Universitas Muhammadiyah Jember

COVID-19, a new strain of coronavirus (CoV), was identified in Wuhan, China, in 2019. No specific therapies are available and investigations regarding COVID-19 treatment are lacking. Liu et al. (2020) successfully crystallised the COVID-19 main protease (Mpro), which is a potential drug target. The present study aimed to assess bioactive compounds found in medicinal plants as potential COVID-19 Mpro inhibitors, using a molecular docking study. Molecular docking was performed using Autodock 4.2, with the Lamarckian Genetic Algorithm, to analyse the probability of docking. COVID-19 Mpro was docked with several compounds, and docking was analysed by Autodock 4.2, Pymol version 1.7.4.5 Edu, and Biovia Discovery Studio 4.5. Nelfinavir and lopinavir were used as standards for comparison. The binding energies obtained from the docking of 6LU7 with native ligand, nelfinavir, lopinavir, kaempferol, quercetin, luteolin-7-glucoside, demethoxycurcumin, naringenin, apigenin-7-glucoside, oleuropein, curcumin, catechin, epicatechin-gallate, zingerol, gingerol, and allicin were -8.37, -10.72, -9.41, -8.58, -8.47, -8.17, -7.99, -7.89, -7.83, -7.31, -7.05, -7.24, -6.67, -5.40, -5.38, and -4.03 kcal/mol, respectively. Therefore, nelfinavir and lopinavir may represent potential treatment options, and kaempferol, quercetin, luteolin-7-glucoside, demethoxycurcumin, naringenin, apigenin-7-glucoside, oleuropein, curcumin, catechin, and epicatechin-gallate appeared to have the best potential to act as COVID-19 Mpro inhibitors. However, further research is necessary to investigate their potential medicinal use.

Coronavirus (COVID-19), which hit in early 2020, changed the way people live and work, and affected industries and organizations all over the world. Many organizations have begun to deliver a new way of working to adapt to these shifts effectively using teleworking or a work from home policy. The purpose of this study was to fill the gaps by investigating several potential predictors of job satisfaction during working from home from the impact of COVID-19 such as work–life balance and work stress. Using a quantitative approach, 472 workers who were forced to work from home all over Indonesia participated, and the responses were analyzed using Smart-PLS software. The study revealed that working from home, work–life balance, and work stress have a significant effect, both directly and indirectly, on job satisfaction. Working from home as a new pace of work can sustain job satisfaction as the current working atmosphere for Indonesian workers. In response to the collectivist setting, working from home can be a positive sign that needs to be paid attention to for the organization.

Penelitian ini membahas tentang motivasi kerja, lingkungan kerja dan budaya kerja terhadap kinerja karyawan. Motivasi kerja (X1), Lingkungan kerja (X2), dan budaya kerja (X3) merupakan variabel independen dan kinerja karyawan sebagai variabel dependen (Y). Populasi dari penelitian ini adalah karyawan Dinas Sosial Kabupaten Jember yang menguji 32 orang. Alat analisis yang digunakan dalam penelitian ini yaitu uji validitas, uji reliabilitas, uji asumsi klasik, analisis regresi linier berganda, uji T, uji F dan uji R2. Hasil pengujian hipotesis pertama (H1) menunjukkan tidak ada pengaruh yang signifikan antara motivasi kerja terhadap kinerja karyawan dengan tingkat signifikasi sebesar 0,549 (p> 0,05). Hipotesis kedua (H2) menunjukkan ada pengaruh yang signifikan antara Lingkungan terhadap kinerja karyawan dengan tingkat signifikasi sebesar 0,009 (p <0,05). Hipotesis tiga (H3) menunjukkan ada pengaruh yang signifikan antara lingkungan kerja terhadap turnover intention dengan tingkat signifikasi sebesar 0,005 (p <0,05). Hasil penelitian menunjukkan lingkungan kerja dan budaya kerja positif dan signifikan terhadap kinerja karyawan. Sementara motivasi kerjatidakengaruhi terhadap kinerja karyawan. Hasil penelitian menunjukkan lingkungan kerja dan budaya kerja positif dan signifikan terhadap kinerja karyawan. Sementara motivasi kerjatidakengaruhi terhadap kinerja karyawan. Hasil penelitian menunjukkan lingkungan kerja dan budaya kerja positif dan signifikan terhadap kinerja karyawan. Sementara motivasi kerjatidakengaruhi terhadap kinerja karyawan.

Background: The impact of hospital readmission reduction program (HRRP) on heart failure (HF) outcomes has been debated. Limited data exist regarding trends of HF readmission rates beyond 30 days from all-payer sources. The aim of this study was to investigate temporal trends of 30- and 90-day HF readmissions rates from 2010 to 2017 in patients from all-payer sources. Methods: The National Readmission Database was utilized to identify HF hospitalizations between 2010 and 2017. In the primary analysis, a linear trend in 30-day and 90-day readmissions from 2010 to 2017 was assessed. While in the secondary analysis, a change in aggregated 30- and 90-day all-cause and HF-specific readmissions pre-HRRP penalty phase (2010–2012) and post-HRRP penalties (2013–2017) was compared. Subgroup analyses were performed based on (1) Medicare versus non-Medicare insurance, (2) low versus high HF volume, and (3) HF with reduced versus preserved ejection fraction (heart failure with reduced ejection fraction and heart failure with preserved ejection fraction). Multiple logistic and adjusted linear regression analyses were performed for annual trends. Results: A total of 6 669 313 index HF hospitalizations for 30-day, and 5 077 949 index HF hospitalizations for 90-day readmission, were included. Of these, 1 213 402 (18.2%) encounters had a readmission within 30 days, and 1 585 445 (31.2%) encounters had a readmission within 90 days. Between 2010 and 2017, both 30 and 90 days adjusted HF-specific and all-cause readmissions increased (8.1% to 8.7%, P trend 0.04, and 18.3% to 19.9%, P trend &lt;0.001 for 30-day and 14.8% to 16.0% and 30.9% to 34.6% for 90-day, P trend &lt;0.001 for both, respectively). Readmission rates were higher during the post-HRRP penalty period compared with pre-HRRP penalty phase (all-cause readmission 30 days: 18.6% versus 17.5%, P &lt;0.001, all-cause readmission 90 days: 32.0% versus 29.9%, P &lt;0.001) across all subgroups except among the low-volume hospitals. Conclusions: The rates of adjusted HF-specific and all-cause 30- and 90-day readmissions have increased from 2010 to 2017. Readmissions rates were higher during the HRRP phase across all subgroups except the low-volume hospitals.

Akt is a major cell survival and angiogenic mediator downstream of angiopoietin-1 (Ang-1)/Tie-2 signaling pathway. We hypothesize that transplantation of mesenchymal stem cells (MSCs) co-overexpressing Ang-1 and Akt lead to better prognosis. Ang-1 and Akt genes were adenovirally transduced into MSCs from male Fischer rats. Cytoprotective effects of transgene overexpression in vitro were assessed by exposure of cells to 8 hours of anoxia. TUNEL and measurement of lactate dehydrogenase showed that MSCs co-overexpressing Ang-1 and Akt (MAAs) were more resistant to anoxia as compared with the nontransduced MSCs or those transduced with Ang-1 or Akt alone. For in vivo studies, after permanent coronary artery occlusion, animals were grouped (n=20/group) to receive intramyocardial injections of 70 microL of basal medium without cells (group 1) or containing 3x10(6) nontransduced MSCs (group 2) or MAAs (group 3). Four animals per group were euthanized on 4, 7, and 14 days after cell transplantation for molecular studies. Extensive survival of MAAs was observed in group 3, which continued to co-overexpress transgenes in rat heart at 2 weeks after cell transplantation. Immunohistology at 4 weeks revealed myogenic differentiation of donor cells at the site of cell graft. Blood vessel density was highest in the infarct and periinfarct regions in group 3 (P<0.05). Echocardiography at 4 weeks showed that heart function indices were significantly improved in group 3 (P<0.05), including ejection fraction and fractional shortening as compared with groups 1 and 2. We conclude that supportive interaction between Ang-1 and Akt during MSC transplantation gave better prognosis via enhanced cell survival, improved angiomyogenesis, and restored global cardiac function.

Creative thinking skills and problem-solving skills were among the competencies that must be possessed by students in the 21st-century, which need to be developed through the learning process, and are still teacher challenge to date. This study aims to improve creative thinking skills, problem-solving skills, and learning outcomes of seventh-grade students by problem-based learning (PBL). This class action research was conducted at State Junior High School 18 of Malang. The subjects was students’ class VIIE. The study was conducted two cycles (repeated seven times). Each cycle referring to Spiral Model by Kemmis, McTaggart, and Nixon. The problem-solving skills data were obtained from student worksheet assessment, the creative thinking skills data were obtained from performance grading rubric and learning outcomes data were obtained from end-of-cycle essay test. The results shows that PBL improves (1) the average of problem solving skills of 27% with the completion rate of 47%,(2) the average of creative thinking skills of 11% with the completion rate of 17.5%, and (3) the average learning outcomes of 13% with the completion rate of 15%. It can concluded that teachers can implement PBL to improve students’ creative thinking skills, problem-solving skills, and learning outcomes.

Penyelenggaraan ujian nasional mengalami permasalahan mulai dari sebelum pelaksanaan, proses pelaksanaan dan pasca pelaksanaan. Pemanfaatan hasil ujian nasonal sebagai satu – satunya indicator keberhasilan siswa selama proses belajar tentunya belum tepat. Sehingga dilakukan perubahan dalam system evaluasi di Indonesia. Penghapusan ujian nasional secara tidak langsung memberikan dampak terhadap proses pembelajaran di sekolah. Sebagai pengganti dari ujian nasonal ini adalah Asesmen Kompetensi Minimum (AKM) dan survey karakter. Tujuan penelitian ini adalah untuk memberikan pengetahuan tentang konsep Asesmen Kompetensi Minimum (AKM) guna meningkatkan kemampuan literasi numerasi siswa di sekolah dasar. Metode penelitian yang digunakan adalah penelitian studi pustaka. Dari hasil penelitian diperoleh bahwa Asesmen dilaksanakan bukan berdasar pada kemampuan menguasai materi sesuai kurikulum seperti dalam ujian nasonal, tetapi dirancang untuk memetakan dan memperbaiki kualiitas pendidikan secara menyeluruh. Asesmen Kompetensi Minimum (AKM) berfokus pada penguasaan kompetensi literasi dan numerasi yang akan diukur. Dengan demikian, pelaksanaan Asesmen Kompetensi Minimum (AKM) diharapkan dapat meningkatkan kemampuan literasi numerasi siswa di sekolah dasar.

Covid-19 pandemic brings changes in many aspects of peoples’ lives throughout the world. The spread of Covid-19 in Indonesia affects the education system in this country. Face-to-face instructions are shifted into full online learnings from home. Despite this quite drastic change, the literature on students’ insights of this matter has still been silent. Thus, the present study elucidates 45 EFL students’ challenges, suggestions and needed materials during these online classes. Rely on qualitative data analysis from written responses and semi-structured interviews, the findings disclosed that these EFL students’ main challenges in attending online courses were the unsteady networks and the less direct interactions. These students mainly suggested the use of video conferencing applications such as zoom or Google meet, though some students chose assignments over those applications. The students also mentioned that they basically needed grammar related materials within the online classes. The findings bring forward the picture of full online learning condition during Covid-19 outbreak on EFL setting in Indonesia.

Metropolitan Urban Mamminasata South Sulawesi, Indonesia as the object of study is explored in the core-peripheral spatial interaction towards the formation of suburban service centers. The problems raised in this study are (i) is there a relationship/correlation between spatial integration, spatial interaction, and urban agglomeration to the formation of urban activity systems and (ii) how the formation of urban activity systems works as a determinant of economic growth, land use change and environmental quality degradation towards sustainable development in the metropolitan city of Mamminasata. Comparative studies of suburban areas have been carried out over three time periods (2001, 2015 and 2019). Data elaboration on observations, surveys and documentation is done to describe urban dynamics in terms of economic, social and environmental aspects. Path analysis is used to address direct effects, indirect effects, differences, and dependencies between urban elements. The gravity model is used to analyze the spatial interactions of the core city with the periphery. The study results show that spatial integration, spatial interaction and urban agglomeration have a positive effect on the system of urban activity and economic growth in the outskirts of the Mamminasata Metropolitan area. The results of this study recommend policy makers and urban planners that land use change, spatial integration and urban spatial interactions on the spatial scale of metropolitan cities to require the implementation of sustainable development concepts oriented towards saving the environment, ensuring fairness in economic access and creating social cohesion, in line with meeting national Metropolitan city development targets by 2030.

The paper seeks to estimate and analize the Modified VAIC (M-VAIC) for measuring the value-based performance of the Indonesian banking sector for year of 2009-2012. M-VAIC is a comprehensive model to measure Intellectual Capital Performance (ICP) based on Value Added Intellectual Coefficient (VAIC™). The findings of this study indicate that the value of M–VAIC of Indonesian banking sector has a rather long range, which is between -21.41 until 5.20. Based on M-VAIC scores, performance of IC is classified into four, namely Top Performers , Good Performers , Performers Common , and Bad Performers . The results show that the ranking of three of the four state banks are on the Top Performers category. M-VAIC can be used to measure the ICP all of industries, not only banks. This is also reinforced by the results of the regression that indicate that the value added (VA) is a function of capital employed and the IC.

Currently, most guidelines on drug-drug interaction (DDI) neither consider the potential effect of genetic polymorphism in the strength of the interaction nor do they account for the complex interaction caused by the combination of DDI and drug-gene interaction (DGI) where there are multiple biotransformation pathways, which is referred to as drug-drug-gene interaction (DDGI). In this systematic review, we report the impact of pharmacogenetics on DDI and DDGI in which three major drug-metabolizing enzymes - CYP2C9, CYP2C19 and CYP2D6 - are central. We observed that several DDI and DDGI are highly gene-dependent, leading to a different magnitude of interaction. Precision drug therapy should take pharmacogenetics into account when drug interactions in clinical practice are expected.

The purpose of this study is to analyze the effect of digital finance, digital marketing and digital payment variables on finance performance. This study uses quantitative methods and data analysis techniques is performed based on Structural Equation Modeling using SmartPLS 3.0 software. The method of selecting the sample using the snowball sampling methods. Online questionnaires were sent to 190 SMEs respondents in the province of Banten Indonesia and evaluated the returned questionnaires. The results of data analysis show that the digital finance had a positive and significant effect on the finance performance, the digital payment had a positive and significant effect on the finance performance and the digital marketing had a positive and significant effect on the finance performance. The findings of this research can provide benefits for MSME actors in developing their business to improve business performance, by paying attention to aspects of MSME digitization and financial literacy of MSME entrepreneurs. Keep in mind, the important role of information technology in business activities requires entrepreneurs to improve their digital literacy.

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masalah yang banyak dialami oleh usia dewasa awal yaitu harus membuat keputusan mengenai karir, pernikahan, stres pekerjaan &amp; keluarga, ansietas, dan depresi. Faktor-faktor yang menyebabkan terjadinya stres yaitu faktor internal dan eksternal, faktor eksternal terdiri dari keadaan fisik, konfik, emosional, dan perilaku. Sedangkan faktor eksternal terdiri dari lingkungan fisik, lingkungan pekerjaan, lingkungan masyarakat, lingkungan keluarga, masalah ekonomi, dan masalah hukum. Beban stres yang dirasa berat dapat memicu seseorang untuk berperilaku negatif, seperti merokok, alkohol, tawuran, seks bebas bahkan penyalahgunaan napza. Penelitian ini bertujuan mengetahui karakteristik mahasiswa tingkat akhir dan mengetahui tingkat stres pada mahasiswa tingkat akhir di Universitas Muhammadiyah Magelang. Penelitian ini menggunakan desain deskritif kualitatif dengan pendekatan cross sectional dengan teknik pengambilan sampel menggunakan purposive sampling, sampel sebanyak 101 mahasiswa. Instrument yang digunakan adalah kuesioner. Hasil penelitan menunjukkan bahwa rata-rata usia mahasiswa 22,01 tahun. Rata-rata masa studi untuk program Diploma III (D3) adalah 6,00 semester, untuk program Sarjana (S1) rata-ratanya adalah 8,05 semester. Tingkat stres pada mahasiswa menunjukkan stres ringan sebanyak 35,6%, stres sedang 57.4 %, dan stres berat sebanyak 6,9 %. Tingkat stres tertinggi dialami oleh jenis kelamin perempuan dengan hasil stres sedang 33,6 %, dan tingkat stres berat 4,0%. Gambaran tingkat stres pada mahasiswa di Universitas Muhammadiyah Magelang menunjukkan stres sedang sebanyak 33,6 %. Kata Kunci: Mahasiswa, Stres THE DESCRIPTION OF STRES LEVELS INCOLLEGE STUDENT ATMUHAMMADIYAH UNIVERSITY MAGELANG ABSTRACTThe problem that many experienced by the early adult age is having to make decisions about career, marriage, job &amp; family stres, anxiety, and depression. Factors that because stres are internal and external factors, external factors consist of physical condition, conflicts, emotional, and behavior. While external factors consist of physical environment, work environment, community environment, family environment, economic problems, and legal issues. Heavily burdened stres can trigger a person to behave negatively, such as smoking, alcohol, brawl, free sex and even drug abuse. This study aims to determine the characteristics of college student and know the level of stres in the college student at the university of muhammadiyah magelang. This research used descriptive qualitative design with cross sectional approach with sampling technique using purposive sampling, 101 college student samples. Instrument used is a questionnaire. Indicated that the average age of college student was 22.01 years. The average duration of program for Diploma III (D3) was 6,00 semesters. For the undergraduate program (S1) the average was 8.05 semesters. The college student stres level showed a mild stres of 35.6 %, moderate stres 57.4 %, and severe stres as many as 6.9 %. The highest level of stres experienced by female with moderate stres 33.6 %, and Severe stres 4.0 %. Description of stres level in college student at Muhammadiyah University of Magelang shows moderate stres as much as 33.6%. Keywords: College student, stres

Intelligence Edge Computing (IEC) is the key enabler of emerging 5G technologies networks and beyond. IEC is considered to be a promising backbone of future services and wireless communication systems in 5G integration. In addition, IEC enables various use cases and applications, including autonomous vehicles, augmented and virtual reality, big data analytic, and other customer-oriented services. Moreover, it is one of the 5G technologies that most enhanced market drivers in different fields such as customer service, healthcare, education methods, IoT in agriculture and energy sustainability. However, 5G technological improvements face many challenges such as traffic volume, privacy, security, digitization capabilities, and required latency. Therefore, 6G is considered to be promising technology for the future. To this end, compared to other surveys, this paper provides a comprehensive survey and an inclusive overview of Intelligence Edge Computing (IEC) technologies in 6G focusing on main up-to-date characteristics, challenges, potential use cases and market drivers. Furthermore, we summarize research efforts on IEC in 5G from 2014 to 2021, in which the integration of IEC and 5G technologies are highlighted. Finally, open research challenges and new future directions in IEC with 6G networks will be discussed.

The leadership of Village Head and his quality of services at Lautang Benteng Office are less than optimal. The head of the village is not maximized in set of employees on time in delivering community services. Likewise, in carrying out its functions, namely the functions of control that has not be

This study analyzes food policy in relation to the existence of local food. This policy, among others, regulates availability, affordability, food institutions and community participation. Solving food availability is done by creating food reserves (central government level, regional government and community). Food reserves can be obtained from domestic production and food imports. Domestic food availability is carried out intensively through diversification of food proclaimed by the government through diversification of food based on local resources. This effort is expected to have a significant impact on the existence of local food, but its implementation up to seven years ago, the existence of local food still cannot occupy the expected position. The deterioration experienced due to past policies that led to the emergence of rice as the main food supremacy of the community, has not yet been restored. And, moreover, the position of imported food, which is increasingly not easily dammed. This study strengthens the analysis above by discussing the existence of local food for example corn, sago or sweet potatoes. Keywords: food policy, local food, food imports

The purpose of this study is describing the implementation of project-based learning model and analysing the student’s creativity improvement in the subject of learning media. We describe the implementation of project-based learning based on our note of the learning syntax during one semester. Then, compared the students’ product to measure their creativity improvement in the aspects of originality, novelty, and flexibility. This study used descriptive-qualitative method and involved the students who took the learning media course as its subjects. The results showed that there was an improvement of the students’ creativity in the project-based learning implementation. The improvement was measured in the making of the manipulatives. The students’ flexibility and novelty were good, while their originality was fair.

Biomass is defined as organic matter from living organisms represented in all kingdoms. It is recognized to be an excellent source of proteins, polysaccharides and lipids and, as such, embodies a tailored feedstock for new products and processes to apply in green industries. The industrial processes focused on the valorization of terrestrial biomass are well established, but marine sources still represent an untapped resource. Oceans and seas occupy over 70% of the Earth’s surface and are used intensively in worldwide economies through the fishery industry, as logistical routes, for mining ores and exploitation of fossil fuels, among others. All these activities produce waste. The other source of unused biomass derives from the beach wrack or washed-ashore organic material, especially in highly eutrophicated marine ecosystems. The development of high-added-value products from these side streams has been given priority in recent years due to the detection of a broad range of biopolymers, multiple nutrients and functional compounds that could find applications for human consumption or use in livestock/pet food, pharmaceutical and other industries. This review comprises a broad thematic approach in marine waste valorization, addressing the main achievements in marine biotechnology for advancing the circular economy, ranging from bioremediation applications for pollution treatment to energy and valorization for biomedical applications. It also includes a broad overview of the valorization of side streams in three selected case study areas: Norway, Scotland, and the Baltic Sea.

The objective of this present research is to analyze the implementation of learning geometry through a scientific learning consisting of three aspects: 1) teacher's activities, 2) students' activities and, 3) the achievement results. The adopted approach is a descriptive-quantitative one and the subject is the Class VII students of Islamic Junior High School in Indonesia. The data were obtained through direct observations in order to gain some knowledge of the teacher's and students' learning activities. The results of the students' learning activities were obtained through geometry tests. The research results showed that the teachers were able to implement the preplanned learning activities and their leaning activities may be able to improve the students' learning activities. Moreover, the five aspects of the scientific approach namely observing, asking questions, reasoning, attempting and presenting, were well implemented. The students' activities were also done as planned and all the aspects of the learning activities as stated in the approach may said to be well implemented. The mean value of students' learning results in groups was found to be 96; meanwhile their individual learning result was found to be 95. This condition showed that the students' learning results were under a very good category.