SUNY Geneseo

Snyder's (1974) Self-Monitoring Scale exhibits a stable factor structure that does not correspond to the five-component theoretical structure he presents. Sets of face-valid items that better approximate the theoretical structure are described. Correlations between these sets of items and measures of other constructs reveal that four of the five components are positively related to social anxiety. Effective social interaction is supposedly the high self-monitor's forte, and social anxiety appears to be incompatible with this. The correlational results therefore question the entire theory and indicate the need for a narrower definition of the construct. Adopting such a definition from Snyder's review article (1979), we present a 13-item Revised Self-Monitoring scale which measures only sensitivity to the expressive behavior of others and ability to modify self-presentation. A 20-item Concern for Appropriateness scale is also described. This scale measures 2 variables that are directly associated with social anxiety--cross-situational variability and attention to social comparison information. Both scales have acceptable internal consistency, and both yield 2 subscale scores as well as a total score. Prospective users of either scale are advised to treat the 3 scores separately.

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTOxidative Strand Scission of Nucleic Acids: Routes Initiated by Hydrogen Abstraction from the Sugar MoietyWendy Knapp PogozelskiWendy Knapp PogozelskiDepartment of Chemistry, State University of New York at Geneseo, Geneseo, New York 14454, and Department of Chemistry, Boston University, Boston, Massachusetts 02215 More by Wendy Knapp Pogozelski and Thomas D. Tullius*Thomas D. TulliusDepartment of Chemistry, State University of New York at Geneseo, Geneseo, New York 14454, and Department of Chemistry, Boston University, Boston, Massachusetts 02215 To whom correspondence should be addressed.More by Thomas D. TulliusCite this: Chem. Rev. 1998, 98, 3, 1089–1108Publication Date (Web):April 21, 1998Publication History Received27 August 1997Revised26 February 1998Published online21 April 1998Published inissue 7 May 1998https://pubs.acs.org/doi/10.1021/cr960437ihttps://doi.org/10.1021/cr960437iresearch-articleACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views3930Altmetric-Citations915LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbohydrates,Crystal cleavage,Genetics,Hydrogen,Hydrogen abstraction Get e-Alerts

The inability of current recommendations to control the epidemic of diabetes, the specific failure of the prevailing low-fat diets to improve obesity, cardiovascular risk, or general health and the persistent reports of some serious side effects of commonly prescribed diabetic medications, in combination with the continued success of low-carbohydrate diets in the treatment of diabetes and metabolic syndrome without significant side effects, point to the need for a reappraisal of dietary guidelines. The benefits of carbohydrate restriction in diabetes are immediate and well documented. Concerns about the efficacy and safety are long term and conjectural rather than data driven. Dietary carbohydrate restriction reliably reduces high blood glucose, does not require weight loss (although is still best for weight loss), and leads to the reduction or elimination of medication. It has never shown side effects comparable with those seen in many drugs. Here we present 12 points of evidence supporting the use of low-carbohydrate diets as the first approach to treating type 2 diabetes and as the most effective adjunct to pharmacology in type 1. They represent the best-documented, least controversial results. The insistence on long-term randomized controlled trials as the only kind of data that will be accepted is without precedent in science. The seriousness of diabetes requires that we evaluate all of the evidence that is available. The 12 points are sufficiently compelling that we feel that the burden of proof rests with those who are opposed.

The purpose of this research is to answer the question: how can a new service development (NSD) program in the financial services industry be managed? More specifically, this research has two objectives: to explore the stages in the NSD process; and to explore how customer input may be obtained in the various stages of the development process. After a review of the new product development literature, the case study methodology involving in‐depth interviews with managers and their customers is described. Analysis of the data showed that there were ten stages in the NSD process, and whether those stages were managed linearly or sequentially was a function of the size of the firm. In addition, how NSD managers obtained customer input in each stage, was uncovered. Implications for NSD managers include which stages to concentrate on, and how to capture customer input.

Chin-Yau Cindy Lin, Victoria R. Fu, A Comparison of Child-Rearing Practices among Chinese, Immigrant Chinese, and Caucasian-American Parents, Child Development, Vol. 61, No. 2, Special Issue on Minority Children (Apr., 1990), pp. 429-433

Despite extensive study, there is little experimental information available as to which of the deoxyribose hydrogen atoms of duplex DNA reacts most with the hydroxyl radical. To investigate this question, we prepared a set of double-stranded DNA molecules in which deuterium had been incorporated specifically at each position in the deoxyribose of one of the four nucleotides. We then measured deuterium kinetic isotope effects on the rate of cleavage of DNA by the hydroxyl radical. These experiments demonstrate that the hydroxyl radical reacts with the various hydrogen atoms of the deoxyribose in the order 5' H > 4' H > 3' H approximately 2' H approximately 1' H. This order of reactivity parallels the exposure to solvent of the deoxyribose hydrogens. Our work therefore reveals the structural basis of the reaction of the hydroxyl radical with DNA. These results also provide information on the mechanism of DNA damage caused by ionizing radiation as well as atomic-level detail for the interpretation of hydroxyl radical footprints of DNA-protein complexes and chemical probe experiments on the structure of RNA and DNA in solution.

Abstract Purpose: The third-generation EGFR tyrosine kinase inhibitor osimertinib is approved to treat patients with EGFR T790M-positive non–small cell lung cancer (NSCLC) who have developed resistance to earlier-generation drugs. Acquired EGFR C797S mutation has been reported to mediate osimertinib resistance in some patients. However, the remaining resistance mechanisms are largely unknown. Experimental Design: We performed mutation profiling using targeted next-generation sequencing (NGS) for 416 cancer-relevant genes on 93 osimertinib-resistant lung cancer patients' samples, mainly cell-free DNAs (cfDNAs), and matched pretreatment samples of 12 patients. In vitro experiments were conducted to functionally study the secondary EGFR mutations identified. Results: EGFR G796/C797, L792, and L718/G719 mutations were identified in 24.7%, 10.8%, and 9.7% of the cases, respectively, with certain mutations coexisting in one patient with different prevalence. L792 and L718 mutants markedly increased the half inhibitory concentration (IC50) of osimertinib in vitro, among which the L718Q mutation conferred the greatest resistance to osimertinib, as well as gefitinib resistance when not coexisting with T790M. Further analysis of the 12 matched pretreatment samples confirmed that these EGFR mutations were acquired during osimertinib treatment. Alterations in parallel or downstream oncogenes such as MET, KRAS, and PIK3CA were also discovered, potentially contributing to the osimertinib-resistance in patients without EGFR secondary mutations. Conclusions: We present comprehensive mutation profiles of a large cohort of osimertinib-resistance lung cancer patients using mainly cfDNA. Besides C797 mutations, novel secondary mutations of EGFR L718 and L792 residues confer osimertinib resistance, both in vitro and in vivo, and are of great clinical and pharmaceutical relevance. Clin Cancer Res; 24(13); 3097–107. ©2018 AACR.

This is the first book that deals with practical stability and its development. It presents a systematic study of the theory of practical stability in terms of two different measures and arbitrary sets and demonstrates the manifestations of general Lyapunov's method by showing how this effective technique can be adapted to investigate various apparently diverse nonlinear problems including control systems and multivalued differential equations.

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion.

Total SAT score, average grade earned in high school, and 32 personality variables are examined via forward multiple regression analyses to identify the best combination for predicting GPA in a sample of 201 psychology students. Average grade earned in high school enters first, accounting for 19% of the variance in GPA. Self-control enters second, and SAT third; these account for 9% and 5% of the variance, respectively. No other predictors accounted for substantial portions of variance. This pattern of results converges with findings reported by other investigators using other measures of personality. It was recommended that the global trait of self-control or conscientiousness be systematically assessed and used in college admissions decisions.

NASA’s InSight (Interior exploration using Seismic Investigations, Geodesy and Heat Transport) mission landed in Elysium Planitia on Mars on 26 November 2018. It aims to determine the interior structure, composition and thermal state of Mars, as well as constrain present-day seismicity and impact cratering rates. Such information is key to understanding the differentiation and subsequent thermal evolution of Mars, and thus the forces that shape the planet’s surface geology and volatile processes. Here we report an overview of the first ten months of geophysical observations by InSight. As of 30 September 2019, 174 seismic events have been recorded by the lander’s seismometer, including over 20 events of moment magnitude Mw = 3–4. The detections thus far are consistent with tectonic origins, with no impact-induced seismicity yet observed, and indicate a seismically active planet. An assessment of these detections suggests that the frequency of global seismic events below approximately Mw = 3 is similar to that of terrestrial intraplate seismic activity, but there are fewer larger quakes; no quakes exceeding Mw = 4 have been observed. The lander’s other instruments—two cameras, atmospheric pressure, temperature and wind sensors, a magnetometer and a radiometer—have yielded much more than the intended supporting data for seismometer noise characterization: magnetic field measurements indicate a local magnetic field that is ten-times stronger than orbital estimates and meteorological measurements reveal a more dynamic atmosphere than expected, hosting baroclinic and gravity waves and convective vortices. With the mission due to last for an entire Martian year or longer, these results will be built on by further measurements by the InSight lander. Geophysical and meteorological measurements by NASA’s InSight lander on Mars reveal a planet that is seismically active and provide information about the interior, surface and atmospheric workings of Mars.

A new set of luminescent platinum(II) diimine complexes has been synthesized and characterized. The anionic ligands in these complexes are arylacetylides. The complexes are brightly emissive in fluid solution with relative emission quantum yields phiem ranging from 3 x 10(-3) to 10(-1). Two series of complexes have been investigated. The first has the formula Pt(Rphen)(C...CC6H5)2 where Rphen is 1,10-phenanthroline substituted in the 5-position with R = H, Me, Cl, Br, NO2, or C...CC6H5, while the second has the formula Pt(dbbpy)(C=CC6H4X)2 where dbbpy = 4,4'-di(tert-butyl)bipyridine and X = H, Me, F, or NO2. From NMR, IR, and electronic spectroscopies, all of the complexes are assigned a square planar coordination geometry with cis-alkynyl ligands. The crystal structure of Pt(phen)(Ce-CC6H4CH3)2 confirms this assignment. All of the complexes exhibit an absorption band at ca. 400 nm that corresponds to a Pt d-->pi*diimine charge-transfer transition. The variation of lambdamax for this band with substituent variation supports this assignment. From similar changes in the energy of the solution luminescence as a function of substituents R and X, the emissive excited state is also of MLCT origin, but with spin-forbidden character on the basis of excited-state lifetime measurements (0.01-5.6 micros). The complexes undergo electron-transfer quenching, showing good Stern-Volmer behavior using 10-methylphenothiazine and N,N,N',N'-tetramethylbenzidine as reductive quenchers. Excited-state reduction potentials are estimated on the basis of a simple thermochemical analysis. Crystal data for Pt(phen)(C...CC6H4CH3)2: monoclinic, space group C2/c, a = 19.0961(1) A, b = 10.4498(1) A, c = 11.8124(2) A, beta = 108.413(1) degrees, V = 2236.49 A3, number of reflections 1614, number of variables 150, R1 = 0.0163, wR2 (I > 2sigma) = 0.0410.

This research examines whether citizens utilize gender stereotypes to infer candidates' ideological orientations. Analysis of data from the 1988-1990-1992 Pooled Senate Election Study reveals that even after candidates' individuating ideological orientations are taken into account, candidate gender still exerts substantial effects on citizens' perceptions of candidates' ideological orientations. The consequences of gender stereotypes for vote choice are important but differ for Democrats and Republicans. For Democratic female candidates, gender ideological stereotypes increase the distance between female candidates and voters, increasing the likelihood citizens will vote for the Republican opponent, ceteris paribus. For Republican female candidates, gender stereotypes for ideology reduce the distance between them and most voters, thereby increasing their electoral prospects.

In a Sounding Board essay, a physician recounts his experience with\nan adult patient diagnosed with acute myelomonocytic leukemia. After the\npatient refused chemotherapy that offered a 25% chance of a long-term cure,\nshe asked the physician's help in planning suicide. Quill, who describes\nhimself as a long-time advocate of active, informed patient choice of\ntreatment and nontreatment, and of a patient's right to die with as much\ncontrol and dignity as possible, dicusses his indirect role in his patient's\ndeath. (KIE abstract)

On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a previous NIF implosion [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys. Rev. Lett. 129, 075001 (2022)PRLTAO0031-900710.1103/PhysRevLett.129.075001]. This achievement is the culmination of more than five decades of research and gives proof that laboratory fusion, based on fundamental physics principles, is possible. This Letter reports on the target, laser, design, and experimental advancements that led to this result.

The concept of “tokenism” has been used widely to explain many of the difficulties women face as they enter traditionally male occupations. Tokenism explains women's occupational experiences and their behavioral responses to those experiences in terms of their numerical proportion, suggesting that barriers to women s full occupational equality can be lowered by the hiring of more women in organizations that are highly-skewed male. This paper suggests that the tokenism hypothesis has not been subjected to rigorous testing and that the research that does exist should lead us to question the adequacy of the concept. This paper concludes that a gender-neutral theory such as tokenism is of limited value in explaining the experiences of either men or women in a society where gender remains important. Further, the focus on tokenism may hinder women's progress to the extent that it turns our attention away from an analysis of the effects of sexism in the workplace and the society as a whole.

BACKGROUND: Preimplantation genetic screening (PGS) has been used in an attempt to determine embryonic aneuploidy. Techniques that use new molecular methods to determine the karyotype of an embryo are expanding the scope of PGS. METHODS: We introduce a new method for PGS, termed 'parental support', which leverages microarray measurements from parental DNA to 'clean' single-cell microarray measurements on embryonic cells and explicitly computes confidence in each copy number call. The method distinguishes mitotic and meiotic copy errors and determines parental source of aneuploidy. RESULTS: Validation with 459 single cells of known karyotype indicated that per-cell false-positive and false-negative rates are roughly equivalent to the 'gold standard' metaphase karyotype. The majority of the cells were run in parallel with a clinical commercial PGS service. Computed confidences were conservative and roughly concordant with accuracy. To examine ploidy in human embryos, the method was then applied to 26 disaggregated, cryopreserved, cleavage-stage embryos for a total of 134 single blastomeres. Only 23.1% of the embryos were euploid, though 46.2% of embryos were mosaic euploid. Mosaicism affected 57.7% of the embryos. Counts of mitotic and meiotic errors were roughly equivalent. Maternal meiotic trisomy predominated over paternal trisomy, and maternal meiotic trisomies were negatively predictive of mosaic euploid embryos. CONCLUSIONS: We have performed a major preclinical validation of a new method for PGS and found that the technology performs approximately as well as a metaphase karyotype. We also directly measured the mechanism of aneuploidy in cleavage-stage human embryos and found high rates and distinct patterns of mitotic and meiotic aneuploidy.

The focus of recent research on square planar Pt(II) diimine dithiolate complexes has been to understand molecular factors that influence their excited state properties and to develop diad and triad systems based on them for use in light-driven reactions. Regarding the former, two series of Pt(diimine)(dithiolate) complexes have been synthesized and studied. All of the compounds display solvatochromic absorption bands and solution luminescence attributable to metal/dithiolate-to-diimine charge transfer excited states of the same orbital parentage. The excited-state energies can be tuned by approximately 1 eV through ligand variation. Excited-state redox potentials have been estimated for all of the complexes from spectroscopic and electrochemical data, and electron transfer quenching rate constants show the expected driving force dependence. Analogous Au(III) systems have been synthesized and characterized including molecular structure determinations of a cationic diimine dithiolate system and a neutral C-deprotonated-2-phenylpyridine derivative. Striking differences exist in the electronic structures of these Au(III) complexes from those of the Pt(II) systems, underscoring the key role of the metal in the excited state structure of the latter. The creation of diads and triads is being undertaken with ligand bridges capable of connecting the Pt(diimine)(dithiolate) moiety with other metal centers. Toward that end, complexes of dipyridocatecholate (dpcat) have been synthesized and characterized. These complexes may serve as models for the linking of chromophore and quencher components of a possible photosynthetic system. The dpcat complexes have been characterized by absorption and steady-state emission spectroscopies. Luminescence and redox properties of these and a related system containing a tetrapyridophenazine (tppz) bridge are described.

BACKGROUND: The discovery and development of novel plant cell wall degrading enzymes is a key step towards more efficient depolymerization of polysaccharides to fermentable sugars for the production of liquid transportation biofuels and other bioproducts. The industrial fungus Trichoderma reesei is known to be highly cellulolytic and is a major industrial microbial source for commercial cellulases, xylanases and other cell wall degrading enzymes. However, enzyme-prospecting research continues to identify opportunities to enhance the activity of T. reesei enzyme preparations by supplementing with enzymatic diversity from other microbes. The goal of this study was to evaluate the enzymatic potential of a broad range of plant pathogenic and non-pathogenic fungi for their ability to degrade plant biomass and isolated polysaccharides. RESULTS: Large-scale screening identified a range of hydrolytic activities among 348 unique isolates representing 156 species of plant pathogenic and non-pathogenic fungi. Hierarchical clustering was used to identify groups of species with similar hydrolytic profiles. Among moderately and highly active species, plant pathogenic species were found to be more active than non-pathogens on six of eight substrates tested, with no significant difference seen on the other two substrates. Among the pathogenic fungi, greater hydrolysis was seen when they were tested on biomass and hemicellulose derived from their host plants (commelinoid monocot or dicot). Although T. reesei has a hydrolytic profile that is highly active on cellulose and pretreated biomass, it was less active than some natural isolates of fungi when tested on xylans and untreated biomass. CONCLUSIONS: Several highly active isolates of plant pathogenic fungi were identified, particularly when tested on xylans and untreated biomass. There were statistically significant preferences for biomass type reflecting the monocot or dicot host preference of the pathogen tested. These highly active fungi are promising targets for identification and characterization of novel cell wall degrading enzymes for industrial applications.

Two general evolutionary hypotheses were tested on 756 White children (397 girls) studied longitudinally: (1) rearing experiences would predict pubertal timing; and (2) children would prove differentially susceptible to rearing. Analysis of pubertal measurements, including some based on repeated physical assessments, showed that mothering and fathering, earlier and later in childhood, predicted pubertal development, but only for girls, with negative parenting appearing most influential; maternal harsh control predicted earlier menarche. Rearing effects varied by infant negative emotionality, proving stronger (and opposite) for girls who in infancy were lower rather than higher in negativity. Maternal menarche, controlled in all analyses, was a stronger predictor than rearing. Findings are discussed in terms of theory development, genetic and nutritional influences, and sample restrictions.