SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Dejnirattisai, W.; Huo, J.; Zhou, Daming; Zahradník, J.; Supasa, P.; Liu, Chang; M. E. Duyvesteyn, Helen; Ginn, H.; Mentzer, A.; Tuekprakhon, A.; Nutalai, Rungtiwa; Wang, Beibei; Dijokaite, Aiste; Khan, Suman; Avinoam, Ori; Bahar, M.; Skelly, D.; Adele, S.; Johnson, S.; Amini, Ali; G. Ritter, Thomas; Mason, Chris; Dold, C.; Pan, D.; Assadi, S.; Bellass, A.; Omo-Dare, Nikki; Koeckerling, D.; Flaxman, A.; Jenkin, D.; Aley, P.; Voysey, M.; A. Costa Clemens, S.; Naveca, F.; Nascimento, V.; Nascimento, Fernanda; Fernandes da Costa, Cristiano; Resende, P.; Pauvolid-Corrêa, A.; Siqueira, M.; Baillie, V.; Serafin, Natali; Kwatra, G.; da Silva, Kelly; Madhi, S.; Nunes, M.; Malik, Tariq; Openshaw, P.; Baillie, J.; Semple, M.; Townsend, A.; A. Huang, Kuan-Ying; Tan, T.; Carroll, M.; Klenerman, P.; Barnes, E.; Dunachie, S.; Constantinides, B.; Webster, H.; Crook, D.; Pollard, A.; Lambe, T.; Paterson, N.; A. Williams, Mark; R. Hall, David; Fry, E.; Mongkolsapaya, J.; Ren, Jingshan; Schreiber, G.; Stuart, D.; Screaton, G.

doi:10.1016/j.cell.2021.12.046

Public

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Shared by NobleBlocks on Jan 1, 2022 • 12:00 AM UTC

Authors:

W. Dejnirattisai

J. Huo

Daming Zhou

Abstract

Summary On 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic ...

Subject

Medicine

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