Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised controlled equivalence trial.

Summary: Background: In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death, and abnormal behaviour and cognition. Some, large human cohort studies demonstrate an association between general anaesthesia at a young age and subsequent neur... View More