University of Salford

BACKGROUND AND OBJECTIVES: The expansion of evidence-based practice across sectors has lead to an increasing variety of review types. However, the diversity of terminology used means that the full potential of these review types may be lost amongst a confusion of indistinct and misapplied terms. The objective of this study is to provide descriptive insight into the most common types of reviews, with illustrative examples from health and health information domains. METHODS: Following scoping searches, an examination was made of the vocabulary associated with the literature of review and synthesis (literary warrant). A simple analytical framework -- Search, AppraisaL, Synthesis and Analysis (SALSA) -- was used to examine the main review types. RESULTS: Fourteen review types and associated methodologies were analysed against the SALSA framework, illustrating the inputs and processes of each review type. A description of the key characteristics is given, together with perceived strengths and weaknesses. A limited number of review types are currently utilized within the health information domain. CONCLUSIONS: Few review types possess prescribed and explicit methodologies and many fall short of being mutually exclusive. Notwithstanding such limitations, this typology provides a valuable reference point for those commissioning, conducting, supporting or interpreting reviews, both within health information and the wider health care domain.

AIM: To produce a framework for the development of a qualitative semi-structured interview guide. BACKGROUND: Rigorous data collection procedures fundamentally influence the results of studies. The semi-structured interview is a common data collection method, but methodological research on the development of a semi-structured interview guide is sparse. DESIGN: Systematic methodological review. DATA SOURCES: We searched PubMed, CINAHL, Scopus and Web of Science for methodological papers on semi-structured interview guides from October 2004-September 2014. Having examined 2,703 titles and abstracts and 21 full texts, we finally selected 10 papers. REVIEW METHODS: We analysed the data using the qualitative content analysis method. RESULTS: Our analysis resulted in new synthesized knowledge on the development of a semi-structured interview guide, including five phases: (1) identifying the prerequisites for using semi-structured interviews; (2) retrieving and using previous knowledge; (3) formulating the preliminary semi-structured interview guide; (4) pilot testing the guide; and (5) presenting the complete semi-structured interview guide. CONCLUSION: Rigorous development of a qualitative semi-structured interview guide contributes to the objectivity and trustworthiness of studies and makes the results more plausible. Researchers should consider using this five-step process to develop a semi-structured interview guide and justify the decisions made during it.

Pilot studies and a literature review suggested that fear-avoidance beliefs about physical activity and work might form specific cognitions intervening between low back pain and disability. A Fear-Avoidance Beliefs Questionnaire (FABQ) was developed, based on theories of fear and avoidance behaviour and focussed specifically on patients' beliefs about how physical activity and work affected their low back pain. Test-retest reproducibility in 26 patients was high. Principal-components analysis of the questionnaire in 210 patients identified 2 factors: fear-avoidance beliefs about work and fear-avoidance beliefs about physical activity with internal consistency (alpha) of 0.88 and 0.77 and accounting for 43.7% and 16.5% of the total variance, respectively. Regression analysis in 184 patients showed that fear-avoidance beliefs about work accounted for 23% of the variance of disability in activities of daily living and 26% of the variance of work loss, even after allowing for severity of pain; fear-avoidance beliefs about physical activity explained an additional 9% of the variance of disability. These results confirm the importance of fear-avoidance beliefs and demonstrate that specific fear-avoidance beliefs about work are strongly related to work loss due to low back pain. These findings are incorporated into a biopsychosocial model of the cognitive, affective and behavioural influences in low back pain and disability. It is recommended that fear-avoidance beliefs should be considered in the medical management of low back pain and disability.

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the validity of the correlations. Many sources of data variability can weaken the apparent correlation between cognitive status and AD neuropathologic changes. Indeed, most persons in advanced old age have significant non-AD brain lesions that may alter cognition independently of AD. Worldwide research efforts have evaluated thousands of human subjects to assess the causes of cognitive impairment in the elderly, and these studies have been interpreted in different ways. We review the literature focusing on the correlation of AD neuropathologic changes (i.e. β-amyloid plaques and neurofibrillary tangles) with cognitive impairment. We discuss the various patterns of brain changes that have been observed in elderly individuals to provide a perspective for understanding AD clinicopathologic correlation and conclude that evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of Aβ plaques and neurofibrillary tangles. Although Aβ plaques may play a key role in AD pathogenesis, the severity of cognitive impairment correlates best with the burden of neocortical neurofibrillary tangles.

This article examines associations between gluten, polymorphisms of the major histocompatibility complex, and mucosal pathology representative of the spectrum of gluten sensitivity. Sequences of wheat, rye, and barley prolamins contain recurring tetrapeptide motifs that are predicted to have beta-reverse-turn secondary structure and that, with in vitro assays, appear active. Structural polymorphisms of major histocompatibility complex subloci identify codon switches within the second exon that control the third hypervariable region in the outer domain of the beta chain. Observations of the intestinal response to gluten reveal five interrelated lesions (preinfiltrative, infiltrative, hyperplastic, destructive, and hypoplastic) that are interpretable as cell-mediated immunologic responses. These responses originate in the lamina propria, where a series of antigen-specific inflammatory processes has now been identified. There is no evidence that celiac sprue is a disease of jejunal enterocytes. Furthermore, the role of intraepithelial space lymphocytes in pathogenesis, if relevant, needs further experimental dissection. Also awaiting further definition are polymorphisms of the celiac lymphocyte antigen receptor and their relationship to gliadin oligopeptide(s) and predisposing genes. The nature and basis of nonresponsive celiac sprue require more thoughtful initiatives to elucidate the immunologic mechanism(s) of unresponsiveness and evaluate possible means of reversal. Finally, a more sensible definition of gluten sensitivity (unhampered by qualitative morphological imagery) is ultimately called for in order to accommodate the biomolecular advances addressed in this review.

Textile industries are responsible for one of the major environmental pollution problems in the world, because they release undesirable dye effluents. Textile wastewater contains dyes mixed with various contaminants at a variety of ranges. Therefore, environmental legislation commonly obligates textile factories to treat these effluents before discharge into the receiving watercourses. The treatment efficiency of any pilot-scale study can be examined by feeding the system either with real textile effluents or with artificial wastewater having characteristics, which match typical textile factory discharges. This paper presents a critical review of the currently available literature regarding typical and real characteristics of the textile effluents, and also constituents including chemicals used for preparing simulated textile wastewater containing dye, as well as the treatments applied for treating the prepared effluents. This review collects the scattered information relating to artificial textile wastewater constituents and organises it to help researchers who are required to prepare synthetic wastewater. These ingredients are also evaluated based on the typical characteristics of textile wastewater, and special constituents to simulate these characteristics are recommended. The processes carried out during textile manufacturing and the chemicals corresponding to each process are also discussed.

The combination of the Internet and emerging technologies such as nearfield communications, real-time localization, and embedded sensors lets us transform everyday objects into smart objects that can understand and react to their environment. Such objects are building blocks for the Internet of Things and enable novel computing applications. As a step toward design and architectural principles for smart objects, the authors introduce a hierarchy of architectures with increasing levels of real-world awareness and interactivity. In particular, they describe activity-, policy-, and process-aware smart objects and demonstrate how the respective architectural abstractions support increasingly complex application.

BACKGROUND: Physical activity has not been objectively measured in prospective cohorts with sufficiently large numbers to reliably detect associations with multiple health outcomes. Technological advances now make this possible. We describe the methods used to collect and analyse accelerometer measured physical activity in over 100,000 participants of the UK Biobank study, and report variation by age, sex, day, time of day, and season. METHODS: Participants were approached by email to wear a wrist-worn accelerometer for seven days that was posted to them. Physical activity information was extracted from 100Hz raw triaxial acceleration data after calibration, removal of gravity and sensor noise, and identification of wear / non-wear episodes. We report age- and sex-specific wear-time compliance and accelerometer measured physical activity, overall and by hour-of-day, week-weekend day and season. RESULTS: 103,712 datasets were received (44.8% response), with a median wear-time of 6.9 days (IQR:6.5-7.0). 96,600 participants (93.3%) provided valid data for physical activity analyses. Vector magnitude, a proxy for overall physical activity, was 7.5% (2.35mg) lower per decade of age (Cohen's d = 0.9). Women had a higher vector magnitude than men, apart from those aged 45-54yrs. There were major differences in vector magnitude by time of day (d = 0.66). Vector magnitude differences between week and weekend days (d = 0.12 for men, d = 0.09 for women) and between seasons (d = 0.27 for men, d = 0.15 for women) were small. CONCLUSIONS: It is feasible to collect and analyse objective physical activity data in large studies. The summary measure of overall physical activity is lower in older participants and age-related differences in activity are most prominent in the afternoon and evening. This work lays the foundation for studies of physical activity and its health consequences. Our summary variables are part of the UK Biobank dataset and can be used by researchers as exposures, confounding factors or outcome variables in future analyses.

Qualitative methods are invaluable for exploring the complexities of health care and patient experiences in particular. Diverse qualitative methods are available that incorporate different ontological and epistemological perspectives. One method of data management that is gaining in popularity among healthcare researchers is the framework approach. We will outline this approach, discuss its relative merits and provide a working example of its application to data management and analysis.

The focus of this article is an examination of translation dilemmas in qualitative research. Specifically it explores three questions: whether methodologically it matters if the act of translation is identified or not; the epistemological implications of who does translation; and the consequences for the final product of how far the researcher chooses to involve a translator in research. Some of the ways in which researchers have tackled language difference are discussed. The medium of spoken and written language is itself critically challenged by considering the implications of similar ‘problems of method’ but in situations where the translation and interpretation issues are those associated with a visual spatial medium, in this case Sign Language. The authors argue that centring translation and how it is dealt with raises issues of representation that should be of concern to all researchers.

Abstract Magnetization, magnetic susceptibility, optical microscopy, X-ray diffraction and neutron diffraction measurements have been made on a quenched sample of Ni2MnGa. Room-temperature neutron diffraction patterns indicate a highly ordered Heusler alloy, L21 type, structure. The alloy is ferromagnetic with a Curie temperature of 376 K, and a magnetic moment of 4·17μB largely confined to the Mn sites, but probably with a small moment <07·3μB associated with the Ni sites. A martensitic phase transition to a complex tetragonal structure occurs on cooling below 202 K. Neutron diffraction oscillation photographs taken using the D12 facility at Institut Laue Langevin, Grenoble, and low-temperature powder neutron diffraction data enabled details of the low temperature crystallographic superlattice and magnetic structure to be determined. Reasons for the structural transformation are discussed.

This paper reviews the origins, techniques and roles associated with action research into information systems (IS). Many consider the approach to be the paragon of post-positivist research methods, yet it has a cloudy history among the social sciences. The paper summarizes the rigorous approach to action research and suggests certain domains of ideal use (such as systems development methodology). For those faced with conducting, reviewing or examining action research, the paper discusses various problems, opportunities and strategies.

We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance ( p &lt; .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion ( p &lt; .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely high-powered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (&lt; 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.

performance One concept in particular which has provided some valuable insights into learning in both academic and other settings is learning style. There is general acceptance that the manner in which individuals choose to or are inclined to approach a learning situation has an impact on performance and achievement of learning outcomes. Whilstand perhaps becauselearning style has been the focus of such a vast number of research and practitioner-based studies in the area, there exist a variety of denitions, theoretical positions, models, interpretations and measures of the construct. To some extent, this can be considered a natural consequence of extensive empirical investigation and is to be expected with any continually developing concept which proves useful in gaining understanding of such a crucial and prevailing endeavour as learning. However, the level of ambiguity and debate is such that even the task of selecting an appropriate instrument for investigation is an onerous one, with the unifying of subsequent ndings within an existing framework problematic, at best. This paper does not seek to achieve an absolute resolve and converge upon the ideal model and measure of learning style, but rather to inform through description and comparison. It is intended as a resource for researchers and professionals who desire a broad appreciation of the area of learning style and who may, previously, have been working with an in-depth understanding but, perhaps, only a narrow awareness of the eld.

Despite growing recognition of the need for qualitative methods in health services research, there have been few attempts to define quality standards for assessing the results. This article acknowledges the desirability of a plurality of standards. However, it is argued that three interrelated criteria can be identified as the foundation of good qualitative health research: interpretation of subjective meaning, description of social context, and attention to lay knowledge. These criteria can be examined in relation to different dimensions of any research report, including theoretical basis, sampling strategy, scope of data collection, description of data collected, and concern with generalizability or typicality. But if the concern is with the appropriateness of care and with understanding the factors that shape lay and clinical behavior, then these criteria must form the basis of a hierarchy of qualitative research evidence.

Software applications (apps) are now prevalent in the digital media environment. They are the site of significant sociocultural and economic transformations across many domains, from health and relationships to entertainment and everyday finance. As relatively closed technical systems, apps pose new methodological challenges for sociocultural digital media research. This article describes a method, grounded in a combination of science and technology studies with cultural studies, through which researchers can perform a critical analysis of a given app. The method involves establishing an app’s environment of expected use by identifying and describing its vision, operating model and modes of governance. It then deploys a walkthrough technique to systematically and forensically step through the various stages of app registration and entry, everyday use and discontinuation of use. The walkthrough method establishes a foundational corpus of data upon which can be built a more detailed analysis of an app’s intended purpose, embedded cultural meanings and implied ideal users and uses. The walkthrough also serves as a foundation for further user-centred research that can identify how users resist these arrangements and appropriate app technology for their own purposes.

As in nursing, recent curriculum reform in radiographer education has resulted in the development of undergraduate programmes, and a study referred to in this paper investigated the activities of supervising radiographers in support of the undergraduate curriculum. Following on from 'ward learning environments' research in nursing, the most important activities which assist radiography students' clinical learning were investigated by means of the Delphi technique. At the design stage, a deficiency in previous work using the technique was identified, in that decisions relating to consensus among research respondents appeared to be based on arbitrary or post hoc rationales rather than predetermined or objective criteria. As the Delphi technique is being increasingly employed in nursing and similar research, it is important to explore issues of consensus, validity and reliability. The paper makes recommendations for improving these aspects in future studies.

Abstract There are infinite numbers of possible arrangements of two parallel cylinders positioned at right angles to the approaching flow direction. Of the infinite arrangements, two distinct groups may be identified: in one group, the cylinders are in a tandem arrangement, one behind the other at any longitudinal spacing; and in the second group, the cylinders face the flow side by side at any transverse spacing. All other combinations of longitudinal and transverse spacings represent staggered arrangements. The tandem arrangement will be treated first. A critical survey of previous research revealed some “odd” features which had been observed and overlooked by various authors. The discontinuity of vortex shedding implies that a similar discontinuity should be expected for the drag force on both cylinders. The measurements of the front (gap) pressures of the downstream cylinder and the base pressures of both cylinders at various spacings reveal a discontinuous “jump” at some critical spacing. The discontinuity is caused by the abrupt change from one stable flow pattern to another at the critical spacing. A new interpretation is given for the existing data on the drag force for both cylinders. The effects of Reynolds number and surface roughness are treated in some detail. Following this, two cylinders arranged side by side to the approaching flow are considered. All the available data on measured forces are compiled together with additional measurements in the range of intermittent changes of drag and lift forces. The bistable nature of the asymmetric flow pattern around each cylinder produces two alternative values of the drag force coupled with two alternative values of the lift force. The introduction of the interference force coefficient exposes the physical origin of two different forces experienced by the cylinders when arranged side by side. Finally, the least reported arrangement of two staggered cylinders is reviewed. The various arrangements are grouped into classes according to the sign of the lift force, or whether the drag force is greater or less than that for a single cylinder. The measurements of drag and lift forces for various arrangements reveal two different regimes for the lift force. In one regime, the lift force directed toward the wake of the upstream cylinder is due to the entrainment of the flow into the fully developed wake of the upstream cylinder. The lift force in this regime reaches a maximum value when the downstream cylinder is near to the upstream wake boundary. In the second regime, at very small spacings, the lift force becomes very large due to an intense gap flow which displaces the wake of the upstream cylinder. The maximum lift force occurs with the downstream cylinder near to the horizontal axis of the upstream cylinder. A discontinuity in the lift force for some staggered arrangements is found and attributed to the bistable nature of the gap flow.

Species distribution models (SDMs) constitute the most common class of models across ecology, evolution and conservation. The advent of ready‐to‐use software packages and increasing availability of digital geoinformation have considerably assisted the application of SDMs in the past decade, greatly enabling their broader use for informing conservation and management, and for quantifying impacts from global change. However, models must be fit for purpose, with all important aspects of their development and applications properly considered. Despite the widespread use of SDMs, standardisation and documentation of modelling protocols remain limited, which makes it hard to assess whether development steps are appropriate for end use. To address these issues, we propose a standard protocol for reporting SDMs, with an emphasis on describing how a study's objective is achieved through a series of modeling decisions. We call this the ODMAP (Overview, Data, Model, Assessment and Prediction) protocol, as its components reflect the main steps involved in building SDMs and other empirically‐based biodiversity models. The ODMAP protocol serves two main purposes. First, it provides a checklist for authors, detailing key steps for model building and analyses, and thus represents a quick guide and generic workflow for modern SDMs. Second, it introduces a structured format for documenting and communicating the models, ensuring transparency and reproducibility, facilitating peer review and expert evaluation of model quality, as well as meta‐analyses. We detail all elements of ODMAP, and explain how it can be used for different model objectives and applications, and how it complements efforts to store associated metadata and define modelling standards. We illustrate its utility by revisiting nine previously published case studies, and provide an interactive web‐based application to facilitate its use. We plan to advance ODMAP by encouraging its further refinement and adoption by the scientific community.

Chapter 1: What Is Case-Based Reasoning? Chapter 2: Understanding CBR Chapter 3: The Application of CBR Chapter 4: Industrial Applications of CBR Chapter 5: CBR and Customer Service Chapter 6: CBR Software Tools Chapter 7: Building a Diagnostic Case-Base Chapter 8: Building, Testing, and Maintaining Case-Bases Chapter 9: Conclusion Chapter 10: Bibliography