University of Electronic Science and Technology of China

Metamaterials are artificial structures that are usually described by effective medium parameters on the macroscopic scale, and these metamaterials are referred to as ‘analog metamaterials’. Here, we propose ‘digital metamaterials’ through two steps. First, we present ‘coding metamaterials’ that are composed of only two types of unit cells, with 0 and π phase responses, which we name ‘0’ and ‘1’ elements, respectively. By coding ‘0’ and ‘1’ elements with controlled sequences (i.e., 1-bit coding), we can manipulate electromagnetic (EM) waves and realize different functionalities. The concept of coding metamaterials can be extended from 1-bit coding to 2-bit coding or higher. In 2-bit coding, four types of unit cells, with phase responses of 0, π/2, π, and 3π/2, are required to mimic the ‘00’, ‘01’, ‘10’ and ‘11’ elements, respectively. The 2-bit coding has greater freedom than 1-bit coding for controlling EM waves. Second, we propose a unique metamaterial particle that has either a ‘0’ or ‘1’ response controlled by a biased diode. Based on this particle, we present ‘digital metamaterials’ with unit cells that possess either a ‘0’ or ‘1’ state. Using a field-programmable gate array, we realize digital control over the digital metamaterial. By programming different coding sequences, a single digital metamaterial has the ability to manipulate EM waves in different manners, thereby realizing ‘programmable metamaterials’. The above concepts and physical phenomena are confirmed through numerical simulations and experiments using metasurfaces. Smart materials offering great freedom in manipulating electromagnetic radiation have been developed. This exciting new concept was realized by Tie Jun Cui and co-workers at the Southeast University, China, who developed digital metamaterials consisting of two kinds of unit cells whose different phase responses allow them to act as ‘0’ and ‘1’ bits. These cells can be judiciously arranged in sequences to enable controlled manipulation of electromagnetic waves. This is one-bit coding; higher-bit coding is possible by employing more kinds of unit cells. The researchers developed a metamaterial cell whose binary response can be controlled by a biased diode. By using a field-programmable gate array, they demonstrated that this digital metamaterial can be programmed. Such metamaterials are attractive for controlling radiation beams in antennas and for realizing other ‘smart’ metamaterials.

Predictable Travel Routines While people rarely perceive their actions to be random, current models of human activity are fundamentally stochastic. Processes that rely on human mobility patterns, like the prediction of new epidemics, traffic engineering, or city planning, could benefit from highly accurate predictive models. To investigate the predictability of human dynamics, Song et al. (p. 1018 ) used the recorded trajectories of millions of mobile phone users, collected by mobile phone companies and anonymized for research purposes. They hypothesized that given the wide range of travel patterns that different users follow, there would be significant differences between their predictability as well: Users who travel less should be easier to predict than those who are constantly on the road. Surprisingly, there was 93% predictability across the whole user base, and individuals' predictability did not in general fall significantly below 80%.

The human brain atlases that allow correlating brain anatomy with psychological and cognitive functions are in transition from ex vivo histology-based printed atlases to digital brain maps providing multimodal in vivo information. Many current human brain atlases cover only specific structures, lack fine-grained parcellations, and fail to provide functionally important connectivity information. Using noninvasive multimodal neuroimaging techniques, we designed a connectivity-based parcellation framework that identifies the subdivisions of the entire human brain, revealing the in vivo connectivity architecture. The resulting human Brainnetome Atlas, with 210 cortical and 36 subcortical subregions, provides a fine-grained, cross-validated atlas and contains information on both anatomical and functional connections. Additionally, we further mapped the delineated structures to mental processes by reference to the BrainMap database. It thus provides an objective and stable starting point from which to explore the complex relationships between structure, connectivity, and function, and eventually improves understanding of how the human brain works. The human Brainnetome Atlas will be made freely available for download at http://atlas.brainnetome.org, so that whole brain parcellations, connections, and functional data will be readily available for researchers to use in their investigations into healthy and pathological states.

autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

In recent years, mobile devices are equipped with increasingly advanced sensing and computing capabilities. Coupled with advancements in Deep Learning (DL), this opens up countless possibilities for meaningful applications, e.g., for medical purposes and in vehicular networks. Traditional cloud-based Machine Learning (ML) approaches require the data to be centralized in a cloud server or data center. However, this results in critical issues related to unacceptable latency and communication inefficiency. To this end, Mobile Edge Computing (MEC) has been proposed to bring intelligence closer to the edge, where data is produced. However, conventional enabling technologies for ML at mobile edge networks still require personal data to be shared with external parties, e.g., edge servers. Recently, in light of increasingly stringent data privacy legislations and growing privacy concerns, the concept of Federated Learning (FL) has been introduced. In FL, end devices use their local data to train an ML model required by the server. The end devices then send the model updates rather than raw data to the server for aggregation. FL can serve as an enabling technology in mobile edge networks since it enables the collaborative training of an ML model and also enables DL for mobile edge network optimization. However, in a large-scale and complex mobile edge network, heterogeneous devices with varying constraints are involved. This raises challenges of communication costs, resource allocation, and privacy and security in the implementation of FL at scale. In this survey, we begin with an introduction to the background and fundamentals of FL. Then, we highlight the aforementioned challenges of FL implementation and review existing solutions. Furthermore, we present the applications of FL for mobile edge network optimization. Finally, we discuss the important challenges and future research directions in FL.

MIMO (multiple-input multiple-output) radar refers to an architecture that employs multiple, spatially distributed transmitters and receivers. While, in a general sense, MIMO radar can be viewed as a type of multistatic radar, the separate nomenclature suggests unique features that set MIMO radar apart from the multistatic radar literature and that have a close relation to MIMO communications. This article reviews some recent work on MIMO radar with widely separated antennas. Widely separated transmit/receive antennas capture the spatial diversity of the target's radar cross section (RCS). Unique features of MIMO radar are explained and illustrated by examples. It is shown that with noncoherent processing, a target's RCS spatial variations can be exploited to obtain a diversity gain for target detection and for estimation of various parameters, such as angle of arrival and Doppler. For target location, it is shown that coherent processing can provide a resolution far exceeding that supported by the radar's waveform.

TALENs are important new tools for genome engineering. Fusions of transcription activator-like (TAL) effectors of plant pathogenic Xanthomonas spp. to the FokI nuclease, TALENs bind and cleave DNA in pairs. Binding specificity is determined by customizable arrays of polymorphic amino acid repeats in the TAL effectors. We present a method and reagents for efficiently assembling TALEN constructs with custom repeat arrays. We also describe design guidelines based on naturally occurring TAL effectors and their binding sites. Using software that applies these guidelines, in nine genes from plants, animals and protists, we found candidate cleavage sites on average every 35 bp. Each of 15 sites selected from this set was cleaved in a yeast-based assay with TALEN pairs constructed with our reagents. We used two of the TALEN pairs to mutate HPRT1 in human cells and ADH1 in Arabidopsis thaliana protoplasts. Our reagents include a plasmid construct for making custom TAL effectors and one for TAL effector fusions to additional proteins of interest. Using the former, we constructed de novo a functional analog of AvrHah1 of Xanthomonas gardneri. The complete plasmid set is available through the non-profit repository AddGene and a web-based version of our software is freely accessible online.

An adaptive particle swarm optimization (APSO) that features better search efficiency than classical particle swarm optimization (PSO) is presented. More importantly, it can perform a global search over the entire search space with faster convergence speed. The APSO consists of two main steps. First, by evaluating the population distribution and particle fitness, a real-time evolutionary state estimation procedure is performed to identify one of the following four defined evolutionary states, including exploration, exploitation, convergence, and jumping out in each generation. It enables the automatic control of inertia weight, acceleration coefficients, and other algorithmic parameters at run time to improve the search efficiency and convergence speed. Then, an elitist learning strategy is performed when the evolutionary state is classified as convergence state. The strategy will act on the globally best particle to jump out of the likely local optima. The APSO has comprehensively been evaluated on 12 unimodal and multimodal benchmark functions. The effects of parameter adaptation and elitist learning will be studied. Results show that APSO substantially enhances the performance of the PSO paradigm in terms of convergence speed, global optimality, solution accuracy, and algorithm reliability. As APSO introduces two new parameters to the PSO paradigm only, it does not introduce an additional design or implementation complexity.

This paper presents a comprehensive literature review on applications of deep reinforcement learning (DRL) in communications and networking. Modern networks, e.g., Internet of Things (IoT) and unmanned aerial vehicle (UAV) networks, become more decentralized and autonomous. In such networks, network entities need to make decisions locally to maximize the network performance under uncertainty of network environment. Reinforcement learning has been efficiently used to enable the network entities to obtain the optimal policy including, e.g., decisions or actions, given their states when the state and action spaces are small. However, in complex and large-scale networks, the state and action spaces are usually large, and the reinforcement learning may not be able to find the optimal policy in reasonable time. Therefore, DRL, a combination of reinforcement learning with deep learning, has been developed to overcome the shortcomings. In this survey, we first give a tutorial of DRL from fundamental concepts to advanced models. Then, we review DRL approaches proposed to address emerging issues in communications and networking. The issues include dynamic network access, data rate control, wireless caching, data offloading, network security, and connectivity preservation which are all important to next generation networks, such as 5G and beyond. Furthermore, we present applications of DRL for traffic routing, resource sharing, and data collection. Finally, we highlight important challenges, open issues, and future research directions of applying DRL.

Abstract The fifth generation (5G) wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized, such as mass connectivity, ultra-reliability, and guaranteed low latency. However, 5G will not meet all requirements of the future in 2030 and beyond, and sixth generation (6G) wireless communication networks are expected to provide global coverage, enhanced spectral/energy/cost efficiency, better intelligence level and security, etc. To meet these requirements, 6G networks will rely on new enabling technologies, i.e., air interface and transmission technologies and novel network architecture, such as waveform design, multiple access, channel coding schemes, multi-antenna technologies, network slicing, cell-free architecture, and cloud/fog/edge computing. Our vision on 6G is that it will have four new paradigm shifts. First, to satisfy the requirement of global coverage, 6G will not be limited to terrestrial communication networks, which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle (UAV) communication networks, thus achieving a space-air-ground-sea integrated communication network. Second, all spectra will be fully explored to further increase data rates and connection density, including the sub-6 GHz, millimeter wave (mmWave), terahertz (THz), and optical frequency bands. Third, facing the big datasets generated by the use of extremely heterogeneous networks, diverse communication scenarios, large numbers of antennas, wide bandwidths, and new service requirements, 6G networks will enable a new range of smart applications with the aid of artificial intelligence (AI) and big data technologies. Fourth, network security will have to be strengthened when developing 6G networks. This article provides a comprehensive survey of recent advances and future trends in these four aspects. Clearly, 6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears.

Among different recommendation techniques, collaborative filtering usually suffer from limited performance due to the sparsity of user-item interactions. To address the issues, auxiliary information is usually used to boost the performance. Due to the rapid collection of information on the web, the knowledge base provides heterogeneous information including both structured and unstructured data with different semantics, which can be consumed by various applications. In this paper, we investigate how to leverage the heterogeneous information in a knowledge base to improve the quality of recommender systems. First, by exploiting the knowledge base, we design three components to extract items' semantic representations from structural content, textual content and visual content, respectively. To be specific, we adopt a heterogeneous network embedding method, termed as TransR, to extract items' structural representations by considering the heterogeneity of both nodes and relationships. We apply stacked denoising auto-encoders and stacked convolutional auto-encoders, which are two types of deep learning based embedding techniques, to extract items' textual representations and visual representations, respectively. Finally, we propose our final integrated framework, which is termed as Collaborative Knowledge Base Embedding (CKE), to jointly learn the latent representations in collaborative filtering as well as items' semantic representations from the knowledge base. To evaluate the performance of each embedding component as well as the whole system, we conduct extensive experiments with two real-world datasets from different scenarios. The results reveal that our approaches outperform several widely adopted state-of-the-art recommendation methods.

Abstract Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight 1 . Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data ( http://www.brainchart.io/ ). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories 2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones 3 , showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.

The review summarizes the recent progress in the synthesis, fundamental properties, morphology, photocatalytic applications and challenges of CdS-based photocatalysts.

Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs, targeted therapeutic drugs have become mainstream cancer treatments. Since the first tyrosine kinase inhibitor imatinib was approved to enter the market by the US Food and Drug Administration (FDA) in 2001, an increasing number of small-molecule targeted drugs have been developed for the treatment of malignancies. By December 2020, 89 small-molecule targeted antitumor drugs have been approved by the US FDA and the National Medical Products Administration (NMPA) of China. Despite great progress, small-molecule targeted anti-cancer drugs still face many challenges, such as a low response rate and drug resistance. To better promote the development of targeted anti-cancer drugs, we conducted a comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification. We present all the approved drugs as well as important drug candidates in clinical trials for each target, discuss the current challenges, and provide insights and perspectives for the research and development of anti-cancer drugs.

This paper reviews the first challenge on single image super-resolution (restoration of rich details in an low resolution image) with focus on proposed solutions and results. A new DIVerse 2K resolution image dataset (DIV2K) was employed. The challenge had 6 competitions divided into 2 tracks with 3 magnification factors each. Track 1 employed the standard bicubic downscaling setup, while Track 2 had unknown downscaling operators (blur kernel and decimation) but learnable through low and high res train images. Each competition had ∽100 registered participants and 20 teams competed in the final testing phase. They gauge the state-of-the-art in single image super-resolution.

The fourth industrial revolution, also labelled Industry 4.0, was beget with emergent and disruptive intelligence and information technologies. These new technologies are enabling ever-higher levels of production efficiencies. They also have the potential to dramatically influence social and environmental sustainable development. Organizations need to consider Industry 4.0 technologies contribution to sustainability. Sufficient guidance, in this respect, is lacking in the scholarly or practitioner literature. In this study, we further examine Industry 4.0 technologies in terms of application and sustainability implications. We introduce a measures framework for sustainability based on the United Nations Sustainable Development Goals; incorporating various economic, environmental and social attributes. We also develop a hybrid multi-situation decision method integrating hesitant fuzzy set, cumulative prospect theory and VIKOR. This method can effectively evaluate Industry 4.0 technologies based on their sustainable performance and application. We apply the method using secondary case information from a report of the World Economic Forum. The results show that mobile technology has the greatest impact on sustainability in all industries, and nanotechnology, mobile technology, simulation and drones have the highest impact on sustainability in the automotive, electronics, food and beverage, and textile, apparel and footwear industries, respectively. Our recommendation is to take advantage of Industry 4.0 technology adoption to improve sustainability impact but each technology needs to be carefully evaluated as specific technology will variably influence industry and sustainability dimensions. Investment in such technologies should consider appropriate priority investment and championing.

Graphene and graphene oxide have attracted tremendous interest over the past decade due to their unique and excellent electronic, optical, mechanical, and chemical properties. This review focuses on the functional modification of graphene and graphene oxide. First, the basic structure, preparation methods and properties of graphene and graphene oxide are briefly described. Subsequently, the methods for the reduction of graphene oxide are introduced. Next, the functionalization of graphene and graphene oxide is mainly divided into covalent binding modification, non-covalent binding modification and elemental doping. Then, the properties and application prospects of the modified products are summarized. Finally, the current challenges and future research directions are presented in terms of surface functional modification for graphene and graphene oxide.

This paper studies the tracking control problem for an uncertain n -link robot with full-state constraints. The rigid robotic manipulator is described as a multiinput and multioutput system. Adaptive neural network (NN) control for the robotic system with full-state constraints is designed. In the control design, the adaptive NNs are adopted to handle system uncertainties and disturbances. The Moore-Penrose inverse term is employed in order to prevent the violation of the full-state constraints. A barrier Lyapunov function is used to guarantee the uniform ultimate boundedness of the closed-loop system. The control performance of the closed-loop system is guaranteed by appropriately choosing the design parameters. Simulation studies are performed to illustrate the effectiveness of the proposed control.

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.

The rapid increase in the volume of data generated from connected devices in industrial Internet of Things paradigm, opens up new possibilities for enhancing the quality of service for the emerging applications through data sharing. However, security and privacy concerns (e.g., data leakage) are major obstacles for data providers to share their data in wireless networks. The leakage of private data can lead to serious issues beyond financial loss for the providers. In this article, we first design a blockchain empowered secure data sharing architecture for distributed multiple parties. Then, we formulate the data sharing problem into a machine-learning problem by incorporating privacy-preserved federated learning. The privacy of data is well-maintained by sharing the data model instead of revealing the actual data. Finally, we integrate federated learning in the consensus process of permissioned blockchain, so that the computing work for consensus can also be used for federated training. Numerical results derived from real-world datasets show that the proposed data sharing scheme achieves good accuracy, high efficiency, and enhanced security.