State Key Laboratory of Structural Analysis for Industrial Equipment

The rich range of biomarkers in sweat and the ability to collect sweat in a non-invasive manner create interest in the use of this biofluid for assessments of health and physiological status, with potential applications that range from sports and fitness to clinical medicine. This paper introduces two important advances in recently reported classes of soft, skin-interfaced microfluidic systems for sweat capture and analysis: (1) a simple, broadly applicable means for collection of sweat that bypasses requirements for physical/mental exertion or pharmacological stimulation and (2) a set of enzymatic chemistries and colorimetric readout approaches for determining the concentrations of creatinine and urea in sweat, throughout ranges that are physiologically relevant. The results allow for routine, non-pharmacological capture of sweat for patient populations, such as infants and the elderly, that cannot be expected to sweat through exercise, and they create potential opportunities in the use of sweat for kidney disease screening/monitoring. Studies on human subjects demonstrate these essential capabilities, with quantitative comparisons to standard methods. The results expand the range of options available in microfluidic sampling and sensing of sweat for disease diagnostics and health monitoring.

Summary The orientations of ground motions are paramount when the pulse‐like motions and their unfavorable seismic responses are considered. This paper addresses the stochastic modeling and synthesizing of near‐fault impulsive ground motions with forward directivity effect taking the orientation of the strongest pulses into account. First, a statistical parametric analysis of velocity time histories in the orientation of the strongest pulse with a specified magnitude and various fault distances is performed. A new stochastic model is established consisting of a velocity pulse model with random parameters and a stochastic approach to synthesize high‐frequency velocity time history. The high‐frequency velocity history is achieved by integrating a stochastic high‐frequency accelerogram, which is generated via the modified K‐T spectrum of residual acceleration histories and then modulated by the specific envelope function. Next, the associated parameters of pulse model, envelope function, and power spectral density are estimated by the least‐square fitting. Some chosen parameters in the stochastic model of near‐fault motions based on correlation analysis are regarded as random variables, which are validated to follow the normal or lognormal distribution. Moreover, the number theoretical method is suggested to select efficiently representative points, for generating artificial near‐fault impulsive ground motions with the feature of the strongest pulse, which can be used to the seismic response and reliability analysis of critical structures conveniently. Finally, the simulated ground motions demonstrate that the synthetic ground motions generated by the proposed stochastic model can represent the impulsive characteristic of near‐fault ground motions. Copyright © 2014 John Wiley & Sons, Ltd.

Mechanical friction and wear account for approximately one third of the present global energy consumption.

Microneedles have recently received much attention as a novel way for transdermal drug delivery. In this paper, a numerical simulation of the insertion process of the microneedle into human skin is reported using the finite element method. A multilayer skin model consisting of the stratum corneum, dermis and underlying hypodermis has been developed. The effective stress failure criterion has been coupled with the element deletion technique to predict the complete insertion process. The numerical results show a good agreement with the reported experimental data for the deformation and failure of the skin and the insertion force. The influences of the mechanical properties of the skin and the microneedle geometry (e.g. tip area, wall angle and wall thickness) on the insertion force are discussed. The numerical results are helpful for the optimum design of the microneedles for the transdermal drug delivery system.

Drug-target residence time (t = 1/k(off), where k(off) is the dissociation rate constant) has become an important index in discovering better- or best-in-class drugs. However, little effort has been dedicated to developing computational methods that can accurately predict this kinetic parameter or related parameters, k(off) and activation free energy of dissociation (ΔG(off)≠). In this paper, energy landscape theory that has been developed to understand protein folding and function is extended to develop a generally applicable computational framework that is able to construct a complete ligand-target binding free energy landscape. This enables both the binding affinity and the binding kinetics to be accurately estimated. We applied this method to simulate the binding event of the anti-Alzheimer's disease drug (-)-Huperzine A to its target acetylcholinesterase (AChE). The computational results are in excellent agreement with our concurrent experimental measurements. All of the predicted values of binding free energy and activation free energies of association and dissociation deviate from the experimental data only by less than 1 kcal/mol. The method also provides atomic resolution information for the (-)-Huperzine A binding pathway, which may be useful in designing more potent AChE inhibitors. We expect this methodology to be widely applicable to drug discovery and development.

A flexible piezoresistive sensor based on interlocked graphene microarrays displays adjustable piezoresistance by changing the contact way of the graphene microarrays.

Cr³⁺ was substituted into Co–Zn ferrite to adjust the Curie temperature and coercivity for self-regulating hyperthermia temperature.

Poly-ether-ether-ketone (PEEK) was deeply investigated as a composite matrix because of its outstanding mechanical properties and thermostability. However, the performance improvement of fiber-reinforced PEEK composites was moderate according to a great number of experimental investigations. An insightful understanding of the deformation and interfacial failure in the PEEK composite is needed to guide the future fabrication of high-performance PEEK plastics. In this paper, Molecular Dynamics (MD) simulation was employed to evaluate the mechanical properties of carbon nanotube (CNT) reinforced PEEK nanocomposites. It was found that the weak interface between CNTs and the PEEK matrix leads to the flaws in the CNT/PEEK nanocomposite. A CNT-functionalization strategy was used to introduce H-bonds between CNTs and the PEEK matrix, improving the overall mechanical performance of the CNT/PEEK nanocomposite. Numerical examples validate that the addition of amino groups on CNTs can significantly improve the interfacial failure shear stress and elastic modulus of the CNT/PEEK nanocomposites. This mechanism study provides evidence and a theoretical basis to improve the mechanical performance of fiber-reinforced PEEK for lightweight structures in advanced equipment.

In this letter, a novel dynamic model of a cable-driven continuum robot is established based on the principle of virtual power, in which the dynamically centralized length of the driving cable is used to simulate the driving process. This loading model implicitly represents the driving loads and explicitly describes the geometrical constraint of cables on the system. The distribution law for friction forces of actuated cables is demonstrated, which can be handily represented by the derived relationship between the tension of the cables and the Lagrange multiplier. This dynamic model is applicable for continuum robots with a single/multi-tandem arm driven by any number of cables. Furthermore, an average stress strategy is developed so that the high-frequency components of the dynamic model can be reasonably controlled in a simple but effective manner, which can strikingly reduce the stiffness of the differential equations. Simulation results show that this strategy significantly improves the simulation efficiency with sound and reasonable precision. A comparison of the results from the numerical simulations and experiments for a cable-driven continuum structure verifies the validity of the proposed model, and the average percentage error for the trajectory between the simulation and experimental results is 1.92%. Moreover, the numerical simulations for the dynamic equations of the cable-driven continuum robot with twenty segments can be run in real-time.

SUMMARY In this paper, the performance of the incompressible SPH (ISPH) method and an improved weakly compressible SPH (IWCSPH) method for free surface incompressible flows are compared and analyzed. In both methods, the Navier–Stokes equations are solved, and no artificial viscosity is used. The ISPH algorithm in this paper is based on the classical SPH projection method with common treatments on solid boundaries and free surfaces. The IWCSPH model includes some advanced corrective algorithms in density approximation and solid boundary treatment (SBT). In density approximation, the moving least squares (MLS) approach is applied to re‐initialize density every several steps to obtain smoother and more stable pressure fields. An improved coupled dynamic SBT algorithm is implemented to obtain stable pressure values near solid wall areas and, thus, to minimize possible numerical oscillations brought in by the solid boundaries. Three representative numerical examples, including a benchmark test for hydrostatic pressure, a dam breaking problem and a liquid sloshing problem, are comparatively analyzed with ISPH and IWCSPH. It is demonstrated that the present IWCSPH is more attractive than ISPH in modeling free surface incompressible flows as it is more accurate and more stable with comparable or even less computational efforts. Copyright © 2013 John Wiley & Sons, Ltd.

Flexible piezoelectric mechanical energy harvesters (MEHs) are of recent interest as an important emerging variant of traditional piezoelectric devices. The design of stacking multilayer MEHs with adhesive in between is an effective way to enhance the magnitude of power generation. Here, we present an analytic model to study the mechanical behavior of the multilayer MEHs based on lead zirconate titanate (PZT) subjected to Euler buckling. Being different from the hypothesis of the plane section for the entire stack, it is found that each polyimide (PI) layer holds plane section of its own, while soft adhesives serve as shear lags. Accordingly, the neutral mechanical plane is split into multiple ones. The deformation is almost the same for each PI layer, as well as PZT arrays, which is very beneficial to avoid the premature failure of devices. The extreme cases and the transition of these cases are all captured quantitatively with a unified analytic model which is verified by the finite element method. A dimensionless parameter is obtained to characterize the degree of the splitting of neutral mechanical plane, which is significant for the design of the multilayer PZT MEHs.

This study investigated the cryogenic mechanical properties of modified nano-ZrO₂ reinforced epoxy composites.

The operation and control of the cable-driven continuum robot (CDCR) is directly determined by the actuation of cables, and the relationship between the driving length and the tension as well as the morphology of the CDCR has not been deeply researched in previous literature. In this article, a novel methodology for perceiving the morphology, tension, and driving state of the robot is proposed, which can be calculated only by the dynamic driving length/speed of cables without using shape sensors and tension sensors. First, a model of the tension distribution along with the cable path is deduced, which takes into account the influence of the sliding friction. Second, a rigid-flexible coupling dynamic model considering the strain of the cable is established. Then, a nonlinear complementary model between the driving state and the tensions of cables is constructed based on the mechanism of cable actuation, and an efficient solution algorithm is presented. Experiments of a single arm driven by two cables and a three-tandem arm driven by multiple cables were conducted to validate the proposed method. The average errors of the perceiving morphology and tension are 1.85% and 7.26%, respectively, and the transaction between the slack and tensional state of the driving cable is accurately captured. In addition, the hysteresis behavior of the cable actuation is also perceived.

Liquid oxygen compatibility mechanism of bromine-modified epoxy resin.

Schematic model of mechanical performance of short fibre reinforced polyamide 6 composites for thermo-oxidative ageing at different ageing temperatures.

One important aspect of stretchable electronics design is to shield the active devices from strains through insertion of a soft layer between devices and substrate. An analytical model is established, which gives linear dependence of strain isolation on the reciprocal of strain-isolation layer thickness, and the reciprocal of device and substrate stiffness. Strain isolation is also linearly proportional to the shear modulus of strain-isolation layer and square of device length.

Sloshing-induced slamming in a rectangular tank with centralized slat-screens with high solidity ratios was experimentally studied under nearly two-dimensional shallow-water conditions with large-amplitude harmonic lateral excitation. The main objective was to identify the solidity ratio that provides an optimal suppressing function on the free-surface elevation and slamming pressure on the vertical tank walls with a frequency domain containing the three lowest natural sloshing frequencies in a clean tank with a water depth-to-tank length ratio of h/l = 0.125 and a high forced sway amplitude. The experiments show that the optimal solidity ratio among four considered slat-screens is approximately 0.6-0.7 for the applied filling level and excitation amplitude in the examined forced frequency range. The results have potential applications in areas such as swash bulkhead design and liquefied-cargo tank design in ship and offshore engineering.

Two-bubble interaction is the most fundamental problem in multi-bubbles dynamics, which is crucial in many practical applications involving air-gun arrays and underwater explosions. In this paper, we experimentally and numerically investigate coalescence, collapse, and rebound of non-buoyant bubble pairs below a rigid wall. Two oscillating vapor bubbles with similar size are generated simultaneously near a rigid wall in axisymmetric configuration using the underwater electric discharge method, and the physical process is captured by a high-speed camera. Numerical simulations are conducted based on potential flow theory coupled with the boundary integral method. Our numerical results show excellent agreement with the experimental data until the splashing of the jet impact sets in. With different ranges of γbw (the dimensionless distance between the rigid wall and the nearest bubble center), the interaction between the coalesced bubble and the rigid wall is divided into three types, i.e., “weak,” “intermediate,” and “strong.” As γbw decreases, the contact point of the two axial jets migrates toward the wall. In “strong interaction” cases, only an upward jet towards the upper rigid wall forms and a secondary jet with a larger width appears at the base of the first jet. The collapsing coalesced bubble in a toroidal form splits into many smaller bubbles due to the instabilities and presents as bubble clouds during the rebounding phase, which may lead to a weakened pressure wave because the focusing energy associated with the collapsing bubble is disintegrated.

Molecular dynamics method is employed to investigate the buckling deformations of single-walled carbon nanotubes (SWCNTs) filled with nickel (Ni), copper (Cu), and platinum (Pt) atoms under axial compression. The critical buckling strains of filled tubes decrease linearly before a critical number of metal atoms and then increase linearly when more atoms are encapsulated. For SWCNT completely filled with metals, its critical strain is larger than that of the hollow tube. Furthermore, the critical strain of SWCNT completely filled with Ni atoms is larger than that of the tube fully filled with Cu or Pt atoms.

A pH regulated morphology evolution process was demonstrated, wherein WO₃ hollow spheres obtained at pH = 0.7 exhibit good RT NO₂ sensing performance.