NobleBlocks

VA Northern Indiana Health Care System

Hospital / health systemFort Wayne, Indiana, United States

Research output, citation impact, and the most-cited recent papers from VA Northern Indiana Health Care System (United States). Aggregated across the NobleBlocks index of 300M+ scholarly works.

Total works
68
Citations
552
h-index
13
i10-index
18
Also known as
VA Northern Indiana Health Care System

Top-cited papers from VA Northern Indiana Health Care System

Peritoneal Dialysis Kinetic Modeling: Validation in a Multicenter Clinical Study
Edward F. Vonesh, John Burkart, Stephen D. McMurray, Paul Williams
1996· Peritoneal Dialysis International73doi:10.1177/089686089601600509

OBJECTIVE: To clinically validate the use of a computer-based kinetic model for peritoneal dialysis (PD) by assessing the level of agreement between measured and modeled values of urea and creatinine clearances and ultrafiltration (UF). DESIGN: An open multicenter observational study. PATIENTS: There were 111 adult continuous ambulatory peritoneal dialysis (CAPD) patients (47 female, 64 male) in four centers. All patients underwent a four-hour peritoneal equilibration test (PET) using 2.5% dextrose but with variable fill volumes (range: 1-3 L). Patients with a residual renal function greater than 10 mL/min were excluded. MAIN OUTCOME MEASURES: Correlations and limits of agreement between measured and modeled values of total weekly urea KT/V, total weekly normalized creatinine clearance (L/week/1.73 m2), daily drain volume (L), net ultrafiltration (L), daily peritoneal urea clearance (L/day), and daily peritoneal creatinine clearance (L/day). Measured values were obtained from 24-hour urine and dialysate collections while modeled values were based on results from the PET in combination with the PD ADEQUEST kinetic program. RESULTS: The results show there is excellent agreement between measured and modeled urea KT/V and creatinine clearances, with concordance correlations of 0.94 and 0.92, respectively. Given the excessive variation and limited range in ultrafiltration values, the concordance correlation between measured and modeled UF was only 0.50. In terms of daily peritoneal clearances and ultrafiltration, the level of precision (i.e., standard deviation) in the differences between modeled and measured values is +/- 1.05 L/day for urea clearance +/- 1.03 L/day for creatinine clearance, and +/- 0.919 L/day for ultrafiltration. By contrast, the level of precision (i.e., standard deviation) in the differences between two measured values is estimated to be +/- 0.979 L/day for urea clearance, +/- 0.802 L/day for creatinine clearance, and +/- 0.707 L/day for ultrafiltration. Defining the limits of clinical agreement to be +/- 2 standard deviations of the differences between two clinically measured 24-hour clearances (or ultrafiltration), we find that 94% of the modeled urea clearances, 87% of the modeled creatinine clearances, and 86% of the modeled ultrafiltration values fall within the limits of clinical agreement. CONCLUSION: Data for a carefully performed PET and overnight exchange can, in combination with a scientifically validated kinetic model, provide clinicians with a powerful mathematical tool for use in CAPD dialysis prescription management. Although not intended to replace actual measurements, kinetic modeling can prove useful as a means for predicting clearances for various alternative prescriptions and perhaps also as a means for checking certain types of noncompliance.

Patients' Views of Causes of Aggression by Patients and Effective Interventions
Ellen C. Fagan-Pryor, Linda Cade Haber, David Dunlap, Judith Lynn Nall +2 more
2003· Psychiatric Services37doi:10.1176/appi.ps.54.4.549

OBJECTIVE: The authors studied patients' perceptions of the causes of aggression by patients and their recommendations for interventions to prevent assaultive behavior. METHODS: A total of 92 inpatient and outpatient veterans, the majority of whom had a psychiatric diagnosis and some a medical diagnosis, answered questions in individual interviews about whether they had ever witnessed an assault. RESULTS: Fifty-two participants had witnessed aggression. Participants' answers about the causes of patient-to-patient and patient-to-staff aggression were categorized into internal factors-cognition, feelings, and symptoms-and interpersonal stressors, such as personality conflicts and abrasive words. The majority of causes identified were in the category of interpersonal stressors-67 percent for patient-to-patient aggression and 60 percent for patient-to-staff aggression. The participants' answers about suggested interventions to prevent both types of aggression were categorized as individual patient, cooperative patient-staff, and staff interventions. For patient-to-patient aggression, 52 percent of the interventions suggested were for staff. This proportion was 74 percent for patient-to-staff aggression. For both types of aggression, only 10 percent of the suggested interventions involved patient-staff cooperation. CONCLUSIONS: The participants indicated that both patients and staff play important parts in causing and in intervening to prevent violence. This information can be used to help plan programs to prevent and intervene in aggressive behavior.

Potential Advantages of Interprofessional Care in Rheumatoid Arthritis
Carrie Engen Marion, Lisa M. Balfe
2011· Journal of Managed Care Pharmacy28doi:10.18553/jmcp.2011.17.s9-b.s25

BACKGROUND: Rheumatoid arthritis (RA) affects over 1 million people in the United States. Although the emergence of new medications has substantially improved treatment options and outcomes for patients with RA, the disease is still a major cause of morbidity and mortality. In addition, significant barriers to adherence characterize RA medication management. A reasonable approach to improving RA patient outcomes entails interprofessional, multidisciplinary models of care. Working with rheumatology specialists, RA multidisciplinary care teams may comprise case managers, pharmacists, physical and occupational therapists, social workers, physiatrists, orthopedists, or other health professionals. Experience and evidence have supported the value of interprofessional, coordinated care models for patients with various chronic diseases. However, potential drawbacks include the costs associated with implementation of such approaches, the extra time required for their administration, and the lack of incentives for clinicians to adopt collaborative care approaches. OBJECTIVES: To summarize the arguments and evidence for interprofessional, multidisciplinary care programs in RA. SUMMARY: Various multidisciplinary models of RA care have been described in the literature. Whereas the case for implementing such models is underscored by the chronic nature of the disease, by its comorbidities and complications, and by barriers to patient medication adherence, cost-effectiveness analyses to document benefits of coordinated interprofessional RA care are lacking. Most studies on interprofessional care in RA are relatively old and have been conducted outside of the United States. Nonetheless, the findings are still relevant and may shed light on potential avenues for the development of new models in this country.

Overcoming Reluctance to Accept Home‐Based Support from an Older Adult Perspective
Lee A. Lindquist, Vanessa Ramirez‐Zohfeld, Chris Forcucci, Priya Sunkara +1 more
2018· Journal of the American Geriatrics Society27doi:10.1111/jgs.15526

OBJECTIVES: To understand older adult perceptions about accepting help at home, in particular fears related to potential loss of independence. DESIGN: Qualitative focus groups. SETTING: Rural, suburban, and urban areas of Fort Wayne, Indiana, and Chicago, Illinois. PARTICIPANTS: Community-dwelling adults aged 65 and older (N=68). MEASUREMENTS: Participants discussed decision-making, reluctance to accept home-based care, barriers, and resources that might affect remaining in the home. Three independent coders used constant comparative analysis to interpret results. RESULTS: Analysis revealed that reluctance to accept home-based support was associated with concerns over inability to complete tasks, perceptions of being burdensome to others, lack of trust in others, and lack of control. To overcome these concerns, some participants reframed the concept of independence to be "interdependence," with people continually depending on each other throughout their lives. Subjects noted that, even if one becomes more limited over time, the recognition that one is still contributing something meaningful to society is important to overcoming refusal of home assistance. Another strategy presented to overcome negative perceptions of accepting assistance in the home was the recognition that helping someone who is in need may engender positive emotions in those providing the help. CONCLUSION: Older adults perceived multiple reasons for refusing home-based assistance and offered potential strategies to overcome this reluctance. Addressing the reasons and promoting strategies to accept home-based support may lead older adults to have fewer unmet home-based needs, enabling them to remain safely in their homes.

Two Consecutive Clusters of Toxic Anterior Segment Syndrome
Wendy Moyle, Robert D. Yee, John K. Burns, Tim Biggins
2012· Optometry and Vision Science20doi:10.1097/opx.0b013e318279e991

PURPOSE: To present clinical findings and etiologic investigation of two consecutive clusters of toxic anterior segment syndrome (TASS) after uncomplicated phacoemulsification cataract surgery. CASE REPORT: At the Veterans Affairs Northern Indiana Health Care System Fort Wayne campus, 11 consecutive patients on two separate days in 2011 underwent clear corneal incision phacoemulsification cataract surgery by the same surgeon. On the first postoperative day, all patients had 1+ to 2+ diffuse limbus to limbus stromal edema and 2+ to 4+ anterior chamber white blood cells. Five eyes had inflammatory plaques on the surface of the intraocular implant, six had fibrin, three had hypopyon, and one had inflammatory debris "puff ball." Visual acuity ranged 20/70 to 20/400. Treatment included moxifloxacin four times a day, diclofenac four times a day, and prednisolone acetate 1% every 1 to 2 hours. In all patients, active inflammation and corneal edema resolved within 6 weeks, and visual outcome was 20/20. Cataract surgery was paused for 5 months after the first cluster of TASS and then immediately paused again after restarting because of a second cluster. Although no specific causes were identified, etiologic investigation resulted in the implementation of multiple changes. The changes included new replacement surgical instruments, disposable irrigation/aspirator tip and handle, risk of residue on reusable instruments minimized, preservative-free medications used when available, ophthalmic ointment eliminated, manufacturers' recommendations followed exactly, and eye instruments processed separately. Toxic anterior segment syndrome did not occur when surgery resumed 11 months after the last cluster. CONCLUSIONS: There are multiple possible etiologies of TASS. However, as in our clusters, specific causes are often not identified. Thorough review of all steps in surgery, processing of equipment and preparation of injectable solutions and materials, and adoption of best practices can prevent additional cases of TASS. Prompt diagnosis and treatment of TASS are extremely important because this leads to a desirable outcome.

Comparison of Registered Nurses' and Nursing Assistants' Choices of Intervention for Aggressive Behaviors
Linda Cade Haber, Ellen C. Fagan-Pryor, Monica Allen
1997· Issues in Mental Health Nursing19doi:10.3109/01612849709010328

This article extends the work conducted by Fagan-Pryor, Femea, and Haber (1994), in which factor analyses were used to examine the congruence between aggressive behavior and type of intervention warranted (verbal, chemical, or physical), as rated by nursing personnel. The purpose of this study was to determine if 88 registered nurses (RNs) and 84 nursing assistants (NAs) would choose similar interventions for 84 aggressive behaviors. The three scales used (labeled Precursor, Defensive, and Acting Out) obtained Cronbach alpha internal consistency reliabilities ranging from .79 to .96. Analyses of variance indicated that RNs and NAs agreed on a set of precursor behaviors for which they would use therapeutic verbal intervention. RN and NA responses differed significantly only in prescribing the use of physical intervention for behaviors on the Defensive and Acting Out scales. In both situations, RNs selected fewer behaviors that required physical intervention than did NAs. Implications for clinical practice are presented.

Medication-use evaluation with a Web application
Muriel Burk, Von Moore, Peter Glassman, Chester B. Good +3 more
2013· American Journal of Health-System Pharmacy16doi:10.2146/ajhp130252

PURPOSE: A Web-based application for coordinating medication-use evaluation (MUE) initiatives within the Veterans Affairs (VA) health care system is described. SUMMARY: The MUE Tracker (MUET) software program was created to improve VA's ability to conduct national medication-related interventions throughout its network of 147 medical centers. MUET initiatives are centrally coordinated by the VA Center for Medication Safety (VAMedSAFE), which monitors the agency's integrated databases for indications of suboptimal prescribing or drug therapy monitoring and adverse treatment outcomes. When a pharmacovigilance signal is detected, VAMedSAFE identifies "trigger groups" of at-risk veterans and uploads patient lists to the secure MUET application, where locally designated personnel (typically pharmacists) can access and use the data to target risk-reduction efforts. Local data on patient-specific interventions are stored in a centralized database and regularly updated to enable tracking and reporting for surveillance and quality-improvement purposes; aggregated data can be further analyzed for provider education and benchmarking. In a three-year pilot project, the MUET program was found effective in promoting improved prescribing of erythropoiesis-stimulating agents (ESAs) and enhanced laboratory monitoring of ESA-treated patients in all specified trigger groups. The MUET initiative has since been expanded to target other high-risk drugs, and efforts are underway to refine the tool for broader utility. CONCLUSION: The MUET application has enabled the increased standardization of medication safety initiatives across the VA system and may serve as a useful model for the development of pharmacovigilance tools by other large integrated health care systems.

Extent of use of long-acting injectable antipsychotics in children and adolescents within Indiana Medicaid
Taylor Modesitt, Erica Kubascik, Carol A. Ott
2018· Mental Health Clinician15doi:10.9740/mhc.2018.09.202

INTRODUCTION: Oral formulations of the antipsychotics aripiprazole, asenapine, lurasidone, olanzapine, paliperidone, quetiapine, and risperidone are indicated for use in pediatrics for several diagnoses. Long-acting injectable (LAI) antipsychotics are of interest in this special population because they may be used due to convenience and desire to improve adherence, despite limited support in the literature. The primary intent of this study is to provide descriptive information on the use of paliperidone palmitate, risperidone microspheres, aripiprazole extended-release injection, and olanzapine pamoate in pediatric patients within Indiana Medicaid. METHODS: This study was a retrospective database analysis, which retrieved information from Indiana Medicaid over a 2-year timeframe spanning from July 1, 2012, through June 30, 2014. The study included the prescription medications filled for all children and adolescents within Indiana Medicaid who received the LAI antipsychotics paliperidone palmitate, risperidone microspheres, aripiprazole extended-release injection, and olanzapine pamoate. RESULTS: From July 1, 2012, through June 30, 2014, 150 Indiana Medicaid patients younger than 18 years old were prescribed a LAI atypical antipsychotic. A total of 1013 LAI atypical antipsychotic doses were billed to Indiana Medicaid during the study period for pediatric patients. Paliperidone palmitate was billed most frequently. DISCUSSION: Long-acting injectable atypical antipsychotics are being prescribed for children and adolescents within Indiana Medicaid, despite minimal clinical evidence supporting use. There is a need for further research in this area to increase generalizability of results and aid in implementation of policies to prevent inappropriate use of LAI antipsychotics in children and adolescents.

High-dose transdermal nicotine replacement for tobacco cessation
Laurie Brokowski, Jiahui Chen, Sara J. Tanner
2014· American Journal of Health-System Pharmacy13doi:10.2146/ajhp130543

PURPOSE: The safety and efficacy of high-dose transdermal nicotine-replacement therapy (NRT) for the treatment of tobacco-use cessation were reviewed. SUMMARY: Transdermal nicotine doses of 7, 14, and 21 mg daily are approved by the Food and Drug Administration for use in tobacco cessation. However, studies have suggested that these doses are more adequate for people who smoke fewer than 20 cigarettes per day. A literature search was conducted to identify English-language studies that evaluated the use of transdermal nicotine doses of ≥42 mg daily. A total of 11 articles were identified, representing 10 separate trials. In terms of safety, the majority of the trials had no reports of serious adverse events related to transdermal NRT at doses of ≥42 mg daily. A dose-response relationship with adverse events occurred in most trials. In terms of efficacy, a numerically higher abstinence rate was achieved with high-dose transdermal NRT in all trials but 1. However, none of the studies showed significant differences in final abstinence rates at follow-up. Some reasons why statistical significance was not achieved in these trials may be related to the limitations of these trials, such as their small samples and the lack of a power calculation. A more robust trial is needed to support higher nicotine transdermal doses in tobacco cessation and to help elucidate which patient population would be most suitable for their use. CONCLUSION: The safety and efficacy of high-dose transdermal NRT for tobacco cessation have not been established in the medical literature.

Helping Seniors Plan for Posthospital Discharge Needs Before a Hospitalization Occurs: Results from the Randomized Control Trial of PlanYourLifespan.org
Lee A. Lindquist, Vanessa Ramirez‐Zohfeld, Priya Sunkara, Chris Forcucci +4 more
2017· Journal of Hospital Medicine12doi:10.12788/jhm.2798

BACKGROUND Hospitalized seniors are frequently too sick to make informed decisions about their postdischarge care. Subsequently, loved ones often make support choices (eg, skilled nursing facility placement, caregivers) at discharge. We sought to advance the timeline for postacute care decisions to before a hospitalization occurs. OBJECTIVE Investigate the effect of PlanYourLifespan.org (PYL) on knowledge of posthospital discharge options. DESIGN Multisite randomized controlled trial. SETTING/PATIENTS Nonhospitalized adults, aged ≥65 years, living in urban, suburban, and rural areas of Texas, Illinois, and Indiana. INTERVENTION PYL is a national, publicly available tool that provides education on posthospital therapy choices and local home‐based resources. MEASUREMENTS Participants completed an in‐person baseline survey, followed by exposure to intervention or attention control (AC) websites, then 1‐month and 3‐month telephone surveys. The primary knowledge outcome was measured with 6 items (possible 0‐6 points) pertaining to hospital discharge needs. RESULTS Among 385 participants randomized, mean age was 71.9 years (standard deviation 5.6) and 79.5% of participants were female. At 1 month, the intervention group had a 0.6 point change (standard deviation = 1.6) versus the AC group who had a ‐0.1 point change in knowledge score. Linear mixed modeling results suggest sex, health literacy level, level of education, income, and history of high blood pressure/kidney disease were significant predictors of knowledge over time. Controlling for these variables, treatment effect remained significant ( P < 0.0001). CONCLUSION Seniors who used PYL demonstrated an increased understanding of posthospitalization and home services compared to the control group. TRIAL REGISTRATION Clinicaltrials.gov Identifier: NCT0 2256072.

SAVE-CLC: An Intervention to Reduce Suicide Risk in Older Veterans following Discharge from VA Nursing Facilities
Katherine Luci, Kelsey Simons, Lauren Hagemann, M. Lindsey Jacobs +3 more
2019· Clinical Gerontologist12doi:10.1080/07317115.2019.1666444

Objective: We describe the development and implementation of a telephonic intervention (SAVE-CLC) piloted at three VA sites for Veterans returning to the community from VA nursing facilities (Community Living Centers or “CLCs”). Care transitions present a known period of medical risk for older adults and may pose increased risk for suicide. Veterans discharging from CLCs are at elevated risk compared to age and gender matched controls.Methods: Using a quality improvement approach, input was gathered from key stakeholders to aid in the development of the intervention. Veterans were screened for depressive symptoms and need for additional support by phone.Results: Of the Veterans who received the SAVE-CLC intervention, 87.9% had at least one prior mental health diagnosis, though only 19.7% had an outpatient mental health appointment arranged at CLC discharge. Results suggest that the intervention is feasible across multiple outpatient settings and is generally well-received by Veterans and caregivers, with 97% of those contacted reporting that the telephone calls were helpful.Conclusion: This flexible, telephone-based intervention addresses the unmet need of integrating mental health care into discharge planning during care transitions.Clinical Implications: SAVE-CLC offers a feasible and acceptable solution to suicide risk in older Veterans exiting a CLC.

Relationships Between Differences in Mother-Father Perceptions and Self-Concept and Depression in Children With Epilepsy
Linda Cade Haber, Joan K. Austin, Gertrude Huster, Kathleen A. Lane +1 more
2003· Journal of Family Nursing11doi:10.1177/1074840702239491

The purpose of this study was to explore relationships between differences in perceptions of mothers and fathers and self-concept and symptoms of depression, respectively, in 69 youth with epilepsy. Multiple regression was used to test whether the absolute difference scores between mothers’ and fathers’ perceptions of family adaptive resources, stigma, their children’s negative coping behaviors, and their attitudes toward epilepsy were predictors of child self-concept and depression after adjusting for epilepsy severity, children’s attitudes toward epilepsy, and children’s ratings of family adaptation. Only the mother-father differences related to children’s negative coping behaviors significantly predicted children’s self-concept and depressive symptoms. Findings suggest that differences in perceptions related to children may be more highly associated with the children’s outcomes than differences related to family characteristics or the children’s illness.

A Qualitative Study of the Change-of-Shift Report at the Patients’ Bedside
John Grimshaw, Daniel Hatch, Melissa Willard, Sam Abraham
2020· The Health Care Manager6doi:10.1097/hcm.0000000000000291

Concerns about patient bedside change-of-shift reporting at a community hospital in northern Indiana stimulated the development of this qualitative phenomenological study. A review of the literature revealed a research deficit in acute care nurses’ perceptions of bedside reporting in relation to compliance. The research question addressed in this study was, “What are acute care nurses’ perceptions of the change-of-shift report at the patients’ bedside?” Personal interviews were conducted on 7 medical, surgical, and intensive care unit nurse participants at a community hospital in northern Indiana. Five themes were identified from the collected data, which included the time factor, continuity of care, visualization, and challenges in the communication of discreet information.

Safety of total dose iron dextran infusion in geriatric patients with chronic kidney disease and iron deficiency anemia
Neville R. Dossabhoy, Steven Turley, Rebecca Gascoyne, Mihály Tapolyai +1 more
2014· Renal Failure5doi:10.3109/0886022x.2014.918785

There are limited data on total dose infusion (TDI) using iron dextran in geriatric chronic kidney disease (CKD) patients with iron-deficiency anemia (IDA). Our goal was to evaluate the safety of TDI in this setting. We conducted a retrospective chart review spanning a 5 year period (2002-2007), including all patients with CKD and IDA who were treated with iron dextran TDI. Patient demographics were noted, and laboratory values for creatinine, hemoglobin and iron stores were recorded pre- and post-dose. TDI diluted in normal saline was administered intravenously over 4-6 hours after an initial test dose. One hundred fifty-three patients received a total of 250 doses of TDI (mean ± SD=971 ± 175 mg); age was 69 ± 12 years and creatinine 3.3 ± 1.9 mg/dL. All stages of CKD were represented (stage 4 commonest). Hemoglobin and iron stores improved post-TDI (P<0.001). None of the patients experienced an anaphylactic reaction or death. Adverse events (AEs) were noted in 8 out of 250 administered doses (3.2%). The most common AEs were itching, chills and back pain. One hundred and ten doses of high molecular weight (HMW) iron dextran produced 6 AEs (5.45%), whereas 140 doses of low molecular weight (LMW) iron dextran produced 2 AEs (1.43%), a non-significant trend (P=0.1433 by Fishers Exact Test). Iron dextran TDI is relatively safe and effective in correcting IDA in geriatric CKD patients. Fewer AEs were noted with the LMW compared to the HMW product. LMW iron dextran given as TDI can save both cost and time, helping to alleviate issues of non-compliance and patient scheduling.

Establishment of Interrater Reliability for a Nursing Extrapyramidal Side Effects (EPS) Assessment Scale
Ellen C. Fagan-Pryor, Deborah L. May
2000· Journal of Nursing Care Quality5doi:10.1097/00001786-200004000-00007

Many patients who receive antipsychotic medications experience dystonia, akinesia, dyskinesia, and akathisia, collectively called Extrapyramidal Symptom Side Effects (EPS). The purpose of this study was to establish interrater reliability for a Nursing EPS Assessment Scale developed to focus on all four symptom areas. Twenty RNs and 12 patients participated in the instrument development studies. After several revisions, interrater reliability significance was demonstrated at the 0.01 level. It was concluded that the Nursing EPS Assessment Scale possessed good interrater reliability for nursing assessment of EPS.

In the presence of death and dying: death attitudes and compassion fatigue among certified nursing assistants in skilled care
Morgan K. Eichorst, Ashley Fromenthal, G Harris, C. Réel +1 more
2024· Aging & Mental Health5doi:10.1080/13607863.2024.2399089

OBJECTIVES: Certified Nursing Assistants (CNAs) are responsible for 80-90% of direct-to-resident care in skilled nursing facilities (SNFs), and may develop close, family-like relationships with their residents. With SNFs becoming a common place of death for older adults, CNAs now find themselves engaging in end-of-life caregiving with limited training and institutional support for emotional outcomes. This study aimed to understand and evaluate the relations between bereavement, death exposure, and compassion fatigue among CNAs, hypothesizing that (a) experiential avoidance moderates the relation between death exposure and negative death attitudes and (b) death attitudes moderate the relation between death exposure and compassion fatigue. METHOD: One hundred and ten CNAs across all shifts from four skilled nursing facilities in the southeastern United States participated in surveys and, potentially, focus groups. RESULTS: Results failed to find support for death exposure being related either to experiential avoidance or negative death attitudes. However, results supported the relation between negative death attitudes and compassion fatigue. CONCLUSION: Implications highlight the need to develop interventions focusing on palliative skills-based training and emotional support of CNAs in their role as end-of-life caregivers. By reducing compassion fatigue, it may be possible to decrease job turnover and increase quality-of-care for residents.

Understanding the Chronic Disease Management Programs: A Comprehensive Literature Review
Grace A Gbigbi-Jackson, John Aguguo, Okelue E Okobi, Oluwatosin B Iyun +2 more
2024· Medical Research Archives4doi:10.18103/mra.v12i7.5647

Chronic diseases, such as diabetes, heart disease, and chronic obstructive pulmonary disease (COPD), persist over a year and necessitate ongoing medical attention or limit daily activities, posing significant challenges to global healthcare systems and economies. Chronic disease management programs (CDMPs) aim to provide comprehensive, patient- centered care worldwide. This review synthesizes evidence from diverse studies, including observational research, systematic reviews, randomized trials, and retrospective analyses, to evaluate CDMP effectiveness across different populations and settings. Positive impacts include Chronic Disease Self- Management Education workshops reducing loneliness among older adults, eHealth interventions enhancing self- management skills and quality of life for chronic kidney disease patients, and lifestyle interventions benefiting cardiovascular health in low-income women. Technological innovations, such as personalized messaging systems, have improved engagement in diabetes prevention. CDMPs are pivotal in enhancing clinical outcomes, patient satisfaction, and reducing healthcare utilization through tailored, multidisciplinary approaches integrating technology. Challenges include ensuring consistent implementation and addressing access disparities. Future research should refine strategies, assess long-term sustainability, and explore innovative approaches to optimize chronic disease management globally. Continuous evolution of CDMPs is essential to mitigate chronic disease impacts, improving health outcomes and quality of life globally. Keywords: Chronic diseases, CDMPs, patient-centered care, effectiveness evaluation, multidisciplinary approaches, global health

Inductive Effect of a Ritonavir-Containing Hepatitis C Treatment Regimen on Warfarin in a Patient—A Case Report
Audrey Rosene, Jaymee L. Gaspar
2018· Journal of Pharmacy Practice3doi:10.1177/0897190018758541

The warfarin management strategy for a mechanical mitral valve patient initiated on a ritonavir-based hepatitis C treatment regimen is described. A 62-year-old male with a past medical history of hepatitis C genotype 1a and stable warfarin dose history was initiated on a concomitant Viekira Pak® (VP) regimen containing ritonavir. Prior to initiation of the VP for hepatitis C treatment, the patient was stable on a warfarin dose of 40 mg/wk for 5 months. During treatment with VP, the patient experienced a markedly decreased international normalized ratio (INR) and warfarin requirements ultimately increased 125% from baseline (90 mg/wk). Effective anticoagulation management throughout and surrounding the treatment period for hepatitis C involved frequent warfarin dose adjustments, including preemptive changes, close monitoring, and repeated use of enoxaparin to ensure adequate thrombotic prophylaxis. This is believed to be the first reported case describing the management of warfarin in a patient with hepatitis C who received VP and required a drastically increased weekly warfarin dose. The possible mechanisms suggestive of this interaction and similar case reports in the literature are discussed.

Appendectomy or not in middle-aged male with non-inflamed appendix in Amyand’s hernia? Case report and literature review☆
David S. Millay, Chiedozie Max Ofoma, Lionel R. Brounts
2020· International Journal of Surgery Case Reports3doi:10.1016/j.ijscr.2020.11.021

INTRODUCTION: An Amyand's hernia is a rare disease where a vermiform appendix is found within an inguinal hernia sac. It is reported in the literature as having an incidence between 0.4%-1.0% of reported hernia cases. Typically, an incidental finding, Amyand's hernia is consequently found more frequently intra-operatively rather than preoperatively. PRESENTATION OF CASE: This case is a recount of a 56-year-old male, who presented in an outpatient setting for the evaluation of right inguinal pain and bulge. The patient was diagnosed with a vermiform appendix within the indirect hernia. The patient underwent elective repair of his inguinal hernia via Transabdominal Preperitoneal (TAPP) approach of the hernia with avoidance of appendectomy. DISCUSSION: An Amyand's hernia presents a challenging diagnosis and the treatment algorithm is contingent on the condition of the appendix in individual cases. This case presents a Type 1 Amyand's hernia that was repaired through laparoscopic approach using prosthetic mesh. The aim of this case study highlights the approach to surgical decision making in the diagnosis and treatment of Amyand's hernia proposed in the current literature. CONCLUSION: This case presents a rare condition known as Amyand's hernia followed by a discussion on the epidemiology, diagnostic workup, and treatment options. Treatment is dependent on the state of the appendix found in the hernia sac and the clinical scenario. Comprehensive literature review shows that the true prevalence of this disease is lower than classically described and still has no clear standardized approaches.

Improving Suicide Risk Detection and Clinical Follow-up after Discharge from Nursing Homes
Michelle M. Hilgeman, Kelsey Simons, Emily Bower, M. Lindsey Jacobs +2 more
2021· Clinical Gerontologist3doi:10.1080/07317115.2021.1927280

Objectives: Suicide Awareness for Veterans Exiting Community Living Centers (SAVE-CLC) is a brief intervention to standardize suicide-risk screening and clinical follow-up after VA nursing home discharge. This paper examines the outcomes of SAVE-CLC compared to care as usual.Methods: A quasi-experimental evaluation was conducted (N = 124) with SAVE-CLC patients (n = 62) matched 1:1 to a pre-implementation comparison group. Data were obtained through VA Corporate Data Warehouse resources and chart reviews. Outcomes examined (within 30/90 days of discharge) included mortality rates, frequency of outpatient mental health visits, emergency department visits, rehospitalizations, depression screens (PHQ-2), and the latency period for outpatient mental health care.Results: A greater portion of SAVE-CLC patients received a depression screen after discharge, n = 42, 67.7% versus n = 8, 12.9%, OR = 14.2 (5.7, 35.3), p < .001. The number of days between discharge and first mental health visit was also substantially shorter for SAVE-CLC patients, M = 8.9, SD = 8.2 versus M = 17.6, SD = 9.1; t = 2.47 (122), p = .02. Significant differences were not observed in emergency department visits, hospitalizations, or mortality.Conclusions: SAVE-CLC is a time-limited intervention for detecting risk and speeding engagement in mental health care in the immediate high-risk post-discharge period.Clinical Implications: Care transitions present an important opportunity for addressing older adults’ suicide risk; brief telephone-based interventions like SAVE-CLC may provide needed support to individuals returning home.