Utah Tech University

Treatment of Osteoarthritis of the Knee: Evidence-Based Guideline, 2nd Edition, is based on a systematic review of the current scientific and clinical research. This guideline contains 15 recommendations, replaces the 2008 AAOS clinical practice guideline, and was reevaluated earlier than the 5-year recommendation of the National Guideline Clearinghouse because of methodologic concerns regarding the evidence used in the first guideline. The current guideline does not support the use of viscosupplementation for the treatment of osteoarthritis of the knee. In addition, the work group highlighted the need for better research in the treatment of knee osteoarthritis.

Biofilm-protected microbial infections in skin are a serious health risk that remains to be adequately addressed. The lack of progress in developing effective treatment strategies is largely due to the transport barriers posed by the stratum corneum of the skin and the biofilm. In this work, we report on the use of Ionic Liquids (ILs) for biofilm disruption and enhanced antibiotic delivery across skin layers. We outline the syntheses of ILs, analysis of relevant physicochemical properties, and subsequent neutralization effects on two biofilm-forming pathogens: Pseudomonas aeruginosa and Salmonella enterica. Further, the ILs were also examined for cytotoxicity, skin irritation, delivery of antibiotics through the skin, and treatment of biofilms in a wound model. Of the materials examined, choline-geranate emerged as a multipurpose IL with excellent antimicrobial activity, minimal toxicity to epithelial cells as well as skin, and effective permeation enhancement for drug delivery. Specifically, choline-geranate was comparable with, or more effective than, bleach treatment against established biofilms of S. enterica and P. aeruginosa, respectively. In addition, choline-geranate increased delivery of cefadroxil, an antibiotic, by >16-fold into the deep tissue layers of the skin without inducing skin irritation. The in vivo efficacy of choline-geranate was validated using a biofilm-infected wound model (>95% bacterial death after 2-h treatment). This work establishes the use of ILs for simultaneous enhancement of topical drug delivery and antibiotic activity.

Three-dimensional specimens of the volant fossil bird Gansus yumenensis from the Early Cretaceous Xiagou Formation of northwestern China demonstrate that this taxon possesses advanced anatomical features previously known only in Late Cretaceous and Cenozoic ornithuran birds. Phylogenetic analysis recovers Gansus within the Ornithurae, making it the oldest known member of the clade. The Xiagou Formation preserves the oldest known ornithuromorph-dominated avian assemblage. The anatomy of Gansus, like that of other non-neornithean (nonmodern) ornithuran birds, indicates specialization for an amphibious life-style, supporting the hypothesis that modern birds originated in aquatic or littoral niches.

Antiseptic agents are the primary arsenal to disinfect skin and prevent pathogens spreading within the host as well as into the surroundings; however the Food and Drug Administration published a report in 2015 requiring additional validation of nearly all current antiseptic agents before their continued use can be allowed. This vulnerable position calls for urgent identification of novel antiseptic agents. Recently, the ability of a deep eutectic, Choline And Geranate (CAGE), to treat biofilms of Pseudomonas aeruginosa and Salmonella enterica was demonstrated. Here it is reported that CAGE exhibits broad-spectrum antimicrobial activity against a number of drug-resistant bacteria, fungi, and viruses including clinical isolates of Mycobacterium tuberculosis, Staphylococcus aureus, and Candida albicans as well as laboratory strains of Herpes Simplex Virus. Studies in human keratinocytes and mice show that CAGE affords negligible local or systemic toxicity, and an ≈180-14 000-fold improved efficacy/toxicity ratio over currently used antiseptic agents. Further, CAGE penetrates deep into the dermis and treats pathogens located in deep skin layers as confirmed by the ability of CAGE in vivo to treat Propionibacterium acnes infection. In combination, the results clearly demonstrate CAGE holds promise as a transformative platform antiseptic agent for preventive as well as therapeutic applications.

Abstract The suitability of a habitat to an animal includes food availability, physical and climatic factors, population interactions, and safety from predators. Mappings of vegetation, soils, and microclimates across ecological landscapes have become standard and important tools for assessing an animal's habitat. More elusive to the researcher, yet of equal importance to the animal, has been the ability to map the predation risk perceived by an animal. Laundré et al., in developing the concept, defined the landscape of fear as the spatial map of the animal's predation cost of foraging. We mapped this landscape of predation costs by measuring the use of depletable food patches (yielding giving up densities [GUDs]) arranged as a grid across the landscape of interest. The landscapes of fear for 3 colonies of Cape ground squirrels (Xerus inauris) in Augrabies Falls National Park, South Africa, revealed large and distinct spatial variation in predation costs that appeared to be governed primarily by proximity to burrows and open sight lines. By converting the GUDs into quitting harvest rates (joules per minute), we believe we have translated the animals' perceptions of risk into a physical map whose contours across the landscape represent lines of equal foraging costs. Among the 3 colonies only 3–22% of the space resulted in low foraging costs (<2,500 J/min), whereas 31–92% of the sampled areas represented very high foraging costs (>5,000 J/min).

Abstract “Splitting” and “lumping” are perpetual problems in vertebrate, especially dinosaur, ichnotaxonomy. Chinese dinosaur ichnotaxonomy, which began in 1940, provides a series of interesting case studies, highlighting the dual problems of historical and dubious ichnotaxonomy. Chinese Mesozoic tetrapod track types have been placed into 63 ichnospecies (one Triassic, 28 Jurassic, and 34 Cretaceous), exclusive of other, non‐type ichnospecies or ichnotaxa identified from China. Fifty‐two (∼83%) of these 63 tetrapod ichnospecies were placed in monospecific ichnogenera. At the ichnogenus level, we prune—either by recognizing nomina dubia or by synonymy—17 from the list of 53 dinosaurian ichnogenera (a 32% reduction), leaving 36 ichnotaxa that we consider valid. Most of the cuts affect Jurassic theropod ichnotaxa, which are reduced from 23 to only nine because most ichnogenera are subjective junior synonyms of Grallator and Eubrontes . Fewer Chinese Cretaceous ichnotaxa (only six of 21 ichnogenera) are obvious nomina dubia or subjective synonyms, suggesting greater east Asian endemism during this time. Because ichnospecies differences are subtle, we provisionally retain ichnospecies as valid pending detailed comparative analyses of congeneric ichnospecies. This synthesis is long overdue and is necessary to address problems of historical and provincial ichnotaxonomy, which severely hamper comparisons of tetrapod ichnofaunas in space and time.

ABSTRACT ChatGPT, a language-learning model chatbot, has garnered considerable attention for its ability to respond to users’ questions. Using data from 14 countries and 186 institutions, we compare ChatGPT and student performance for 28,085 questions from accounting assessments and textbook test banks. As of January 2023, ChatGPT provides correct answers for 56.5 percent of questions and partially correct answers for an additional 9.4 percent of questions. When considering point values for questions, students significantly outperform ChatGPT with a 76.7 percent average on assessments compared to 47.5 percent for ChatGPT if no partial credit is awarded and 56.5 percent if partial credit is awarded. Still, ChatGPT performs better than the student average for 15.8 percent of assessments when we include partial credit. We provide evidence of how ChatGPT performs on different question types, accounting topics, class levels, open/closed assessments, and test bank questions. We also discuss implications for accounting education and research.

Although research demonstrates many negative family outcomes associated with single-parent households, little is known about processes that lead to positive outcomes for these families. Using 3 waves of longitudinal data, we examined how maternal dispositional optimism and life stressors are associated with parenting and child outcomes in 394 single mother African American families. Confirming prior research, we found that mothers' childhood adversities, current economic pressure, and internalizing problems were associated with lower levels of maternal warmth and child management and with lower child school competence. Extending previous studies, we found that maternal optimism was a positive resource, predicting lower levels of maternal internalizing symptoms and higher levels of effective child management and moderating the impact of economic stress on maternal internalizing problems. These findings highlight the need for further investigation of processes and resources that promote positive outcomes for African American mother-headed families and single mother families in general.

OBJECTIVES: Panoramic radiography was used to determine (1) intrarater and inter-rater reliability in assessing temporomandibular joint (TMJ) condylar morphology; (2) alteration in condylar shape in patients with temporomandibular disorders (TMD) and controls when matched by age, gender, and state of dentition; and (3) prevalence of condylar abnormalities in individuals with and without TMD. METHODS: One hundred panoramic radiographs were randomly selected from a hospital clinic (45 TMD and 55 non-TMD patients). The images were cropped to include only the temporomandibular apparatus and were independently evaluated by three examiners without knowledge of the patient's clinical status. Multiple statistical tests were performed to evaluate the accumulated data. RESULTS: Intrarater reliability demonstrated substantial agreement, while inter-rater reliability was fair. There was no difference in condylar morphology between patient groups, but mild condylar change was prevalent in all age groups, regardless of TMD status. CONCLUSIONS: Morphological condylar abnormalities are present on panoramic images in all adult age ranges, regardless of status of the dentition or presence of TMD. Condylar shape alone is not an indicator of TMD, and minor condylar discrepancies may have no significance in TMD.

Synopsis Suuwassea emilieae is a recently described dinosaur taxon discovered in the Upper Jurassic Morrison Formation of the western United States and the only non‐diplodocid flagellicaudatan (Dinosauria: Sauropoda) known from North America. It retains sauropod symplesiomorphies that are unexpected in a Late Jurassic taxon and thus sheds light on the evolutionary origins of the Flagellicaudata. Despite being comparatively small, the holotype of Suuwassea demonstrates hallmarks of relatively advanced age. A phylogenetic analysis of 30 taxa and 331 characters retains Suuwassea in a trichotomy with the Diplodocidae (Apatosaurus + (Diplodocus + Barosaurus)) and the Dicraeosauridae (Dicraeosaurus +Amargasaurus). This lack of resolution is probably due to a combination of missing data, character conflict and poor incorporation of specimens referred to diplodocid taxa that differ from their holotype specimens and species holotypes. Middle Jurassic palaeobiogeographical reconstructions conflict with the hypothetical distribution of flagellicaudatans in the Middle and Late Jurassic based on their phylogeny, implying that physical barriers, such as epeiric seas, were not responsible for limiting their initial radiation. The postparietal foramen shared by Suuwassea, Dicraeosaurus, Tornieria and Amargasaurus may correlate to preferred existence in near‐shore, terrestrial environments.

With the accelerating pace of global change, it is imperative that we obtain rapid inventories of the status and distribution of wildlife for ecological inferences and conservation planning. To address this challenge, we launched the SNAPSHOT USA project, a collaborative survey of terrestrial wildlife populations using camera traps across the United States. For our first annual survey, we compiled data across all 50 states during a 14-week period (17 August-24 November of 2019). We sampled wildlife at 1,509 camera trap sites from 110 camera trap arrays covering 12 different ecoregions across four development zones. This effort resulted in 166,036 unique detections of 83 species of mammals and 17 species of birds. All images were processed through the Smithsonian's eMammal camera trap data repository and included an expert review phase to ensure taxonomic accuracy of data, resulting in each picture being reviewed at least twice. The results represent a timely and standardized camera trap survey of the United States. All of the 2019 survey data are made available herein. We are currently repeating surveys in fall 2020, opening up the opportunity to other institutions and cooperators to expand coverage of all the urban-wild gradients and ecophysiographic regions of the country. Future data will be available as the database is updated at eMammal.si.edu/snapshot-usa, as will future data paper submissions. These data will be useful for local and macroecological research including the examination of community assembly, effects of environmental and anthropogenic landscape variables, effects of fragmentation and extinction debt dynamics, as well as species-specific population dynamics and conservation action plans. There are no copyright restrictions; please cite this paper when using the data for publication.

BACKGROUND: Fossil tracks made by non-avian theropod dinosaurs commonly reflect the habitual bipedal stance retained in living birds. Only rarely-captured behaviors, such as crouching, might create impressions made by the hands. Such tracks provide valuable information concerning the often poorly understood functional morphology of the early theropod forelimb. METHODOLOGY/PRINCIPAL FINDINGS: Here we describe a well-preserved theropod trackway in a Lower Jurassic ( approximately 198 million-year-old) lacustrine beach sandstone in the Whitmore Point Member of the Moenave Formation in southwestern Utah. The trackway consists of prints of typical morphology, intermittent tail drags and, unusually, traces made by the animal resting on the substrate in a posture very similar to modern birds. The resting trace includes symmetrical pes impressions and well-defined impressions made by both hands, the tail, and the ischial callosity. CONCLUSIONS/SIGNIFICANCE: The manus impressions corroborate that early theropods, like later birds, held their palms facing medially, in contrast to manus prints previously attributed to theropods that have forward-pointing digits. Both the symmetrical resting posture and the medially-facing palms therefore evolved by the Early Jurassic, much earlier in the theropod lineage than previously recognized, and may characterize all theropods.

The present investigation examined the relations between the cultural belief of familism and various aspects of family functioning and child adjustment, including interparental conflict, parenting, and children's attachment to school, in a sample of 549 two-parent Mexican-origin families. The results indicated that parents' familistic values were negatively associated with interparental conflict for both mothers and fathers. Parents' familistic values were also indirectly associated with parenting through the marital relationship. Interparental conflict was negatively associated with nurturant-involved parenting for both parents, but particularly for fathers. Interparental conflict had an indirect negative effect on children's attachment to school via mothers' and fathers' nurturant-involved parenting. Both paternal and maternal nurturant-involved parenting behaviors were positively associated with children's attachment to school across two time points. Child gender differences are also discussed.

Summary A growing body of literature suggests that some plants may engage in a game of Tragedy of the Commons when competing for soil resources. Two annual plants sharing a whole space will produce more roots per individual and less reproductive yield per individual than one plant with half the space to itself. Several papers have recently suggested that the increase in soil volume in going from a single plant to two competitor plants (as has been the case in empirical tests of the above prediction) may produce the increased root proliferation independent of the competitor. We extend the Tragedy of the Commons model of Gersani et al . (2001 ) to explicitly consider the separate effects of volume per plant ( V ) and nutrient concentration per unit volume ( N ) on root proliferation and yield of plants that ‘own’ their space relative to plants that share their space with a competitor. We then use simulations resulting from the model to evaluate existing data and the new perspectives provided by recent challenges to the conceptual basis for the Tragedy of the Commons. When N is held constant, increasing V should produce an almost linear increase in root proliferation and net nutrient profit for reproduction. The increase in roots should be more pronounced for two plants sharing their space, and the increase in yield should be more pronounced for plants with exclusive access to half the space. When V ¥ N is held constant, roots per plant should at first increase and then decline with increased volume. The difference between a plant that ‘owns’ its space vs. one that shares its space with a competitor should be less pronounced as V increases. Synthesis . We use this model to help clarify some confusion surrounding the Tragedy of the Commons theory of below‐ground competition by showing how issues raised by others are not incompatible with the approach used to generate the Tragedy of the Commons theory and highlight future opportunities for research on root growth strategies.

Abstract This paper examines the connections linking recent changes in Latino migration, the American meatpacking industry, and American immigration policy. As the meatpacking industry has vertically integrated and shifted to rural non-union areas throughout the South, it has grown increasingly dependent on short-term low-skilled employees. This process can be understood as the industrialization of meatpacking, where profitability depends on continuous high-throughput production. To succeed, the industrialization of meatpacking requires a large pool of easily replaceable labor that has no control over the pace work on of the shop floor. At the same time, as immigrants have been drawn to these new company towns, American immigration policy has turned increasingly towards border enforcement. We argue that the presence of illegal immigrants within the factories reduces the bargaining power of shop workers and increases employer control. Most studies of immigration have focused on the supply of migrant labor, the immigrants attracted to higher paying jobs. We argue that valuable insight is gained by looking at the manufacturers' demand for cheap labor and the implementation of an industrial strategy that requires it.

Abstract The research increases our understanding of a build‐to‐order supply chain (BOSC) by examining the effects of two distinct yet related strategies on applied supply chain knowledge and market performance: a build‐to‐order (BTO) and a just‐in‐time (JIT) strategy. The results show that a BTO strategy positively affects market performance through its influence on the application of supply chain knowledge downstream with customers. Although a JIT strategy does affect the upstream application of knowledge with suppliers, the latter does not predict market performance. Theoretical and managerial implications are presented.

Abstract: Vertebrae of Suuwassea demonstrate an interesting combination of plesiomorphies and autapomorphies among known members of the Flagellicaudata. The cranial cervical vertebrae have proportions close to Diplodocus but resemble those of Apatosaurus except by having greatly reduced cranial and caudal spinozygapophyseal laminae. As a result, they have craniocaudally compressed, caudally positioned spinous processes excavated on all sides by fossae. The cranial thoracic vertebrae are again similarly proportioned as those of Diplodocus but are morphologically similar to those of Apatosaurus. The most distinguishing feature of Suuwassea caudal vertebrae are the short, amphiplatyan, distalmost ‘whiplash’ caudal vertebrae. These may be either a retention of or a reversal to the plesiomorphic sauropod condition because classic flagellicaudatan, biconvex distalmost caudals occur in the Middle Jurassic of England.

In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins is mediated by the β-barrel assembly machinery (BAM). The mechanism employed by BAM is complex and so far- incompletely understood. Here, we report the structures of BAM in nanodiscs, prepared using polar lipids and native membranes, where we observe an outward-open state. Mutations in the barrel domain of BamA reveal that plasticity in BAM is essential, particularly along the lateral seam of the barrel domain, which is further supported by molecular dynamics simulations that show conformational dynamics in BAM are modulated by the accessory proteins. We also report the structure of BAM in complex with EspP, which reveals an early folding intermediate where EspP threads from the underside of BAM and incorporates into the barrel domain of BamA, supporting a hybrid-barrel budding mechanism in which the substrate is folded into the membrane sequentially rather than as a single unit.

In a collaborative effort to identify key aspects of heavy-duty diesel injector behavior, the Engine Combustion Network (ECN) Spray C and Spray D injectors were characterized in three independent research laboratories using constant volume pre-burn vessels and a heated constant-pressure vessel. This work reports on experiments with nominally identical injectors used in different optically accessible combustion chambers, where one of the injectors was designed intentionally to promote cavitation. Optical diagnostic techniques specifically targeted liquid- and vapor-phase penetration, combustion indicators, and sooting behavior over a large range of ambient temperatures—from 850 K to 1100 K. Because the large-orifice injectors employed in this work result in flame lengths that extend well beyond the optical diagnostics’ field-of-view, a novel method using a characteristic volume is proposed for quantitative comparison of soot under such conditions. Further, the viability of extrapolating these measurements downstream is considered. The results reported in this publication explain trends and unique characteristics of the two different injectors over a range of conditions and serve as calibration targets for numerical efforts within the ECN consortium and beyond. Building on agreement for experimental results from different institutions under inert conditions, apparent differences found in combustion indicators and sooting behavior are addressed and explained. Ignition delay and soot onset are correlated and the results demonstrate the sensitivity of soot formation to the major species of the ambient gas (i.e., carbon dioxide, water, and nitrogen in the pre-burn ambient versus nitrogen only in the constant pressure vessel) when holding ambient oxygen volume percent constant.

Purpose The purpose of this paper is to examine the impact of supply chain lead‐time averages and variability on an organization's financial performance. Design/methodology/approach The “executive” list for manufacturers, consisting of 1,264 individuals of the Institute of Supply Management provided the study's sampling frame, with surveys sent to 402 firms and responses obtained from 210 firms. The empirical model is tested using LISREL. Findings The results show that as variance in supply chain lead‐times increases, the financial performance of the organization decreases. Of equal significance, the results show that average supply chain lead‐times have no direct impact on financial performance. The results also indicate that demand uncertainty associates with greater supply chain lead‐time variance and that production technology routineness associates with lower supply chain lead‐time variance. Product complexity and organizational size have no impact on supply chain lead‐time variance or supply chain lead‐time average. Research limitations/implications The research is an initial effort to understand variance in supply chain systems. An ongoing challenge in this area is operationalization of measures and data collection techniques that go beyond a single firm and examine a network of organizations cooperating in a value‐added supply chain. Practical implications The results suggest that managing the variance in a supply chain system may be more important to an organization's financial performance than managing averages. Originality/value This is particularly significant since organizations often act contrary to these findings, focusing scarce resources on reducing average lead‐times rather than on reducing variability in supply chain lead‐times.