Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Munro, A.; Janani, L.; Cornelius, V.; Aley, P.; Babbage, G.; Baxter, D.; Bula, M.; Cathie, K.; Chatterjee, Krishna; Dodd, Kate; Enever, Y.; Gokani, K.; Goodman, A.; Green, C.; Harndahl, Linda; Haughney, J.; Hicks, A.; A. van der Klaauw, A.; Kwok, Jonathan; Libri, V.; Llewelyn, M.; McGregor, A.; Minassian, A.; Moore, P.; Mughal, M.; Mujadidi, Y.; Murira, J.; Osanlou, O.; Osanlou, R.; R Owens, Daniel; Pacurar, Mihaela; Palfreeman, A.; Pan, D.; Rampling, T.; Regan, K.; Saich, Stephen; Salkeld, J.; Saralaya, D.; Sharma, S.; Sheridan, Ray; Sturdy, A.; Thomson, E.; Todd, Shirley; Twelves, C.; Read, R.; Charlton, S.; Hallis, B.; Ramsay, M.; Andrews, N.; Nguyen-Van-Tam, J.; Snape, M.; Liu, Xinxue; Faust, S.; Riordan, A.; Ustianowski, A.; A Rogers, Chris; Hughes, Stephen; Longshaw, Laura; Stockport, Jane; Hughes, Rachel; Grundy, L.; Tudor Jones, Lona; Guha, Arpan; Snashall, Emma; Eadsforth, T.; Reeder, S.; Storton, K.; Munusamy, Malathi; Tandy, B.; Egbo, Akamino; Cox, S.; Ahmed, N.; Shenoy, Anil; Bousfield, R.; Wixted, D.; Gutteridge, H.; Mansfield, B.; Herbert, Christopher; Holliday, K.; Calderwood, J.; Barker, D.; Brandon, J.; Tulloch, H.; Colquhoun, Suzie; Thorp, H.; Radford, H.; Evans, Julie; Baker, H.; Thorpe, J.; Batham, S.; Hailstone, J.; Phillips, R.; Kumar, Dileep; Westwell, F.; Makia, Fiona; Hopkins, N.; Barcella, L.; Mpelembue, M.; Dabagh, M.; Lang, Matilda; Khan, F.; Adebambo, Olumide; Chita, S.; Corrah, T.; Whittington, A.; John, L.; Roche, S.; Wagstaff, L.; Farrier, A.; Bisnauthsing, K.; Serafimova, T.; Nanino, Elisa; Cooney, E.; Wilson-Goldsmith, Jaimie; Nguyen, H.; Mazzella, A.; Jackson, Beth; Aslam, Suahil; Bawa, Tanveer; Broadhead, S.; Farooqi, S.; M. Piper, Joshua; Weighell, Rowena; Pickup, L.; Shamtally, Djamila; Domingo, Jason; Kourampa, Evgenia; Hale, C.; Gibney, J.; Stackpoole, Michael; Rashid-Gardner, Zalina; Lyon, R.; McDonnell, Chloe; Cole, C.; Stewart, Anna; Mcmillan, G.; Savage, Mary; Beckett, H.; Moorbey, Chantelle; Desai, A.; Brown, Claire; Naker, Kush; Qureshi, Ehsaan; Trinham, Charlotte; Sabine, Charlotte; Moore, Sophie; Hurdover, Steve; Justice, E.; J. Smith, David; Plested, E.; Ferreira da Silva, Carla; White, Rachel; Robinson, H.; Cifuentes, L.; Morshead, Gertraud; Drake-Brockman, R.; Kinch, P.; Kasanyinga, Mwila; Clutterbuck, E.; Bibi, S.; S V Stuart, Arabella; Shaw, R.; Singh, Michael; Champaneri, Trishna; Irwin, Margaret; Khan, Mohammed; E Kownacka, Alicja; Nabunjo, Martha; Osuji, C.; Hladkiwskyj, John; Galvin, D.; K Patel, Gitaben; Mouland, J.; Longhurst, B.; Moon, M.; Giddins, Beth; Pereira Dias Alves, C.; Richmond, L.; Minnis, C.; Baryschpolec, S.; Elliott, Scott; Fox, L.; A. Graham, Victoria; Baker, Natalie; Godwin, K.; Buttigieg, Karren; Knight, Chanice; J. Brown, Phillip; Lall, Paminder; Shaik, Imam; Chiplin, Emily; Brunt, Emily; Leung, Stephanie; Allen, Lauren; Thomas, Steve; Fraser, Sara; Choi, Bea; Gouriet, Jade; Freedman, A.; Perkins, J.; Gowland, Andrew; Macdonald, J.; Seenan, J.; Starinskij, Igor; Seaton, A.; Peters, E.; Singh, S.; Gardside, Ben; Bonnaud, Avril; Davies, Ceri; Gordon, Elizabeth; Keenan, S.; Hall, Jane; Wilkins, S.; Tasker, S.; James, R.; Seath, Ingrid; Littlewood, Kelly; Newman, J.; Boubriak, I.; Suggitt, Debbie; Haydock, Helen; Bennett, S.; Woodyatt, W.; Hughes, K.; Bell, Judith; Coughlan, Tricia; van Welsenes, Donald; Kamal, M.; Cooper, Chris; Tunstall, Simon; Ronan, Nicholas; Cutts, R.; Dare, T.; T. N. Yim, Y.; Whittley, Sarah; Ricamara, Marivic; Hamal, Shama; Adams, Kirsty; Baker, H.; Driver, Kimberley; Turner, N.; Rawlins, T.; Roy, Subarna; Merida-Morillas, Marta; Sakagami, Yukari; Andrews, Antonette; Goncalves cordeiro, Lillian; Stokes, Matthew; Ambihapathy, W.; Spencer, Joanne; Parungao, Nina; Berry, L.; Cullinane, James; Presland, L.; Ross-Russell, Amy; C. Warren, Sarah; Baker, Jonathan; Oliver, A.; Buadi, A.; Lee, Kim; Haskell, L.; Romani, R.; Bentley, I.; Whitbred, Tim; Fowler, S.; T. Gavin, John; Magee, Alan; Watson, Tara; Nightingale, Kari; Marius, P.; Summerton, Eloise; Locke, Emily; Honey, ThomasJack; Lingwood, Aidan; de la Haye, Anastasia; S. Elliott, R.; Underwood, Karen; King, M.; Davies-Dear, Sharon; Horsfall, E.; Chalwin, Olivia; Burton, H.; Edwards, C.; Welham, B.; Garrahy, Sarah; Hall, F.; Ladikou, Eleni; Mullan, D.; Hansen, D.; Campbell, Marion; Dos Santos, Filipa; Habash-Bailey, Haniah; Lakeman, N.; Branney, D.; Vamplew, L.; Hogan, A.; Frankham, J.; Wiselka, M.; Vail, D.; Wenn, V.; Renals, V.; Ellis, K.; Lewis-Taylor, Jessica; Magan, J.; C. Hardy, Anna; Appleby, Kim

doi:10.1016/S0140-6736(21)02717-3

Public

Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Shared by NobleBlocks on Dec 2, 2021 • 12:00 AM UTC

Authors:

A. Munro

L. Janani

V. Cornelius

Abstract

Background Few data exist on the comparative safety and immunogenicity of different COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection of booster vaccines, we investigated the reactogenicity and immunogenicity of seven different COVID-19 vaccines as a third dos...

Subject

Medicine

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