Integrated genomic and molecular characterization of cervical cancer

D. Burk, Robert; Chen, Zigui; Saller, Charles; Tarvin, Katherine; L. Carvalho, Andre; Scapulatempo-Neto, Cristovam; C. Silveira, Henrique; H. Fregnani, José; J. Creighton, Chad; L. Anderson, Matthew; Castro, Patricia; S. Wang, Sophia; Yau, Christina; Benz, Christopher; Gordon Robertson, A.; Mungall, Karen; Lim, Lynette; Bowlby, Reanne; Sadeghi, Sara; Brooks, Denise; Sipahimalani, Payal; Mar, Richard; Ally, Adrian; Clarke, Amanda; J. Mungall, Andrew; Tam, Angela; Lee, Darlene; Chuah, Eric; E. Schein, Jacqueline; Tse, Kane; Kasaian, Katayoon; Ma, Yussanne; A. Marra, Marco; Mayo, Michael; Balasundaram, Miruna; Thiessen, Nina; Dhalla, Noreen; Carlsen, Rebecca; A. Moore, Richard; A. Holt, Robert; J. M. Jones, Steven; Wong, Tina; Pantazi, Angeliki; Parfenov, Michael; Kucherlapati, Raju; Hadjipanayis, Angela; Seidman, Jonathan; Kucherlapati, Melanie; Ren, Xiaojia; W. Xu, Andrew; Yang, Lixing; J. Park, Peter; Lee, Semin; Rabeno, Brenda; Huelsenbeck-Dill, Lori; Borowsky, Mark; Cadungog, Mark; Iacocca, Mary; Petrelli, Nicholas; Swanson, Patricia; I. Ojesina, Akinyemi; A. Murray, Bradley; Zhang, Hailei; D. Cherniack, Andrew; Sougnez, Carrie; Sekhar Pedamallu, Chandra; Lichtenstein, Lee; Meyerson, Matthew; S. Noble, Michael; I. Heiman, David; Voet, Doug; Getz, Gad; Saksena, Gordon; Kim, Jaegil; Shih, Juliann; Cho, Juok; S. Lawrence, Michael; Gehlenborg, Nils; Lin, Pei; Beroukhim, Rameen; Frazer, Scott; B. Gabriel, Stacey; E. Schumacher, Steven; Le, Xuan; Sandusky, George; N. Adebamowo, Sally; Akeredolu, Teniola; Adebamowo, Clement; M. Reynolds, Sheila; Shmulevich, Ilya; Shelton, Candace; Crain, Daniel; Mallery, David; Curley, Erin; Gardner, Johanna; Penny, Robert; Morris, Scott; Shelton, Troy; Liu, Jia; Lolla, Laxmi; Chudamani, Sudha; Wu, Ye; Birrer, Michael; D. McLellan, Michael; H. Bailey, Matthew; A. Miller, Christopher; A. Wyczalkowski, Matthew; S. Fulton, Robert; C. Fronick, Catrina; Lu, Charles; R. Mardis, Elaine; L. Appelbaum, Elizabeth; K. Schmidt, Heather; A. Fulton, Lucinda; G. Cordes, Matthew; Li, Tiandao; Ding, Li; K. Wilson, Richard; S. Rader, Janet; Behmaram, Behnaz; Uyar, Denise; Bradley, William; Wrangle, John; Pastore, Alessandro; A. Levine, Douglas; Dao, Fanny; Gao, Jianjiong; Schultz, Nikolaus; Sander, Chris; Ladanyi, Marc; Einstein, Mark; Teeter, Randall; Benz, Stephen; Wentzensen, Nicolas; Felau, Ina; C. Zenklusen, Jean; Bodelon, Clara; A. Demchok, John; Yang, Liming; Sheth, Margi; L. Ferguson, Martin; Tarnuzzer, Roy; Yang, Hannah; Schiffman, Mark; Zhang, Jiashan; Wang, Zhining; Davidsen, Tanja; Olaniyan, Olayinka; M. Hutter, Carolyn; J. Sofia, Heidi; A. Gordenin, Dmitry; Chan, Kin; A. Roberts, Steven; J. Klimczak, Leszek; Van Waes, Carter; Chen, Zhong; D. Saleh, Anthony; Cheng, Hui; Parfitt, Jeremy; Bartlett, John; Albert, Monique; Arnaout, Angel; Sekhon, Harman; Gilbert, Sebastien; Peto, Myron; Myers, Jerome; Harr, Jodi; Eckman, John; Bergsten, Julie; Tucker, Kelinda; Anne Zach, Leigh; Y. Karlan, Beth; Lester, Jenny; Orsulic, Sandra; Sun, Qiang; Naresh, Rashi; Pihl, Todd; Wan, Yunhu; Zaren, Howard; Sapp, Jennifer; Miller, Judy; Drwiega, Paul; M. Leraas, Kristen; M. Lichtenberg, Tara; Zmuda, Erik; Bowen, Jay; Frick, Jessica; M. Gastier-Foster, Julie; Wise, Lisa; Gerken, Mark; C. Ramirez, Nilsa; Danilova, Ludmila; Cope, Leslie; B. Baylin, Stephen; B. Salvesen, Helga; P. Vellano, Christopher; Ju, Zhenlin; Diao, Lixia; Zhao, Hao; Chong, Zechen; C. Ryan, Michael; Martinez-Ledesma, Emmanuel; G. Verhaak, Roeland; Averett Byers, Lauren; Yuan, Yuan; Chen, Ken; Ling, Shiyun; B. Mills, Gordon; Lu, Yiling; Akbani, Rehan; Seth, Sahil; Liang, Han; Wang, Jing; Han, Leng; N. Weinstein, John; A. Bristow, Christopher; Zhang, Wei; S. Mahadeshwar, Harshad; Sun, Huandong; Tang, Jiabin; Zhang, Jianhua; Song, Xingzhi; Protopopov, Alexei; R. Mills Shaw, Kenna; Chin, Lynda; Olabode, Oluwole; DiSaia, Philip; Radenbaugh, Amie; Haussler, David; Zhu, Jingchun; Stuart, Josh; Chalise, Prabhakar; Koestler, Devin; L. Fridley, Brooke; K. Godwin, Andrew; Madan, Rashna; Ciriello, Giovanni; Martinez, Cathleen; Higgins, Kelly; Bocklage, Therese; Todd Auman, J.; M. Perou, Charles; Tan, Donghui; S. Parker, Joel; A. Hoadley, Katherine; D. Wilkerson, Matthew; A. Mieczkowski, Piotr; Skelly, Tara; Veluvolu, Umadevi; Neil Hayes, D.; Kimryn Rathmell, W.; P. Hoyle, Alan; V. Simons, Janae; Wu, Junyuan; E. Mose, Lisle; G. Soloway, Matthew; Balu, Saianand; Meng, Shaowu; R. Jefferys, Stuart; Bodenheimer, Tom; Shi, Yan; Roach, Jeffrey; B. Thorne, Leigh; Boice, Lori; Huang, Mei; D. Jones, Corbin; Zuna, Rosemary; Walker, Joan; Gunderson, Camille; Snowbarger, Carie; Brown, David; Moxley, Katherine; Moore, Kathleen; Andrade, Kelsi; Landrum, Lisa; Mannel, Robert; McMeekin, Scott; Johnson, Starla; Nelson, Tina; Elishaev, Esther; Dhir, Rajiv; Edwards, Robert; Bhargava, Rohit; G. Tiezzi, Daniel; M. Andrade, Jurandyr; Noushmehr, Houtan; Gilberto Carlotti Jr, Carlos; Pretti da Cunha Tirapelli, Daniela; J. Weisenberger, Daniel; J. Van Den Berg, David; T. Maglinte, Dennis; S. Bootwalla, Moiz; H. Lai, Phillip; Triche Jr, Timothy; M. Swisher, Elizabeth; J. Agnew, Kathy; Simon Shelley, Carl; W. Laird, Peter; Schwarz, Julie; Grigsby, Perry; Mutch, David

doi:10.1038/NATURE21386

Public

Integrated genomic and molecular characterization of cervical cancer

Shared by NobleBlocks on Jan 20, 2017 • 12:00 AM UTC

Authors:

Robert D. Burk

Zigui Chen

Charles Saller

Abstract

Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns ...

Subject

Cervical cancer

APOBEC

ARID1A

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!