Comprehensive Molecular Characterization of Urothelial Bladder Carcinoma

Weinstein, J.; Akbani, Rehan; Broom, B.; Wang, Wenyi; Verhaak, R.; McConkey, D.; Lerner, S.; Morgan, M.; Creighton, C.; Smith, Carolyn; Cherniack, A.; Kim, Jaegil; Pedamallu, C.; Noble, M.; Al-Ahmadie, H.; Reuter, V.; Rosenberg, J.; Bajorin, D.; Bochner, B.; Solit, D.; Koppie, T.; Robinson, B.; Gordenin, D.; Fargo, D.; Klimczak, L.; Roberts, S.; Au, J.; Laird, P.; Hinoue, T.; Schultz, N.; Ramirez, Ricardo; Hansel, D.; Hoadley, K.; Y. Kim, William; S. Damrauer, Jeffrey; Baylin, S.; Mungall, A.; G. Robertson, A.; Chu, Andy; Kwiatkowski, D.; Sougnez, C.; Cibulskis, K.; T. Lichtenstein, Lee; Sivachenko, A.; Stewart, Chip; Lawrence, M.; Getz, G.; Lander, E.; Gabrie, S.; Donehower, L.; Carter, S.; Saksena, G.; Schumacher, S.; Freeman, S.; Jung, Joonil; Bhatt, A.; J Pugh, Trevor; Beroukhim, R.; Meyerson, M.; Ally, Adrian; Balasundaram, M.; Butterfield, Y.; Dhalla, Noreen; Hirst, Carrie; Holt, R.; J. M. Jones, Steven; Lee, Darlene; Li, H.; Marra, M.; Mayo, Michael; A. Moore, Richard; Schein, J.; Sipahimalani, Payal; Tam, Angela; Thiessen, N.; Wong, Tina; Wye, N.; Bowlby, R.; Chuah, E.; Guin, R.; Shen, Hui; Bootwalla, M.; Triche, T.; H. Lai, Phillip; V. Berg, D.; Weisenberger, D.; Balu, S.; Bodenheimer, T.; Hoyle, A.; Jefferys, S.; Meng, S.; E. Mose, Lisle; Simons, J.; G. Soloway, Mathew; Wu, Junyuan; Parker, J.; Hayes, D.; Roach, J.; Buda, Elizabeth; D. Jones, Corbin; Mieczkowski, P.; Tan, Donghui; Veluvolu, Umadevi; Waring, S.; Auman, J.; Perou, C.; Wilkerson, M.; G Santoso, Netty; G Parfenov, Michael; Ren, X.; Pantazi, A.; Hadjipanayis, Angela; Seidman, J.; Kucherlapati, R.; Lee, Semin; Yang, Lixing; Park, P.; W. Xu, A.; Protopopov, A.; Zhang, Jianhua; Bristow, C.; S. Mahadeshwar, Harshad; Seth, S.; Song, Xingzhi; Tang, Jiabin; Zeng, Dong; Chin, L.; C. Guo, Charles; D. Casasent, Tod; Liu, Wenbin; Ju, Z.; C. Motter, Thomas; Peng, Bo; C. Ryan, Michael; Su, X.; Yeon Yang, Ji; Lorenzi, P.; Yao, Hui; Zhang, Nianxiang; Zhang, Jiexin; Mills, G.; Cho, Juok; Dicara, D.; Frazer, S.; Gehlenborg, Nils; I Heiman, David; Lin, Pei; Liu, Yingchun; Stojanov, P.; Voet, D.; Zhang, Hailei; Zou, L.; Bernard, Brady; Kreisberg, Dick; M. Reynolds, Sheila; Rovira, Hector; Shmulevich, I.; Gao, Jianjiong; Jacobsen, A.; A. Aksoy, B.; Antipin, Y.; Ciriello, G.; Dresdner, Gideon; E. Gross, Benjamin; Lee, William; Reva, B.; Shen, R.; Sinha, Rileen; O. Sumer, S.; Weinhold, Nils; Ladanyi, M.; Sander, C.; Benz, C.; E. Carlin, Daniel; Haussler, D.; Ng, S.; O. Paull, Evan; M. Stuart, Joshua; Zhu, Jingchun; Liu, Yuexin; Zhang, Wei; Taylor, B.; Lichtenberg, T.; Zmuda, E.; Barr, T.; D. Black, Aaron; M George, Myra; Hanf, B.; Helsel, Carmen; McAllister, Cynthia; Ramirez, N.; R. Tabler, Teresa; Weaver, Stephanie; Wise, L.; Bowen, Jay; Gastier-Foster, J.; Jian, W.; A Tello, Sebrina; Ittman, M.; D. Castro, Patricia; D. McClenden, Whitney; Gibbs, R.; Saller, Charles; Tarvin, Katherine; DiPiero, Jennifer; L Owens, Jennifer; Bollag, R.; Li, Qiang; Weinberger, P.; Czerwinski, Christine; Huelsenbeck-Dill, L.; Iacocca, M.; Petrelli, N.; Rabeno, B.; Swanson, P.; Shelton, T.; E. Curley, Erin; Gardner, J.; Mallery, D.; Penny, R.; V. Bằng, N.; Thi Hong Hanh, Phan; Kohl, B.; Le, X.; Duc Phu, Bui; A. Thorp, Richard; Tien, N.; Q. Vinh, L.; Sandusky, G.; Burks, E.; Christ, K.; Gee, J.; Holway, A.; Moinzadeh, A.; Sorcini, A.; Sullivan, T.; Garcia-Grossman, I.; Regazzi, A.; Boice, L.; Rathmell, W.; Thorne, L.; Bastacky, S.; Davies, B.; Dhir, R.; Gingrich, J.; Hrebinko, R.; Maranchie, J.; Nelson, J.; Parwani, A.; Bshara, W.; Gaudioso, Carmelo; Morrison, C.; Alexopoulou, V.; Bartlett, J.; Engel, J.; Kodeeswaran, S.; Antic, T.; O’Donnell, P.; Smith, N.; Steinberg, G.; C. Egea, Sophie; Gomez-Fernandez, C.; M. Herbert, Lynn; Jordá, M.; Soloway, M.; Beaver, Allison; Carter, Suzie; Kapur, P.; Lewis, C.; Lotan, Y.; Bondaruk, J.; Czerniak, B.; Skinner, E.; Aldape, K.; Jensen, M.; Kahn, A.; Pihl, T.; Pot, D.; Srinivasan, D.; Wan, Yunhu; Ferguson, M.; Zenklusen, J.; Davidsen, Tanja; Demchok, J.; Shaw, K.; Sheth, Margi; Tarnuzzer, R.; Wang, Zhining; Yang, Liming; Hutter, C.; Ozenberger, B.; Sofia, H.; Eley, G.

doi:10.1038/nature12965

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Comprehensive Molecular Characterization of Urothelial Bladder Carcinoma

Shared by NobleBlocks on Jan 29, 2014 • 12:00 AM UTC

Authors:

J. Weinstein

Rehan Akbani

B. Broom

Abstract

Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. So far, no molecularly targeted agents have been approved for treatment of the disease. As part of The Cancer Genome Atlas project, we report here an integrated analysis of 131 uro...

Subject

Medicine

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