University of South Wales

The application of anaerobic digestion technology is growing worldwide because of its economic and environmental benefits. As a consequence, a number of studies and research activities dealing with the determination of the biogas potential of solid organic substrates have been carrying out in the recent years. Therefore, it is of particular importance to define a protocol for the determination of the ultimate methane potential for a given solid substrates. In fact, this parameter determines, to a certain extent, both design and economic details of a biogas plant. Furthermore, the definition of common units to be used in anaerobic assays is increasingly requested from the scientific and engineering community. This paper presents some guidelines for biomethane potential assays prepared by the Task Group for the Anaerobic Biodegradation, Activity and Inhibition Assays of the Anaerobic Digestion Specialist Group of the International Water Association. This is the first step for the definition of a standard protocol.

In this paper, the stability and stabilization problems for a class of switched linear systems with mode-dependent average dwell time (MDADT) are investigated in both continuous-time and discrete-time contexts. The proposed switching law is more applicable in practice than the average dwell time (ADT) switching in which each mode in the underlying system has its own ADT. The stability criteria for switched systems with MDADT in nonlinear setting are firstly derived, by which the conditions for stability and stabilization for linear systems are also presented. A numerical example is given to show the validity and potential of the developed techniques.

derived free radical and non-radical species generation. To understand how many reasons underpin oxidative stress, one must first re-cast free radical and non-radical species in a positive light because their deliberate generation enables the brain to achieve critical functions (e.g. synaptic plasticity) through redox signalling (i.e. positive functionality). Using free radicals and non-radical derivatives to signal sensitises the brain to oxidative stress when redox signalling goes awry (i.e. negative functionality). To advance mechanistic understanding, we rationalise 13 reasons why the brain is susceptible to oxidative stress. Key reasons include inter alia unsaturated lipid enrichment, mitochondria, calcium, glutamate, modest antioxidant defence, redox active transition metals and neurotransmitter auto-oxidation. We review RNA oxidation as an underappreciated cause of oxidative stress. The complex interplay between each reason dictates neuronal susceptibility to oxidative stress in a dynamic context and neural identity dependent manner. Our discourse sets the stage for investigators to interrogate the biochemical basis of oxidative stress in the brain in health and disease.

Faigenbaum, AD, Kraemer, WJ, Blimkie, CJR, Jeffreys, I, Micheli, LJ, Nitka, M, and Rowland, TW. Youth resistance training: Updated position statement paper from the National Strength and Conditioning Association. J Strength Cond Res 23(5): S60-S79, 2009-Current recommendations suggest that school-aged youth should participate daily in 60 minutes or more of moderate to vigorous physical activity that is developmentally appropriate and enjoyable and involves a variety of activities (219). Not only is regular physical activity essential for normal growth and development, but also a physically active lifestyle during the pediatric years may help to reduce the risk of developing some chronic diseases later in life (196). In addition to aerobic activities such as swimming and bicycling, research increasingly indicates that resistance training can offer unique benefits for children and adolescents when appropriately prescribed and supervised (28,66,111,139,147,234). The qualified acceptance of youth resistance training by medical, fitness, and sport organizations is becoming universal (5,6,8,12,18,33,104,167,192,215). Nowadays, comprehensive school-based programs are specifically designed to enhance health-related components of physical fitness, which include muscular strength (169). In addition, the health club and sport conditioning industry is getting more involved in the youth fitness market. In the U.S.A., the number of health club members between the ages of 6 and 17 years continues to increase (127,252) and a growing number of private sport conditioning centers now cater to young athletes. Thus, as more children and adolescents resistance train in schools, health clubs, and sport training centers, it is imperative to determine safe, effective, and enjoyable practices by which resistance training can improve the health, fitness, and sports performance of younger populations. The National Strength and Conditioning Association (NSCA) recognizes and supports the premise that many of the benefits associated with adult resistance training programs are attainable by children and adolescents who follow age-specific resistance training guidelines. The NSCA published the first position statement paper on youth resistance training in 1985 (170) and revised this statement in 1996 (72). The purpose of the present report is to update and clarify the 1996 recommendations on 4 major areas of importance. These topics include (a) the potential risks and concerns associated with youth resistance training, (b) the potential health and fitness benefits of youth resistance training, (c) the types and amount of resistance training needed by healthy children and adolescents, and (d) program design considerations for optimizing long-term training adaptations. The NSCA based this position statement paper on a comprehensive analysis of the pertinent scientific evidence regarding the anatomical, physiological, and psychosocial effects of youth resistance training. An expert panel of exercise scientists, physicians, and health/physical education teachers with clinical, practical, and research expertise regarding issues related to pediatric exercise science, sports medicine, and resistance training contributed to this statement. The NSCA Research Committee reviewed this report before the formal endorsement by the NSCA. For the purpose of this article, the term children refers to boys and girls who have not yet developed secondary sex characteristics (approximately up to the age of 11 years in girls and 13 years in boys; Tanner stages 1 and 2 of sexual maturation). This period of development is referred to as preadolescence. The term adolescence refers to a period between childhood and adulthood and includes girls aged 12-18 years and boys aged 14-18 years (Tanner stages 3 and 4 of sexual maturation). The terms youth and young athletes are broadly defined in this report to include both children and adolescents. By definition, the term resistance training refers to a specialized method of conditioning, which involves the progressive use of a wide range of resistive loads and a variety of training modalities designed to enhance health, fitness, and sports performance. Although the term resistance training, strength training, and weight training are sometimes used synonymously, the term resistance training encompasses a broader range of training modalities and a wider variety of training goals. The term weightlifting refers to a competitive sport that involves the performance of the snatch and clean and jerk lifts. This article builds on previous recommendations from the NSCA and should serve as the prevailing statement regarding youth resistance training. It is the current position of the NSCA that: A properly designed and supervised resistance training program is relatively safe for youth. A properly designed and supervised resistance training program can enhance the muscular strength and power of youth. A properly designed and supervised resistance training program can improve the cardiovascular risk profile of youth. A properly designed and supervised resistance training program can improve motor skill performance and may contribute to enhanced sports performance of youth. A properly designed and supervised resistance training program can increase a young athlete's resistance to sports-related injuries. A properly designed and supervised resistance training program can help improve the psychosocial well-being of youth. A properly designed and supervised resistance training program can help promote and develop exercise habits during childhood and adolescence.

This review describes the features of modern infrared imaging technology and the standardization protocols for thermal imaging in medicine. The technique essentially uses naturally emitted infrared radiation from the skin surface. Recent studies have investigated the influence of equipment and the methods of image recording. The credibility and acceptance of thermal imaging in medicine is subject to critical use of the technology and proper understanding of thermal physiology. Finally, we review established and evolving medical applications for thermal imaging, including inflammatory diseases, complex regional pain syndrome and Raynaud's phenomenon. Recent interest in the potential applications for fever screening is described, and some other areas of medicine where some research papers have included thermal imaging as an assessment modality. In certain applications thermal imaging is shown to provide objective measurement of temperature changes that are clinically significant.

SUMMARY The method given in this paper is typically applicable to those inventory problems where a product is procured by a single customer from a single supplier. An example has been solved to illustrate the method.

This paper aims to review the problem of colour in textile effluents, the different classes of dyes available and their contribution to the problem. Through new regulations, pressure is being placed on water companies all over the world to reduce the amount of colour in sewage effluent. Dyes exhibit low toxicity to mammals and aquatic organisms and therefore colour consents are normally applied for aesthetic and industrial reasons rather than for prevention of toxicity. The absorbance, ADMI values and concentrations of dyes in effluent are examined here with particular reference to reactive azo dyes used in cotton processing. Colour consents, the problem of colour in textile wastewaters and the importance for research in this area are also discussed. Dye concentrations of 0.01 g dm−3 up to 0.25 g dm−3 have been cited as being present in dyehouse effluent, depending on the dyes and processes used. ADMI values ranged from 50 to 3890 units for the dyeing of cotton. It was concluded that 1500 ADMI units was a reasonable value to aim for when simulating coloured effluents. Simulated textile effluents may be used for research purposes. These should resemble real wastes as closely as possible, but it is often difficult to replicate the ADMI values, absorbance and spectra of real effluents. The concentrations of dye used in simulated effluents examined in literature varied from 0.01 g dm−3 to 7 g dm−3. As absorbance and ADMI values change with the types of dye used, it is difficult to relate these values to dye concentrations. A concentration of 0.18 g dm−3 of a Red or Yellow dye or 0.43 g dm−3 of a blue dye would provide an ADMI of approximately 1500 units and fits within the range of dye concentrations presented in literature. A dye mixture simulating colour in a real textile effluent is suggested and some limitations of simulating actual wastewaters discussed. © 1999 Society of Chemical Industry

AIM: These international clinical practice recommendations (CPR) for developmental coordination disorder (DCD), initiated by the European Academy of Childhood Disability (EACD), aim to address key questions on the definition, diagnosis, assessment, intervention, and psychosocial aspects of DCD relevant for clinical practice. METHOD: Key questions in five areas were considered through literature reviews and formal expert consensus. For recommendations based on evidence, literature searches on 'mechanisms', 'assessment', and 'intervention' were updated since the last recommendations in 2012. New searches were conducted for 'psychosocial issues' and 'adolescents/adults'. Evidence was rated according to the Oxford Centre for Evidence-Based Medicine (level of evidence [LOE] 1-4) and transferred into recommendations. For recommendations based on formal consensus, two meetings of an international, multidisciplinary expert panel were conducted with a further five Delphi rounds to develop good clinical practice (GCP) recommendations. RESULTS: Thirty-five recommendations were made. Eight were based on the evidence from literature reviews (three on 'assessment', five on 'intervention'). Twenty-two were updated from the 2012 recommendations. New recommendations relate to diagnosis and assessment (two GCPs) and psychosocial issues (three GCPs). Additionally, one new recommendation (LOE) reflects active video games as adjuncts to more traditional activity-oriented and participation-oriented interventions, and two new recommendations (one GCP, one LOE) were made for adolescents and adults with DCD. INTERPRETATION: The CPR-DCD is a comprehensive overview of DCD and current understanding based on research evidence and expert consensus. It reflects the state of the art for clinicians and scientists of varied disciplines. The international CPR-DCD may serve as a basis for national guidelines. WHAT THIS PAPER ADDS: Updated international clinical practice guidelines on developmental coordination disorder (DCD). Refined and extended recommendations on clinical assessment and intervention for DCD. A critical synopsis of current research on mechanisms of DCD. A critical synopsis of psychosocial issues in DCD, with implications for clinical practice. The first international recommendations to consider adolescents and adults with DCD.

This note concerns the problem of the robust stability of a linear system with a time-varying delay and polytopic-type uncertainties. In order to construct a parameter-dependent Lyapunov functional for the system, we first devised a new method of dealing with a time-delay system without uncertainties. In this method, the derivative terms of the state, which is in the derivative of the Lyapunov functional, are retained and some free weighting matrices are used to express the relationships among the system variables, and among the terms in the Leibniz-Newton formula. As a result, the Lyapunov matrices are not involved in any product terms of the system matrices in the derivative of the Lyapunov functional. This method is then easily extended to a system with polytopic-type uncertainties. Numerical examples demonstrate the validity of the proposed criteria.

BACKGROUND: Sleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether treating insomnia leads to a reduction in paranoia and hallucinations. METHODS: We did this single-blind, randomised controlled trial (OASIS) at 26 UK universities. University students with insomnia were randomly assigned (1:1) with simple randomisation to receive digital cognitive behavioural therapy (CBT) for insomnia or usual care, and the research team were masked to the treatment. Online assessments took place at weeks 0, 3, 10 (end of therapy), and 22. The primary outcome measures were for insomnia, paranoia, and hallucinatory experiences. We did intention-to-treat analyses. The trial is registered with the ISRCTN registry, number ISRCTN61272251. FINDINGS: Between March 5, 2015, and Feb 17, 2016, we randomly assigned 3755 participants to receive digital CBT for insomnia (n=1891) or usual practice (n=1864). Compared with usual practice, the sleep intervention at 10 weeks reduced insomnia (adjusted difference 4·78, 95% CI 4·29 to 5·26, Cohen's d=1·11; p<0·0001), paranoia (-2·22, -2·98 to -1·45, Cohen's d=0·19; p<0·0001), and hallucinations (-1·58, -1·98 to -1·18, Cohen's d=0·24; p<0·0001). Insomnia was a mediator of change in paranoia and hallucinations. No adverse events were reported. INTERPRETATION: To our knowledge, this is the largest randomised controlled trial of a psychological intervention for a mental health problem. It provides strong evidence that insomnia is a causal factor in the occurrence of psychotic experiences and other mental health problems. Whether the results generalise beyond a student population requires testing. The treatment of disrupted sleep might require a higher priority in mental health provision. FUNDING: Wellcome Trust.

Purpose The purpose of this paper is to critically review the core findings from recently published place‐based crime prevention research. The paper aims to critically evaluate the available evidence on the contribution of crime prevention through environmental design as a crime prevention strategy. Design/methodology/approach Large‐scale evaluations of crime prevention through environmental design (CPTED) are reviewed with a view to clarifying current knowledge on the evidence of crime prevention through environmental design. Findings The review concludes that there is a growing body of research that supports the assertion that crime prevention through environmental design is effective in reducing both crime and fear of crime in the community. Research limitations/implications Although the paper may not review all the evaluations of CPTED, it nonetheless provides a detailed compilation and overview of the most significant research in the area, including an extensive and modern bibliography on the subject. Research implications will be the subject of a forthcoming paper. Practical implications CPTED is an increasingly fashionable approach and is being implemented on a global scale. Additionally, individual components such as territoriality, surveillance, maintenance, access control, activity support and target‐hardening are being widely deployed. However, the evidence currently available is inconclusive and much criticised, which effectively prevents widespread intervention and investment by central government. The paper details the difficulties associated with demonstrating the effectiveness of CPTED. Originality/value The paper concludes that although empirical proof has not been definitively demonstrated, there is a large and growing body of research, which supports the assertion that crime prevention through environmental design is a pragmatic and effective crime prevention tool. This review provides an extensive bibliography of contemporary crime prevention through environmental design and a follow‐up paper will discuss the future research priorities for it.

In this note, we consider the problems of stochastic stability and sliding-mode control for a class of linear continuous-time systems with stochastic jumps, in which the jumping parameters are modeled as a continuous-time, discrete-state homogeneous Markov process with right continuous trajectories taking values in a finite set. By using Linear matrix inequalities (LMIs) approach, sufficient conditions are proposed to guarantee the stochastic stability of the underlying system. Then, a reaching motion controller is designed such that the resulting closed-loop system can be driven onto the desired sliding surface in a limited time. It has been shown that the sliding mode control problem for the Markovian jump systems is solvable if a set of coupled LMIs have solutions. A numerical example is given to show the potential of the proposed techniques.

This paper is concerned with the state estimation and sliding-mode control problems for continuous-time Markovian jump singular systems with unmeasured states. Firstly, a new necessary and sufficient condition is proposed in terms of strict linear matrix inequality (LMI), which guarantees the stochastic admissibility of the unforced Markovian jump singular system. Then, the sliding-mode control problem is considered by designing an integral sliding surface function. An observer is designed to estimate the system states, and a sliding-mode control scheme is synthesized for the reaching motion based on the state estimates. It is shown that the sliding mode in the estimation space can be attained in a finite time. Some conditions for the stochastic admissibility of the overall closed-loop system are derived. Finally, a numerical example is provided to illustrate the effectiveness of the proposed theory.

Infrared thermal imaging of the skin has been used for several decades to monitor the temperature distribution of human skin. Abnormalities such as malignancies, inflammation, and infection cause localized increases in temperature which show as hot spots or as asymmetrical patterns in an infrared thermogram. Even though it is nonspecific, infrared thermology is a powerful detector of problems that affect a patient's physiology. While the use of infrared imaging is increasing in many industrial and security applications, it has declined in medicine probably because of the continued reliance on first generation cameras. The transfer of military technology for medical use has prompted this reappraisal of infrared thermology in medicine. Digital infrared cameras have much improved spatial and thermal resolutions, and libraries of image processing routines are available to analyze images captured both statically and dynamically. If thermographs are captured under controlled conditions, they may be interpreted readily to diagnose certain conditions and to monitor the reaction of a patient's physiology to thermal and other stresses. Some of the major areas where infrared thermography is being used successfully are neurology, vascular disorders, rheumatic diseases, tissue viability, oncology (especially breast cancer), dermatological disorders, neonatal, ophthalmology, and surgery.

This paper is focused on reliable fuzzy <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$H_{\infty }$</tex></formula> controller design for active suspension systems with actuator delay and fault. The Takagi–Sugeno (T–S) fuzzy model approach is adapted in this study with the consideration of the sprung and the unsprung mass variation, the actuator delay and fault, and other suspension performances. By the utilization of the parallel-distributed compensation scheme, a reliable fuzzy <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$H_{\infty }$</tex></formula> performance analysis criterion is derived for the proposed T–S fuzzy model. Then, a reliable fuzzy <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$H_{\infty }$</tex></formula> controller is designed such that the resulting T–S fuzzy system is reliable in the sense that it is asymptotically stable and has the prescribed <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$H_{\infty }$</tex></formula> performance under given constraints. The existence condition of the reliable fuzzy <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$H_{\infty }$</tex></formula> controller is obtained in terms of linear matrix inequalities (LMIs) Finally, a quarter-vehicle suspension model is used to demonstrate the effectiveness and potential of the proposed design techniques.

The current manuscript has been adapted from the official position statement of the UK Strength and Conditioning Association on youth resistance training. It has subsequently been reviewed and endorsed by leading professional organisations within the fields of sports medicine, exercise science and paediatrics. The authorship team for this article was selected from the fields of paediatric exercise science, paediatric medicine, physical education, strength and conditioning and sports medicine.

Abstract The beneficial effects of learners interacting in online programmes have been widely reported. Indeed, online discussion is argued to promote student‐centred learning. It is therefore reasonable to suggest that the benefits of online discussion should translate into improved student performance. The current study examined the frequency of online interaction of 122 undergraduates and compared this with their grades at the end of the year. The findings revealed that greater online interaction did not lead to significantly higher performance for students achieving passing grades; however, students who failed in their courses tended to interact less frequently. Other factors that may be salient in online interactions are discussed.

In this letter, a new method is proposed for stability analysis of neural networks (NNs) with a time-varying delay. Some less conservative delay-dependent stability criteria are established by considering the additional useful terms, which were ignored in previous methods, when estimating the upper bound of the derivative of Lyapunov functionals and introducing the new free-weighting matrices. Numerical examples are given to demonstrate the effectiveness and the benefits of the proposed method.

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper first investigates the stability and <formula formulatype="inline"> <tex Notation="TeX">$l_{2}$</tex></formula>-gain problems for a class of discrete-time switched systems with average dwell time (ADT) switching by allowing the Lyapunov-like functions to increase during the running time of subsystems. The obtained results then facilitate the studies on the issue of asynchronous control, where “asynchronous” means the switching of the controllers has a lag to the switching of system modes. In light of the proposed Lyapunov-like functions, the desired mode-dependent controllers can be designed since the unmatched controllers are allowed to perform in the interval of asynchronous switching before the matched ones are applied. The problem of asynchronous <formula formulatype="inline"><tex Notation="TeX">$H_{\infty}$</tex></formula> control for the underlying systems in linear cases is then formulated. The conditions of the existence of admissible asynchronous <formula formulatype="inline"> <tex Notation="TeX">$H_{\infty}$</tex></formula> controllers are derived, and a numerical example is provided to show the potential of the developed results. </para>

BACKGROUND: MicroRNAs (miRNAs) are a group of short (approximately 22 nt) non-coding RNAs that play important regulatory roles. MiRNA precursors (pre-miRNAs) are characterized by their hairpin structures. However, a large amount of similar hairpins can be folded in many genomes. Almost all current methods for computational prediction of miRNAs use comparative genomic approaches to identify putative pre-miRNAs from candidate hairpins. Ab initio method for distinguishing pre-miRNAs from sequence segments with pre-miRNA-like hairpin structures is lacking. Being able to classify real vs. pseudo pre-miRNAs is important both for understanding of the nature of miRNAs and for developing ab initio prediction methods that can discovery new miRNAs without known homology. RESULTS: A set of novel features of local contiguous structure-sequence information is proposed for distinguishing the hairpins of real pre-miRNAs and pseudo pre-miRNAs. Support vector machine (SVM) is applied on these features to classify real vs. pseudo pre-miRNAs, achieving about 90% accuracy on human data. Remarkably, the SVM classifier built on human data can correctly identify up to 90% of the pre-miRNAs from other species, including plants and virus, without utilizing any comparative genomics information. CONCLUSION: The local structure-sequence features reflect discriminative and conserved characteristics of miRNAs, and the successful ab initio classification of real and pseudo pre-miRNAs opens a new approach for discovering new miRNAs.