Mechanistic Biomarkers Provide Early and Sensitive Detection of Acetaminophen-Induced Acute Liver Injury at First Presentation to Hospital

J. Antoine, Daniel; W. Dear, James; Starkey Lewis, Philip; Platt, Vivien; Coyle, Judy; Masson, Moyra; H. Thanacoody, Ruben; J. Gray, Alasdair; J. Webb, David; G. Moggs, Jonathan; D. Bateman, Nicholas; E. Goldring, Christopher; B. Park, Kevin

doi:10.1002/hep.26294

Public

Mechanistic Biomarkers Provide Early and Sensitive Detection of Acetaminophen-Induced Acute Liver Injury at First Presentation to Hospital

Shared by NobleBlocks on Aug 1, 2013 • 12:00 AM UTC

Authors:

Daniel J. Antoine

James W. Dear

Philip Starkey Lewis

Abstract

Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world. Early identification would facilitate patient-individualized treatment strategies. We investigated the potential of a panel of novel biomarkers (with enhanced liver ex...

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