Molecular Self-Assembly of Bioorthogonal Aptamer-Prodrug Conjugate Micelles for Hydrogen Peroxide and pH-Independent Cancer Chemodynamic Therapy.

W, Xuan; Y, Xia; T, Li; L, Wang; Y, Liu; W, Tan

doi:10.1021/jacs.9b10755

Public

Molecular Self-Assembly of Bioorthogonal Aptamer-Prodrug Conjugate Micelles for Hydrogen Peroxide and pH-Independent Cancer Chemodynamic Therapy.

Shared by NobleBlocks on Dec 31, 2019 • 12:00 AM UTC

Authors:

Xuan W

Xia Y

Li T

Abstract

Chemodynamic therapy (CDT) has demonstrated new possibilities for selective and logical cancer intervention by specific manipulation of dysregulated tumorous free radical homeostasis. Current CDT methods largely rely on conversion of endogenous hydrogen peroxide (H2O2) into highly toxic hydroxyl rad...

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