Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.

Luesch, H.; Moore, R.; Paul, V.; Mooberry, S.; Corbett, T.

doi:10.1021/NP010049Y

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Isolation of Dolastatin 10 from the Marine Cyanobacterium Symploca Species VP642 and Total Stereochemistry and Biological Evaluation of Its Analogue Symplostatin 1

Shared by NobleBlocks on Jun 28, 2001 • 12:00 AM UTC

Authors:

Hendrik Luesch

Richard E. Moore

Valerie J. Paul

Abstract

The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and we now report its isolation from the marine cyanobacterium Symploca sp. VP642 from Palau. The chemically related analogue symplostatin 1 (2) has been reisolated from Guamanian and Hawaii...

Subject

Depsipeptide

Biology

Isolation (microbiology)

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