Universidade Nove de Julho

autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

O objetivo deste artigo a apresentao de um exemplo de forma mais didtica de uso da modelaem de Equaes Estruturais com o software SmathPLS 2.0 M3. O referido programa usa o mtodo de Mnimos Quadrados Parciais e busca atender situaes muito frequentes na pesquisa de Marketing: Ausncia de distribuies simtricas das variveis mensuradas, teoria ainda em fase inicial ou com pouca cristalizao, modelos formativos e/ou quantidade menor de dados. O uso crescente do SmartPLS vem mostrado a robusteza e aplicabilidade do modelo nas pesquisas da rea.DOI: 10.5585/remark.v13i2.2717

Universidade Federal de Goiás

Abstract Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3–6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017—and more than 80% in some low- and middle-income regions—was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing—and in some countries reversal—of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.

The objective of this article is to present a didactic example of Structural Equation Modeling using the software SmartPLS 2.0 M3. The program mentioned uses the method of Partial Least Squares and seeks to address the following situations frequently observed in marketing research: Absence of symmetric distributions of variables measured by a theory still in its beginning phase or with little “consolidation”, formative models, and/or a limited amount of data. The growing use of SmartPLS has demonstrated its robustness and the applicability of the model in the areas that are being studied.

O trabalho objetiva apresentar um panorama geral dos movimentos sociais da atualidade, com destaque para a América Latina, e apresentar um mapeamento de suas principais formas no Brasil. Nesse sentido, reflete sobre o caráter educativo de suas ações, tanto para seus participantes como para a sociedade em geral e para os órgãos públicos. A premissa básica é de que os movimentos sociais são fontes de inovação e matrizes geradoras de saber. Entretanto, como não se trata de um processo isolado, mas de caráter político-social, o trabalho analisa as articulações na rede de relações que os movimentos estabelecem na conjuntura política, econômica e sociocultural do país, para compreender os fatores que geram as aprendizagens e os valores da cultura política que vão sendo construídos. Destacam-se os movimentos que ocorrem nas áreas da educação formal e da educação não formal.

A modelagem de equaes estruturais (Structural Equation Modeling -SEM) cada vez mais usada como um mtodo para a conceituao e desenvolvimento de aspectos tericos nas cincias sociais aplicadas, em particular na rea de marketing, pois mais e mais h a necessidade de avaliar vrios constructos e relaes latentes complexas. Tambm, constructos de segunda ordem podem ser modelados fornecendo uma melhor compreenso terica de relaes com boa parcimnia. Modelagens do tipo SEM so, em particular, bem adequadas para investigar as relaes complexas entre os vrios constructos. Os dois mtodos analticos SEM mais prevalentes so os baseados em covarincia SEM (CB-SEM) e os baseados em varincia SEM (PLS-SEM). Embora cada tcnica tenha suas vantagens e limitaes, neste artigo vamos nos concentrar no CB-SEM com o AMOS para ilustrar sua aplicao na anlise das relaes entre orientao para o cliente, a orientao para os funcionrios e desempenho da empresa. Tambm ser demonstrado como constructos de segunda ordem so teis para modelar os componentes de pr-atividade e responsividade dessas relaes.DOI: 10.5585/remark.v13i2.2718

The Analytic Hierarchy Process (AHP) is widely used by decision makers and researchers. The definition of criteria and the calculation of their weight are central in this method to assess the alternatives. However, there are few studies that focus on them. The purpose of this study is to develop a systematic review of literature on the real cases that applied AHP to evaluate how the criteria are being defined and measured. In the 33 cases selected, they mainly used literature to build the criteria and AHP or Fuzzy AHP to calculate their weight, while other techniques were used to evaluate alternatives.

Introduction: Intravenous(IV) immunoglobulin(Ig) treatment is known to alleviate behavioral deficits in the experimentally induced model of sepsis. To delineate the mechanisms by which IVIg treatment prevents neuronal dysfunction, an array of immunological and apoptosis markers was investigated. Methods: Sepsis was induced by cecal ligation perforation(CLP) in rats. The animals were divided into five groups; sham, control, CLP + saline, CLP + immunoglobulin G IgG(250 mg/kg,iv), and CLP + immunoglobulins enriched with immunoglobulin M-IgGAM(250 mg/kg,iv). Blood and brain samples were taken in two sets of experiments after CLP to see the early(24 hrs) and late(10 days) effects of treatment. Total complement activity, complement 3(C3) and soluble complement C5b-9 levels were measured in sera of rats using ELISA-based methods. Cerebral complement content was analyzed by Western Blot. Immune cell infiltration and gliosis were examined by immunohistochemistry using cluster of differentiation 3, CD4, CD8, CD11b, CD19 and glial fibrillary acidic protein antibodies. Apoptotic neuronal death was investigated by TUNEL staining and Western Blot-based semi-quantitative evaluation of brain homogenates by bax and bcl-2 antibodies. Results: IV IgG and IgGAM administration significantly reduced systemic complement activity but increased serum C3 and soluble C5b-9 levels. Likewise, Western Blot data showed slightly increased C5b-9 expression and significantly reduced C1q expression in brain samples of IgGAM-treated but not IgG-treated septic rats especially in the first day of administration. No cerebral cellular infiltrates were observed in treated and non-treated septic rats. By contrast, IV IgG and IgGAM treatment induced considerable amelioration in glial cell proliferation which was increased in non-treated rats. IgG and IgGAM treated rats exhibited significantly reduced numbers of apoptotic neurons and cerebral expression levels of bax and bcl-2 as compared to nontreated rats. Conclusions: We suggest that IV IgG and IgGAM administration ameliorates neuronal dysfunction and behavioral deficits by reducing apoptotic cell death and glial cell proliferation. IgGAM treatment might be suppressing classical complement pathway by reducing C1q expression.

In evergreen tropical forests, the extent, magnitude, and controls on photosynthetic seasonality are poorly resolved and inadequately represented in Earth system models. Combining camera observations with ecosystem carbon dioxide fluxes at forests across rainfall gradients in Amazônia, we show that aggregate canopy phenology, not seasonality of climate drivers, is the primary cause of photosynthetic seasonality in these forests. Specifically, synchronization of new leaf growth with dry season litterfall shifts canopy composition toward younger, more light-use efficient leaves, explaining large seasonal increases (~27%) in ecosystem photosynthesis. Coordinated leaf development and demography thus reconcile seemingly disparate observations at different scales and indicate that accounting for leaf-level phenology is critical for accurately simulating ecosystem-scale responses to climate change.

Purpose – This study proposes a new method to investigate adoption of new technologies and tests this method by looking into the determinants of internet banking adoption in Brazil.

Photodynamic therapy (PDT) is a clinical modality used to treat cancer and infectious diseases. The main agent is the photosensitizer (PS), which is excited by light and converted to a triplet excited state. This latter species leads to the formation of singlet oxygen and radicals that oxidize biomolecules. The main motivation for this review is to suggest alternatives for achieving high-efficiency PDT protocols, by taking advantage of knowledge on the chemical and biological processes taking place during and after photosensitization. We defend that in order to obtain specific mechanisms of cell death and maximize PDT efficiency, PSes should oxidize specific molecular targets. We consider the role of subcellular localization, how PS photochemistry and photophysics can change according to its nanoenvironment, and how can all these trigger specific cell death mechanisms. We propose that in order to develop PSes that will cause a breakthrough enhancement in the efficiency of PDT, researchers should first consider tissue and intracellular localization, instead of trying to maximize singlet oxygen quantum yields in in vitro tests. In addition to this, we also indicate many open questions and challenges remaining in this field, hoping to encourage future research.

Unmitigated spread in Brazil Despite an extensive network of primary care availability, Brazil has suffered profoundly during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Using daily data from state health offices, Castro et al. analyzed the pattern of spread of COVID-19 cases and deaths in the country from February to October 2020. Clusters of deaths before cases became apparent indicated unmitigated spread. SARS-CoV-2 circulated undetected in Brazil for more than a month as it spread north from Sã o Paulo. In Manaus, transmission reached unprecedented levels after a momentary respite in mid-2020. Faria et al. tracked the evolution of a new, more aggressive lineage called P.1, which has 17 mutations, including three (K417T, E484K, and N501Y) in the spike protein. After a period of accelerated evolution, this variant emerged in Brazil during November 2020. Coupled with the emergence of P.1, disease spread was accelerated by stark local inequalities and political upheaval, which compromised a prompt federal response. Science , abh1558 and abh2644, this issue p. 821 and p. 815

BACKGROUND: Pulmonary rehabilitation is a proven, effective intervention for people with chronic respiratory diseases including chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD) and bronchiectasis. However, relatively few people attend or complete a program, due to factors including a lack of programs, issues associated with travel and transport, and other health issues. Traditionally, pulmonary rehabilitation is delivered in-person on an outpatient basis at a hospital or other healthcare facility (referred to as centre-based pulmonary rehabilitation). Newer, alternative modes of pulmonary rehabilitation delivery include home-based models and the use of telehealth. Telerehabilitation is the delivery of rehabilitation services at a distance, using information and communication technology. To date, there has not been a comprehensive assessment of the clinical efficacy or safety of telerehabilitation, or its ability to improve uptake and access to rehabilitation services, for people with chronic respiratory disease. OBJECTIVES: To determine the effectiveness and safety of telerehabilitation for people with chronic respiratory disease. SEARCH METHODS: We searched the Cochrane Airways Trials Register, and the Cochrane Central Register of Controlled Trials; six databases including MEDLINE and Embase; and three trials registries, up to 30 November 2020. We checked reference lists of all included studies for additional references, and handsearched relevant respiratory journals and meeting abstracts. SELECTION CRITERIA: All randomised controlled trials and controlled clinical trials of telerehabilitation for the delivery of pulmonary rehabilitation were eligible for inclusion. The telerehabilitation intervention was required to include exercise training, with at least 50% of the rehabilitation intervention being delivered by telerehabilitation. DATA COLLECTION AND ANALYSIS: We used standard methods recommended by Cochrane. We assessed the risk of bias for all studies, and used the ROBINS-I tool to assess bias in non-randomised controlled clinical trials. We assessed the certainty of evidence with GRADE. Comparisons were telerehabilitation compared to traditional in-person (centre-based) pulmonary rehabilitation, and telerehabilitation compared to no rehabilitation. We analysed studies of telerehabilitation for maintenance rehabilitation separately from trials of telerehabilitation for initial primary pulmonary rehabilitation. MAIN RESULTS: We included a total of 15 studies (32 reports) with 1904 participants, using five different models of telerehabilitation. Almost all (99%) participants had chronic obstructive pulmonary disease (COPD). Three studies were controlled clinical trials. For primary pulmonary rehabilitation, there was probably little or no difference between telerehabilitation and in-person pulmonary rehabilitation for exercise capacity measured as 6-Minute Walking Distance (6MWD) (mean difference (MD) 0.06 metres (m), 95% confidence interval (CI) -10.82 m to 10.94 m; 556 participants; four studies; moderate-certainty evidence). There may also be little or no difference for quality of life measured with the St George's Respiratory Questionnaire (SGRQ) total score (MD -1.26, 95% CI -3.97 to 1.45; 274 participants; two studies; low-certainty evidence), or for breathlessness on the Chronic Respiratory Questionnaire (CRQ) dyspnoea domain score (MD 0.13, 95% CI -0.13 to 0.40; 426 participants; three studies; low-certainty evidence). Participants were more likely to complete a program of telerehabilitation, with a 93% completion rate (95% CI 90% to 96%), compared to a 70% completion rate for in-person rehabilitation. When compared to no rehabilitation control, trials of primary telerehabilitation may increase exercise capacity on 6MWD (MD 22.17 m, 95% CI -38.89 m to 83.23 m; 94 participants; two studies; low-certainty evidence) and may also increase 6MWD when delivered as maintenance rehabilitation (MD 78.1 m, 95% CI 49.6 m to 106.6 m; 209 participants; two studies; low-certainty evidence). No adverse effects of telerehabilitation were noted over and above any reported for in-person rehabilitation or no rehabilitation. AUTHORS' CONCLUSIONS: This review suggests that primary pulmonary rehabilitation, or maintenance rehabilitation, delivered via telerehabilitation for people with chronic respiratory disease achieves outcomes similar to those of traditional centre-based pulmonary rehabilitation, with no safety issues identified. However, the certainty of the evidence provided by this review is limited by the small number of studies, of varying telerehabilitation models, with relatively few participants. Future research should consider the clinical effect of telerehabilitation for individuals with chronic respiratory diseases other than COPD, the duration of benefit of telerehabilitation beyond the period of the intervention, and the economic cost of telerehabilitation.

ABSTRACT International luxury businesses are challenged by the identification and satisfaction of the common needs and desires of global market segments. Although luxury goods have become available to a wider range of consumers, the traditional conspicuous consumption model has been transformed into a new experiential luxury sensibility that is marked by a change in the way that consumers define luxury. Based on an empirical study in collaboration with American, European, and Asian researchers, the results provide evidence that consumers in various parts of the world purchase or wish to purchase luxury products for varied reasons but that such consumers generally possess similar values. Regardless of their countries of origin, the basic motivational drivers of luxury consumers are similar among the financial, functional, personal, and social dimensions of luxury value perceptions, although the relative importance of these dimensions varies.

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Sleep deprivation is common in Western societies and is associated with increased cardiovascular morbidity and mortality in epidemiological studies. However, the effects of partial sleep deprivation on the cardiovascular system are poorly understood. In the present study, we evaluated 13 healthy male volunteers (age: 31 ± 2 yr) monitoring sleep diary and wrist actigraphy during their daily routine for 12 nights. The subjects were randomized and crossover to 5 nights of control sleep (>7 h) or 5 nights of partial sleep deprivation (<5 h), interposed by 2 nights of unrestricted sleep. At the end of control and partial sleep deprivation periods, heart rate variability (HRV), blood pressure variability (BPV), serum norepinephrine, and venous endothelial function (dorsal hand vein technique) were measured at rest in a supine position. The subjects slept 8.0 ± 0.5 and 4.5 ± 0.3 h during control and partial sleep deprivation periods, respectively (P < 0.01). Compared with control, sleep deprivation caused significant increase in sympathetic activity as evidenced by increase in percent low-frequency (50 ± 15 vs. 59 ± 8) and a decrease in percent high-frequency (50 ± 10 vs. 41 ± 8) components of HRV, increase in low-frequency band of BPV, and increase in serum norepinephrine (119 ± 46 vs. 162 ± 58 ng/ml), as well as a reduction in maximum endothelial dependent venodilatation (100 ± 22 vs. 41 ± 20%; P < 0.05 for all comparisons). In conclusion, 5 nights of partial sleep deprivation is sufficient to cause significant increase in sympathetic activity and venous endothelial dysfunction. These results may help to explain the association between short sleep and increased cardiovascular risk in epidemiological studies.

O trabalho apresenta um estudo sobre a educação não-formal e seu papel no processo educativo mais geral. Considera-se a educação não-formal como uma área de conhecimento ainda em construção. Estuda-se a possibilidade deste processo em conselhos de escolas e o aprendizado que resulta da participação da sociedade civil nestes conselhos. O trabalho se divide em duas partes: a primeira tem caráter teórico e discute a categoria educação não-formal em si, seu campo e atributos. Por meio da análise comparativa, busca-se diferenciá-la da educação formal e da educação informal. A segunda investiga a categoria da educação não - formal em conselhos escolares, e em movimentos sociais que atuam na área da educação.

Hitherto implemented economic mechanisms and development processes have led the planet to face numerous environmental and ecological depletion challenges. In light of this, Circular Economy emerges as an effective tool for triggering a sustainable development process. This article aims to present different perspectives and concepts of circular economy. To that end, a qualitative study was conducted and the methodology of systematic literature review was applied, so as to obtain solid knowledge about the theme, using the most recent and relevant articles. Scielo, Science Direct and Google Scholar database were the source of the articles that met the defined criteria, described in six steps: search key words; only scientific articles considered; publication between 2015 and 2020; in English; with 100 or more citations; relevant content to the theme. As a result, an extract of the researched articles and a comparison between the scientific literature on this subject is presented, showing some evolution of the aspects of the Circular Economy, such as designing of new products, emerging of new legislation and adoption by industry. Although the study was not conclusive on how the evolution of Circular Economy will take place, authors suggest future studies to assess the transition towards an economic circularity. Also, it is recommended that future studies consider case studies as a model for assessing Ciruclar Economy progress in the light of legislation and economic interests.

Purpose – Research on entrepreneurial orientation (EO) has attracted researchers’ attention for over 30 years. The purpose of this paper is to comprehensively analyze the body of literature resulting from 30 years of research in EO, and to answer the following questions: what are the major themes that have emerged? What areas are missing? What degree of convergence do we see in the field of EO, and what concepts/topics has the field converged around? Design/methodology/approach – A bibliometric study with a sample of 405 articles published from January 1987 to July 2014 was developed. Techniques of bibliometric, lexical, and content analysis were used. The analysis involved: the evolution of published articles; the main authors, their nationalities, and institutional affiliations; citation and co-citations analysis; the journals that have published the most articles; and the most frequently-searched topics. Opting for bibliometric techniques permit an analysis of a larger number of articles and a greater variety of articles than other methodologies such as meta-analyses and systematic review studies. Accordingly, a more comprehensive look at the field of EO can be taken. Findings – Two distinct but complementary classifications are proposed to characterize the body of the literature resulting from 30 years of research in EO. The first one demonstrates that the field presents a convergence of the themes in four axis which together comprise studies on EO: performance, strategy, entrepreneurial attitude, and management. The second one presents the frequency of occurrence of the themes in the field: high-frequency themes or classical themes, frequently in the literature; moderate-frequency themes or emerging issues have not been sufficiently explored; low-frequency themes or potential opportunities related to understudied issues and contexts less frequently surveyed. A future research agenda is proposed for emerging themes and specific contexts. Practical implications – The identification of key themes in the field of EO contributes to assess the research evolution in order to recognize emerging themes and contexts, and the research gaps. With this, it is possible to lead new studies to cover a lack of research and advance knowledge in the field. The themes most studied also show the contribution for EO to organizational practice, especially in relation to the impact on the performance, the stimulus to the development of innovations, and the effects on organizational growth. Additionally, the identification of the authors most cited, most productive on the theme and the identification of the core journals for publishing of the area is recommended as a general reference for researchers interested in the topic of EO. Social implications – Although EO literature has been widely developed in Anglo regions (especially in the USA and UK) and Germanic Europe (especially Spain), there are others lacking these studies, especially Latin America, sub-Saharan Africa, Eastern Europe, and Middle East, with rare articles published internationally. The results can guide the advancement of research in these different contexts and realities where even issues more widely treated in the literature have been unexplored. The lack of studies in certain contexts can lead to new studies for inserting new insights into EO, such as potential differences between developed regions and in development. For regions where the studies on EO are more developed, the results of this paper contribute to signaling issues and contexts little explored that may be the focus of attention. Originality/value – The generation of literature indicators of EO through bibliometric fills a research gap on the theme, providing a more comprehensive view of the field and of the current status of the research on EO. Identifying the most frequent topics in EO literature, and little-explored themes and contexts makes it possible to propose an agenda for future research and knowledge generation on EO. Thus, it is suggested the development of studies focus on emerging themes like growth, learning, knowledge, resources, and capabilities; also in specific contexts with potential for aggregating new knowledges in the EO field such as family firms, non-profit organizations, social contexts, the public sector, university, spin-off, firms in emerging and developing economies.