers and young adults. MEASUREMENTS: Chlamydia trachomatis infection detected in urine specimens by ligase chain reaction assay and leukocyturia detected by leukocyte esterase testing. RESULTS: The prevalence of chlamydial infection among female participants was 8.6% and declined with increasing age; among male participants, it was 5.4% and increased with increasing age. In female participants, independent predictors of infection were being 17 years of age or younger (odds ratio [OR], 1.49), having had two or more sex partners in the previous 2 months (OR, 1.61), and having genitourinary symptoms (OR, 1.46). In male participants, independent predictors were being of nonwhite race or ethnicity (OR, 2.00 to 3.08), having had two or more sex partners in the previous 2 months (OR, 1.57), and having used a condom during the most recent sexual encounter (OR, 0.67). For identifying infection in male participants, the sensitivity of leukocyte esterase testing was 58.9%, the specificity was 94.9%, the positive predictive value was 38.4%, and the negative predictive value was 97.7%. CONCLUSIONS: Chlamydial infection is common in teenagers and young adults in community settings. The urine ligase chain reaction assay will permit widespread screening for C. trachomatis, but leukocyte esterase testing had low sensitivity for selecting persons for screening with this assay. Indicators of chlamydial infection differed substantially in male and female participants.

S ummary Stomatal opening and closing was followed with a diffusion porometer in beech (Fagus grandi‐folia Ehrh.), maple (Acer rubrum L.), oak (Quercus rubra L.) and yellow poplar (Liriodendron tulipifera L.) in a situation where illuminance could be changed by placing shades over the trees. In all four species the stomata opened quicker than they closed. The time to reach an equilibrium stomatal resistance was constant for a species but varied between species, for all changes in illuminance greater than 3000 ft‐candles. To open to a constant leaf resistance took from 3 minutes in beech to 20 minutes in yellow poplar; oak and maple were intermediate at 12 minutes. Beech required 12 minutes to close to a constant leaf resistance, maple 18, oak 20, and yellow poplar 36 minutes. When the change in illuminance was less than 3000 ft‐candles, the stomata took longer to reach a new equilibrium in all species except yellow poplar. Also beech stomata opened and closed in dimmer light than yellow poplar. The rates of stomatal opening and closing correlated well with the known shade tolerance of the species.

Norepinephrine (NE) is widely implicated in opiate withdrawal, but much less is known about its role in opiate-induced locomotion and reward. In mice lacking dopamine beta-hydroxylase (DBH), an enzyme critical for NE synthesis, we found that NE was necessary for morphine-induced conditioned place preference (CPP; a measure of reward) and locomotion. These deficits were rescued by systemic NE restoration. Viral restoration of DBH expression in the nucleus tractus solitarius, but not in the locus coeruleus, restored CPP for morphine. Morphine-induced locomotion was partially restored by DBH expression in either brain region. These data suggest that NE signaling by the nucleus tractus solitarius is necessary for morphine reward.

BACKGROUND: Human primordial germ cells (PGCs) can give rise to pluripotent stem cells such as embryonal carcinoma cells (ECCs) and embryonic germ cells (EGCs). METHODS: In order to determine whether PGCs express markers associated with pluripotency in EGCs and ECCs, the following study cross examines the expression patterns of multiple pluripotent markers in the human fetal ovary, 5.5-15 weeks post-fertilizaton (pF) and relates this expression with the ability to derive pluripotent EGCs in vitro. RESULTS: Specific subpopulations were identified which included OCT4(+)/Nanog(+)/cKIT(+)/VASA(+) PGCs and oogonia. Interestingly, these cells also expressed SSEA1 and alkaline phosphatase (AP) and SSEA4 expression occurred throughout the entire gonad. Isolation of SSEA1(+) cells from the gonad resulted in AP(+) EGC colony formation. The number of OCT4(+) or Nanog(+) expressing cells peaked by week 8 and then diminished after week 9 pF, as oogonia enter meiosis. In addition, the efficiency of EGC derivation was associated with the number of OCT4(+) cells. TRA-1-60 and TRA-1-81 were only detected in the lining of the mesonephric ducts and occasionally in the gonad. CONCLUSIONS: These results demonstrate that PGCs, a unipotent cell, express most, but not all, of the markers associated with pluripotent cells in the human fetal ovary.

Primordial black holes, formed from rare peaks in the primordial fluctuations $\zeta$, are non-rotating at zeroth order in $\zeta_{\rm rms}$. We show that the spin also vanishes at first order in $\zeta_{\rm rms}$, suggesting the dimensionless spin parameter $a_{\rm rms} \sim \zeta_{\rm rms}^2$. We identify one quadratic contribution to the spin by calculating (and extrapolating to the formation time) the torque on a black hole due to ambient acoustic waves. For a reasonable density of primordial black holes this implies a percent level spin parameter.

Thermal decomposition of layered zinc hydroxide double salts provides an interesting alternative synthesis for particles of zinc oxide. Here, we examine the sequence of changes occurring as zinc hydroxide chloride monohydrate (Zn5(OH)8Cl2·H2O) is converted to crystalline ZnO by thermal decomposition. The specific surface area of the resultant ZnO measured by BET was 1.3 m(2) g(-1). A complicating and important factor in this process is that the thermal decomposition of zinc hydroxide chloride is also accompanied by the formation of volatile zinc-containing species under certain conditions. We show that this volatile compound is anhydrous ZnCl2 and its formation is moisture dependent. Therefore, control of atmospheric moisture is an important consideration that affects the overall efficiency of ZnO production by this process.

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Electronystagmography and rotary vestibular testing are of definite but limited value in screening the dizzy patient. Objective identification of a vestibular abnormality is valuable, but there is an additional need to appraise the functional capacity of those suffering central or peripheral disorders causing spatial disorientation or disequilibrium. Records of 175 patients undergoing posturography in the author's practice over a 1-year period were reviewed. Diagnosis was established by conventional neurotologic means including computerized electronystag-mography. Abnormal results on posturography were identified by criteria established through the national users group of Equi-Test participants. There were 112 peripheral cases with 50 (45%) abnormal on posturography, in contrast to 53 central patients with 38 (72%) abnormal. Posturography established a functional level of balance in certain peripheral and central disorders and provides limited but significant aid to assist in distinguishing between the two.

Abstract: Nowtopia identifies a new basis for a shared experience of class. Specifically, the exodus from wage labor on one side, and the embrace of meaningful, freely chosen and “free” (unpaid) work on the other. A product of three decades of decomposition of the working class, nowtopians are different from “drop‐outs” in general, or surplus populations that constitute the necessary “outside” to capital, in their conscious withdrawal from capitalist culture and concerted rejection of the value form. In emergent convivial “nowtopian” communities, largely grounded in unpaid practical work which creatively meets needs such as transportation (the bicycling subculture), food (urban gardening/agriculture), and communication (open‐source communities), we see a gradual reversal of the extreme atomization of modern life. While facing the threat of corruption via re‐integration into the system, this constellation of practices, if taken together, is an elaborate, decentralized, uncoordinated collective research and development effort exploring a potentially post‐capitalist, post‐petroleum future.