GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Pairo-Castineira, E.; Rawlik, K.; Bretherick, A.; Qi, Ting; Wu, Yang; Nassiri, I.; McConkey, G.; Zechner, M.; Klarić, L.; Griffiths, Fiona; Oosthuyzen, W.; Kousathanas, A.; Richmond, Anne; E. Millar, Jonathan; D Russell, Clark; Malinauskas, T.; Thwaites, R.; Morrice, K.; S. Keating, Sean; Maslove, D.; Nichol, Alistair; Semple, M.; Knight, J.; Shankar-Hari, M.; Summers, C.; J. Hinds, Charles; Horby, P.; Ling, L.; McAuley, D.; Montgomery, Hugh; Openshaw, P.; Begg, Colin; Walsh, T.; Tenesa, A.; Flores, C.; Riancho, J.; Rojas-Martínez, A.; Lapunzina, P.; Johnny Manu Emma Latha Ruth J. Kenneth Heather Cei Clohisey Millar Shankar-Hari Aitkin Aravindan Arms, Sara; Johnny Manu Clohisey Millar Shankar-Hari, Sara; Clohisey, S.; E. Millar, Jonathan; Shankar-Hari, M.; Latha Ruth J. Kenneth Heather Ceilia Adam Primmy R Aitkin Aravindan Armstrong Baillie Biggs Boz Brown, Emma; Aitkin, E.; Aravindan, Latha; Armstrong, Ruth-Ann; K. Baillie, J.; Biggs, Heather; Boz, Ceilia; Brown, Adam; Chikowore, Primmy; Clark, R.; Coutts, A.; Coyle, J.; Cullum, Louise; Das, Sukamal; Day, Nicky; Donnelly, Lorna; Duncan, Esther; Finernan, Paul; Fourman, M.; Furlong, A.; Furniss, J.; Gallagher, B.; Gilchrist, T.; Golightly, A.; Griffiths, Fiona; Hafezi, K.; Hamilton, D.; Hendry, Ross; Kearns, Naomi; Law, D.; Law, Rachel; Law, Sarah; Lidstone-Scott, R.; Lauder, C.; Macgillivray, L.; Maclean, Alan; Mal, Hanning; McCafferty, Sarah; Mcmaster, Ellie; Meikle, J.; Moore, S.; Murphy, S.; Mybaya, Hellen; Odam, M.; Oosthuyzen, W.; Zheng, Chenqing; Chen, Jiantao; Parkinson, Nick; Paterson, T.; Tucker, P.; Schon, K.; Stenhouse, Andy; Das, Mihaela; C. Swets, Maaike; Szoor-McElhinney, Helen; Taneski, Filip; Turtle, L.; Wackett, Tony; Ward, Mairi; Weaver, J.; Wrobel, N.; Zechner, M.; Neus Tim Owen Rosario Martina Christopher Aneta Sa Pan Grau Jones Lim Marotti Whitton Bociek Campos A, Jacqueline; Pan, Jacqueline; Grau, Neus; Jones, T.; Lim, Rosario; Marotti, Martina; Whitton, C.; Bociek, A.; Campos, S.; Arbane, G.; Shankar-Hari, M.; Ostermann, M.; Cha, Min-hye; DAmato, Fabiola; Kosifidou, Eirini; Lorah, Shelley; Morera, Kyma; Laura Keith Jeremy Stephen Evie Jessica Abigail Jo Bircham Brady Hugill Henning Bonner Headlam Jones, Sarah; Bircham, S.; Brady, Laura; Hugill, K.; Henning, J.; Bonner, S.; Headlam, E.; K Jones, Jessica; List, A.; Morley, Joanne; Welford, A.; Kamangu, Bobette; Ratnakumar, Anitha; Shoremekun, Abiola; Raine Fatima Jack Sarah Matthew Catherine Ruth Mau Alldis Astin-Chamberlain Bibi Biddle Blow Bolton B, Zoe; Alldis, Z.; Astin-Chamberlain, R.; Bibi, F.; Biddle, J.; Blow, S.; Bolton, M.; Borra, C.; Bowles, Ruth; Burton, Maudrian; Choudhury, Y.; Cox, Amber; Easthope, A.; Ebano, P.; Fotiadis, Stavros; Gurasashvili, J.; Halls, Rosslyn; Hartridge, Pippa; Kallon, D.; Kassam, J.; Lancoma-Malcolm, I.; Matharu, Maninderpal; May, P.; Mitchelmore, O.; Newman, Tabitha; D. Patel, Mital; Pheby, J.M.; Pinzuti, Irene; Prime, Z.; Prysyazhna, O.; Shiel, Julian; Taylor, Melanie; Tierney, C.; Zongo, O.; Wood, S.; Żak, A.; Collier, David; Christopher Lisa Minnie David Nageswar Lucy Michel Mundy Thompson Pritchard Gellamucho Cartlidge Band, Manuela; Mundy, Manuela; Thompson, Christopher; Pritchard, L.; Gellamucho, M.; Cartlidge, D.; Bandla, N.; Bailey, Lucy; Davies, M.; Delaney, Jane; Scott, Leanne; Frater David Munzir Arunkumar Samuel Zoe Dharam Ku Abdelrazik Alasdair Carter Elhassan Ganesan Jenkin, Marwa; Abdelrazik, M.; Alasdair, Frater; Carter, David; Elhassan, M.; Ganesan, A.; Jenkins, Samuel; Lamond, Z.; Purohit, D.; Rohit, Kumar; Saleem, Malik; Wall, A.; Xavier, K.; Bakthavatsalam, Dhanalaksmi; Gehad, Kirolos; Gnanapragasam, P.; Jain, K.; Jain, Swati; Malik, Abdul; Pappachan, Naveen; Moreno-Cuesta, J.; Haldeos, A.; Vincent, R.; Oziegb, Maryjane; Maeve Eleanor Maria Clare Ellen Abigail Monalisa E Cavazza Cockrell Corcoran Depante Finney Jerome Kn, Anna; Cavazza, A.; Cockrell, Maeve; Corcoran, E.; Depante, M.; Finney, C.; Jerome, E.; Knighton, A.; Nayak, Monalisa; Pappa, Evita; Saha, Rohit; Saha, Sian; Dodd, A.; O’Reilly, Kevin; Mcphail, M.; Clarey, E.; Noble, H.; Smith, John; Stephen Anthony Maie David Dorota Sarah Ziortza El Coghlan Brett Gordon Templeton Antcliffe Banach Da, Phoebe; Coghlan, Phoebe; Brett, Stephen; Gordon, A.; Templeton, Maie; Antcliffe, D.; Banach, D.; Darnell, S.; Fernandez, Z.; Jepson, E.; Mohammed, Amal; Rojo, Roceld; Arias, S.; Gurung, A.; Wong, J.; David O. Emily Brian Maria Lopez Suleman Alicia A. Fernandez-Roman Hamilton Johnson Johnston Martinez, Jaime; Fernandez-Roman, Jaime; O. Hamilton, David; Johnson, Emily; W. Johnston, Brian; Martinez, M.; Mulla, Suleman; Waite, A.; Williams, K.; Waugh, V.; Welters, I.; Emblem, Jessica; Norris, M.; Shaw, D.; Sally Paula Stuart Neil Soya Grace Jung Jean Bashyal Beer Hutton McKechnie Davidson Mathew Read, Archana; Bashyal, A.; Beer, S.; Hutton, P.; McKechnie, S.; Davidson, N.; Mathew, Soya; Readion, Grace; Ryu, J.; Wilson, Jean; Kay Megan Eoghan Petra Muhammad Charlotte Esther A Agrawal Elston Jones Meaney Polgarova Elbehery Sum, Shruti; Agrawal, S.; Elston, Kayla; Jones, Megan; D Meaney, Eoghan; Polgarova, P.; Elbehery, Muhammad; Summers, C.; Daubney, E.; Ng, A.; Marshall, Jocelyn; Pathan, N.; Stroud, Katerina; White, Deborah; Saima Amy Martin Margaret Cecilia Lucy Julia Shuyi Andrew Ashraf Clark Dent Langley Peters Ryan Samps, Angela; Andrew, Angela; Ashraf, Saima; Clark, Amy; Dent, M.; Langley, M.; Peters, C.; Ryan, L.; Sampson, J.; Wei, Shuying; Baddeley, A.; Meredith, M.; Morris, L.; Gibbons, A.; A. McLoughlin, Lisa; Castro Victoria Deborah Lijun Georgia Obiageri Abi Delgado Clark Dawson Ding Durrant Ezeobu Harrison, Carlos; Delgado, C.; Clark, Victoria; Dawson, D.; Ding, Lijun; Durrant, Georgia; Ezeobu, O.; Harrison, Abiola; Hurt, W.; Kanu, Rebecca; Kinch, Ashley; Leaver, S.; Lisboa, A.; Mathew, Jisha; Patel, K.; Saluzzio, R.; Rawlins, J.; Samakomva, T.; Shah, Nirav; Sicat, Christine; Texeira, J.; de Queiroz, J.G.B.; Fernandes Da Gloria, Edna; Maccacari, E.; Yun, Nikki; Manna, S.; Farnell-Ward, S.; Maizcordoba, Maria; Thanasi, Maria; Haji Ali, Hawakin; Lina Musarat Bobby Sam Tatiana Lace Helen Mandeep- Hastings Grauslyte Hussain Ruge King Pogreban Rosa, Janice; Hastings, J.; Grauslyte, L.; Hussain, Musarat; Ruge, Bobby; King, Sam; Pogreban, T.; Rosaroso, L.; Smith, H.; Phull, M.; Adams, N.; R. Franke, George; George, A.; Šalčiūtė, E.; Wong, Joanna; Dunne, K.; Flower, L.; Sharland, E.; Sra, Sukhmani; Marie Lucy Lucy Kenneth Maria Sophie Kate Sarah Ka Andrew Callaghan Barclay Marshall Baillie Amamio B, Gillian; Andrew, G.; Callaghan, M.; Barclay, L.; Marshall, L.; Baillie, K.; Amamio, Maria; Birch, Sophie; Briton, K.; Clark, Sarah; Doverman, Katerine; Hope, D.; Mcculloch, Corrienne; Simpson, Scott; A. Singleton, Joseph; Meryem David Rebecca Jonathan Jacyntha Adam India Fernandez Allen Baptista Crowe Fox Khera Loveridge, Rita; Fernández, Rita; Allen, Meryem; Baptista, David; Crowe, R.; Fox, J.; Khera, J.; Loveridge, Adam; Mckenley, India; Morino, E.; Naranjo, Andrés; O’connor, D.; Simms, R.; Sollesta, K.; Swain, A.; Venkatesh, H.; Herdman-Grant, Rosie; Joseph, Anosh; Steve David Helen Lutece Helen Zoe Shenu Andrew Nown Rose Pogson Boxall Brimfield Claridge Daly Ge, Angela; Nown, Angela; Rose, S.; Pogson, D.; Boxall, H.; Brimfield, L.; Claridge, Helen; Daly, Z.; George, Shenu; Gribbin, A.; Sean Owen Anna Shiney Anne Emma Gemma Tamas Abby K Cheema Cutler Richards Roynon-Reed Cherian Heron W, Yusuf; Cheema, Y.; Cutler, S.; Richards, O.; Roynon-Reed, A.; Cherian, S.; E. Heron, A.; Williams, Gemma; Szakmany, T.; Waters, A.; Collins, Kim; Dunhill, Jill; Jones, F.; Morris, Rebecca; Ship, Lucy; Cardwell, Amynta; Ravi Rachel Srikanth Dabheoc Jack Joseph Christoph Ali Bhatterjee Bolton Chukkambotla Coleman Dalziel, Syamlan; Ali, Syamlan; Bhatterjee, Ravi; Bolton, Rachel; Chukkambotla, S.; Coleman, Dabheoc; Dalziel, J.; Dykes, Joseph; Fine, Christopher; Gay, Bethan; Goddard, W.; Goodchild, Drew; Harling, Rhiannan; Hijazi, M.; Keith, S.; Khan, Meherunnisa; Matt, Roseanna; Ryan-Smith, J.; Saad, Samuel; Springle, P.; Thomas, Jacqueline; Truman, N.; Kazi, Aayesha; Smith, Matthew; Collier, H.; Davison, C.; Duberley, S.; Hargreaves, Jeanette; Hartley, J.; Patel, Tahera; Smith, E.; Emma Ahmed Clare Susan Hywel Matthew Sara Liane Re Kent Goodwin Zaki Tibke Hopkins Gerrard Jackson Be, Alissa; Kent, A.; Goodwin, E.; Zaki, Ahmed; Tibke, C.; Hopkins, Susan; Gerrard, Hywel; Jackson, M.; Bennett, S.; Marsh, Liane; M. Mills, Rebecca; Helen Angela Steve Stacey Lisa Gemma Stacey Tracy Bell Campbell Dawson Dodds Duffy Gallagher McCaffe, Jessica; Bell, J.; Campbell, H.; C. Dawson, Angela; Dodds, S.; Duffy, Stacey; Gallagher, L.; L McCafferty, Gemma; Short, S.; Smith, Tracy; Thomas, K.; Walker, C.; Reynolds, Jessica; Yates, B.; Mckie, H.; Panteli, Maria; Thompson, M.; Waddell, Gail; Azmerelda Charlie Rumanah Rhianna Emily Imrun Fara De Beger Abraheem Dunmore Girach Jones London Nagr, Sarah; De Beger, Sarah; Abraheem, A.; J. Dunmore, Charlotte; Girach, R.; Jones, Rhianna; London, Emily; Nagra, I.; Nasir, F.; Sainsbury, Hannah; Smedley, C.; Brearey, S.; Burchett, C.; Cawley, K.; Faulkner, M.; Jeffrey, H.; Bamford, P.; Shaikh, F.; Slack, L.; Davies, A.; Jose Cebrian Ruth Karen John Alice Rajdeep Elizabe Brooke Suarez Charlesworth Hansson Norris Poole Sa, Hollie; Brooke, Hollie; C. Suarez, J.; Charlesworth, R.; Hansson, Karen; Norris, J.; Poole, A.; S Sandhu, Rajdeep; Smithson, Elizabeth; Thirumaran, M.; Wagstaff, V.; Buckley, S.; Sloan, B.; Rose, A.; E. Major, Amy; Metcalfe, A.; Pauline Susan Alexandre Louise Stephen Clare Matt Almaden-Boyle Austin Chapman Eros Cabrelli Cole Wh, Christine; Almaden-Boyle, C.

doi:10.1038/s41586-023-06034-3

Public

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Shared by NobleBlocks on May 17, 2023 • 12:00 AM UTC

Authors:

E. Pairo-Castineira

K. Rawlik

A. Bretherick

Abstract

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling ( JAK1 ), monocyte–macrophage activation and endothelial permeability ( PDE4A ), immunometabolism ( SLC2A5 and AK5 ), and host factors required for viral entry and replication ( TMPRS...

Subject

Medicine

Research Assistant

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