SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability.

X Pfister, Sophia; Ahrabi, Sara; Zalmas, Lykourgos-Panagiotis; Sarkar, Sovan; Aymard, François; Z Bachrati, Csanád; Helleday, Thomas; Legube, Gaëlle; B La Thangue, Nicholas; C G Porter, Andrew; C Humphrey, Timothy

doi:10.1016/j.celrep.2014.05.026

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SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability.

Shared by NobleBlocks on Jun 26, 2014 • 12:00 AM UTC

Authors:

Sophia X Pfister

Sara Ahrabi

Lykourgos-Panagiotis Zalmas

Abstract

Modulating chromatin through histone methylation orchestrates numerous cellular processes. SETD2-dependent trimethylation of histone H3K36 is associated with active transcription. Here, we define a role for H3K36 trimethylation in homologous recombination (HR) repair in human cells. We find that dep...

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