Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

J. Elliott, Michael; N. Maini, Ravinder; Feldmann, Marc; Long‐Fox, Alice; Charles, Peter; Katsikis, Peter; M. Brennan, Fionula; Walker, Jean; Bijl, Hanny; Ghrayeb, John; N. Woody, James

doi:10.1002/art.1780361206

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Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

Shared by NobleBlocks on Dec 1, 1993 • 12:00 AM UTC

Authors:

Michael J. Elliott

Ravinder N. Maini

Marc Feldmann

Abstract

Abstract Objective. To evaluate the safety and efficacy of a chimeric monoclonal antibody to tumor necrosis factor α (TNFα) in the treatment of patients with rheumatoid arthritis (RA). Methods. Twenty patients with active RA were treated with 20 mg/kg of anti‐TNFα in an open phase I/II trial lasting...

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