University of Education, Winneba

Vibration of a chain of particles interacting by nonlinear force is investigated. Using a transformation exact solutions to the equation of motion are aimed at. For a special type of interaction potential of the form \begin{aligned} \phi(r){=}\frac{a}{b}e^{-br}+ar+\text{const.},\ (a,b{>}0) \end{aligned} exact solutions are actually obtained in terms of the Jacobian elliptic functions. It is shown that the system has N “normal modes”. Expansion due to vibration or “thermal expansion” of the chain is also discussed.

To find N-soliton solutions of the K.d.V. equation, a method which can be also applicable to the so-called K.d.V.-like equation is presented. This equation belongs to another series than the class of equations solvable by inverse scattering method for Schrödinger equation.

Analytic solutions to the equation of motion in anharmonic one-dimensional lattice are given. Wave-trains and solitary-waves which propagate in the lattice are studied with reference to the limiting cases of the system of hard spheres and to the continnm limit.

In this article waves in nonlinear lattice or in nonlinear medium are studied. One of the aims is to seek for the point of view to deal with the great majority of phenomena related to nonlinear waves in general. For one dimensional nonlinear lattice analytic and computer-experimental treatments have been developed. It has been found that a certain kind of pulse-like waves (solitons) is the fundamental motion in nonlinear lattice vibration. If two or more solitons collide, they interact non-linearly, pass through one another and, when they separate, return to their original forms. Thus solitons are conserved and behave like particles.

1. The goal of this study was to characterize the agonist pharmacology of human 5-HT2A, 5-HT2B and 5-HT2C (VSV) receptors expressed in CHO-K1 (Chinese hamster ovary) cells. 2. We used a fluorometric imaging plate reader (FLIPR) which allows rapid detection of rises in intracellular calcium levels upon the addition of agonists. 3. Stimulation of all three receptors by 5-HT caused a robust concentration dependent increase in intracellular calcium levels. No such effect was observed from non-transfected control CHO-K1 cells. 4. The rank order of potency of agonists at the different receptor subtypes varied. Tryptamines, BW-723C86, d-norfenfluramine, Ro 60-0175 and LSD exhibited the following rank order of potency; 5-HT2B>5-HT2C>5-HT2A. Piperazines such as m-Chlorophenylpiperazine (mCPP), ORG-12962, MK-212 and also ORG-37684 exhibited a rank order of potency of 5-HT2C>5-HT2B>5-HT2A. The phenylisopropylamines DOI and DOB had a rank order of 5-HT2A>5-HT2B>5-HT2C. 5. Many agonists tested had partial agonist actions when compared to 5-HT, and a wide range of relative efficacies were exhibited, which was cell line dependent. For example, mCPP had a relative efficacy of 65% at 5-HT2C receptors but <25% at either 5-HT2A or 5-HT2B receptors. 6. Interpretation of literature values of functional assays using different cell lines, different receptor expression levels and different receptor isoforms, is complex. Species differences and the previous use of antagonist radioligands to characterize agonist potency in binding assays emphasizes the importance of studying agonists in the same experiment using the same assay conditions and parental cell lines.

In recent years, empowerment and resource orientation have become vital guidelines for many of the sciences. For the field of deaf education, it is also highly important to look carefully at these guidelines if we are to acquire a better understanding as regards both the situation of the parents involved and the development of the deaf and hard of hearing children themselves. A resource-oriented approach to deaf education has therefore proved especially helpful. If both the theoretical and practical aspects of educating deaf and hard of hearing children are to benefit, research on parental experience with deafness and research on the socioemotional development of the children must always be combined and studied in the context of resource availability. In a study of 213 mothers and 213 fathers of deaf and hard of hearing children, we used an array of different questionnaires (PSI, SDQ, SOC, F-SozU, etc.) to examine the correlation between parental resources, sociodemographic variables, parental stress experience, and child socioemotional problems by way of a path analysis model. The results show that high parental stress is associated with frequent socioemotional problems in the children, thus emphasizing the importance of a resource-oriented consulting and support strategy in early intervention, because parental access to personal and social resources is associated with significantly lower stress experience. Child development seems to profit enormously from a resource-oriented support concept. In addition, the results confirm two earlier findings: parents with additionally handicapped children are especially stressed and the child's communicative competence makes for a more sound prediction than its linguistic medium (spoken language or sign). The path models for mothers and fathers agree in all essential factors. The results are discussed with a view to their meaning for pedagogical practice, and recommendations for further research are given (longitudinal data, more representative samples, cochlear implant).

BACKGROUND: For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framework to quantify health loss due to diseases, injuries, and associated risk factors. This paper presents GBD 2023 findings on disease and injury burden and risk-attributable health loss, offering a global audit of the state of world health to inform public health priorities. This work captures the evolving landscape of health metrics across age groups, sexes, and locations, while reflecting on the remaining post-COVID-19 challenges to achieving our collective global health ambitions. METHODS: The GBD 2023 combined analysis estimated years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 375 diseases and injuries, and risk-attributable burden associated with 88 modifiable risk factors. Of the more than 310 000 total data sources used for all GBD 2023 (about 30% of which were new to this estimation round), more than 120 000 sources were used for estimation of disease and injury burden and 59 000 for risk factor estimation, and included vital registration systems, surveys, disease registries, and published scientific literature. Data were analysed using previously established modelling approaches, such as disease modelling meta-regression version 2.1 (DisMod-MR 2.1) and comparative risk assessment methods. Diseases and injuries were categorised into four levels on the basis of the established GBD cause hierarchy, as were risk factors using the GBD risk hierarchy. Estimates stratified by age, sex, location, and year from 1990 to 2023 were focused on disease-specific time trends over the 2010-23 period and presented as counts (to three significant figures) and age-standardised rates per 100 000 person-years (to one decimal place). For each measure, 95% uncertainty intervals [UIs] were calculated with the 2·5th and 97·5th percentile ordered values from a 250-draw distribution. FINDINGS: Total numbers of global DALYs grew 6·1% (95% UI 4·0-8·1), from 2·64 billion (2·46-2·86) in 2010 to 2·80 billion (2·57-3·08) in 2023, but age-standardised DALY rates, which account for population growth and ageing, decreased by 12·6% (11·0-14·1), revealing large long-term health improvements. Non-communicable diseases (NCDs) contributed 1·45 billion (1·31-1·61) global DALYs in 2010, increasing to 1·80 billion (1·63-2·03) in 2023, alongside a concurrent 4·1% (1·9-6·3) reduction in age-standardised rates. Based on DALY counts, the leading level 3 NCDs in 2023 were ischaemic heart disease (193 million [176-209] DALYs), stroke (157 million [141-172]), and diabetes (90·2 million [75·2-107]), with the largest increases in age-standardised rates since 2010 occurring for anxiety disorders (62·8% [34·0-107·5]), depressive disorders (26·3% [11·6-42·9]), and diabetes (14·9% [7·5-25·6]). Remarkable health gains were made for communicable, maternal, neonatal, and nutritional (CMNN) diseases, with DALYs falling from 874 million (837-917) in 2010 to 681 million (642-736) in 2023, and a 25·8% (22·6-28·7) reduction in age-standardised DALY rates. During the COVID-19 pandemic, DALYs due to CMNN diseases rose but returned to pre-pandemic levels by 2023. From 2010 to 2023, decreases in age-standardised rates for CMNN diseases were led by rate decreases of 49·1% (32·7-61·0) for diarrhoeal diseases, 42·9% (38·0-48·0) for HIV/AIDS, and 42·2% (23·6-56·6) for tuberculosis. Neonatal disorders and lower respiratory infections remained the leading level 3 CMNN causes globally in 2023, although both showed notable rate decreases from 2010, declining by 16·5% (10·6-22·0) and 24·8% (7·4-36·7), respectively. Injury-related age-standardised DALY rates decreased by 15·6% (10·7-19·8) over the same period. Differences in burden due to NCDs, CMNN diseases, and injuries persisted across age, sex, time, and location. Based on our risk analysis, nearly 50% (1·27 billion [1·18-1·38]) of the roughly 2·80 billion total global DALYs in 2023 were attributable to the 88 risk factors analysed in GBD. Globally, the five level 3 risk factors contributing the highest proportion of risk-attributable DALYs were high systolic blood pressure (SBP), particulate matter pollution, high fasting plasma glucose (FPG), smoking, and low birthweight and short gestation-with high SBP accounting for 8·4% (6·9-10·0) of total DALYs. Of the three overarching level 1 GBD risk factor categories-behavioural, metabolic, and environmental and occupational-risk-attributable DALYs rose between 2010 and 2023 only for metabolic risks, increasing by 30·7% (24·8-37·3); however, age-standardised DALY rates attributable to metabolic risks decreased by 6·7% (2·0-11·0) over the same period. For all but three of the 25 leading level 3 risk factors, age-standardised rates dropped between 2010 and 2023-eg, declining by 54·4% (38·7-65·3) for unsafe sanitation, 50·5% (33·3-63·1) for unsafe water source, and 45·2% (25·6-72·0) for no access to handwashing facility, and by 44·9% (37·3-53·5) for child growth failure. The three leading level 3 risk factors for which age-standardised attributable DALY rates rose were high BMI (10·5% [0·1 to 20·9]), drug use (8·4% [2·6 to 15·3]), and high FPG (6·2% [-2·7 to 15·6]; non-significant). INTERPRETATION: Our findings underscore the complex and dynamic nature of global health challenges. Since 2010, there have been large decreases in burden due to CMNN diseases and many environmental and behavioural risk factors, juxtaposed with sizeable increases in DALYs attributable to metabolic risk factors and NCDs in growing and ageing populations. This long-observed consequence of the global epidemiological transition was only temporarily interrupted by the COVID-19 pandemic. The substantially decreasing CMNN disease burden, despite the 2008 global financial crisis and pandemic-related disruptions, is one of the greatest collective public health successes known. However, these achievements are at risk of being reversed due to major cuts to development assistance for health globally, the effects of which will hit low-income countries with high burden the hardest. Without sustained investment in evidence-based interventions and policies, progress could stall or reverse, leading to widespread human costs and geopolitical instability. Moreover, the rising NCD burden necessitates intensified efforts to mitigate exposure to leading risk factors-eg, air pollution, smoking, and metabolic risks, such as high SBP, BMI, and FPG-including policies that promote food security, healthier diets, physical activity, and equitable and expanded access to potential treatments, such as GLP-1 receptor agonists. Decisive, coordinated action is needed to address long-standing yet growing health challenges, including depressive and anxiety disorders. Yet this can be only part of the solution. Our response to the NCD syndemic-the complex interaction of multiple health risks, social determinants, and systemic challenges-will define the future landscape of global health. To ensure human wellbeing, economic stability, and social equity, global action to sustain and advance health gains must prioritise reducing disparities by addressing socioeconomic and demographic determinants, ensuring equitable health-care access, tackling malnutrition, strengthening health systems, and improving vaccination coverage. We live in times of great opportunity. FUNDING: Gates Foundation and Bloomberg Philanthropies.

The effects of two different systems on selected biomechanical parameters of walking gait, while carrying loads of varying magnitude, were investigated. Ten healthy males who were not regularly engaged in carrying tasks walked a distance of 20 m for ten trials for each of the following five conditions: (i) normal walking without any external load; (ii) 20% and (iii) 40% body weight carried using a backpack system; and (iv) 20% and (v) 40% body weight carried using a doublepack system which distributed the load equally between the front and back of the subjects. The experimental set-up consisted of a Kistler force platform interfaced to a Tektronix 4051 Graphic Calculator, two super 8 mm movie cameras and a photoelectric timing system. Force data (417 Hz) were obtained for ten trials along with side- and rear-view film data (100 fps) for three of the trials for each of the subject conditions. In addition, selected aspects of foot-position data were acquired from a minimum of six footprints from one trial for each subject condition. Walking speed was controlled at 4·5 ± 0·3km/h. Parameters describing the temporal relationship of the gait pattern and values describing the spatial relationship of foot position were evaluated. Selected variables describing the components of the ground-reaction-force-time curves were also examined. Finally, selected kinematic and kinetic parameters were evaluated for four functional subphases of the support period. Comparisons using a one-way ANOVA with repeated measures were conducted to examine differences between parameters describing the load-carrying conditions and normal gait. Results from the analysis revealed that both the light and heavy loads substantially modified the normal walking gait pattern. Interactions between the load conditions and carrying systems were tested using separate two-way ANOVA with repeated measures. Significant ordinal interactions as well as significant main effects were found between the two carrying systems for some parameters, suggesting that the doublepack system was more effective than the conventional backpack system, especially for carrying the heavy load.

This study aimed at accessing the impact of Covid-19 on Ghana’s teaching and learning. The study employed a Descriptive survey design in which 11 items Likert-scale type of questionnaires was administered to 214 respondents mainly students in the second cycle and tertiary institutions of Ghana. The study employed simple random sampling technique in selecting the respondents for the study. The study revealed some challenges students encounter in the close down of schools due to the outbreak of the pandemic Covid-19: Students are unable to study effectively from the house thus, making the online system of learning very ineffective. Again, parents are incapable of assisting their wards on how to access online learning platform, neither can they entirely supervise the learning of their children at home without any complications. It came to light that the pandemic really has had a negative impact on their learning as many of them are not used to effectively learn by themselves. The e-learning platforms rolled out also poses challenge to majority of the students because of the limited access to internet and lack of the technical knowhow of these technological devices by most Ghanaian students. The study therefore recommends that students should be introduced to e-learning platforms to supplement classroom teaching and learning. Article visualizations:

A simple method for deriving the Bäcklund transformation from the Riccatti form of inverse method is presented for the nonlinear evolution equations.

The article questions the universal relevance of the communicative approach to language teaching in view of the cultural conflicts arising from the introduction of a predominantly Western language teaching approach to Far Eastern cultures. The central argument is that, for the communicative approach to be made suitable for Asian conditions, it needs to be both culturally attuned and culturally accepted. It is suggested that ‘mediating’ can serve as a useful tool in this process. In this way the nature of what eventually takes place in the classroom involves the teacher's ability to both filter the method to make it appropriate to the local cultural norms, and to re-define the teacher-student relationship in keeping with the cultural norms embedded in the method itself.

Microbes are found all over the globe with some few exceptions, including sterilized surfaces. They include normal flora that is nonpathogenic, which contribute to the larger percentage, and pathogenic species which are few. Hence, the activities of humans cannot be completely separated from microbes. Thus, many pathogenic microbes have found their way into fresh fruits and vegetables which are a great source of a healthy diet for humans. The growing demand for fresh fruits and vegetables has necessitated larger production. The larger production of vegetables within the shortest possible time to meet the growing demand has placed them at a higher risk of contamination with the pathogenic microbes, making the safety of consumers uncertain. Study of sources of contamination and type of pathogenic etiological agents isolated from fresh fruits and vegetables includes Bacillus cereus , Campylobacter jejuni , Clostridium botulinum , E. coli O157: H7, Listeria monocytogenes , Salmonella spp. , Shigella , Staphylococcus , and Vibrio cholera . Several measures have proven to be effective in controlling contamination of microbes and they include the establishment of surveillance systems to monitor the production chain and thoroughly washing vegetables with vinegar water. Saltwater and other washing techniques are effective but caution should be taken to make sure one does not use one cycle of water for washing all vegetables. The consumption of fresh fruits and vegetables is still encouraged by this review but significant measures must be taken to check the safety of these products before consumption.

Transformation theories for nonlinear discrete systems are summarized. As a model system, the special interest is paid on a one-dimensional exponential lattice (Toda lattice) with infinite length. Bäcklund transformation and a canonical transformation for Toda lattice is explicitly presented. It is shown that the Bäcklund transformation is closely related to inverse scattering method and the existence of an infinite number of conservation laws. A remarkable transformation which relates solutions of Toda lattice equation and a nonlinear self-dual network equation is found. The transformation may be thought as a discrete version of the well-known Miura transformation. Furthermore, it is shown that a class of nonlinear differential-difference equations which appear to have N-solution solutions can be derived naturally from the Volterra system. It is suggested that the Volterra system which is first order in time is a fundamental equation in the theory of lattice soliton. In the presentation mathematical similarities between continuous and discrete case are emphasized.

A simple expression for the magnetoresistance of the antiferromagnetic metals due to the electron-spin scattering by the s - d interaction is obtained using the molecular field approximation for the spin system. The expression includes the ferromagnetic case. It is shown that in the antiferromagnetic case the positive magnetoresistance appears below the transition point, in contrast to the negative-magnetoresistance in the case of the para or ferromagnetic case. In the ferromagnetic case the negative magnetoresistance shows a deep and finite valley at the transition point, which is consistant with the experiments of the ferromagnetic rare-earth metals such as Gd and Tb.

This research paper aims at examining the concept of sustainability in the Ghanaian construction industry with the objective of identifying possible barriers to sustainable construction in the Ghanaian construction industry. Consequently, research data was collected through a questionnaire survey of randomly selected professionals in the construction industry in Ghana. Data collected was mainly analyzed using Relative Importance Index to rank barriers identified. The results show that key barriers to sustainable construction are lack of demand for sustainable buildings, lack of strategy to promote sustainable construction, higher initial cost, lack of public awareness and lack of government support.

Abstrak: Penelitian ini bertujuan untuk menggali, mengkaji, dan mendiskripsikan pelaksanaan pen- didikan karakter disiplin di sekolah dasar dan diharapkan dapat ditemukan kebijakan yang mendukung keberhasilan pendidikan karakter. Penelitian ini pendekatan kualitatif. Penelitian dilakukan di SD Muhammadiyah Sapen Yogyakarta, dengan subjek kepala sekolah, guru, dan siswa. Data dikumpulkan melalui observasi, wawancara, dan dokumentasi. Teknik pemeriksaan keabsahan data yang digunakan adalah teknik triangulasi. Hasil penelitian menunjukkan bahwa dalam melaksanakan pendidikan karakter disiplin di SD Muhammadiyah Sapen dilakukan melalui sembilan kebijakan, yaitu (1) membuat program pendidikan karakter; (2) menetapkan aturan sekolah dan aturan kelas; (3) melakukan sholat Dhuha dan Sholat Dhuhur berjamaah; (4) membuat pos afektif di setiap kelas; (5) memantau perilaku kedisiplinan siswa di rumah melalui buku catatan kegiatan harian; (6) memberikan pesan-pesan afektif di berbagai sudut sekolah; (7) melibatkan orang tua; (8) melibatkan komite sekolah; dan (9) menciptakan iklim kelas yang kondusif. Kata Kunci: pendidikan karakter disiplin, sekolah dasar

The current research aims to examine the combined effect of magnetic and electric field on micropolar nanofluid between two parallel plates in a rotating system. The nanofluid flow between two parallel plates is taken under the influence of Hall current. The flow of micropolar nanofluid has been assumed in steady state. The rudimentary governing equations have been changed to a set of differential nonlinear and coupled equations using suitable similarity variables. An optimal approach has been used to acquire the solution of the modelled problems. The convergence of the method has been shown numerically. The impact of the Skin friction on velocity profile, Nusslet number on temperature profile and Sherwood number on concentration profile have been studied. The influences of the Hall currents, rotation, Brownian motion and thermophoresis analysis of micropolar nanofluid have been mainly focused in this work. Moreover, for comprehension the physical presentation of the embedded parameters that is, coupling parameter N1 , viscosity parameter Re, spin gradient viscosity parameter N2, rotating parameter Kr, Micropolar fluid constant N3, magnetic parameter M, Prandtl number Pr, Thermophoretic parameter Nt, Brownian motion parameter Nb, and Schmidt number Sc have been plotted and deliberated graphically.

The idea of Matthew effects in reading—the widening achievement gap between good and poor readers—has attracted considerable attention in education research in the past 25 years. Despite the popularity of the topic, however, empirical studies that have analyzed the core assumption of Matthew effects in reading have produced inconsistent results. This review summarizes the empirical findings on the development of early interindividual differences in reading. We did not find strong support for the general validity of a pattern of widening achievement differences or for a pattern of decreasing achievement differences in reading. The inclusion of moderating variables, however, allowed a clearer picture to be painted. Matthew effects were more likely to occur for measures of decoding efficiency, vocabulary, and composite reading scores when the achievement tests were not affected by deficits in measurement precision. Furthermore, moderators such as the applied analytic method or the orthographic consistency of the language were of less importance for the emergence of Matthew effects in reading. An additional meta-analysis of studies reporting correlations between a baseline level and a growth parameter yielded a small, negative mean correlation (r = −.214), which again was moderated by properties of the measures. Possible explanations for the reported findings are discussed.

BACKGROUND: Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 provides cause-specific mortality estimates measured in counts, rates, and years of life lost (YLLs). GBD 2023 aimed to enhance our understanding of the relationship between age and cause of death by quantifying the probability of dying before age 70 years (70q0) and the mean age at death by cause and sex. This study enables comparisons of the impact of causes of death over time, offering a deeper understanding of how these causes affect global populations. METHODS: GBD 2023 produced estimates for 292 causes of death disaggregated by age-sex-location-year in 204 countries and territories and 660 subnational locations for each year from 1990 until 2023. We used a modelling tool developed for GBD, the Cause of Death Ensemble model (CODEm), to estimate cause-specific death rates for most causes. We computed YLLs as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. Probability of death was calculated as the chance of dying from a given cause in a specific age period, for a specific population. Mean age at death was calculated by first assigning the midpoint age of each age group for every death, followed by computing the mean of all midpoint ages across all deaths attributed to a given cause. We used GBD death estimates to calculate the observed mean age at death and to model the expected mean age across causes, sexes, years, and locations. The expected mean age reflects the expected mean age at death for individuals within a population, based on global mortality rates and the population's age structure. Comparatively, the observed mean age represents the actual mean age at death, influenced by all factors unique to a location-specific population, including its age structure. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 250-draw distribution for each metric. Findings are reported as counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2023 include a correction for the misclassification of deaths due to COVID-19, updates to the method used to estimate COVID-19, and updates to the CODEm modelling framework. This analysis used 55 761 data sources, including vital registration and verbal autopsy data as well as data from surveys, censuses, surveillance systems, and cancer registries, among others. For GBD 2023, there were 312 new country-years of vital registration cause-of-death data, 3 country-years of surveillance data, 51 country-years of verbal autopsy data, and 144 country-years of other data types that were added to those used in previous GBD rounds. FINDINGS: The initial years of the COVID-19 pandemic caused shifts in long-standing rankings of the leading causes of global deaths: it ranked as the number one age-standardised cause of death at Level 3 of the GBD cause classification hierarchy in 2021. By 2023, COVID-19 dropped to the 20th place among the leading global causes, returning the rankings of the leading two causes to those typical across the time series (ie, ischaemic heart disease and stroke). While ischaemic heart disease and stroke persist as leading causes of death, there has been progress in reducing their age-standardised mortality rates globally. Four other leading causes have also shown large declines in global age-standardised mortality rates across the study period: diarrhoeal diseases, tuberculosis, stomach cancer, and measles. Other causes of death showed disparate patterns between sexes, notably for deaths from conflict and terrorism in some locations. A large reduction in age-standardised rates of YLLs occurred for neonatal disorders. Despite this, neonatal disorders remained the leading cause of global YLLs over the period studied, except in 2021, when COVID-19 was temporarily the leading cause. Compared to 1990, there has been a considerable reduction in total YLLs in many vaccine-preventable diseases, most notably diphtheria, pertussis, tetanus, and measles. In addition, this study quantified the mean age at death for all-cause mortality and cause-specific mortality and found noticeable variation by sex and location. The global all-cause mean age at death increased from 46·8 years (95% UI 46·6-47·0) in 1990 to 63·4 years (63·1-63·7) in 2023. For males, mean age increased from 45·4 years (45·1-45·7) to 61·2 years (60·7-61·6), and for females it increased from 48·5 years (48·1-48·8) to 65·9 years (65·5-66·3), from 1990 to 2023. The highest all-cause mean age at death in 2023 was found in the high-income super-region, where the mean age for females reached 80·9 years (80·9-81·0) and for males 74·8 years (74·8-74·9). By comparison, the lowest all-cause mean age at death occurred in sub-Saharan Africa, where it was 38·0 years (37·5-38·4) for females and 35·6 years (35·2-35·9) for males in 2023. Lastly, our study found that all-cause 70q0 decreased across each GBD super-region and region from 2000 to 2023, although with large variability between them. For females, we found that 70q0 notably increased from drug use disorders and conflict and terrorism. Leading causes that increased 70q0 for males also included drug use disorders, as well as diabetes. In sub-Saharan Africa, there was an increase in 70q0 for many non-communicable diseases (NCDs). Additionally, the mean age at death from NCDs was lower than the expected mean age at death for this super-region. By comparison, there was an increase in 70q0 for drug use disorders in the high-income super-region, which also had an observed mean age at death lower than the expected value. INTERPRETATION: We examined global mortality patterns over the past three decades, highlighting-with enhanced estimation methods-the impacts of major events such as the COVID-19 pandemic, in addition to broader trends such as increasing NCDs in low-income regions that reflect ongoing shifts in the global epidemiological transition. This study also delves into premature mortality patterns, exploring the interplay between age and causes of death and deepening our understanding of where targeted resources could be applied to further reduce preventable sources of mortality. We provide essential insights into global and regional health disparities, identifying locations in need of targeted interventions to address both communicable and non-communicable diseases. There is an ever-present need for strengthened health-care systems that are resilient to future pandemics and the shifting burden of disease, particularly among ageing populations in regions with high mortality rates. Robust estimates of causes of death are increasingly essential to inform health priorities and guide efforts toward achieving global health equity. The need for global collaboration to reduce preventable mortality is more important than ever, as shifting burdens of disease are affecting all nations, albeit at different paces and scales. FUNDING: Gates Foundation.

Sustainable construction efforts in some countries have been unsuccessful due to numerous barriers to its successful implementation. This study identifies and priorities likely barriers to successful implementation of sustainable construction in the Ghanaian construction industry and measures to overcome potential barriers. A multiple research approach involving semi-structured interviews and a questionnaire survey was adopted for the study. Interviews were carried out amongst purposively selected 18 contractors and 16 consultants whereas questionnaire survey was conducted among 100 randomly selected practitioners (58 Architects, 37 Quantity Surveyors and 5 Structural Engineers) to examine the relevance of the identified factors in the Ghanaian context. The factors identified as barriers to successful implementation of sustainable construction and measures to overcome potential barriers to sustainable construction were evaluated and ranked according to their mean scores. The five strongest barriers to the implementation of sustainable construction in Ghana are ranked as cultural change resistance, lack of government commitment, fear of higher investment costs, lack of professional knowledge, and lack of legislation respectively. Factor analysis using the SPSS Version 16 package enabled the barriers identified to be grouped under six components as 1) Financial barriers, 2) Political barriers, 3) Management/ Leadership barriers, 4) Technical barriers, 5) Socio-cultural barriers, 6) Knowledge/ Awareness barriers. The results of this study would enable the Ghanaian construction industry to be successful in its quest to implement sustainable construction. This will be possible through the implementation of the measures suggested to remove potential barriers to the implementation of sustainable construction. Identification of barriers and measures to overcome potential barriers are steps towards successful implementation of the sustainability concept in the Ghanaian construction industry.